RESUMO
In the title compound, C(20)H(19)N(3)O, the dihedral angles formed by the pyrazolone ring with the two phenyl rings are 64.27â (6) and 17.00â (6)°. The mol-ecular structure is stabilized by intra-molecular N-Hâ¯O and C-Hâ¯O hydrogen bonds. In the crystal, the mol-ecules are linked into chains along the b axis by inter-molecular C-Hâ¯O hydrogen bonds.
RESUMO
The title compound, C(20)H(19)N(3)O, exists in a keto-enamine tautomeric form. The pyrazolone ring makes dihedral angles of 20.52â (10) and 77.73â (5)° with the two phenyl rings and an intra-molecular N-Hâ¯O hydrogen bond occurs. A weak inter-molecular C-Hâ¯O hydrogen bond is observed in the crystal structure. The allyl group is disordered over two positions, with site-occupancy factors of 0.533â (5) and 0.467â (5).
RESUMO
In the title compound, C(18)H(20)N(2)O(3), the dihedral angle between the indole ring system (r.m.s. deviation = 0.018â Å) and the hy-droxy-methyl-enepyrrolidine-2,4-dione plane (r.m.s. deviation = 0.036â Å) is 9.87â (7)°. The keto and enol groups are involved in an intra-molecular O-Hâ¯O hydrogen bond. An intra-molecular C-Hâ¯O inter-action also occurs. The sec-butyl group is disordered over two orientations corresponding to an approximate 180° rotation about the N-C bond, with occupancies of 0.670â (6) and 0.330â (6). In the crystal, mol-ecules are linked into chains along the c axis by C-Hâ¯O hydrogen bonds.
RESUMO
In the title compound, C(16)H(19)NO(4), a potent new herbicide, the dihedral angle between the benzene and pyrrolidine rings is 11.09â (8)°. Intra-molecular O-Hâ¯O and C-Hâ¯O hydrogen bonds are observed.
RESUMO
OBJECTIVE: To study the relationship between the inhibitory effects of Tongxie Yaofang, a compound traditional Chinese herbal medicine, on the contraction of the colonic smooth muscle isolated from rats and calcium mobilization. METHODS: By measuring the tension of the isolated colonic smooth muscle strips, the inhibitory effects of Tongxie Yaofang on the contraction induced by acetylcholine (ACh), KCl and exhausting Ca(2+) of internal calcium store were assessed respectively. RESULTS: Tongxie Yaofang could concentration-dependently inhibit the contraction of isolated rat colonic smooth muscle strips induced by KCl and exhausting the Ca(2+) of internal calcium store. Tongxie Yaofang could also inhibit the tension of the second contractile phase induced by ACh (P<0.01, vs control), but had no influence on the first contractile phase. CONCLUSION: Tongxie Yaofang can inhibit the contraction of isolated rat colonic smooth muscle strips mainly by preventing the influx of extracellular Ca(2+), which may be associated with blocking voltage-dependent channel, store-operated channel and receptor-operated channel, but not by preventing the release of internal Ca(2+) from calcium store.
Assuntos
Cálcio/metabolismo , Colo/efeitos dos fármacos , Medicamentos de Ervas Chinesas/farmacologia , Contração Muscular/efeitos dos fármacos , Animais , Colo/fisiologia , Masculino , Músculo Liso , Ratos , Transdução de Sinais/efeitos dos fármacosRESUMO
In the title compound, C(21)H(23)N(3)O, the dihedral angles formed by the pyrazolone ring with two phenyl rings are 10.38â (8) and 76.94â (6)°. The sec-butyl-amino group is disordered over two positions, with refined site-occupancy factors of 0.730â (4) and 0.270â (4). The compound could potentially be ligand stabilized in the solid state in a keto-enamine tautomeric form. The amine functionality is involved in an intra-molecular N-Hâ¯O hydrogen bond, while weak inter-molecular C-Hâ¯O and C-Hâ¯N hydrogen bonds participate in the formation of the crystal structure.
RESUMO
In the polymeric title complex, [Cu(C(7)H(3)N(2)O(2)S)(2)(H(2)O)(2)](n), the Cu(II) centre is surrounded by three 1,2,3-benzothia-diazole-7-carboxyl-ate and two water mol-ecules. A 1,2,3-benzothia-diazole-7-carboxyl-ate ligand bridges two Cu(II) centres, with a Cuâ¯Cu distance of 9.006â (2)â Å. The four O atoms in the equatorial planes around each Cu(II) centre form a distorted square-planar arrangement, while the distorted square-pyramidal coordination is completed by the symmetry-related N atoms of the bridging 1,2,3-benzothia-diazole-7-carboxyl-ate ligands. In the crystal structure, inter-molecular O-Hâ¯O and O-Hâ¯N hydrogen bonds link the mol-ecules into a three-dimensional supra-molecular network.
RESUMO
In the title compound, C(25)H(23)N(3)O(2), the dihedral angles formed by the pyrazolone ring with the three aromatic rings are 14.59â (7), 79.35â (5) and 87.10â (6)°. Three intra-molecular C-Hâ¯O, C-Hâ¯N and N-Hâ¯O hydrogen-bond inter-actions are present. The crystal structure is stabilized by two weak inter-molecular C-Hâ¯O and C-Hâ¯N hydrogen-bond inter-actions.
RESUMO
The title compound, C(18)H(23)NO(5), a potential herbicide, has an enol group that is intra-molecularly hydrogen bonded to a keto O atom. The dihedral angle between the six-membered ring formed by the enol group and the aromatic benzene ring is 53.35â (6)°.