Study of nuclear modification factors of deuteron and anti-deuteron in Pb-Pb collisions at [Formula: see text].

The nuclear modification factors ([Formula: see text]) of d and [Formula: see text] have been studied using the parton and hadron cascade model plus the dynamically constrained phase space coalescence model in peripheral (40-60%) and central (0-5%) Pb-Pb collisions at [Formula: see text] with [Formula: see text]. It is found that the [Formula: see text] of [Formula: see text] is similar to that of hadrons ([Formula: see text]) and the [Formula: see text] of antiparticles is the same as that of particles. The suppression effect of d is more significant than that of baryons and mesons in the high-[Formula: see text] region. The suppression of [Formula: see text] at high-[Formula: see text] strongly depends on event centrality and mass of the particles, i.e., the central collision is more suppressed than the peripheral collision. Besides, the yield ratios and double ratios for different particle species, and the coalescence parameter [Formula: see text] for ([Formula: see text]) in pp and Pb-Pb collisions are discussed, respectively. It is observed that the yield ratios and double ratios of d to p and p to [Formula: see text] are similar to those of their anti-particles in three different collision systems, suggesting that the suppressions of matter ([Formula: see text]) and the corresponding antimatter ([Formula: see text]) are around the same level.

Relationship between expression of COX-2, TNF-α, IL-6 and autoimmune-type recurrent miscarriage.

OBJECTIVE: To investigate the roles of COX-2, TNF-α, IL-6 in the pathogenesis of autoimmune-type recurrent spontaneous abortion (RSA). METHODS: RT-PCR was used to detect the mRNA of COX-2, TNF-α, IL-6 in the trophoblast cells of murine RSA and normal pregnant models. The COX-2, TNF-α, IL-6 protein expressions were determined by using immunohistochemisry staining method. The COX-2, TNF-α, IL-6 protein expressions were determined by ELISA. RESULTS: The embryo loss rates in experiment group was significantly higher than that in normal pregnancy control group, the expression of COX-2, TNF-α, IL-6 in the trophoblast cells of murine RSA and normal pregnant models. The expression of COX-2 in autoimmune-type recurrent spontaneous abortion was significantly lesser than in normal pregnant models. The expression of TNF-α, IL-6 in autoimmune-type recurrent spontaneous abortion was significantly higher than in normal pregnant models. There was a positively correlation between TNF-α and IL-6. There was no relationship between COX-2, TNF-α and IL-6. CONCLUSIONS: The abnormal expression of COX-2, TNF-α and IL-6 may result in RSA.