RESUMO
Solitary plasmocytoma is a rare tumor accounting for 5% of all plasma cell neoplasias. The diagnosis is based on identification of the localized tumor composed of monoclonal plasma cells identical to those observed in multiple myeloma, and absence of the signs in favor of a disseminated form. We report the case of a52-year-old man who presented a growth of the chest wall in the left axillary region. Imaging disclosed a mass of tissue with a large zone of osteolysis of the 6th rib and infiltration of the chest wall. Surgical biopsy for pathology study and immunohistochemistry enabled the diagnosis of costal plasmocytoma. Blood protein immunoelectrophoresis revealed a monoclonal kappa type IgG. Bence-Jones proteinuria was positive. Search for other localizations was negative and the diagnosis of solitary plasmocytoma was retained. Radiotherapy was delivered and the patient has remained in remission at one year. Costal localization is rare for solitary plasmocytoma. The diagnosis is based on imaging findings and pathology. Radiotherapy is the treatment of choice but with the risk of progression with other bone lesions, the development of medullary plasmocytosis and multiple myeloma. Factors predictive of systemic recurrence have not been identified. Regular surveillance is required.
Assuntos
Neoplasias Ósseas/diagnóstico , Plasmocitoma/diagnóstico , Costelas , Neoplasias Ósseas/radioterapia , Humanos , Cadeias kappa de Imunoglobulina/sangue , Masculino , Pessoa de Meia-Idade , Plasmocitoma/radioterapia , Proteinúria/etiologiaRESUMO
Rheumatoid arthritis is a multi-factorial autoimmune disease in which patho-physiological mechanisms have been partially elucidated these past few years. These recent advances have led to new and effective treatments that must be started early in the course of the disease. This review focuses on new serological markers, the anti citrullinated peptides antibodies which seem to be useful in early diagnosis and prognosis of rheumatoid arthritis and probably provide new insights in its pathogenesis.
Assuntos
Artrite Reumatoide/diagnóstico , Biomarcadores , Peptídeos Cíclicos , Artrite Reumatoide/sangue , Artrite Reumatoide/imunologia , Biomarcadores/análise , Biomarcadores/sangue , Diagnóstico Precoce , Ensaio de Imunoadsorção Enzimática/métodos , Ensaio de Imunoadsorção Enzimática/normas , Humanos , Prognóstico , Reprodutibilidade dos Testes , Sensibilidade e EspecificidadeRESUMO
Idiopathic pulmonary haemosiderosis is a rare disease of unknown etiopathogeny which is characterized by hemoptysis due to alveolar haemorrhage. We report the case of a 16 years-old girl with idiopathic pulmonary haemosiderosis, diagnosed through clinical, radiological, cytological and histopathological data. The finding of myeloperoxydase-anti-neutrophil cytoplasmic antibodies (ANCA) positivity led us to suspect an associated vasculitis which was not further demonstrated.
Assuntos
Anticorpos Anticitoplasma de Neutrófilos/sangue , Hemossiderose/imunologia , Pneumopatias/imunologia , Adolescente , Anti-Inflamatórios/administração & dosagem , Anti-Inflamatórios/uso terapêutico , Biópsia , Ensaio de Imunoadsorção Enzimática , Feminino , Técnica Indireta de Fluorescência para Anticorpo , Seguimentos , Hemoptise/etiologia , Hemorragia/etiologia , Hemossiderose/diagnóstico , Hemossiderose/diagnóstico por imagem , Hemossiderose/tratamento farmacológico , Hemossiderose/patologia , Humanos , Pulmão/patologia , Pneumopatias/diagnóstico , Pneumopatias/diagnóstico por imagem , Pneumopatias/tratamento farmacológico , Pneumopatias/patologia , Prednisona/administração & dosagem , Prednisona/uso terapêutico , Alvéolos Pulmonares , Radiografia Torácica , Fatores de Tempo , Resultado do TratamentoAssuntos
Anticorpos Antinucleares/análise , DNA Topoisomerases Tipo I/imunologia , Ensaio de Imunoadsorção Enzimática , Imunoensaio , Immunoblotting , Escleroderma Sistêmico/imunologia , Adulto , Diagnóstico Diferencial , Ensaio de Imunoadsorção Enzimática/métodos , Feminino , Humanos , Imunoensaio/métodos , Immunoblotting/métodos , Masculino , Escleroderma Sistêmico/diagnósticoRESUMO
Cryoglobulins are immunoglobulins which reversibly precipitate at cold temperatures. They are usually accompanied with polymorphic clinical manifestations and biological abnormalities. Cryoglobulins are associated with various clinical disorders which include autoimmune diseases, lymphoproliferative and infectious disorders. Because of their low concentration, detection and quantitation of cryoglobulins need very rigorous conditions when collecting blood from patients.
Assuntos
Doenças Autoimunes/diagnóstico , Crioglobulinas/análise , Doenças Autoimunes/fisiopatologia , Crioglobulinas/imunologia , Diagnóstico Diferencial , Humanos , Infecções/diagnóstico , Infecções/imunologia , Transtornos Linfoproliferativos/diagnóstico , Transtornos Linfoproliferativos/imunologiaRESUMO
Immunoblotting and ELISA methods are now employed for the detection of anti Ro/SSA and anti La/SSB antibodies sometimes more often than double immunodiffusion or counter-immunoelectrophoresis. We have developed an immunoblotting technique for the detection of anti Ro/SSA and anti-La/SSB antibodies. This assay named IB-Hela, which uses a Hela cell extract, was compared with the double immunodiffusion technique like two other commercial immunoassays (Elisa test from Sanofi-diagnostic Pasteur and Line immunoassay from Innogenetics). This evaluation shows a good agreement especially in the case of Ro/SSA antibodies detection. IB-Hela seems to be useful in the La/SSB detection with a better sensitivity than the double immunodiffusion technique. We conclude that the IB Hela is helpful for the search for anti-Ro/SSA and anti-La/SSB autoantibodies and that it can be used as an alternative method to the classical techniques of immunodiffusion and counter immunoelectrophoresis.
Assuntos
Anticorpos Antinucleares/sangue , Autoantígenos/imunologia , Immunoblotting/métodos , RNA Citoplasmático Pequeno , Ribonucleoproteínas/imunologia , Especificidade de Anticorpos , Doenças Autoimunes/sangue , Doenças Autoimunes/imunologia , Extratos Celulares , Doenças do Tecido Conjuntivo/sangue , Doenças do Tecido Conjuntivo/imunologia , Ensaio de Imunoadsorção Enzimática , Células HeLa , Humanos , Imunodifusão , Lúpus Eritematoso Sistêmico/sangue , Lúpus Eritematoso Sistêmico/imunologia , Doença Mista do Tecido Conjuntivo/sangue , Doença Mista do Tecido Conjuntivo/imunologia , Kit de Reagentes para Diagnóstico , Escleroderma Sistêmico/sangue , Escleroderma Sistêmico/imunologia , Sensibilidade e Especificidade , Antígeno SS-BAssuntos
Anticorpos Antinucleares/imunologia , Lúpus Eritematoso Sistêmico/imunologia , Adolescente , Adulto , Anticorpos Antinucleares/sangue , Anticorpos Antinucleares/classificação , Criança , Ensaio de Imunoadsorção Enzimática , Feminino , Técnica Indireta de Fluorescência para Anticorpo , Humanos , Imunodifusão , Lúpus Eritematoso Sistêmico/sangue , Lúpus Eritematoso Sistêmico/diagnóstico , Masculino , Pessoa de Meia-Idade , Sensibilidade e Especificidade , TunísiaRESUMO
We report the case of a young Tunisian woman hospitalised for reasons of general ill health. A immunological check-up revealed autoimmune disturbances and in particular anti-ribosomal P antibodies. We discuss the possible relation of these antibodies to the hepatitis C infection from which the patient was also suffering.
Assuntos
Autoanticorpos/sangue , Doenças Autoimunes/complicações , Doenças Autoimunes/imunologia , Hepatite C/complicações , Proteínas Ribossômicas/imunologia , Adulto , Antivirais/uso terapêutico , Doenças Autoimunes/sangue , Ensaio de Imunoadsorção Enzimática , Feminino , Técnica Indireta de Fluorescência para Anticorpo , Hepatite C/diagnóstico , Hepatite C/terapia , Humanos , Immunoblotting , Interferon-alfa/uso terapêutico , Reação em Cadeia da PolimeraseAssuntos
Autoanticorpos/análise , Mitocôndrias/imunologia , Animais , Doadores de Sangue , Doenças do Tecido Conjuntivo/diagnóstico , Doenças do Tecido Conjuntivo/imunologia , Diagnóstico Diferencial , Estudos de Avaliação como Assunto , Técnica Indireta de Fluorescência para Anticorpo , Humanos , Immunoblotting , Cirrose Hepática Biliar/diagnóstico , Cirrose Hepática Biliar/imunologia , Hepatopatias/diagnóstico , Hepatopatias/imunologia , RatosRESUMO
We searched for antibodies to hepatitis C in a sample of 3079 Tunisians in the suburban area of Tunis. 30 people were positive by ELISA and 22 were confirmed by immunoblotting. This result represents a prevalence of 0.71% which is close to the values reported in European countries of the Mediterranean area.
Assuntos
Anticorpos Anti-Hepatite C/sangue , Hepatite C/diagnóstico , Ensaio de Imunoadsorção Enzimática , Hepatite C/epidemiologia , Humanos , Immunoblotting , Tunísia/epidemiologiaRESUMO
In this study, we have analyzed the clinical and serological features related to 16 Tunisian children in whom diagnosis of systemic lupus erythematosus was made before or at the age of 15. Renal involvement was found in 75% of cases and renal biopsies have mostly revealed severe histologic patterns. All of the patients who have been followed received corticosteroids and in some cases required additional cytotoxic drugs in order to control disease activity. Five children died in a context of a renal failure. This study of childhood lupus in Tunisia confirms that the clinical course of this disease in children is often aggressive.
Assuntos
Lúpus Eritematoso Sistêmico/epidemiologia , Adolescente , Criança , Feminino , Seguimentos , Humanos , Lactente , Lúpus Eritematoso Sistêmico/complicações , Lúpus Eritematoso Sistêmico/imunologia , Nefrite Lúpica/epidemiologia , Nefrite Lúpica/etiologia , Masculino , Prognóstico , Estudos Retrospectivos , Fatores de TempoRESUMO
The evolution of immunological parameters in mediterranean visceral leishmaniasis reveal a type III mixed cryoglobulin with rhumatoid factor activity and antileishmania antibodies. This cryoglobulin follows the clinical signs of the disease and disappear under treatment. The authors insist on the transitory character of this cryoglobulin which is in relation with polyclonal stimulation of the immune system by parasitical infection.