1.
Bioorg Med Chem Lett
; 12(5): 779-82, 2002 Mar 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11859001
RESUMO
Dual COX-2/5-LO inhibitors are described as potential new therapeutic agents for inflammatory diseases. A surprisingly potent effect of a 5-LO pharmacophoric group on the COX-2 inhibition is presented as well as pharmacological in vitro and in vivo results.