RESUMO
The Wnt signalling pathway plays a role in the direction of embryological development and maintenance of stem cell populations. Heritable alterations in genes encoding molecules of the Wnt pathway, including mutation and epigenetic events, have been demonstrated in a variety of cancers. It has been proposed that disruption of this pathway is a significant step in the development of many tumours. Interactions between beta-catenin--the effector molecule of the Wnt pathway--and the androgen receptor highlight the pathway's relevance to urological malignancy. Mutation or altered expression of Wnt genes in tumours may give prognostic information and treatments are being developed which target this pathway.
Assuntos
Proteínas do Citoesqueleto/fisiologia , Peptídeos e Proteínas de Sinalização Intercelular/fisiologia , Neoplasias da Próstata/fisiopatologia , Transdução de Sinais , Transativadores/fisiologia , Transformação Celular Neoplásica , Humanos , Peptídeos e Proteínas de Sinalização Intercelular/biossíntese , Peptídeos e Proteínas de Sinalização Intercelular/genética , Masculino , Prognóstico , Neoplasias da Próstata/genética , Neoplasias da Próstata/terapia , Proteínas Tirosina Quinases , Receptores Androgênicos/fisiologia , Proteínas Wnt , beta CateninaRESUMO
Seven patients developed Pseudomonas aeruginosa urinary tract infections following urodynamic studies, over a two-month period. One patient developed septicaemia and meningitis and died following rupture of a berry aneurysm. Two others required hospital admission for intravenous antibiotic treatment. Pseudomonas aeruginosa was isolated from a pressure dome which covered the pressure transducer of the urodynamic system used for assessing bladder pressure. The device packaging carried the symbol designating this as a 'single use' product, but as an economy measure, a local decision had been taken to change the device monthly.