4E analysis of a two-stage refrigeration system through surrogate models based on response surface methods and hybrid grey wolf optimizer.

Refrigeration systems are complex, non-linear, multi-modal, and multi-dimensional. However, traditional methods are based on a trial and error process to optimize these systems, and a global optimum operating point cannot be guaranteed. Therefore, this work aims to study a two-stage vapor compression refrigeration system (VCRS) through a novel and robust hybrid multi-objective grey wolf optimizer (HMOGWO) algorithm. The system is modeled using response surface methods (RSM) to investigate the impacts of design variables on the set responses. Firstly, the interaction between the system components and their cycle behavior is analyzed by building four surrogate models using RSM. The model fit statistics indicate that they are statistically significant and agree with the design data. Three conflicting scenarios in bi-objective optimization are built focusing on the overall system following the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) and Linear Programming Technique for Multidimensional Analysis of Preference (LINMAP) decision-making methods. The optimal solutions indicate that for the first to third scenarios, the exergetic efficiency (EE) and capital expenditure (CAPEX) are optimized by 33.4% and 7.5%, and the EE and operational expenditure (OPEX) are improved by 27.4% and 19.0%. The EE and global warming potential (GWP) are also optimized by 27.2% and 19.1%, where the proposed HMOGWO outperforms the MOGWO and NSGA-II. Finally, the K-means clustering technique is applied for Pareto characterization. Based on the research outcomes, the combined RSM and HMOGWO techniques have proved an excellent solution to simulate and optimize two-stage VCRS.

A transformer fine-tuning strategy for text dialect identification.

Online medical consultation can significantly improve the efficiency of primary health care. Recently, many online medical question-answer services have been developed that connect the patients with relevant medical consultants based on their questions. Considering the linguistic variety in their question, social background identification of patients can improve the referral system by selecting a medical consultant with a similar social origin for efficient communication. This paper has proposed a novel fine-tuning strategy for the pre-trained transformers to identify the social origin of text authors. When fused with the existing adapter model, the proposed methods achieve an overall accuracy of 53.96% for the Arabic dialect identification task on the Nuanced Arabic Dialect Identification (NADI) dataset. The overall accuracy is 0.54% higher than the previous best for the same dataset, which establishes the utility of custom fine-tuning strategies for pre-trained transformer models.

Pharmacotherapeutics Applications and Chemistry of Chalcone Derivatives.

Chalcones have been well examined in the extant literature and demonstrated antibacterial, antifungal, anti-inflammatory, and anticancer properties. A detailed evaluation of the purported health benefits of chalcone and its derivatives, including molecular mechanisms of pharmacological activities, can be further explored. Therefore, this review aimed to describe the main characteristics of chalcone and its derivatives, including their method synthesis and pharmacotherapeutics applications with molecular mechanisms. The presence of the reactive α,ß-unsaturated system in the chalcone's rings showed different potential pharmacological properties, including inhibitory activity on enzymes, anticancer, anti-inflammatory, antibacterial, antifungal, antimalarial, antiprotozoal, and anti-filarial activity. Changing the structure by adding substituent groups to the aromatic ring can increase potency, reduce toxicity, and broaden pharmacological action. This report also summarized the potential health benefits of chalcone derivatives, particularly antimicrobial activity. We found that several chalcone compounds can inhibit diverse targets of antibiotic-resistance development pathways; therefore, they overcome resistance, and bacteria become susceptible to antibacterial compounds. A few chalcone compounds were more active than conventional antibiotics, like vancomycin and tetracycline. On another note, a series of pyran-fused chalcones and trichalcones can block the NF-B signaling complement system implicated in inflammation, and several compounds demonstrated more potent lipoxygenase inhibition than NSAIDs, such as indomethacin. This report integrated discussion from the domains of medicinal chemistry, organic synthesis, and diverse pharmacological applications, particularly for the development of new anti-infective agents that could be a useful reference for pharmaceutical scientists.

A Cloud Enabled Crop Recommendation Platform for Machine Learning-Driven Precision Farming.

Modern agriculture incorporated a portfolio of technologies to meet the current demand for agricultural food production, in terms of both quality and quantity. In this technology-driven farming era, this portfolio of technologies has aided farmers to overcome many of the challenges associated with their farming activities by enabling precise and timely decision making on the basis of data that are observed and subsequently converged. In this regard, Artificial Intelligence (AI) holds a key place, whereby it can assist key stakeholders in making precise decisions regarding the conditions on their farms. Machine Learning (ML), which is a branch of AI, enables systems to learn and improve from their experience without explicitly being programmed, by imitating intelligent behavior in solving tasks in a manner that requires low computational power. For the time being, ML is involved in a variety of aspects of farming, assisting ranchers in making smarter decisions on the basis of the observed data. In this study, we provide an overview of AI-driven precision farming/agriculture with related work and then propose a novel cloud-based ML-powered crop recommendation platform to assist farmers in deciding which crops need to be harvested based on a variety of known parameters. Moreover, in this paper, we compare five predictive ML algorithms-K-Nearest Neighbors (KNN), Decision Tree (DT), Random Forest (RF), Extreme Gradient Boosting (XGBoost) and Support Vector Machine (SVM)-to identify the best-performing ML algorithm on which to build our recommendation platform as a cloud-based service with the intention of offering precision farming solutions that are free and open source, as will lead to the growth and adoption of precision farming solutions in the long run.

Synergy between machine learning and natural products cheminformatics: Application to the lead discovery of anthraquinone derivatives.

Cheminformatics utilizing machine learning (ML) techniques have opened up a new horizon in drug discovery. This is owing to vast chemical space expansion with rocketing numbers of expected hits and lead compounds that match druggable macromolecular targets, in particular from natural compounds. Due to the natural products' (NP) structural complexity, uniqueness, and diversity, they could occupy a bigger space in pharmaceuticals, allowing the industry to pursue more selective leads in the nanomolar range of binding affinity. ML is an essential part of each step of the drug design pipeline, such as target prediction, compound library preparation, and lead optimization. Notably, molecular mechanic and dynamic simulations, induced docking, and free energy perturbations are essential in predicting best binding poses, binding free energy values, and molecular mechanics force fields. Those applications have leveraged from artificial intelligence (AI), which decreases the computational costs required for such costly simulations. This review aimed to describe chemical space and compound libraries related to NPs. High-throughput screening utilized for fractionating NPs and high-throughput virtual screening and their strategies, and significance, are reviewed. Particular emphasis was given to AI approaches, ML tools, algorithms, and techniques, especially in drug discovery of macrocyclic compounds and approaches in computer-aided and ML-based drug discovery. Anthraquinone derivatives were discussed as a source of new lead compounds that can be developed using ML tools for diverse medicinal uses such as cancer, infectious diseases, and metabolic disorders. Furthermore, the power of principal component analysis in understanding relevant protein conformations, and molecular modeling of protein-ligand interaction were also presented. Apart from being a concise reference for cheminformatics, this review is a useful text to understand the application of ML-based algorithms to molecular dynamics simulation and in silico absorption, distribution, metabolism, excretion, and toxicity prediction.

Towards making the fields talks: A real-time cloud enabled IoT crop management platform for smart agriculture.

Agriculture is the primary and oldest industry in the world and has been transformed over the centuries from the prehistoric era to the technology-driven 21st century, where people are always solving complex problems with the aid of technology. With the power of Information and Communication Technologies (ICTs), the world has become a global village, where every digital object that prevails in the world is connected to each other with the Internet of Things (IoT). The fast proliferation of IoT-based technology has revolutionized practically every sector, including agriculture, shifting the industry from statistical to quantitative techniques. Such profound transformations are reshaping traditional agricultural practices and generating new possibilities in the face of various challenges. With the opportunities created, farmers are now able to monitor the condition of crops in real time. With the automated IoT solutions, farmers can automate tasks in the farmland, as these solutions are capable of making precise decisions based on underlying challenges and executing actions to overcome such difficulties, alerting farmers in real-time, eventually leading to increased productivity and higher harvest. In this context, we present a cloud-enabled low-cost sensorized IoT platform for real-time monitoring and automating tasks dealing with a tomato plantation in an indoor environment, highlighting the necessity of smart agriculture. We anticipate that the findings of this study will serve as vital guides in developing and promoting smart agriculture solutions aimed at improving productivity and quality while also enabling the transition to a sustainable environment.

Spatial position constraint for unsupervised learning of speech representations.

The success of supervised learning techniques for automatic speech processing does not always extend to problems with limited annotated speech. Unsupervised representation learning aims at utilizing unlabelled data to learn a transformation that makes speech easily distinguishable for classification tasks, whereby deep auto-encoder variants have been most successful in finding such representations. This paper proposes a novel mechanism to incorporate geometric position of speech samples within the global structure of an unlabelled feature set. Regression to the geometric position is also added as an additional constraint for the representation learning auto-encoder. The representation learnt by the proposed model has been evaluated over a supervised classification task for limited vocabulary keyword spotting, with the proposed representation outperforming the commonly used cepstral features by about 9% in terms of classification accuracy, despite using a limited amount of labels during supervision. Furthermore, a small keyword dataset has been collected for Kadazan, an indigenous, low-resourced Southeast Asian language. Analysis for the Kadazan dataset also confirms the superiority of the proposed representation for limited annotation. The results are significant as they confirm that the proposed method can learn unsupervised speech representations effectively for classification tasks with scarce labelled data.