RESUMO
We detected some serious inaccuracies and mistakes. Therefore, the article, "Circular RNA circ-NT5C2 acts as a potential novel biomarker for prognosis of osteosarcoma, by W.-B. Nie, L.-M. Zhao, R. Guo, M.-X. Wang, F.-G. Ye, published in Eur Rev Med Pharmacol Sci 2018; 22 (19): 6239-6244-DOI: 10.26355/eurrev_201810_16030-PMID: 30338784" has been withdrawn. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/16030.
RESUMO
OBJECTIVE: Recent evidence suggests that circular RNAs (circRNAs) play important roles in multiple diseases, including cancer. Circ-NT5C2 was reported to be up-regulated in osteosarcoma. However, the clinical significance of circ-NT5C2 remains largely unclear. The aim of the current study was to investigate the value of circ-NT5C2 for the prognosis of patients with osteosarcoma. PATIENTS AND METHODS: the expression of circ-NT5C2 in osteosarcoma tissues and corresponding normal tissues were explored by quantitative real-time polymerase chain reaction (qRT-PCR) experiments. The association of circ-NT5C2 expression with clinicopathological factors or the prognosis of osteosarcoma patients was also analyzed. Kaplan-Meier survival analysis was performed to analyze the association of circ-NT5C2 expression with overall survival (OS) and disease-free survival (DFS) of patients. Univariate and multivariate Cox-regression analyses were used to identify risk factors for poor prognosis. RESULTS: Our data showed a significant increase of circ-NT5C2 expression in osteosarcoma tissues compared with adjacent normal bone tissues (p < 0.01). In addition, we found that the level of circ-NT5C2 in osteosarcoma was strongly correlated with clinical stage (p = 0.006) and distant metastasis (p = 0.001). Importantly, patients with high expression of circ-NT5C2 had a shorter OS (p = 0.006) and DFS (p = 0.001) than those with low expression of circ-NT5C2. Finally, Cox regression analyses showed that high circ-NT5C2 expression might be an independent prognostic parameter to predict poor prognosis. CONCLUSIONS: Our findings indicated that circ-NT5C2 is significantly up-regulated in osteosarcoma tissues. Circ-NT5C2 may represent a new marker of prognosis in osteosarcoma.
Assuntos
Biomarcadores Tumorais/metabolismo , Neoplasias Ósseas/metabolismo , Osteossarcoma/metabolismo , RNA Circular/metabolismo , Adulto , Biomarcadores Tumorais/genética , Neoplasias Ósseas/genética , Neoplasias Ósseas/mortalidade , Neoplasias Ósseas/patologia , Progressão da Doença , Intervalo Livre de Doença , Feminino , Regulação Neoplásica da Expressão Gênica , Humanos , Masculino , Estadiamento de Neoplasias , Osteossarcoma/genética , Osteossarcoma/mortalidade , Osteossarcoma/patologia , RNA Circular/genética , Fatores de Risco , Transdução de Sinais , Adulto JovemRESUMO
Fifty patients with signs of cervical instability (Group A) and 50 persons without them (group B) were studied. Lateral roentgenograms of the cervical vertebrae of each case were taken in flexion, neutral and extension positions. The cervical lordosis, range of motion of the cervical spine (flexion-extension), angular displacement (AD) and horizontal displacement (HD) were also measured. The results show that cervical lordosis of group A was more straight than group B and the reverse curves and S-shaped curves were observed on the films of Group A. The range of motion of the cervical spinae in group A was less than that in group B (P < 0.05), while AD and HD in the former group were both remarkably larger than those in the latter. AD was seen mostly at C3, and C4,5, and HD was mostly at C3,4,5 and rarely at C6. These results indicate, that there was corresponding changes on X-ray films in patients with symptoms of cervical spinal instability and the symptoms selected could be used as the symptoms of degenerative instability. The methods and criteria for diagnosis of cervical spinal instability and its treatment were discussed in the paper.