The impact of various antiplatelet strategies on the incidence of gouty arthritis in hospitalized patients with acute cerebral infarction.

OBJECTIVES: 1.To explore the incidence of concurrent gouty arthritis (GA) during hospitalization in patients with different subtypes of acute stroke. 2.To investigate disparities in acute cerebral infarction patients with coexisting GA undergoing various antiplatelet strategies. MATERIALS AND METHODS: Data from acute stroke patients admitted to the Affiliated Panyu Central Hospital of Guangzhou Medical University, from January 2019 to December 2021, underwent screening. The incidence of GA in acute stroke patients of various subtypes were analyzed. Subsequently, we divided cerebral infarction cases into three cohorts based on distinct antiplatelet therapies: the aspirin group, the dual antiplatelet therapy group (DAPT，aspirin plus clopidogrel), and the clopidogrel group. Investigate disparities in acute cerebral infarction patients with coexisting GA undergoing various antiplatelet strategies. RESULTS: A total of 12,381 patients with acute stroke were screened in this study. The incidence of GA in various subtypes of acute stroke was as follows: cerebral infarction (3.56 %, n = 9890), TIA (1.81 %, n = 443), cerebral hemorrhag (0.64 %, n = 1713), and SAH (0.30 %, n = 335). The incidence of GA in patients with ischemic stroke is higher than that of hemorrhagic stroke (χ2 = 49.258, p<0.001). No significant differences were observed in the incidence of GA among three different antiplatelet therapy groups. But there was marginal statistical difference in the incidence of GA between the aspirin group and the DAPT group (P = 0.051), as well as between the clopidogrel group and the DAPT group (P = 0.059). CONCLUSIONS: The incidence of GA in patients with ischemic stroke is higher than that of hemorrhagic stroke. No significant differences were observed in the incidence of GA in acute cerebral infarction across various antiplatelet Strategies. The marginal statistical difference in the incidence of GA between the single antiplatelet group and the DAPT group requires further investigation.

Scalable Customization of Crystallographic Plane Controllable Lithium Metal Anodes for Ultralong-Lasting Lithium Metal Batteries.

A formidable challenge to achieve the practical applications of rechargeable lithium (Li) metal batteries (RLMBs) is to suppress the uncontrollable growth of Li dendrites. One of the most effective solutions is to fabricate Li metal anodes with specific crystal plane, but still lack of a simple and high-efficient approach. Herein, a facile and controllable way for the scalable customization of polished Li metal anodes with highly preferred (110) and (200) crystallographic orientation (donating as polished Li(110) and polished Li(200), respectively) by regulating the times of accumulative roll bonding, is reported. According to the inherent characteristics of polished Li(110)/Li(200), the influence of Li atomic structure on the electrochemical performance of RLMBs is deeply elucidated by combining theoretical calculations with relative experimental proofs. In particular, a polished Li(110) crystal plane is demonstrated to induce Li+ uniform deposition, promoting the formation of flat and dense Li deposits. Impressively, the polished Li(110)||LiFePO4 full cells exhibit unprecedented cycling stability with 10 000 cycles at 10 C almost without capacity degradation, indicating the great potential application prospect of such textured Li metal. More valuably, this work provides an important reference for low-cost, continued, and large-scale production of Li metal anodes with highly preferred crystal orientation through roll-to-roll manufacturability.

Hierarchical Ohmic Contact Interface Engineering for Efficient Hydrazine-Assisted Hydrogen Evolution Reaction.

Hydrazine oxidation reaction coupled with hydrogen evolution reaction (HER) is an effective strategy to achieve low energy water splitting for hydrogen production. In order to realize the application of hydrazine-assisted HER system, researchers have been focusing on the development of electrocatalysts with integrated dual active sites, while the performance under high current density is still unsatisfying. In this work, hierarchical Ohmic contact interface engineering is designed and used as a bridge between the NiMo and Ni2 P heterojunction toward industrial current density applications, with the charge transfer impedance greatly eliminated via such a pathway with low energy barrier. As a proof-of-concept, the importance of charge redistribution and energy barrier at the Ohmic contact interface is investigated by significantly reducing the voltage of overall hydrazine splitting (OHzS) at high current density. Intriguingly, the NiMo/Ni2 P hierarchical Ohmic contact heterojunction can drive current densities of 100 and 500 mA cm-2 with only 181 and 343 mV cell voltage in the OHzS electrolyzer with high electrocatalytic stability. The proposed hierarchical Ohmic contact interface engineering paves new avenue for hydrogen production with low energy consumption.

Anion-Immobilized Gel Polymer Electrolyte with a High Ion Transference Number for High-Performance Lithium/Sodium Metal Batteries.

Due to their high energy density, lithium/sodium metal batteries (LMBs/SMBs) are expected to be the next generation of energy storage systems. However, the further application of alkali metal batteries based on liquid electrolytes is limited due to increasing safety concerns. Gel polymer electrolytes (GPEs), which combine the advantages of the high ionic conductivity of liquid electrolytes and excellent mechanical properties of solid polymer electrolytes, are considered to play an irreplaceable role in the realization of high-performance alkali metal batteries. In this work, a flexible boron-containing GPE (B-GPE) with a cross-linked polymer network structure is prepared by a UV-induced process. The as-prepared B-GPE exhibits good ionic conductivity and has an extremely high ion transference number due to the electron-withdrawing effect of the boron moiety and the facile electrolyte uptake ability of the ethylene oxide chain. Furthermore, a "gentle" electrode/electrolyte contact is designed by a one-step in situ polymerization method, which can enhance ion transport within the electrode and at the electrode/electrolyte interface due to the presence of a continuous polymer phase for ion conduction. Therefore, LMBs and SMBs containing B-GPE are able to effectively inhibit the growth of dendrites while exhibiting excellent cycling stability. These comprehensive results indicate that this novel B-GPE possesses potential applications for high-performance alkali metal batteries.

Aloin Attenuates Oxidative Stress, Inflammation, and CCl4-Induced Liver Fibrosis in Mice: Possible Role of TGF-ß/Smad Signaling.

Liver fibrosis refers to the excessive buildup of extracellular matrix (ECM) components in liver tissue. It is considered a pathological response to liver damage for which there is no effective treatment. Aloin, an anthraquinone compound isolated from the aloe plant, has shown good pharmacological effects in the treatment of gastric cancer, ulcerative colitis, myocardial hypertrophy, traumatic brain injury, and other diseases; however, its specific impact on liver fibrosis remains unclear. To address this gap, we conducted a study to explore the mechanisms underlying the potential antifibrotic effect of aloin. We constructed a mouse liver fibrosis model using carbon tetrachloride (CCl4) dissolved in olive oil as a modeling drug. Additionally, a cellular model was developed by using transforming growth factor ß1 (TGF-ß1) as a stimulus applied to hepatic stellate cells. After aloin intervention, serum alanine aminotransferase, hepatic hydroxyproline, and serum aspartate aminotransferase were reduced in mice after aloin intervention compared to CCl4-mediated liver injury without aloin intervention. Aloin relieved the oxidative stress caused by CCl4 via reducing hepatic malondialdehyde in liver tissue and increasing the level of superoxide dismutase. Aloin treatment decreased interleukin (IL)-1ß, IL-6, and tumor necrosis factor-α and increased the expression of IL-10, which inhibited the inflammatory response in liver injury. In addition, aloin inhibited the activation of hepatic stellate cells and reduced the level of α-smooth muscle actin (α-SMA) and collagen type I. In cell and animal experiments, aloin attenuated liver fibrosis, acting through the TGF-ß/Smad2/3 signaling pathway, and mitigated CCl4- and TGF-ß1-induced inflammation. Thus, the findings of this study provided theoretical data support and a new possible treatment strategy for liver fibrosis.

Plant Transpiration-Inspired Biomass-Based Device with Underwater Oleophobicity for Efficient General-Purpose Solar-Driven Oily Wastewater Purification.

The remediation of wastewater containing oily pollutants is imperative to mitigate the serious threats posed to the safety of fresh water, human well-being, and the environment. Current membrane separation technologies are severely restricted by their limitations for separating various types of oily pollutants with low sustainability. Herein, by imitating the plant transpiration in nature, we designed a solar-driven device composed of natural biomass sugar cane stem, chitosan/carboxymethyl cellulose, and graphite powders to separate versatile oily pollutants from the wastewater. Owing to its superior solar absorption capacity, microchannels for water transportation, and underwater oleophobicity, the resultant evaporator not only exhibited an excellent evaporation rate of 1.41 kg m-2 h-1 but also demonstrated an admirable purification efficiency of 99.9% for oily wastewater. Moreover, the device can maintain a stable evaporation rate and the original structure even in oily wastewater containing strong acid, alkali, or hypersaline components. Therefore, this work provides an effective approach to producing clean water from versatile wastewater.

Giant teratoma with isolated intestinal duplication in adult: A case report and review of literature.

BACKGROUND: A combination of diseases is a rare phenomenon. Their clinical manifestations can vary, and the diagnosis can be challenging. Intestinal duplication is a rare congenital malformation, whereas retroperitoneal teratoma is a tumor in the retroperitoneal space, derived from the remaining embryonic tissue. There are relatively few clinical findings on adult retroperitoneal benign tumors. It is hard to believe that these two rare diseases can happen to the same person. CASE SUMMARY: A 19-year-old woman complaining of abdominal pain with nausea and vomiting was admitted. Abdominal computed tomography angiography was suggested for invasive teratoma. Intraoperative exploration revealed that the giant teratoma was connected to an isolated intestinal tract in the retroperitoneum. The postoperative pathological examination revealed that mature giant teratoma was present with intestinal duplication. This was a rare intraoperative finding that was successfully treated surgically. CONCLUSION: The clinical manifestations of intestinal duplication malformation are various, and difficult to diagnose before the operation. The possibility of intestinal replication should be considered when intraperitoneal cystic lesions are present.

Potential Antioxidative Activity of Homocysteine in Erythrocytes under Oxidative Stress.

Homocysteine is an amino acid containing a free sulfhydryl group, making it probably contribute to the antioxidative capacity in the body. We recently found that plasma total homocysteine (total-Hcy) concentration increased with time when whole blood samples were kept at room temperature. The present study was to elucidate how increased plasma total-Hcy is produced and explore the potential physiological role of homocysteine. Erythrocytes and leukocytes were separated and incubated in vitro; the amount of total-Hcy released by these two kinds of cells was then determined by HPLC-MS. The effects of homocysteine and methionine on reactive oxygen species (ROS) production, osmotic fragility, and methemoglobin formation in erythrocytes under oxidative stress were studied. The reducing activities of homocysteine and methionine were tested by ferryl hemoglobin (Hb) decay assay. As a result, it was discovered that erythrocytes metabolized methionine to homocysteine, which was then oxidized within the cells and released to the plasma. Homocysteine and its precursor methionine could significantly decrease Rosup-induced ROS production in erythrocytes and inhibit Rosup-induced erythrocyte's osmotic fragility increase and methemoglobin formation. Homocysteine (but not methionine) was demonstrated to enhance ferryl Hb reduction. In conclusion, erythrocytes metabolize methionine to homocysteine, which contributes to the antioxidative capability under oxidative stress and might be a supplementary protective factor for erythrocytes against ROS damage.

Liquid Metal-Tailored PEDOT:PSS for Noncontact Flexible Electronics with High Spatial Resolution.

Electric field-based noncontact flexible electronics (EF-NFEs) allow people to communicate with intelligent devices through noncontact human-machine interactions, but current EF-NFEs with limited detections (usually <20 cm) distance often lack a high spatial resolution. Here, we report a versatile material for preparing EF-NFE devices with a high spatial resolution to realize everyday human activity detection. Eutectic gallium-indium alloy (EGaIn) was introduced into poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) chains to fabricate this material, named Ga-PP. The introduction of EGaIn successfully regulates the intra- and interchain interactions of PEDOT chains and thus increases the π-electron accumulation on Ga-PP chains, which facilitates improvement of the electron storage of Ga-PP and its noncontact sensing ability. The water solubility of the obtained Ga-PP can reach approximately 15 mg/mL, comparable to that of commercial PEDOT:PSS, thus making Ga-PP suitable for various design strategies to prepare EF-NFE devices. We demonstrate that a conductive textile with a noncontact sensing ability can be achieved by immersing a commercial silk fabric into a Ga-PP solution for 5 min. With a detection distance exceeding 1 m, the prepared Ga-PP-based conductive textile (Ga-PP-CT) possesses outstanding noncontact sensing sensitivity, showing advantages in tracing the locations of signal sources and distinguishing motion states. Surprisingly, even when placed in water, Ga-PP-CT can be used to monitor the movement signals of athletes in different sporting events and output specific noncontact response signals for different sports. Intriguingly, the Ga-PP solution itself can be used to construct noncontact sensing conductive circuits, displaying the potential to be incorporated into smart electronics.

Risk factors associated with radiolucent foreign body inhalation in adults: a 10-year retrospective cohort study.

BACKGROUND: Foreign body aspiration (FBA) is a serious condition with high morbidity and mortality rates. Although chest radiography is generally the first radiologic modality used in diagnosis, a substantial percentage of foreign bodies are radiolucent in adults with diagnosis challenging. METHODS: Retrospective review of adult patients with FBA diagnosed by flexible electronic bronchoscopy from 2012 to 2022 collecting demographics, history, hospital presentation, radiographic, and operative details. Risk factors associated with radiolucent foreign body inhalation in adults were explored using appropriate statistical methods. RESULTS: Between 1 January 2012 and 1 January 2022, 114 adult patients diagnosed with FBA were enrolled. The median age of participants was 65 years (IQR 52-74). Multidetector computed tomography (MDCT) examinations identified 28 cases (25%) showing direct visualization of the foreign body (defined as the radiopaque group) and 86 cases (75%) in the radiolucent group. Multivariable stepwise linear regression analysis showed increased odds of radiolucent foreign body inhalation in adults associated with pneumonic patches in MDCT (OR 6.99; 95% CI 1.80-27.22; P = 0.005) and plants/meat foreign bodies (OR 6.17; 95% CI 1.12-33.96; P = 0.04). A witnessed choking history (OR 0.02; 95% CI 0-0.14; P < 0.001) was a protective factor of radiolucent foreign body inhalation in adults. CONCLUSIONS: Unlike radiopaque FBA, in those presenting with a suspected radiolucent foreign body aspiration, the diagnosis is far more challenging. Risk factors such as lacking a choking history, non-resolving pneumonia (pneumonic patches) in MDCT findings, and plants/meat foreign bodies may help in the early diagnosis of radiolucent foreign body inhalation in adults. Further prospective multicenter studies should be conducted to validate the findings.

Nanoconfined Space: Revisiting the Charge Storage Mechanism of Electric Double Layer Capacitors.

The electric double layer capacitor (EDLC) has been recognized as one of the most appealing electrochemical energy storage devices. Nanoporous materials with relatively high specific surface areas are generally used as the electrode materials for electric double layer capacitors (EDLCs). The past decades have witnessed anomalous phenomena of EDLCs under nanoconfined space, which to a large degree doubt the conventional recognition. However, there are currently still no deep insights and consensus on the mechanism of these striking discoveries. In this Perspective, we start with a brief introduction to contextualize the significance of EDLCs, especially with electrode materials of nanoconfined space. Next, we briefly review the landmark studies in light of the charge storage mechanism of EDLCs, mainly focusing on the study of nanoporous materials for EDLCs. Subsequently, we reexamine the basic concepts under nanoconfined space and some representative in situ characterization techniques applied to understand the charge storage mechanism of EDLCs. Finally, we provide general conclusions and insights into the future research directions in the field of EDLCs.

Deciphering the role of LiNO3 additives in Li-S batteries.

The ultrahigh theoretical energy density of lithium-sulfur (Li-S) batteries has attracted intensive research interest. However, most of the long-term cycling performance parameters are strongly dependent on the utilization of the electrolyte, which is considered as an indispensable component in Li-S batteries. Over the past few decades, numerous research studies around LiNO3 as an electrolyte additive have been carried out and have been confirmed to significantly upgrade the electrochemical performance of Li-S batteries, but the mechanism of performance improvement is still not well-understood. In this minireview, we revisit the controversial issues surrounding LiNO3 based on recent representative studies, provide a comprehensive understanding of the role of LiNO3 in the Li-S battery system, and specifically discuss what the panoramic view of the solid electrolyte interface film formed by LiNO3 on the surface of Li metal anodes looks like. Finally, we present general conclusions and unique insights into the future development of Li-S batteries. This minireview aims to provide a tutorial reference for researchers who are ready to enter or are active in the field of Li-S batteries.

Ti2C3Tx/Polyurethane Constructed by Gas-Liquid Interface Self-Assembly for Underwater Sensing.

Nowadays, multifunctional, easily prepared, and highly sensitive flexible sensors have attracted extensive attention and are gradually used in various scenarios. Here, we report the design of the Ti2C3Tx/polyurethane composites prepared by a facile gas-liquid interface self-assembly. The obtained flexible sensor has a wide detection range (∼900%), a low-stress detection limit (<1%), a high sensitivity (GF = 1.3, strain from 0 to 100%), and a fast response time (<140 ms). The multifunctional stress sensor can be applied to not only wearable motion monitoring and detection of various signals but also the detection of underwater human motion, as well as different motion states and swimming frequencies of toy fish in water, demonstrating its great prospects in a variety of applications, such as human movement monitoring and marine biological detection and research.

A MOF derived bifunctional electrocatalyst Ni3ZnC0.7-Mo2C with enhanced performance for overall water splitting.

The efficiency and cost of electrocatalysts are critical factors restricting their application in water electrochemical decomposition. In recent years, transition metal carbides (TMCs) have been highlighted due to their unique characteristics for water splitting: good conductivity and stability. However, their electrochemical performance required further optimization. In this work, a distinct non-solvent method was utilized to achieve a Ni3ZnC0.7-Mo2C/Ni foam (NF) catalyst, which exhibited a nanoflower structure with efficient exposed active sites. Moreover, the synergistic effect between the Mo and Ni species greatly affected its HER and OER performance. Ni3ZnC0.7-Mo2C/NF showed excellent electrocatalytic performance with small overpotentials of 58 mV and 257 mV at 10 mA cm-2 for the HER and OER, respectively. To our delight, the overall water splitting could be driven by only 1.56 V. This work not only demonstrates an excellent bifunctional electrocatalyst for overall water splitting but also provides another method for polymetallic carbide preparation and activity optimization.

Liquid metal-tailored gluten network for protein-based e-skin.

Designing electronic skin (e-skin) with proteins is a critical way to endow e-skin with biocompatibility, but engineering protein structures to achieve controllable mechanical properties and self-healing ability remains a challenge. Here, we develop a hybrid gluten network through the incorporation of a eutectic gallium indium alloy (EGaIn) to design a self-healable e-skin with improved mechanical properties. The intrinsic reversible disulfide bond/sulfhydryl group reconfiguration of gluten networks is explored as a driving force to introduce EGaIn as a chemical cross-linker, thus inducing secondary structure rearrangement of gluten to form additional ß-sheets as physical cross-linkers. Remarkably, the obtained gluten-based material is self-healing, achieves synthetic material-like stretchability (>1600%) and possesses the ability to promote skin cell proliferation. The final e-skin is biocompatible and biodegradable and can sense strain changes from human motions of different scales. The protein network microregulation method paves the way for future skin-like protein-based e-skin.

Bifunctional catalysts of Ni nanoparticle coupled MoO2 nanorods for overall water splitting.

The development of active and cost-effective bifunctional catalysts is crucial for water dissociation through electrolysis. In this study, bifunctional catalysts with Ni nanoparticles (NPs) anchored on MoO2 nanorods have been synthesized via in situ dissolution of NiMoO4-ZIF under an inert atmosphere without using hydrogen gas. The Ni-MoO2 catalyst exhibits high electrocatalytic activity by modulating the calcination temperature. Benefitingfrom the MOF transformation and accompanying Ni particles' outward diffusion, a precisely designed interface heterostructure between Ni and MoO2 was constructed. As a result, the optimized Ni-MoO2 catalyst achieves extremely low overpotentials of only 24 mV and 275 mV at 10 mA cm-2 for the hydrogen evolution reaction and oxygen evolution reaction, respectively. Furthermore, the catalyst required a small cell voltage of 1.55 V to deliver a current density of 10 mA cm-2 and remained stable over 20 h for overall water splitting. The proposed MOF-derived heterojunction protocol provides a general approach for designing and fabricating transition metal oxide catalysts for water electrolysis.

Loofah Sponge-Derived Hygroscopic Photothermal Absorber for All-Weather Atmospheric Water Harvesting.

The loofah gourd is like a natural water tank that stores underground water and drains it out after aging, leaving only a three-dimensional network consisting of hollow and interconnected fibers. This phenomenon inspired us to fabricate a solar-energy-powered sorption-based atmospheric water harvesting device using a loofah sponge. Herein, moisture absorption and photothermal conversion strategies are rationally designed to fast release the absorbed water. This is accomplished by filling the hollow and connected loofah fiber with LiCl and replacing the original luffa peel with a bacterial cellulose (BC)/carbon nanotube (CNT) photothermal conversion membrane. As a result, loofah/BC/CNT (LBC)@LiCl presents a high water absorption capacity of 2.65 g g-1 at 90% relative humidity (RH) and fast water release performance of 1.33 kg m-2 h-1 under 1.0 sun. Noticeably, ∼1.92-2.40 kg LBC@LiCl can produce daily drinking water for adults (2000-2500 mL) in one night outdoors at ∼66% RH, proving that it is a feasible method to overcome the drinking water shortage of poor and arid areas using cheap and renewable biomass material.

Ultrastable Zinc Anode by Simultaneously Manipulating Solvation Sheath and Inducing Oriented Deposition with PEG Stability Promoter.

Aqueous zinc-ion batteries are a low-cost and safe energy storage system, but suffer from detrimental side reactions and Zn dendrites due to the strong interactions between Zn2+ and water molecules in the electrolytes, and random Zn2+ deposition on the anode surface. Here, an electrolyte involving a dual-functional additive of polyethylene glycol (PEG) to bypass these issues is reported. The electrolyte can not only tailor the solvation sheath of Zn2+ but also enable favorably oriented deposition of Zn2+ on the anode surface. The dendrite-free Zn anode in Zn//Zn cells is obtained with high Columbic efficiency (98.8%) and long cycling lifespan (1500 h), six times longer than that of electrolyte without PEG at 0.25 mA cm-2 . What is more, the excellent cycling stability of the prepared batteries (Zn//V2 O5 ·1.6 H2 O) suggests that the developed tailoring strategy may propel a promising pathway for stabilizing Zn metal anodes.

In Situ Electrochemical Transformation toward Structure Optimized VEG@MXene Cathode for Enhanced Zinc-Ion Storage.

Vanadium-based derivatives, featuring affordable cost and high theoretical capacity, have gathered widespread interest in the context of aqueous zinc-ion batteries (ZIBs). However, the further application of vanadium-based materials is hindered by the limited electrical conductivity and cycling lifespan. Herein, 1D chain-like structure vanadyl ethylene glycolate (VEG, (VO(CH2 O)2 )), growing on the Ti3 C2 Tx MXene nanosheets, is synthesized via a one-step oil-bath heating process as cathode materials for ZIBs. Benefiting from the hybrid structure with high conductivity and abundant reactive sites, the VEG@MXene cathode exhibits a remarkable specific capacity (360.3 mAh g-1 at 0.5 A g-1 ), and impressive capacity retention (up to 85.2% after 3000 cycles at 10 A g-1 ). Mechanism analysis reveals a gradual phase transition from the original VEG on MXene to the stable Zn3 V2 O7 (OH)2 ·2H2 O nanoflakes accompanied by continuous zinc ion intercalation/deintercalation, offering more pathways for zinc ion transport. This work suggests that engineering conductivity-enhanced vanadium-based materials is a rational approach for developing promising cathode materials of ZIBs.

The 100 most cited articles on pancreatic neuroendocrine tumors from 2000 to 2020: a bibliometric analysis.

PURPOSE: The present study attempted to identify 100 most cited articles on pancreatic neuroendocrine tumors and characterize them via bibliometric analysis whereby it would provide an insight into the progress and trend in this field. METHODS: Records regarding pancreatic neuroendocrine tumors and published between 2000 and 2020 were retrieved in 2021 through the Web of Science to identify the 100 most cited articles. RESULTS: The 100 articles were screened in 17 434 records. The number of citations of the top-cited articles ranged from 151 to 1867. These articles were published in 47 journals among which the Journal of Clinical Oncology produced the most articles (n = 10). The USA contributed most of the articles (n = 44). Articles enrolled came from 58 institutions; the University of California System of the USA came to the top (n = 7). More than half of the articles were clinical studies (n = 55), basic science research reports accounting for a quarter. In clinical topics (n = 73), treatment issues were the most concerned (n = 21), in which more articles focused on targeted inhibitors. Articles about gene mutation were cited most frequently in basic science topics (n = 27). CONCLUSIONS: This bibliometric analysis reflected the brief the progress and highlighted current trend in pancreatic neuroendocrine tumor research, providing references for further study.