Are preoperative Kattan and Stephenson nomograms predicting biochemical recurrence after radical prostatectomy applicable in the Chinese population?

PURPOSE: Kattan and Stephenson nomograms are based on the outcomes of patients with prostate cancer recruited in the USA, but their applicability to Chinese patients is yet to be validated. We aim at studying the predictive accuracy of these nomograms in the Chinese population. PATIENTS AND METHODS: A total of 408 patients who underwent laparoscopic or open radical resection of prostate from 1995 to 2009 were recruited. The preoperative clinical parameters of these patients were collected, and they were followed up regularly with PSA monitored. Biochemical recurrence was defined as two or more consecutive PSA levels >0.4 ng/mL after radical resection of prostate or secondary cancer treatment. RESULTS: The overall observed 5-year and 10-year biochemical recurrence-free survival rates were 68.3% and 59.8%, which was similar to the predicted values by the Kattan and Stephenson nomograms, respectively. The results of our study achieved a good concordance with both nomograms (Kattan: 5-years, 0.64; Stephenson: 5-years, 0.62, 10-years, 0.71). CONCLUSIONS: The incidence of prostate cancer in Hong Kong is increasing together with the patients' awareness of this disease. Despite the fact that Kattan nomograms were derived from the western population, it has been validated in our study to be useful in Chinese patients as well.

Computed tomographic appearance of Prolene Hernia System and polypropylene mesh plug inguinal hernia repair.

PURPOSE: To describe the normal postoperative computed tomographic (CT) appearance of inguinal hernia repair with the Prolene (polypropylene) Hernia System and polypropylene mesh plug. MATERIALS AND METHODS: The medical records for 480 consecutive patients who underwent inguinal mesh hernioplasty were reviewed to identify posthernioplasty pelvic CT scans. The presence or absence of the appearance and size of focal inguinal findings at CT for each groin was recorded by 2 radiologists in consensus. The CT scan reports and medical records were reviewed to determine prospective interpretations of these inguinal findings. FINDINGS: Posthernoplasty CT scans were identified in 26 patients, of whom, 20 had Prolene Hernia System (unilateral, n = 20; bilateral, n = 1) or mesh plug (unilateral, n = 5; bilateral, n = 1) repairs. These patients consisted of 23 men and 3 women with a mean age of 63 years (range, 36-89 years). For Prolene Hernia System hernioplasty patients, ipsilateral focal inguinal findings were found at CT in 21 of 22 groins. These focal findings had a mean size of 2.6 +/- 0.4 by 2.0 +/- 0.5 cm and were ringlike in 9, nodular in 7, and feathery in appearance in 5 groins. For mesh-plug hernioplasty, ipsilateral nodular focal inguinal findings were found in all 6 of 6 groins at CT. In 2 patients, nodular focal inguinal findings were mistaken for lymphadenopathy on the prospective CT report. CONCLUSION: Focal inguinal findings from mesh plug inguinal hernioplasty are common, have characteristic appearances at CT, and should not be mistaken as lymphadenopathy.