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1.
Pathol Res Pract ; 209(5): 319-22, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23618686

RESUMO

This study reports a female patient who suffered from primary myelofibrosis at 38 years of age, breast cancer with myeloid metaplasia at 49 years of age, and pleural effusion and multiple subcutaneous nodules at 62 years of age. She was finally diagnosed with immature NK-cell leukemia or AML without maturation with CD56 expression transformation of extramedullary hematopoiesis that developed in the pleura, and died 11 months later. Atypical cells in the pleural effusion had surface markers of CD13, CD33, CD34, and CD56 using a fluorescence-activated cell sorter analysis, and were positive for myeloperoxidase, CD34, CD43, and CD56 in a cell block material using an immunohistochemical method. Megakaryocytic and erythroblastic cells were also seen in the pleural effusion.


Assuntos
Neoplasias da Mama/patologia , Antígeno CD56/metabolismo , Leucemia/patologia , Células T Matadoras Naturais/patologia , Neoplasias Pleurais/patologia , Mielofibrose Primária/patologia , Adulto , Biomarcadores Tumorais/metabolismo , Neoplasias da Mama/complicações , Neoplasias da Mama/metabolismo , Evolução Fatal , Feminino , Hematopoese Extramedular/fisiologia , Humanos , Leucemia/complicações , Leucemia/metabolismo , Leucemia Linfoide/complicações , Leucemia Linfoide/metabolismo , Leucemia Linfoide/patologia , Leucemia Mieloide Aguda/complicações , Leucemia Mieloide Aguda/metabolismo , Leucemia Mieloide Aguda/patologia , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas , Derrame Pleural/complicações , Derrame Pleural/metabolismo , Derrame Pleural/patologia , Neoplasias Pleurais/complicações , Neoplasias Pleurais/metabolismo , Mielofibrose Primária/complicações , Mielofibrose Primária/metabolismo
2.
Int J Surg Pathol ; 20(2): 201-4, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21813545

RESUMO

This report describes a 60-year-old man with concurrent gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) and classical Hodgkin lymphoma (CHL). Atypical, medium-sized, lymphoid cells proliferated in the mucosa to muscular layer of the stomach showing a lymphoepithelial lesion; admixed with Hodgkin/Reed-Sternberg (HRS) cells and an inflammatory cell background. MALT lymphoma cells expressed CD20, CD79a, PAX5, and BOB.1, and HRS cells expressed CD30, CD15, Epstein-Barr virus-encoded RNA, and EBV-latent membrane protein 1. Only CHL invaded into the regional lymph nodes. Two possibilities of transformation of MALT lymphoma into CHL and de novo CHL within MALT lymphoma are discussed.


Assuntos
Linfoma Composto/patologia , Doença de Hodgkin/patologia , Linfoma de Zona Marginal Tipo Células B/patologia , Segunda Neoplasia Primária , Neoplasias Gástricas/patologia , Idoso , Biomarcadores Tumorais/metabolismo , Transformação Celular Neoplásica , Terapia Combinada , Linfoma Composto/metabolismo , Linfoma Composto/terapia , Evolução Fatal , Mucosa Gástrica/patologia , Doença de Hodgkin/metabolismo , Doença de Hodgkin/terapia , Humanos , Linfoma de Zona Marginal Tipo Células B/metabolismo , Linfoma de Zona Marginal Tipo Células B/terapia , Masculino , Invasividade Neoplásica , Células de Reed-Sternberg/patologia , Neoplasias Gástricas/metabolismo
3.
Int J Surg Pathol ; 20(1): 83-8, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21632635

RESUMO

This study reports a 59-year-old man who suffered from multiple skeletal muscle amyloidomas and showed a rapidly fatal course. He noticed left inguinal pain and gait disturbance due to muscle weakness of the left leg. Protein in urine (3.3 g/d) and Bence-Jones protein of the κ type (2.3 g/d) were detected. Bone marrow aspiration showed 11.6% monoclonal plasma cells in nucleated cells. A core needle-biopsied and resected left inguinal tumor showed the deposition of eosinophilic amorphous materials positive for Congo red stain and the κ-light chain. He was diagnosed with plasma cell myeloma with AL (amyloid light chain) amyloidosis. Multiple soft-part tumors developed, grew rapidly, and he died 3 months after admission. At autopsy, 3 large amyloidomas were observed in the skeletal muscles, and prominent amyloid deposits were also seen in the diaphragm, intercostal muscle, iliopsoas muscle, and cervical skeletal muscles examined. Massive amyloid materials deposited diffusely in the propria muscularis of the gastrointestinal tract: the tongue to the rectum.


Assuntos
Amiloidose/patologia , Mieloma Múltiplo/patologia , Músculo Esquelético/patologia , Doenças Musculares/patologia , Amiloidose/complicações , Autopsia , Proteína de Bence Jones/metabolismo , Evolução Fatal , Humanos , Cadeias kappa de Imunoglobulina/metabolismo , Masculino , Pessoa de Meia-Idade , Mieloma Múltiplo/complicações , Doenças Musculares/etiologia
4.
Int J Surg Pathol ; 20(3): 272-5, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21911431

RESUMO

This study reports a 54-year-old man who was a carpenter by occupation. He suffered from left chest and back pain and left pleural effusion. Peripheral blood showed granulocytosis and high serum titers of granulocyte-colony stimulating factor (G-CSF) and CYFRA. He died 20 months later. At autopsy, a pleural tumor located around the left lung and thickening of the pericardium, diaphragm, and esophagus by tumor infiltration was seen. The tumor proliferated in papillary and solid alveolar patterns by neoplastic cells. They were positive for calretinin, D2-40, CK5/6, HBME-1, G-CSF, CK19, and E-cadherin. He was diagnosed with G-CSF-producing epithelioid malignant pleural mesothelioma.


Assuntos
Fator Estimulador de Colônias de Granulócitos/biossíntese , Mesotelioma/metabolismo , Neoplasias Pleurais/metabolismo , Autopsia , Humanos , Masculino , Mesotelioma/patologia , Pessoa de Meia-Idade , Derrame Pleural Maligno/etiologia , Neoplasias Pleurais/patologia
5.
Pathol Int ; 61(12): 752-5, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22126384

RESUMO

We describe a patient who was diagnosed with classical Hodgkin lymphoma (CHL) at 67-years-old and peripheral T-cell lymphoma, not otherwise specified (PTCL) at 76-years-old, and died 5 months later. Both tumors showed prominent epithelioid cell reaction admixed with neoplastic cells. Hodgkin and Reed-Sternberg cells in the swollen lymph node were positive for CD30 and EBV-encoded RNA (EBER). PTCL cells in the skin tumor were positive for cytoplasmic CD3ε, CD4 and EBER. A rearrangement band of the T-cell receptor gene was detected in the skin tumor. This case is the first documented EBV-associated composite lymphoma composed of CHL and PTCL. The patient may show the possibility that both EBV infection and/or immunodeficiency induce the development of CHL and PTCL.


Assuntos
Linfoma Composto/virologia , Infecções por Vírus Epstein-Barr/complicações , Doença de Hodgkin/virologia , Linfoma de Células T Periférico/virologia , Transtornos Linfoproliferativos/virologia , Idoso , Artrite Reumatoide/epidemiologia , Comorbidade , Linfoma Composto/patologia , Evolução Fatal , Feminino , Doença de Hodgkin/patologia , Humanos , Linfoma de Células T Periférico/patologia
6.
Surg Today ; 41(9): 1270-4, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21874429

RESUMO

We report a case of pelioid-type well-differentiated hepatocellular carcinoma (HCC) in a 54-year-old woman with a history of taking oral contraceptives. She was not infected with hepatitis viruses and her liver function test results were normal. Contrast-enhanced computed tomography showed an irregular-shaped and remarkably enhanced tumor with central necrosis. The tumor was vaguely nodular without capsules, and consisted of multiple pelioid cysts and sinusoidal dilatations with transitional forms between them. The pelioid cysts were directly surrounded by neoplastic cells with fatty degeneration. Since pelioid-type HCC has similar radiological and pathological features to peliosis hepatis, it is difficult to differentiate them based on drug history and imaging studies. The detection of stromal invasion into the portal area is necessary to distinguish well-differentiated HCC from benign hepatic tumors.


Assuntos
Carcinoma Hepatocelular/induzido quimicamente , Anticoncepcionais Orais/efeitos adversos , Neoplasias Hepáticas/induzido quimicamente , Carcinoma Hepatocelular/diagnóstico , Diagnóstico Diferencial , Feminino , Humanos , Fígado/patologia , Neoplasias Hepáticas/diagnóstico , Pessoa de Meia-Idade , Peliose Hepática/diagnóstico
7.
Pathol Int ; 60(7): 520-3, 2010 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20594274

RESUMO

We describe a 66-year-old woman with Epstein-Barr virus-associated lymphoproliferative disorder with lung and gastric tumors. We identified two lung tumors measuring 13 and 20 mm in diameter that consisted of CD30-, CD15-, and CD20-positive Hodgkin- and Reed-Sternberg-like cells and heterogeneous cellular infiltrates in a pronounced nodular pattern, with necrosis and vasculitis, diagnosed as nodular sclerosis classical Hodgkin lymphoma. A gastric tumor showed low-grade extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type. Neoplastic cells in all tumors expressed Epstein-Barr virus-encoded RNA based on in situ hybridization. The present case is a rare composite lymphoma arising from different extranodal organs, associated with EBV infection. Her medical history included gamma-knife therapy for clinical diagnosis with a suspicion of cerebral lymphoma.


Assuntos
Doença de Hodgkin/patologia , Neoplasias Pulmonares/patologia , Linfoma de Zona Marginal Tipo Células B/patologia , Neoplasias Primárias Múltiplas/patologia , Neoplasias Gástricas/patologia , Idoso , Infecções por Vírus Epstein-Barr/complicações , Feminino , Doença de Hodgkin/virologia , Humanos , Hibridização In Situ , Neoplasias Pulmonares/virologia , Linfoma de Zona Marginal Tipo Células B/virologia , Neoplasias Primárias Múltiplas/virologia , Neoplasias Gástricas/virologia
8.
Pathol Int ; 60(8): 591-4, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-20618738

RESUMO

An autopsy case of intrahepatic cholangiocarcinoma (ICC) with a peculiar form of extensive portal invasion is reported here. A 76-year-old woman presented with anorexia and abdominal discomfort. A high level of serum carbohydrate antigen 19-9 and endoscopically detected esophageal varices were found. Obvious mass lesion was not identified on CT scan and no portal blood flow was found. The patient died 6 months after admission. At autopsy multiple irregular shaped tumors in the liver were found. The size of the largest one was 3 x 2 cm. These tumors were well-differentiated adenocarcinomas with partial mucinous carcinoma morphology. Surprisingly, portal veins contained mucinous fluid and the inner surface was lined with a single layer of tumor cells but not endothelial cells. Invasion of carcinoma into the tissue outside the blood vessels was hardly observed in organs other than the liver. This form of extensive invasion of the tumor, termed intimal carcinoma spreading, caused complete obstruction of the portal system. To our knowledge there has been no report on this type of portal invasion of ICC.


Assuntos
Ductos Biliares Intra-Hepáticos/patologia , Colangiocarcinoma/patologia , Neoplasias Hepáticas/patologia , Idoso , Feminino , Humanos
9.
APMIS ; 115(1): 75-9, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17223853

RESUMO

We report on a fetal autopsy case in which a congenital cervical immature teratoma was diagnosed. A 24-year-old Japanese woman had carried a male fetus that was aborted because of a cervical tumor at 20 weeks 5 days of gestation. The cervical tumor weighed 93 g and measured 7.5x5.5x5 cm. The soft tumor was encapsulated by a fibrous layer, was solid with small cysts on the cut surface, and showed a brain-like appearance. The tumor was composed of neoplastic cells derived from the three germ cell layers: ectoderm, mesoderm, and endoderm. The cells showed both immature and mature features. Small areas of thyroid tissue were detected in the cervical tumor. The left lobe of the thyroid gland was not observed, but the right lobe of the thyroid gland was present laterally between the trachea and the esophagus. Therefore, we concluded that the cervical tumor had arisen in the left lobe of the thyroid gland rather than from the soft tissue of the neck.


Assuntos
Neoplasias de Cabeça e Pescoço/patologia , Teratoma/secundário , Neoplasias da Glândula Tireoide/patologia , Neoplasias do Colo do Útero/secundário , Aborto Eugênico , Adulto , Feminino , Doenças Fetais/patologia , Neoplasias de Cabeça e Pescoço/diagnóstico , Neoplasias de Cabeça e Pescoço/embriologia , Humanos , Masculino , Gravidez , Teratoma/diagnóstico , Teratoma/embriologia , Neoplasias da Glândula Tireoide/diagnóstico , Neoplasias da Glândula Tireoide/embriologia
10.
Pathol Res Pract ; 201(8-9): 603-8, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-16259115

RESUMO

We report on a 50-year-old man with dystrophic localized amyloidosis who noticed a soft tumor in his left thigh about 20 years ago, after which the tumor has gradually enlarged. The multicystic tumor showed hemorrhage, hematoma, necrosis, fibrosis, and tiny nodules and various polymorphous granulomas were observed. One was rich in eosinophilic amorphous materials and cholesterol crystals, and was poor in cell reaction. Another was formed by granuloma consisting of multinucleated giant cells, foamy cells, and macrophages. Transitional granulomas between the two were also observed. The materials showed eosinophilia and red staining and apple-green birefringence in polarized light by alkaline Congo-red stain, and they were also resistant to potassium permanganate pretreatment. They were also positive for amyloid P component and consistently negative for amyloid A, kappa- and lambda-light chains, beta2-microglobulin, and transthyretin. Therefore, it was suggested that this might be an amyloid derived from the hematoma, which has not been reported to date.


Assuntos
Amiloidose/patologia , Tecido Conjuntivo/patologia , Cistos/patologia , Hematoma/patologia , Amiloide/metabolismo , Amiloidose/metabolismo , Amiloidose/cirurgia , Corantes , Vermelho Congo , Tecido Conjuntivo/metabolismo , Tecido Conjuntivo/cirurgia , Cistos/metabolismo , Cistos/cirurgia , Diagnóstico Diferencial , Hematoma/metabolismo , Hematoma/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias de Tecidos Moles/diagnóstico , Coxa da Perna , Resultado do Tratamento
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