Construction and validation of a musculoskeletal disease risk prediction model for underground coal miners.

Objective: To understand the prevalence among underground coal miners of musculoskeletal disorders (MSDs), analyze the risk factors affecting MSDs, and develop and validate a risk prediction model for the development of MSDs. Materials and methods: MSD questionnaires were used to investigate the prevalence of work-related musculoskeletal disorders among 860 underground coal miners in Xinjiang. The Chinese versions of the Effort-Reward Imbalance Questionnaire (ERI), the Burnout Scale (MBI), and the Self-Rating Depression Inventory (SDS) were used to investigate the occupational mental health status of underground coal miners. The R4.1.3 software cart installation package was applied to randomly divide the study subjects into a 1:1 training set and validation set, screen independent predictors using single- and multi-factor regression analysis, and draw personalized nomogram graph prediction models based on regression coefficients. Subject work characteristic (ROC) curves, calibration (Calibrate) curves, and decision curves (DCA) were used to analyze the predictive value of each variable on MSDs and the net benefit. Results: (1) The prevalence of MSDs was 55.3%, 51.2%, and 41.9% since joining the workforce, in the past year, and in the past week, respectively; the highest prevalence was in the lower back (45.8% vs. 38.8% vs. 33.7%) and the lowest prevalence was in the hips and buttocks (13.3% vs. 11.4% vs. 9.1%) under different periods. (2) Underground coal miners: the mean total scores of occupational stress, burnout, and depression were 1.55 ± 0.64, 51.52 ± 11.53, and 13.83 ± 14.27, respectively. (3) Univariate regression revealed a higher prevalence of MSDs in those older than 45 years (49.5%), length of service > 15 years (56.4%), annual income <$60,000 (79.1%), and moderate burnout (43.2%). (4) Binary logistic regression showed that the prevalence of MSDs was higher for those with 5-20 years of service (OR = 0.295, 95% CI: 0.169-0.513), >20 years of service (OR = 0.845, 95% CI: 0.529-1.350), annual income ≥$60,000 (OR = 1.742, 95% CI: 1.100-2.759), and severe burnout (OR = 0.284, 95% CI: 0.109-0.739), and that these were independent predictors of the occurrence of MSDs among workers in underground coal mine operations (p < 0.05). (5) The areas under the ROC curve for the training and validation sets were 0.665 (95% CI: 0.615-0.716) and 0.630 (95% CI: 0.578-0.682), respectively, indicating that the model has good predictive ability; the calibration plots showed good agreement between the predicted and actual prevalence of the model; and the DCA curves suggested that the predictive value of this nomogram model for MSDs was good. Conclusion: The prevalence of MSDs among workers working underground in coal mines was high, and the constructed nomogram showed good discriminatory ability and optimal accuracy.

Influence of the interaction between parental myopia and poor eye habits when reading and writing and poor reading posture on prevalence of myopia in school students in Urumqi, China.

BACKGROUND: To evaluate the prevalence of myopia in school students in Urumqi, China, and explore the influence of the interaction between parental myopia and poor reading and writing habits on myopia to identify the at-risk population and provide evidence to help school students avoid developing myopia. METHODS: A cross-sectional survey was conducted with 6,883 school students aged 7-20 years in Urumqi in December 2019. The Standard Eye Chart and mydriatic optometry were used to determine whether students had myopia. Falconer's method was used to calculate the heritability of parental myopia. Multivariate unconditional logistic regression models were used to analyze the risk factors for myopia and the additive and multiplicative interaction of parental myopia and poor reading and writing habits. RESULTS: After standardizing the age of the 6,883 students, the overall prevalence rate of myopia was 47.50 %. The heritability of parental myopia was 66.57 % for boys, 67.82 % for girls, 65.02 % for the Han group, and 52.71 % for other ethnicities. There were additive interactions between parental myopia and poor reading and writing habits; among them, parental myopia and poor eye habits when reading and writing (the distance between the eyes and book is less than 30 cm when reading and writing, fingers block the sight of one eye while holding the pen, and leaning one's body when reading and writing; habit 1) increased the risk of myopia by 10.99 times (odds ratio [OR] = 10.99, 95 % confidence interval [CI] = 8.33-14.68), parental myopia and poor reading posture (reading while lying down, walking, or in the car; habit 2) increased the risk of myopia by 5.92 times (OR = 5.92, 95 % CI = 4.84-7.27). There was no multiplicative interaction between parental myopia and habit 1 or habit 2 (OR = 0.69, 95 % CI = 0.44-1.08; OR = 0.89, 95 % CI = 0.66-1.21, respectively). CONCLUSION: The prevalence of myopia among students in Urumqi, Xinjiang is relatively high. The risk of developing myopia is affected by parental myopia and poor reading and writing habits. In addition, parental myopia amplifies the harm caused by poor reading and writing habits, thereby increasing the risk of myopia. Students with parents who have myopia should be targeted during myopia prevention efforts.

Decreased chromobox homologue 7 expression is associated with epithelial-mesenchymal transition and poor prognosis in cervical cancer.

The aim of this study was to evaluate the association of the chromobox homologue 7 (CBX7) expression with the epithelial-mesenchymal transition in cervical cancer (CC), as well as with the disease prognosis. CBX7, E-cadherin (E-cad), and vimentin (VIM) expression levels were detected with immunohistochemistry. The relationship between the expression of CBX7, E-cad, and VIM expression and conventional clinicopathological characteristics of CC were evaluated. The positive expression rates of CBX7 and E-cad in the CC tissues were lower than the adjacent non-tumorous cervical tissues. Moreover, the VIM expression level was higher. The CBX7 expression was positively correlated with the E-cad expression, whereas was negatively correlated with the VIM expression. Furthermore, CBX7 was associated with the disease clinical staging, histological differentiation, lymph node metastasis, and vascular invasion. Patients with negative CBX7 expression showed decreased overall survival rates compared with those with low or high CBX7 expression. Multivariate Cox regression analysis indicated that the decreased CBX7 expression was an independent predictor for the poor prognosis of CC. In conclusion, the absence of CBX7 is associated with the histologic differentiation, lymphatic metastasis, vascular invasion, and poor prognosis of CC. CBX7 may be an independent prognostic factor for the prognosis of CC patients.

The relationship between occupational stress, musculoskeletal disorders and the mental health of coal miners: The interaction between BDNF gene, TPH2 gene polymorphism and the environment.

OBJECTIVE: Mental disorders are prevalent among the population and seriously endanger people's working ability as well as their physical and mental health. This study employed stratified cluster random sampling to examine occupational stress, musculoskeletal disorders (MSDs) and the mental health status of 1675 coal miners in Xinjiang. METHODS: A cross-sectional investigation was carried out, and BDNF (rs6265, rs10835210) gene polymorphism and TPH2(rs4570625, rs4131347) gene polymorphism were identified in 30% of the study's participants. This study aimed to analyze the relationship between mental disorders, occupational stress and MSDs, and to explore the role of gene-gene and gene-environment interactions in respect to the incidence of psychological disorders. On this basis, the risk prediction model of mental disorders was constructed. RESULTS: The study identified the following risk factors for mental disorders among coal miners: Female, age, four shifts, coal miners, college education or above, single, occupational stress, and MSDs. MSDs, BDNF gene (rs6265) and TPH2 gene (rs4570625) are directly related to mental disorders, and interactions were found between MSDs and BDNF gene (rs6265),TPH2 gene (rs4570625), affecting the incidence of mental disorders. The Bayesian network model of mental disorders showed that MSDs, educational level, TPH2 gene (rs4570625) and marital status had a higher influence on mental disorders. Monthly income and educational level can indirectly affect mental disorders through occupational stress. BDNF gene (rs6265) and TPH2 gene (rs4570625) can indirectly affect mental disorders through MSDs. There may be an interaction between MSDs and educational level. CONCLUSIONS: Besides demographic characteristics, occupational stress and musculoskeletal disorders are also factors affecting the mental health of coal miners. It was found that BDNF rs10835210, TPH2 rs4570625 and TPH2 rs4131347 interact with each other, increasing the risk of mental disorders among coal miners.

Effects of Occupational Radiation Exposure on Job Stress and Job Burnout of Medical Staff in Xinjiang, China: A Cross-Sectional Study.

BACKGROUND Although the potential effects of long-term and low-dose radiation exposure on physical health have attracted considerable attention, few systematic evaluations have been reported regarding the mental health of occupational groups. This study sought to investigate the effects of occupational radiation exposure on job stress and job burnout of medical radiation staff. MATERIAL AND METHODS Using cluster random sampling, a total of 1573 medical radiation workers were initially selected from 10 hospitals in Xinjiang, China, and 1396 valid questionnaires were finally collected. Job stress and job burnout were assessed using the Effort-Reward Imbalance (ERI) questionnaire and the Chinese Maslach Burnout Inventory (CMBI), respectively. RESULTS The percentages of medical radiation staff experiencing job stress and job burnout were 53.08% and 63.32%, respectively. A statistically significant difference in job stress was observed in association with age, ethnicity, professional title, marital status, radiation work type, radiation working years, family history, hypertension, obesity, smoking, and drinking (P<0.05). A statistically significant difference in job burnout was observed in association with age, sex, ethnicity, professional title, educational level, marital status, job post, radiation work type, radiation working years, family history, hypertension, diabetes, and obesity (P<0.05). Female (odds ratio [OR]=0.75, 95% confidence interval [CI]: 0.58-0.98), senior professional title (OR=0.64, 95% CI: 0.43-0.96), and radiation work types of nuclear medicine (OR=0.15, 95% CI: 0.07-0.33) and radiotherapy (OR=0.54, 95% CI: 0.36-0.79) were protective factors, and job stress (OR=4.57, 95% CI: 3.55-5.91) was the risk factor for job burnout of medical radiation staff. CONCLUSIONS Medical radiation staff experience high levels of job stress and job burnout. The interventions of occupational physical examination, personal dose monitoring, occupational health education, and management optimization are recommended to relieve job stress and job burnout and enhance occupational health of medical radiation staff.

A Cross-Sectional Epidemiological Survey of Work-Related Musculoskeletal Disorders and Analysis of Its Influencing Factors among Coal Mine Workers in Xinjiang.

This study is to investigate the prevalence of work-related musculoskeletal disorders (MSDs) and the influencing factors among coal mine workers employed in on-site operations. The job burnout scale and MSD scale were implemented to investigate a random sample of 1,500 coal mine workers working in on-site operations in Xinjiang, China. In total, 1,325 valid questionnaires were collected, with a recovery rate of 88.33% (1,325/1,500). The rate of job burnout was 90%, of which 39.8% were categorized as mild burnout, 43.8% as moderate burnout, and 6.4% as severe burnout; the average job burnout score was 50.77 ± 11.93. The annual prevalence of MSDs was 65.6%, with the highest annual prevalence in the waist (50.7%), followed by the neck, shoulder, and knee, and the lowest prevalence in the elbow (18.8%). Of the areas of the body affected by work-related MSDs, the highest proportion of requests for leave of absence was related to the waist, accounting for 25.7% of requests, while the lowest proportion (13.4%) was related to the wrist. In addition, the incidence of MSDs increased with the years of service. The lowest incidence of MSDs was associated with the two-shift and three-group working pattern. The prevalence of MSDs in the neck and waist was higher in women than in men. The prevalence of MSDs in various body parts increased with the years of service. Moreover, multiple logistic regression indicated that three shifts with four groups (OR = 1.096, 95% CI: 0.832-1.445), working more than 10 years (OR = 3.396, 95% CI: 2.369-5.748), working more than 20 years (OR = 3.008, 95% CI: 1.419-6.337), significant bending (OR = 2.062, 95% CI: 1.400-3.038), forward neck tilting (OR = 1.572, 95% CI: 1.071-2.281), maximum force operation within a short period of time (OR = 1.7222, 95% CI: 1.164-2.547), repeated movement of upper arms or fingers (OR = 1.495, 95% CI: 1.034-2.161), slip or fall incidents (OR = 1.124, 95% CI: 1.039-1.216), work under conditions of cold or temperature variations (OR = 1.911, 95% CI: 1.342-2.720), mild burnout (OR = 1.492, 95% CI: 1.016-2.191), moderate burnout (OR = 1.852, 95% CI: 1.267-2.708), and severe burnout (OR = 2.001, 95% CI: 1.145-3.496) were risk factors for MSDs. In conclusion, there is a high annual prevalence of MSDs among the coal mine workers employed in on-site operations in Xinjiang, China. Measures to reduce this prevalence are required.

Associations of occupational stress with job burn-out, depression and hypertension in coal miners of Xinjiang, China: a cross-sectional study.

OBJECTIVE: Strategies and measures for fighting occupational stress in China are inadequate. This study aimed to determine the level of occupational stress in coal miners and to assess the associations between occupational stress and job burn-out, depression and hypertension. The results could provide clues for preventive measures and strategies to improve the psychological well-being of this population. DESIGN: Cross-sectional study. SETTING: Xinjiang Coal Administration Bureau. PARTICIPANTS: Four coal mines were selected randomly (computer-generated random number-based selection process) from the 21 coal mines of Xinjiang, and all miners with >1 year of employment were screened for participation. PRIMARY AND SECONDARY OUTCOME MEASURES: A general demographic questionnaire, the Self-rating Depression Scale, the Effort-Reward Imbalance (ERI) model and the Maslach Burn-out Inventory. RESULTS: A total of 1400 questionnaires were collected, including 1334 (95.3%) valid questionnaires. This survey indicated that 1107 (83.0%) participants with an ERI score >1 (high occupational stress) and 227 (12.8%) had ERI ≤1. Severe depression was found in 21.7% of the participants. Job burn-out was positively correlated with occupational stress, which was, in turn, associated with depression. Multivariable linear regression analysis showed that depression (ß=0.006, p=0.012), sex (ß=0.358, p<0.001) and occupational stress (ß=0.702, p<0.001) were independently associated with job burn-out. Working years (ß=-0.086, p=0.015) and job burn-out (ß=0.022, p<0.001) were directly associated with depression. CONCLUSION: This study highlights that occupational stress may affect job burn-out, depression symptoms and hypertension. A higher degree of occupational stress was associated with poorer mental status and hypertension.