Neiguan (PC6) acupoint stimulation for preventing chemotherapy-induced nausea and vomiting: a cost-effective supplement in guideline-inconsistent chemotherapy-induced nausea and vomiting prophylaxis subgroup.

OBJECTIVE: To assess the efficacy and safety of Neiguan (PC6) acupoint acustimulation in preventing chemotherapy-induced nausea and vomiting (CINV), especially for patients with guideline-inconsistent CINV prophylaxis (GICP) due to personal reasons METHODS: From January 2021 to December 2021, 373 patients suffered from solid malignancy were recruited according to the inclusion criteria. Complete response (no emesis and no rescue medication use) rate during the overall phase (0-120 h of each chemo-cycle) was the primary assessment of CINV control. The Functional Living Index-Emesis (FLIE) questionnaire was investigated among these patients as a secondary 'quality of life' objective to assess the impact of CINV on patients' daily life by recording score of nausea and vomiting. RESULTS: With acustimulation of Neiguan (PC6) acupuncture point through a portable, noninvasive and user-friendly device, in terms of complete response rate and scores in nausea/vomiting by FLIE questionnaire, patients achieve a better outcome in highly emetogenic chemotherapy (HEC) induced CINV, especially GICP subgroup. Meanwhile, analysis also demonstrated this tendency existed in other patients with HEC/GCCP (guideline consistent CINV prophylaxis) and moderate emetogenic chemotherapy, although the difference was not significant. CONCLUSION: Considering advantages of Neiguan (PC6) acustimulation such as noninvasive, covered by medical insurance and few side effects, we believe it would be an ideal auxiliary tool in CINV control, especially in patients who receive highly emetogenic chemo-protocol and are reluctant to GCCP for economic reasons.

Influence of the Anatomical Structure on the Hemodynamics of Iliac Vein Stenosis.

Few reports study the effects of the anatomical structure of the iliac vein on hemodynamics and the methods to reduce and delay in-stent thrombosis. The anatomical structure of iliac vein stenosis was used to establish vascular models with different stenosis rates, taper angle, and left branch tilt angle in the work. The influence of anatomical structure on hemodynamics was revealed through theoretical research and in vitro experimental verification. A real iliac vein model was built based on computed tomography angiography (CTA) images, and hemorheological parameters including time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI) and relative residence time (RRT) were analyzed by computational fluid dynamics (CFD). The results showed that iliac vein stenosis could significantly increase the wall shear stress (WSS) of the blood vessels at the stenosis site and outside the intersection area, which was easy to produce eddy currents in the distal blood vessels. With the increased taper angle, the proportion of low-wall shear stress areas and the risk of thrombosis increased. A small tilt angle could aggravate the influence of narrow blood vessels on the blood flow characteristics and vascular wall. The numerical simulation results were consistent with the theoretical research results, and the experimental study verified the correctness of the simulation. The work is helpful to further understand the hemodynamic characteristics of the iliac vein, providing a scientific reference for clinical treatment and diagnosis.

Aerobic training methods for high school soccer / Métodos de treino aeróbico para o futebol de ensino médio / Métodos de entrenamiento aeróbico para el fútbol de la escuela secundaria

ABSTRACT Introduction: Fatigue impairs exercise activity in high school students, and it is detrimental to explore aerobic training when fatigue cannot be alleviated. This factor limits the ability to exploit the full potential of young athletes for soccer. Objective: Implement a healthy development protocol for soccer application in high school. Methods: This article used a literature review among other research methods. The analysis was devoted to aerobic training for endurance in soccer for students in high school. The specific methods of implementing the developed protocol in high schools were studied. Finally, effective measures for improving students' physical fitness were presented. Results: Judging from the situation, the duration of each training session in high school soccer is closely related to the coaches' ability. High-level coaches tend to organize the duration of training according to the perceived effects in soccer practice, considering the physical and technical characteristics of the sport itself. Conclusion: Soccer endurance training can also promote the long-term development of soccer education while meeting students' actual exercise needs. It is important to carry out soccer aerobic training applied to high school. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO Introdução: A fadiga prejudica a atividade do exercício físico nos alunos do ensino secundário, sendo prejudicial explorar os treinos aeróbicos quando a fadiga não pode ser aliviada. Esse fator limita a capacidade de explorar o máximo potencial de jovens atletas para o futebol. Objetivo: Implementar um protocolo de desenvolvimento sadio para a aplicação do futebol no ensino médio. Métodos: Este artigo utilizou a revisão bibliográfica entre outros métodos de investigação. A análise foi dedicada ao treino aeróbico para a resistência no futebol dos estudantes no ensino médio. Estudou-se os métodos específicos de implementação do protocolo elaborado nas escolas de ensino médio. Finalmente, foram apresentadas as medidas eficazes para melhorar a condição física dos estudantes. Resultados: A julgar pela situação em tela, a duração de cada sessão de treino no futebol do ensino médio está intimamente relacionada com a capacidade dos treinadores. Os treinadores de alto nível tendem a organizar a duração do treino de acordo com os efeitos perceptíveis na prática do futebol, considerando as características físicas e técnicas do próprio esporte. Conclusão: A formação de resistência no futebol pode também promover o desenvolvimento a longo prazo da educação futebolística ao mesmo tempo em que satisfaz as necessidades reais de exercício físico dos estudantes, sendo de grande importância realizar a formação do treino aeróbico no futebol aplicado ao ensino médio. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción: La fatiga perjudica la actividad del ejercicio en los estudiantes de secundaria, y es perjudicial explorar el entrenamiento aeróbico cuando la fatiga no se puede aliviar. Este factor limita la capacidad de explotar el máximo potencial de los jóvenes deportistas para el fútbol. Objetivo: Implementar un protocolo de desarrollo saludable para la aplicación del fútbol en la escuela secundaria. Métodos: Este artículo utilizó, entre otros métodos de investigación, la revisión de la literatura. El análisis se dedicó al entrenamiento aeróbico de resistencia en el fútbol para estudiantes de secundaria. Se estudiaron los métodos específicos de aplicación del protocolo elaborado en los institutos. Por último, se presentaron las medidas eficaces para mejorar la aptitud física de los alumnos. Resultados: A juzgar por la situación en la pantalla, la duración de cada sesión de entrenamiento en el fútbol de la escuela secundaria está estrechamente relacionada con la capacidad de los entrenadores. Los entrenadores de alto nivel tienden a organizar la duración del entrenamiento en función de los efectos percibidos en la práctica del fútbol, teniendo en cuenta las características físicas y técnicas del propio deporte. Conclusión: El entrenamiento de la resistencia en el fútbol también puede promover el desarrollo a largo plazo de la educación futbolística al tiempo que satisface las necesidades reales de ejercicio físico de los estudiantes, y es de gran importancia llevar a cabo la formación del entrenamiento aeróbico en el fútbol aplicado a la escuela secundaria. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

A deep learning-based approach toward differentiating scalp psoriasis and seborrheic dermatitis from dermoscopic images.

Objectives: This study aims to develop a new diagnostic method for discriminating scalp psoriasis and seborrheic dermatitis based on a deep learning (DL) model, which uses the dermatoscopic image as input and achieved higher accuracy than dermatologists trained with dermoscopy. Methods: A total of 1,358 pictures (obtained from 617 patients) with pathological and diagnostic confirmed skin diseases (508 psoriases, 850 seborrheic dermatitides) were randomly allocated into the training, validation, and testing datasets (1,088/134/136) in this study. A DL model concerning dermatoscopic images was established using the transfer learning technique and trained for diagnosing two diseases. Results: The developed DL model exhibits good sensitivity, specificity, and Area Under Curve (AUC) (96.1, 88.2, and 0.922%, respectively), it outperformed all dermatologists in the diagnosis of scalp psoriasis and seborrheic dermatitis when compared to five dermatologists with various levels of experience. Furthermore, non-proficient doctors with the assistance of the DL model can achieve comparable diagnostic performance to dermatologists proficient in dermoscopy. One dermatology graduate student and two general practitioners significantly improved their diagnostic performance, where their AUC values increased from 0.600, 0.537, and 0.575 to 0.849, 0.778, and 0.788, respectively, and their diagnosis consistency was also improved as the kappa values went from 0.191, 0.071, and 0.143 to 0.679, 0.550, and 0.568, respectively. DL enjoys favorable computational efficiency and requires few computational resources, making it easy to deploy in hospitals. Conclusions: The developed DL model has favorable performance in discriminating two skin diseases and can improve the diagnosis, clinical decision-making, and treatment of dermatologists in primary hospitals.

Clinical validation of pinopode as a marker of endometrial receptivity: a randomized controlled trial.

OBJECTIVE: To determine the clinical value of pinopodes in the human. DESIGN: Randomized controlled trial. SETTING: Academic fertility center. PATIENT(S): From December 2014 to December 2016, in a phase I trial, 363 patients were recruited in their first IVF cycles. In a phase II trial, 136 patients with at least two previous embryo implantation failures were recruited. INTERVENTION(S): In the phase I trial, in the midluteal phase, endometrial tissues were obtained for scanning electron microscopy, and their IVF treatment outcomes were followed up. In the phase II trial, participants were allocated into two groups by random number table, and the experimental group had twice the number of the control group. Individual ETs (iETs) were performed in the experimental group, while frozen-thawed embryos were routinely transferred in the control group. MAIN OUTCOME MEASURE(S): Clinical pregnancy rate (CPR) and ongoing pregnancy rate (OPR). RESULT(S): In the phase I trial, through receiver operation characteristic curve analysis, the optimal pinopode scoring for successful clinical pregnancy was determined to be 85. The CPR (74.29% vs. 19.77%) and OPR (62.86% vs 11.86%) were significantly higher in the patients whose pinopode scoring was >85. In the phase II trial, the CPR was dramatically higher in the iET group (33.82% vs. 8.11%). CONCLUSION(S): Pinopode scoring is a reliable marker of endometrial receptivity, and iET based on pinopode scoring is a promising solution for recurrent implantation failure. TRIAL REGISTRATION NUMBERS: ChiCTR-OOC-14005617; ChiCTR-OOC-15005882.

[Correlation factors of lymph node metastasis in patients with clinical stage T1a non-small cell lung cancer].

OBJECTIVE: To explore the relationship between the lymph node metastasis and clinicopathological features in patients with clinical stage T1a non-small cell lung cancer (NSCLC). METHODS: Clinicopathological data of a total of 418 patients who underwent lobectomy and systematic lymph node dissection were retrospectively analyzed. Logistic regression was used to analyze the relationship between lymph node metastasis and clinicopathological features. RESULTS: Lymph node metastasis was observed in 25 patients. There were 122 patients who were diagnosed as ground glass opacity with no lymph node metastasis. 399 patients had subcarinal dissection, among them 7 patients were found to have lymph node metastasis. Univariate analysis showed that gender, smoking history, diameter of lymph node, ground glass opacity (GGO), differentiation of the tumor and tumor site were the factors affecting lymph node metastasis (all P < 0.05). Logistic regression analysis showed that diameter of lymph node, differentiation of the tumor and the site of lesion were independent risk factors for lymph node metastasis of NSCLC. CONCLUSIONS: Tumor in the left lung, poor differentiation, and diameter of lymph nodes ≥ 1 cm on the preoperative CT image are independent risk factors for lymph node metastasis of NSCLC, hence we should pay attention before surgery and systematic lymph node dissection should be done. For patients with poor differentiation and lymph nodes ≥ 1 cm, subcarinal lymph nodes dissection is recommended for the sake of higher possibility of lymph node metastasis. For patients with ground glass opacity ≤ 2 cm, the lymph node metastasis is extremely rare, therefore, selective lymph node dissection is reconmmended.

Simple method of optical ring cavity design and its applications.

When an optical ring cavity is designed, the beam radii at some special positions, especially at the beam waists are very interested in, since the gain mediums, nonlinear crystals and others important optical elements are generally located at the beam waist. In this paper, we firstly presented a simple method for designing optical ring cavities based on the self-consistency theory and the fact that q parameter is uniquely determined by the waist beam radius and its position. This approach is different from ABCD method and it no longer requires cumbersome calculation. The calculations of designing optical ring cavities are simplified because q parameter only has imaginary part at beam waist plane. Moreover, designing the resonant cavity through the calculation of beam waist radii and their position has great practical significance, because it is very easy to adjust the waist radii and the positions at the important optical elements. We employed this method to design an end-pumped six-mirror ring cavity continuous-wave passively mode locked laser. The experiment of a highly stabilized continuous-wave mode locked (CWML) laser was investigated and the results coincided with the theoretical studies very well. The investigation results show that the simple method can be used to design optical ring cavities conveniently, intuitively and efficiently.

A simple method for astigmatic compensation of folded resonator without Brewster window.

A folded resonator requires an oblique angle of incidence on the folded curved mirror, which introduces astigmatic distortions that limit the performance of the lasers. We present a simple method to compensate the astigmatism of folded resonator without Brewster windows for the first time to the best of our knowledge. Based on the theory of the propagation and transformation of Gaussian beams, the method is both effective and reliable. Theoretical results show that the folded resonator can be compensated astigmatism completely when the following two conditions are fulfilled. Firstly, when the Gaussian beam with a determined size beam waist is obliquely incident on an off-axis concave mirror, two new Gaussian beam respectively in the tangential and sagittal planes are formed. Another off-axis concave mirror is located at another intersection point of the two new Gaussian beams. Secondly, adjusting the incident angle of the second concave mirror or its focal length can make the above two Gaussian beam coincide in the image plane of the second concave mirror, which compensates the astigmatic aberration completely. A side-pumped continues-wave (CW) passively mode locked Nd:YAG laser was taken as an example of the astigmatically compensated folded resonators. The experimental results show good agreement with the theoretical predictions. This method can be used effectively to design astigmatically compensated cavities resonator of high-performance lasers.

Rat bone marrow mesenchymal stem cells improve regeneration of thin endometrium in rat.

OBJECTIVE: To investigate whether bone marrow mesenchymal stem cell (BMSC) treatment could improve the regeneration of endometrium and improve the endometrial receptivity in an experimental model of thin endometrium. DESIGN: Randomized, control trial, animal research. SETTING: National key laboratory. ANIMAL(S): Sprague-Dawley rats. INTERVENTION(S): Bone marrow mesenchymal stem cell transplantation by tail vein IV injection. MAIN OUTCOME MEASURE(S): Endometrial thickness, the expression of mark proteins for endometrial cell, and endometrial receptivity. RESULT(S): The endometrium was significantly thicker and the expression of cytokeratin, vimentin, integrin αγß3, and leukemia inhibitor factor were significantly stronger compared with the control group. Some proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α) messenger RNA (mRNA) and interleukin-1ß mRNA, were significantly down-regulated, and anti-inflammatory cytokines, such as fibroblast growth factor-ß (bFGF) mRNA and interleukin-6 mRNA, were significantly up-regulated in the experimental group compared with the control group. CONCLUSION(S): The BMSCs have beneficial effect on thin endometrium, and may play a role through migration and immunomodulatory of BMSCs.