1.
J Org Chem
; 88(13): 8279-8285, 2023 Jul 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37257025
RESUMO
A method for chemoselective reduction of 2-pyridyl ketones and related N-heteroaryl compounds catalyzed by cobalt stearate using DMF as a hydride source is developed. The ketone substrate is activated by chelation with cobalt, which makes the present method highly chemoselective. A possible reaction mechanism is proposed on the basis of control experiments.