1.
Bioorg Med Chem Lett
; 20(12): 3565-8, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20488702
RESUMO
A series of novel azobicyclo[3.3.0]octane derivatives were synthesized and evaluated as dipeptidyl peptidase 4 (DPP-4) inhibitors. The effort resulted in the discovery of inhibitor 2a, which exhibited excellent efficacies in an oral glucose tolerance test. Introduction of methyl group (2j) could prolong the inhibition of serum DPP-4 activity.