Disordered Gut Microbiome and Alterations in Metabolic Patterns Are Associated With Hypertensive Left Ventricular Hypertrophy.

BACKGROUND: Left ventricular hypertrophy (LVH) is most common when driven by hypertension, and it is a strong independent risk factor for adverse cardiovascular events and death. Some animal models support a role for gut microbiota and metabolites in the development of LVH, but cohort studies confirming these findings in populations are lacking. METHODS AND RESULTS: We investigated the alterations of gut microbiota and metabolites in 30 patients with hypertension, 30 patients with hypertensive LVH, and 30 matched controls on the basis of 16S rDNA and metabolomic analyses. Thirty stool and 90 serum samples were collected in fasting conditions. ANOVA/Kruskal-Wallis/Pearson's χ2/Fisher's exact test and Bonferroni's correction were used (P<0.0167) for comparison among the 3 groups. A regression analysis and subgroup analysis were performed between gut microbiota and left ventricular mass index (LVMI) and metabolites and LVMI, respectively. Spearman correlation analysis was performed between metabolites and flora and metabolites and LVMI. We observed LVH-enriched Faecalitalea (ß=6758.55 [95% CI, 2080.92-11436.18]; P=0.009), Turicibacter (ß=8424.76 [95% CI, 2494.05-14355.47]; P=0.01), Ruminococcus torques group (ß=840.88 [95% CI, 223.1-1458.67]; P=0.013), and Erysipelotrichaceae UCG-003 (ß=856.37 [95% CI, 182.76-1529.98]; P=0.019) were positively correlated with LVMI. A total of 1141 (in sera) and 2657 (in feces) metabolites were identified. There was a sex-specific association between metabolites and LVMI. Significant changes in metabolic pathways in LVH were also observed, especially bile acid and lipid metabolism pathways. CONCLUSIONS: Our study demonstrated the disordered gut microbiota and microbial metabolite profiles in LVH. This highlights the roles of gut bacteria and metabolite in this disease and could lead to new intervention, diagnostic, or management paradigms for LVH. REGISTRATION: URL: https://www.chictr.org.cn; Unique Identifier: ChiCTR2200055603.

Experimental investigation of influence of amide polymer on loess for subgrade.

The effects of moisture and drying shrinkage can lead to uneven settlement, cracking, and other diseases in loess subgrade. The objective of this study was to investigate the effects of amide polymer (AP) on the permeability, mechanical properties and crack resistance of loess by orthogonal experiments. The basic properties of AP and the permeability, mechanical properties, and dry-wet variation properties of polymer-modified loess were tested, and a scale model verification and simulation analysis were conducted. In this paper, water migration in subgrade is regulated by improving the water sensitivity of loess. By reducing the variation range of subgrade water content, the stress accumulation in subgrade caused by water is weakened. The results show that the curing time and mechanical properties of AP are directly affected by the oxidant and reducing agent, and the mechanical properties of AP are compatible with the characteristics of loess. AP filled the grain gap and reduced the permeability of loess by 34.05-280.83%. The ductility of polymer-modified loess is significantly increased, and the strain of peak strength is increased by 17.21-126.36%. AP can regulate moisture change, reduce the surface tension between particles, and reduce stress concentration. The strength loss rate was reduced by 19.98-51.21% by enhancing the cracking resistance and weakening the strength loss caused by dry and wet cycling. The increase of upper layer moisture content in the scale model of polymer-modified loess subgrade is reduced by 31.38-36.11%.

Relationship between four insulin resistance surrogates and left ventricular hypertrophy among hypertensive adults: a case-control study.

Background: Hypertension-induced left ventricular hypertrophy (LVH) is intricately linked to insulin resistance (IR). This research aimed to elucidate the relationship of advanced indices, namely the triglyceride-glucose (TyG) index, the TyG adjusted for body mass index (TyG-BMI), the triglycerides-to-high-density lipoprotein cholesterol ratio (TG/HDL-c), and the metabolic score for IR (METS-IR), with LVH in hypertensive cohorts. Methods: This analytical case-control investigation encompassed 800 individuals aged 18 or above from the Cardiology Department of the Second Affiliated Hospital of Baotou Medical College over a span from January 2021 to April 2022. Data extraction was conducted from inpatient records. The nexus between the four metrics and LVH susceptibility was ascertained via logistic regression models. Furthermore, the receiver operating characteristic (ROC) curve's area (AUC) shed light on the discriminative capacities of the distinct IR indicators for LVH, considering other concomitant risk variables. Results: Post multifaceted covariate adjustments, the fourth quartile figures for TyG-BMI emerged as the most starkly significant (OR: 5.211, 95% CI: 2.861-9.492), succeeded by METS-IR (OR: 4.877, 95% CI: 2.693-8.835). In juxtaposition with other IR-derived indices (TyG and TG/HDL-c), TyG-BMI manifested the paramount AUC (AUC: 0.657; 95% CI: 0.606-0.708). Concurrently, METS-IR exhibited commendable predictive efficacy for LVH (AUC: 0.646; 95% CI: 0.595-0.697). Conclusion: TyG-BMI and METS-IR displayed superior discriminative capabilities for LVH, underscoring their potential as supplementary indicators in gauging LVH peril in clinical settings and prospective epidemiological research.

Regulation of PM2.5 on mitochondrial damage in H9c2 cells through miR-421/SIRT3 pathway and protective effect of miR-421 inhibitor and resveratrol.

Fine particulate matter (PM2.5) exposure is associated with cardiovascular disease (CVD) morbidity and mortality. Mitochondria are sensitive targets of PM2.5, and mitochondrial dysfunction is closely related to the occurrence of CVD. The epigenetic mechanism of PM2.5-triggered mitochondrial injury of cardiomyocytes is unclear. This study focused on the miR-421/SIRT3 signaling pathway to investigate the regulatory mechanism in cardiac mitochondrial dynamics imbalance in rat H9c2 cells induced by PM2.5. Results illustrated that PM2.5 impaired mitochondrial function and caused dynamics homeostasis imbalance. Besides, PM2.5 up-regulated miR-421 and down-regulated SIRT3 gene expression, along with decreasing p-FOXO3a (SIRT3 downstream target gene) and p-Parkin expression and triggering abnormal expression of fusion gene OPA1 and fission gene Drp1. Further, miR-421 inhibitor (miR-421i) and resveratrol significantly elevated the SIRT3 levels in H9c2 cells after PM2.5 exposure and mediated the expression of SOD2, OPA1 and Drp1, restoring the mitochondrial morphology and function. It suggests that miR-421/SIRT3 pathway plays an epigenetic regulatory role in mitochondrial damage induced by PM2.5 and that miR-421i and resveratrol exert protective effects against PM2.5-incurred cardiotoxicity.

Heavy metals (HMs) pollution in the aquatic environment: Role of probiotics and gut microbiota in HMs remediation.

The presence of heavy metals (HMs) in aquatic ecosystems is a universal concern due to their tendency to accumulate in aquatic organisms. HMs accumulation has been found to cause toxic effects in aquatic organisms. The common HMs-induced toxicities are growth inhibition, reduced survival, oxidative stress, tissue damage, respiratory problems, and gut microbial dysbiosis. The application of dietary probiotics has been evolving as a potential approach to bind and remove HMs from the gut, which is called "Gut remediation". The toxic effects of HMs in fish, mice, and humans with the potential of probiotics in removing HMs have been discussed previously. However, the toxic effects of HMs and protective strategies of probiotics on the organisms of each trophic level have not been comprehensively reviewed yet. Thus, this review summarizes the toxic effects caused by HMs in the organisms (at each trophic level) of the aquatic food chain, with a special reference to gut microbiota. The potential of bacterial probiotics in toxicity alleviation and their protective strategies to prevent toxicities caused by HMs in them are also explained. The dietary probiotics are capable of removing HMs (50-90%) primarily from the gut of the organisms. Specifically, probiotics have been reported to reduce the absorption of HMs in the intestinal tract via the enhancement of intestinal HM sequestration, detoxification of HMs, changing the expression of metal transporter proteins, and maintaining the gut barrier function. The probiotic is recommended as a novel strategy to minimize aquaculture HMs toxicity and safe human health.

Within-day variation and health risk assessment of trihalomethanes (THMs) in a chlorinated indoor swimming pool in China.

Trihalomethanes (THMs) are the most common species of disinfection by-products (DBPs) in swimming pools and have received widespread attention due to their risk to public health. However, studies examining within-day variation and the carcinogenic health risks from exposure to THMs in indoor swimming pools are limited. Our study aimed to detect the within-day variation of four THMs categories and carcinogenic health risk in indoor swimming pool water in Taiyuan, China, and to examine the correlations between THMs and environmental parameters. Our results showed chloroform (TCM) was the most abundant component in THMs with median concentrations from 0.038-0.118 µg/m3. TCM and THMs were significantly positively correlated with FCl and significantly negatively correlated with the cumulative number of swimmers (CNS) in the swimming pool. The concentration of total THMs and TCM, lifetime average daily doses (LADD) of TCM, and the total lifetime cancer risks (ELCR) values of THMs declined with time with the highest level occurring at 8:00 am. ELCR values of THMs were in the range of 1.368 × 10-5-1.968 × 10-5, which exceeded the negligible risk level (10-6) defined by US EPA. Our results suggest that THM occurrence and the carcinogenic health risks in pool water varied temporally. Exposure to pool water THMs may pose a carcinogenic risk to human health, especially at the pool's opening time.

Study on Cracking Law of Earthen Soil under Dry Shrinkage Condition.

Earthen sites are easily eroded by the natural environment, resulting in a large number of micro cracks on the surface. In order to explore the internal relationship between environmental factors and the cracking law of soil sites, this paper carries out dry shrinkage tests of different soil layers at the Zhouqiao site, reconstructs the study on cracking law of earthen soil under dry shrinkage-conditioned microstructure of site soil at different depths based on electron microscope pictures and finite element method, and explores the influence of different moisture content on the cracking of soil samples at the site. The results show that under conditions of dry shrinkage, the thickness of the soil layer has the greatest influence on the cracking of site soil samples. Due to the internal water loss and shrinkage of the soil sample, the thinner the soil layer, the more often the soil layer cracks first. The crack rate of the soil sample with a thickness of 1 cm is nearly three times higher than that of the soil sample with a thickness of 5 cm. Through numerical simulation analysis, it is found that the evolution process of soil fractures at the Zhouqiao site is mainly divided into the formation stages of initial stress field, single main fracture, secondary fracture and fracture network. The formation time of the secondary fracture is longer than that of the initial stress field and single main fracture, and the cracking of the upper soil sample is more serious than that of the lower soil sample. Under conditions of dry shrinkage, the particle arrangement of the soil sample is relatively loose, and there are many cracks inside, which provides evaporation and infiltration channels for water, forming unrecoverable weak pores, and finally, the cracks start to sprout at the weak points. The research results provide some reference for the disease mechanism and safety analysis of earthen sites.

Experimental Study on Properties of Modified City Wall Soil.

Due to the special geographical location, climatic characteristics, special soil properties and the flood zone of the Yellow River in Kaifeng, the groundwater level in the lower reaches of the river basin is high and contains much salt. The matrix suction and surface free energy of the Kaifeng city wall earthen site changed under capillary action, resulting in cracking, peeling and efflorescence to varying degrees. In order to reduce the deterioration of the Kaifeng city wall caused by environmental erosion, a select lime with excellent mechanical properties and waterproof methanesiliconic acid sodium salt with excellent water resistance were chosen to reinforce the earthen sites. In this paper, 0%, 3%, 5% and 7% lime, and 0%, 1%, 2% and 3% waterproof materials were selected to determine four types of imitation site soil with 16 different mix proportion samples. Further, samples with different mixing ratios were subjected to direct shear, a disintegration test, and a microscopic scanning electron microscope test. The results show that under different normal stresses, with the increase in waterproof material content, the growth rate of shear strength of imitation site soil ranges from 1.82% to 10.81%. With the increase in lime content, the shear strength of imitation site soil increases rapidly, up to 38.16%. Both materials can improve the shear strength of the soil site. Under reinforcement with the two materials, the cohesive force of the imitation site soil can be improved at a maximum rate of 59.23%, and the internal friction angle changes in the range of 36.72°-41.61°. Compared with the sample without waterproof material, the mass water absorption rate of the sample with waterproof material decreases in the range of 2.76-27.77, and with the increase in waterproof material, the mass water absorption rate of the sample gradually decreases. The chemical reaction products of the waterproof materials and lime can play a filling role in silty clay; filling micro-pores and micro-cracks between soil particles.

Relations between white coat effect of blood pressure and arterial stiffness.

The aim of this study was to analyze the relationship between brachial-ankle pulse wave velocity (b-a PWV) and white coat effect (WCE), that is the difference between the elevated office blood pressure (BP) and the lower mean daytime pressure of ambulatory BP, in a mixed population of normotention, untreated sustained hypertension, sustained controlled hypertension, sustained uncontrolled hypertension, white coat hypertension, white coat uncontrolled hypertension. A total of 444 patients with WCE for systolic BP (54.1% female, age 61.86 ± 13.3 years) were enrolled in the study. Patients were separated into low WCE (<9.5 mm Hg) and high WCE (≥9.5 mm Hg) according to the median of WCE. The subjects with a high WCE showed a greater degree of arterial stiffness than those with a low WCE for systolic BP values (P < .05). The b-a PWV were 17.2 ± 3.3 m/s and 18.4 ± 3.4 m/s in low WCE and high WCE, respectively. The b-a PWV increased with the increase of WCE, showing a positive correlation between them (P > .05 for non-linearity). The significant association between the high WCE and the b-a PWV was confirmed by the results of multiple regression analysis after adjusting for confounding factors (ß = .78, 95% Cl .25-1.31, P = . 004). Similar results were observed in subgroups. In conclusion, WCE is significantly associated with arterial stiffness. More research is needed to determine the WCE and target organ damage.

Effect of dibutyl phthalate on microalgal growth kinetics, nutrients removal, and stress enzyme activities.

The dibutyl phthalate (DPB) is an emerging plasticizer contaminant that disrupts the biological processes of primary producers, especially phytoplankton. In this study, two microalgal species (Chlorella sp. GEEL-08 and Tetradesmus dimorphus GEEL-04) were exposed to various concentrations of DBP extending from 0 to 100 mg/L. The growth kinetics, N-nitrate, and P-phosphate removal efficiency were assessed. The response enzymes such as malonaldehyde (MDA) and superoxide dismutase (SOD) were also investigated. The results revealed that the Chlorella sp. GEEL-08 at 10 mg/L concentration of DBP exhibited higher growth (0.88 OD680nm) compared to T. dimorphus GEEL-04 (0.80 OD680nm). More than 94% of N and P were removed from culture media by both microalgal species. The DBP (>50 mg/L) significantly exacerbates the growth of both microalgae species and the growth inhibition ratio was in the range of 3.6%-25.9%. The SOD activity and MDA were higher in T. dimorphus culture media than in the culture media of Chlorella sp. The results reflect the hazard and the risk of plasticizers on primary producers in the ecosystem.

Experimental Study on Effects of Aging Time on Dry Shrinkage Cracking of Lime Soils.

The effect of aging on the internal mechanism of the dry shrinkage cracking of lime soil was studied from the perspective of macroscopic cracking phenomenon and microscopic composition change, and the reasonable aging time of lime soil was determined. Large numbers of cracks often occur in buildings constructed using lime soil, which impacts sustainable development and building environmental protection. This study explored the influence of aging time on the mechanical properties and shrinkage cracking of lime soil. The influence of aging time was evaluated using a triaxial compression test; using the dry-wet cycle, sieving, pH, and other tests, the influence of aging time on volume crack rate, expansion shrinkage rate, particle size distribution, and pH was analyzed. Scanning electron microscopy and X-ray diffraction experiments were used to analyze changes in the lime soil particle structure for different aging times and the formation of new substances. The results show that as aging time increases, the stress-strain curve of the soil softens significantly, shear strength deteriorates, and cohesion decreases. When the aging time is 6 h, the expansion rate and shrinkage rate at the center of the soil sample are the maximum. The volume fracture and expansion shrinkage rates decrease first, and then plateau with aging time, with the changes remaining stable after 72 h; these rate decreases are positively correlated with the change rate of pH. The formation of Ca(OH)2 affects the sample pH, and the changes in pH, Ca(OH)2, and CaO tend to be stable. With an increase in aging time, the proportion of particles of a size less than 0.1 mm decreases, and that of particles of size 0.1-0.5 mm increases. After 72 h of aging, the particle size proportion remains unchanged. Reasonable aging time can, thus, reduce the hydration reaction of lime, improve particle agglomeration effects, and reduce the crack development of the soil.

Study on deterioration mechanism of soil in Zhouqiao site under salinization.

Alkalinity production is one of the most typical and widespread salinization hazards on the Loess Plateau. Based on the characterization of typical flooding sites and the results of salt monitoring, this study investigates the deterioration mechanism of salinization on Zhouqiao site. The orthogonal test was used to simulate the effects of different concentrations of MgSO4, NaCl and CaCl2 under natural conditions on the quality change, salt analysis out location, surface phenomenon, strength and electrical conductivity of the soil at the Zhouqiao site, and to make a preliminary analysis on the mechanism of saline deterioration of the site soil. The results show that the soil column mass increased significantly under the action of salt, and the rate of salt absorption in the soil column decreased when the critical value was reached, and the critical values were different under the action of different kinds of salts. The rate of salt analysis is also influenced by the salt concentration and the number of cycles, which gradually increases with the increase of salt concentration and the number of cycles. The nominal strength of the soil column with the number of cycles, but occasionally increases. The conductivity increases with the number of cycles, and the magnitude distribution of the conductivity of the soil column under the action of different salts is not exactly the same.

Experimental Study on the Cracking and Mechanical Properties of Lime Soil with Different Slaking Conditions of Newly Repaired Earthen City Walls.

In this paper, a method to control the lime reaction by different slaking conditions is proposed to reduce the occurrence of cracks in newly repaired earthen city walls. The effects and mechanisms of the slaking time (0 h, 12 h, 24 h, 48 h and 72 h), lime content (10%, 15% and 20%), and moisture content (14%, 18% and 22%) on the cracking and mechanical properties of lime soil were analyzed by the test results of surface cracks, triaxial compression, particle gradation, pH value, X-ray diffraction and scanning electron microscope. The results show that proper slaking of lime soil specimens can reduce surface cracks and improve mechanical properties. After 12 h of appropriate slaking, the crack rate of the lime soil with 20% content decreased by 97.13%, the cohesion increased by 20.27%, and the internal friction angle decreased by 11.27%. However, the mechanical properties decreased when the slaking time was too long. After 72 h of slaking, the cohesion of 20% lime soil decreased by 8.21% and the internal friction angle increased by 2.82%. Further analysis shows that the appropriate slaking conditions can regulate the reaction rate and alkali environment, control the lime produced cementitious substances, improve the particle gradation and further reduce the occurrence of surface cracks. These results provide a basis for the restoration technology of newly repaired earthen city walls.

Experimental Study on Restoration Materials of Newly Earthen Ruins under Different Slaking Times.

The newly repaired Kaifeng City Wall has serious cracks, shedding and other issues on the surface, which constitute a significant problem. It is of great significance for the restoration of Kaifeng City Wall to explore the repair materials and techniques suitable for Kaifeng City Wall. The pH, particle gradation, compressive strength and SEM were tested on soil samples with different lime and MgO contents under different slaking times. With the increase of slaking time, the pH value first increased and then decreased. The relationship between pH value and strength showed three stages. The strength of lime-containing soil samples increased first, then decreased and then increased. The MgO content of soil samples showed an opposite trend. The particle gradation was significantly improved with increasing aging time. The main reason for the reduction of soil strength is the calcium carbonate crystals and magnesite microcracks produced by lime and MgO in the later stage of slaking.

Study on the Expansion Law of Dry Shrinkage Cracks in Silty Clay.

Fracture characteristics are the basis of silty clay fracture research, and its quantitative description is helpful to explore the engineering properties of silty clay. The silty clay samples with different moisture contents and different aspect ratios were prepared by the controlled variable method for the drying shrinkage test. The crack image processing and crack feature extraction were performed by PS and IPP software, and the relationship between the crack propagation characteristic parameters and the change in humidity and sample moisture content during drying shrinkage were analyzed to explore the crack development law. The results show that under the continuous action of the environment, cracks were generated at the initial high temperature (46 °C). When the temperature changed from a high temperature (46 °C) to a low temperature (27 °C), the moisture content decreased faster, and the crack developed rapidly. Later, from low temperature (12 °C) to high temperature (46 °C), the water content and crack parameters remained basically unchanged; the cracks of the samples with a high moisture content appeared early, developed rapidly, and damaged seriously. When the aspect ratio was 6:1, the crack developed vertically, and when the aspect ratio was less than 6:1, the secondary crack was about 90° from the upper crack.

Experimental Study on the Mix Ratio of Restored Heritage Building Adobe.

The reciprocating action of the external environment gradually reduces the mechanical properties and water stability of original heritage buildings, resulting in the gradual loss of their cultural value. In this paper, the adobe for the construction of raw soil and cultural relics in western Henan is taken as the research object. The local plain soil is used as the raw material, and the adobe samples are prepared with modified materials such as quicklime and sodium methyl silicate, in order to improve its mechanical properties and water stability. The degree of correlation between the compressive strength, capillary water absorption, pH value, particle size distribution, and the electrical conductivity of modified raw adobe, as well as the modification mechanism of the microstructure, was studied. The results show that the addition of quicklime and sodium methyl silicate can enhance the compressive strength and water resistance of the modified raw adobe, and the optimum dosage is 1.5% sodium methyl silicate; with the increase of the curing age, the compressive strength of the single-mixed quicklime sample, the single mixed sodium methyl silicate samples, and the composite sample were increased by 1.94 times, 12.6 times and 2.61 times, respectively, compared with the plain soil samples, and with the increase of compressive strength, the pH, conductivity and capillary water absorption of the samples decreased continuously. It is evident from the particle gradation test and SEM images that the internal pores of the samples in the modified group become smaller, and the particle structure of the sample doped with sodium methyl silicate is the densest. The results of the study provide support for the restoration of the soil and cultural-relic buildings.

Study on Deterioration Law and Mechanism of Gray Brick Due to Salt Crystallization.

Salinization has an important impact on the degradation of ancient masonry buildings, and systematically mastering the law of salt migration and degradation of ancient masonry buildings is an important part of the protection of ancient buildings. In this paper, the damage law of gray bricks under the action of salt crystallization is studied. The orthogonal test method is used to carry out cyclic degradation tests on gray bricks. The nominal strength is proposed as a mechanical parameter to measure the structural damage of grey bricks, and the change in compressive strength and crystallization pressure of the samples after the test is measured and analyzed. The results show that the damage of different salts in the gray bricks shows a certain difference. Magnesium sulfate and sodium chloride cause significant damage to the surface of the gray bricks, while calcium chloride does not cause significant damage to the surface of the gray bricks. When the concentrations of sodium chloride solution, calcium chloride solution and magnesium sulfate solution are less than 13.73 mol/L, 11.47 mol/L and 17 mol/L, respectively, the nominal strength of gray brick samples increases; In the range of 9.9 mol/L and 4.73-8.94 mol/L, the crystallization pressure began to appear inside the sample. The research results provide an important scientific basis for evaluating the damage caused by salting to the damage of porous ancient building materials such as masonry.

Experimental Study on the Effect of Carbonation Reaction on the Properties of Imitation Site Soil.

In this study, sodium methylsilicate and lime were selected to prepare the same proportion of Imitation Site Soil, and according to the principle of carbonation reaction of restoration materials, the effect of carbonation reaction on the performance of restoration soil of earthen sites was studied. The study has good significance for the conservation and restoration of earthen sites. The samples were cured with CO2 concentration and curing age as variables. After curing, the samples were tested to determine their water-resistant properties, uniaxial compressive strength, and pH value and a micro scanning electron microscope was used. The results indicated that the carbonation reaction can quickly improve the water resistance and compressive strength of imitation site soil, and reduced the water absorption by 16.67% compared to the specimens conditioned at 0.03% CO2 concentration. The UCS of specimens at 5%, 10%, and 15% CO2 concentrations increased by 72.22%, 131.19%, and 219.27%, respectively, compared with those at 0.03% CO2 concentration after the specimens were environmentally maintained in the carbonation chamber at 0.03%, 5%, 10%, and 15% CO2 concentrations for 120 h, respectively. The internal particle gradation of the imitation site soil improved after carbonation. These results provide a basis for improving the restoration technology of earthen sites.

Research on the Mechanism and Prevention Methods of the Drying Shrinkage Effect of Earthen Sites.

In view of the fact that it is easy for the ancient city soil site of Cai Kingdom to expand and crack when encountering water, this paper explores the methods to improve the expansion and shrinkage deformation, dry shrinkage cracks and easy water absorption characteristics of the expanded site soil based on a lime and silicone hydrophobic agent. In this paper, the expansive clay in the old city site of Cai Kingdom in Zhumadian was taken as the research object, and the dry-shrinkage fissure test of saturated expansive soil was carried out, to study the influencing factors of the dry-shrinkage cracking of expansive soil in this area. The site soil was modified with lime and glue powder, and the fissure image was quantitatively analyzed by MATLAB. The test shows that the smaller the particle size, the faster the evaporation of water and the smaller the surface fissure rate; the thicker the thickness of the soil sample, the greater the surface fissure rate and the greater the crack width; and with the increase in the number of drying and wetting cycles, the surface fissure rate of the soil sample increases. In this paper, lime and waterproof materials are used to improve the expansive soil. This not only reduces the dry shrinkage crack rate, but also improves the waterproof performance and durability of expansive soil.

Developing a Cancer Digital Twin: Supervised Metastases Detection From Consecutive Structured Radiology Reports.

The development of digital cancer twins relies on the capture of high-resolution representations of individual cancer patients throughout the course of their treatment. Our research aims to improve the detection of metastatic disease over time from structured radiology reports by exposing prediction models to historical information. We demonstrate that Natural language processing (NLP) can generate better weak labels for semi-supervised classification of computed tomography (CT) reports when it is exposed to consecutive reports through a patient's treatment history. Around 714,454 structured radiology reports from Memorial Sloan Kettering Cancer Center adhering to a standardized departmental structured template were used for model development with a subset of the reports included for validation. To develop the models, a subset of the reports was curated for ground-truth: 7,732 total reports in the lung metastases dataset from 867 individual patients; 2,777 reports in the liver metastases dataset from 315 patients; and 4,107 reports in the adrenal metastases dataset from 404 patients. We use NLP to extract and encode important features from the structured text reports, which are then used to develop, train, and validate models. Three models-a simple convolutional neural network (CNN), a CNN augmented with an attention layer, and a recurrent neural network (RNN)-were developed to classify the type of metastatic disease and validated against the ground truth labels. The models use features from consecutive structured text radiology reports of a patient to predict the presence of metastatic disease in the reports. A single-report model, previously developed to analyze one report instead of multiple past reports, is included and the results from all four models are compared based on accuracy, precision, recall, and F1-score. The best model is used to label all 714,454 reports to generate metastases maps. Our results suggest that NLP models can extract cancer progression patterns from multiple consecutive reports and predict the presence of metastatic disease in multiple organs with higher performance when compared with a single-report-based prediction. It demonstrates a promising automated approach to label large numbers of radiology reports without involving human experts in a time- and cost-effective manner and enables tracking of cancer progression over time.