RESUMO
Papular acantholytic dermatosis of the vulva is a rare, chronic disorder and is an entity that remains to be fully understood. It shares clinical and histopathological overlap with Darier disease and Hailey-Hailey disease. We describe a 30-year-old woman with papular acantholytic dermatosis of the vulva. The lesions consisted of whitish papules and erosions on the labia majora. Histologically, there was hyperkeratosis and focal parakeratosis with acantholytic and dyskeratotic cells. She did not respond completely to topical steroids but clinical improvement occurred after the use of topical tacrolimus.
Assuntos
Acantólise/tratamento farmacológico , Inibidores de Calcineurina/administração & dosagem , Tacrolimo/administração & dosagem , Doenças da Vulva/tratamento farmacológico , Acantólise/patologia , Administração Tópica , Adulto , Feminino , Humanos , Doenças da Vulva/patologiaRESUMO
An 80-year-old man was admitted to hospital with low-grade fever, weight loss, asthenia and anorexia. Physical examination revealed generalised ichthyosis with palmoplantar hyperkeratosis. CT scan showed retroperitoneal and inguinal lymph node enlargement. An inguinal lymph node biopsy revealed Hodgkin's disease (nodular-sclerosing subtype). The patient received chemotherapy, showing a clear improvement of both skin lesions and lymph nodes.
Assuntos
Doença de Hodgkin/diagnóstico , Ictiose/diagnóstico , Síndromes Paraneoplásicas/diagnóstico , Idoso de 80 Anos ou mais , Doença de Hodgkin/tratamento farmacológico , Doença de Hodgkin/patologia , Humanos , Ictiose/patologia , Linfonodos/patologia , Masculino , Síndromes Paraneoplásicas/patologiaRESUMO
Report of a case of erythema multiforme-like eruption due to the use of rubber gloves. After several complementary studies, including epicutaneous and skin prick tests, we concluded that the eruption was secondary to sensitization to carbamates and thiuram. The main differential diagnosis in this case was allergic contact dermatitis to latex in natural rubber gloves. This entity is less frequent than might be expected, because it is usually due to intermediate chemical compounds used in rubber manufacturing, such as vulcanization accelerators; among of these latter compounds are thiurams and carbamates. Erythema multiforme-like eruption is a rare manifestation of contact dermatitis. Several cases have been reported, most of which have been due to contact with plants, metals or topical non-steroidal anti-inflammatory drugs. Its mechanism is still unclear, but it seems to be a type IV hypersensitivity reaction.