RESUMO
In a pilot study involving methamphetamine dependents receiving deep Transcranial Magnetic Stimulation (dTMS) targeting the medial prefrontal and cingulate cortices with H7 coil (Brainsway, Israel), we assessed clinical outcomes from patients receiving 20 sessions of dTMS treatments over 4 weeks (5 days on, 2 days off). Although the primary outcome was the behavioral changes related to addiction, we encountered a phenomenon of robust increases in sexual dreams and emission in a patient recruited for this study, which may inform alterations in cortical excitability following dTMS treatment.
Assuntos
Sonhos/fisiologia , Ejaculação/fisiologia , Córtex Pré-Frontal , Comportamento Sexual/fisiologia , Estimulação Magnética Transcraniana/métodos , Adulto , Transtornos Relacionados ao Uso de Anfetaminas/terapia , Humanos , Masculino , Projetos Piloto , Resultado do TratamentoRESUMO
A new series of spiro-bicyclic bisborane catalysts has been prepared by means of hydroboration reactions of C2 -symmetric spiro-bicyclic dienes with HB(C6 F5 )2 and HB(p-C6 F4 H)2 . When used for hydrogenation of quinolines, these catalysts give excellent yields and enantiomeric excesses, and show turnover numbers of up to 460. The most attractive feature of these metal-free hydrogenation reactions was the broad functional-group tolerance, making this method complementary to existing methods for quinoline hydrogenation.
RESUMO
We prepared a new class of chiral C2 -symmetric bicyclic bisborane catalysts by addition reactions of internal dienes with the Piers borane, HB(C6 F5 )2 , and an analogue, HB(p-C6 F4 H)2 . The dependence of the addition pattern on the reaction temperature allowed us to selectively prepare two diastereomeric catalysts from a single diene precursor. The bisboranes prepared in situ exhibited excellent activity (turnover numbers up to 200 at -40 °C) and enantioselectivity (up to 95 %â ee) in imine hydrogenation reactions.