1.
Org Biomol Chem
; 21(10): 2086-2090, 2023 03 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36806856
RESUMO
The enantioselective conjugate addition of malonates to α,ß-unsaturated aldehydes catalysed by 4-oxalocrotonate tautomerase is described. High conversions, high enantioselectivities, and good isolation yields were achieved for a range of substrates. We further completed a four-step synthesis of the antidepressant (+)-femoxetine by utilizing this reaction and an enzymatic reductive amination reaction.