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The energy storage capacity of porous carbon materials is closely tied to their surface structure and chemical properties. However, developing an innovative and straightforward approach to synthesize yolk-shell carbon spheres (YCs) remains a great challenge till date. Herein, we prepared a series of porous nitrogen-doped yolk-shell carbon spheres (NYCs) via a "pyrolysis-capture" method. This method involves coating the resorcinol-formaldehyde (RF) resin sphere with a layer of compact silica shell induced by 2-methylimidazole (ME) catalysis to produce a confined nano-space. Based on the confined effect of compact silica shell, volatile gases emitted from the RF resin and ME during pyrolysis can not only diffuse into the pores of the RF resin but can also be captured to form an outer carbon shell. This results in the tunable structures of NYCs materials. As the pyrolysis temperature rises, the shell thickness of NYCs reduces, the pore size expands, the roughness increases, and the N/O content of surface elements is enhanced. Notably, as an electrode material used forsupercapacitors,the optimized NYCs-800 exhibits excellent performance with a capacitance of 301.2F g-1 at the current density of 1 A/g and outstanding cycling life stability of 96.1% after 10,000 cycles. These results signify that controlling the surface structure and chemical properties of NYCs materials is an effective approach for constructing advanced energy storage materials.
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Loess regions face significant challenges in quantifying hydrological processes and assessing geological environmental risks due to the prevalent development of preferential pathways and the limitations of existing monitoring technologies. To advance this knowledge, this study presents an improved electrical resistivity tomography (ERT) device, specifically designed for loess moisture observations. By refining the testing principle, power supply mode, and data collection method within the existing ERT framework, the new device offers unmanned operation, automatic data acquisition, remote transmission, and cost efficiency. It effectively tracks water movement and groundwater level fluctuations across various hydrological conditions, supporting long-term online monitoring of hydrological processes of loess slopes. Through the analysis of monitoring data and classification of 12 observed preferential flow types, water movement in loess systems can be generalized into four general patterns: uniform infiltration, preferential infiltration, inflowing diffusion, and lateral flow. This generalized scheme provides a simplified modeling approach for other researchers to quantify slope hydrodynamics and to assess geological safety risks involving preferential flow. Based on these insights and field investigations, a conceptual framework is proposed to elucidate the seepage-structure synergistic initiating mechanism of loess landslides. This framework suggests that water entry and movement patterns within the slope depend on the slope geological structure related to preferential pathways and the prevailing hydrological scenarios. Landslide occurs as the result of the progressive failure and reciprocal evolution between the slope hydrological environments and geological structure, which may also pose potential eco-hydrological risks. The outcome advances the development of slope hydrological monitoring technology and enhances the understanding of water movement laws and the associated geological environmental risks in loess slope systems, which is of vital importance to the early warning methods of loess landslides that account for preferential flow and for theoretical modeling of preferential flow in related disciplines.
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Plasmon-mediated chemical reaction (PMCR) is a highly attractive field of research. Here we report in situ surface-enhanced Raman spectroscopic (SERS) monitoring of plasmonic-mediated SS bond-forming reaction. The reaction is thought to be a self-coupling reaction proceeding by photoinduced aromatic SC bond arylation. Surprisingly, the SC arylation and SS coupling are found to be occurred on both partially oxidized silver and silver nanoparticles. The results demonstrated that silver oxide or hydroxide and small molecule donor sacrifice agent played a crucial role in the reaction. This work facilitates the in-situ manipulation and characterization of the active silver electrode interface in conjunction with electrochemistry, and also establishes a promising new guideline for surface plasmon resonance photocatalytic reactions on metal nanostructures with high efficiency.
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Four previously undescribed isoprenoid flavonoids (2-5) were isolated from Sophora davidii, along with five known analogues. The structures of the compounds were established through comprehensive analysis of spectroscopic data, including HRESIMS, 1D and 2D NMR, and absolute configurations determined by theoretical calculations, including ECD and NMR calculation. The cytotoxic effects of the isolated compounds on human HT29 colon cancer cells were evaluated using the MTT assay, compound 1 exhibited cytotoxicity against human HT29 colon cancer cells with an IC50 value of 8.39 ± 0.09 µM. Studies conducted with compound 1 in HT29 cells demonstrated that it may induce apoptosis and autophagy in HT29 by promoting the phosphorylation of P38 MAPK and inhibiting the phosphorylation of Erk MAPK.
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Antineoplásicos Fitogênicos , Apoptose , Autofagia , Flavonoides , Sophora , Humanos , Sophora/química , Autofagia/efeitos dos fármacos , Apoptose/efeitos dos fármacos , Células HT29 , Estrutura Molecular , Flavonoides/farmacologia , Flavonoides/isolamento & purificação , Antineoplásicos Fitogênicos/farmacologia , Antineoplásicos Fitogênicos/isolamento & purificação , Compostos Fitoquímicos/farmacologia , Compostos Fitoquímicos/isolamento & purificação , China , Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo , Terpenos/farmacologia , Terpenos/isolamento & purificação , FosforilaçãoRESUMO
The highly infectious characteristics of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), highlight the necessity of sensitive and rapid nucleocapsid (N) protein-based antigen testing for early triage and epidemic management. In this study, a colorimetric and photothermal dual-mode lateral flow immunoassay (LFIA) platform for the rapid and sensitive detection of the SARS-CoV-2 N protein was developed based on gold nanorods (GNRs), which possessed tunable local surface plasma resonance (LSPR) absorption peaks from UV-visible to near-infrared (NIR). The LSPR peak was adjusted to match the NIR emission laser 808 nm by controlling the length-to-diameter ratio, which could maximize the photothermal conversion efficiency and achieve photothermal detection signal amplification. Qualitative detection of SARS-CoV-2 N protein was achieved by observing the strip color, and the limit of detection was 2 ng mL-1, while that for photothermal detection was 0.096 ng mL-1. Artificial saliva samples spiked with the N protein were analyzed with the recoveries ranging from 84.38% to 107.72%. The intra-assay and inter-assay coefficients of variation were 6.76% and 10.39%, respectively. We further evaluated the reliability of this platform by detecting 40 clinical samples collected from nasal swabs, and the results matched well with that of nucleic acid detection (87.5%). This method shows great promise in early disease diagnosis and screening.
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COVID-19 , Colorimetria , Proteínas do Nucleocapsídeo de Coronavírus , Ouro , Nanotubos , SARS-CoV-2 , Ouro/química , Nanotubos/química , SARS-CoV-2/imunologia , Colorimetria/métodos , Humanos , COVID-19/diagnóstico , Imunoensaio/métodos , Proteínas do Nucleocapsídeo de Coronavírus/imunologia , Proteínas do Nucleocapsídeo de Coronavírus/química , Limite de Detecção , Raios Infravermelhos , Fosfoproteínas/análise , Fosfoproteínas/química , Fosfoproteínas/imunologiaRESUMO
A traditional Chinese medicine ingredient, dendrobine, has been demonstrated to have anti-inflammatory properties. However, due to its poor anti-inflammatory properties, its clinical use is limited. Consequently, we have designed and synthesized 32 new amide/sulfonamide dendrobine derivatives and screened their anti-inflammatory activities inâ vitro. Experiments showed that nitric oxide (NO) generation in lipopolysaccharide (LPS)-induced RAW264.7 cells was strongly reduced by derivative 14, with an IC50 of 2.96â µM. Western blot research revealed that 14 decreased the concentration-dependent expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (INOS). Molecular docking was used to predict the binding of the inflammation-associated proteins COX-2 and INOS to compound 14.
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Amidas , Ciclo-Oxigenase 2 , Lipopolissacarídeos , Simulação de Acoplamento Molecular , Óxido Nítrico Sintase Tipo II , Óxido Nítrico , Sulfonamidas , Animais , Camundongos , Células RAW 264.7 , Sulfonamidas/química , Sulfonamidas/farmacologia , Sulfonamidas/síntese química , Lipopolissacarídeos/antagonistas & inibidores , Lipopolissacarídeos/farmacologia , Óxido Nítrico Sintase Tipo II/metabolismo , Óxido Nítrico Sintase Tipo II/antagonistas & inibidores , Óxido Nítrico/antagonistas & inibidores , Óxido Nítrico/biossíntese , Óxido Nítrico/metabolismo , Ciclo-Oxigenase 2/metabolismo , Amidas/química , Amidas/farmacologia , Amidas/síntese química , Relação Estrutura-Atividade , Anti-Inflamatórios/farmacologia , Anti-Inflamatórios/química , Anti-Inflamatórios/síntese química , Estrutura Molecular , Relação Dose-Resposta a Droga , Anti-Inflamatórios não Esteroides/farmacologia , Anti-Inflamatórios não Esteroides/síntese química , Anti-Inflamatórios não Esteroides/químicaRESUMO
Silica nanoparticles (SiNPs) with a chemically modified surface typically have a complicated chemical composition, which can significantly differ from their intended design. In this study, we systematically studied the effects of two surface modification methods on active-targeting of intracellular organelles of SiNPs: (1) the widely used step-by-step approach, which involves modifying SiNPs in two steps, i.e., the outer surface of SiNPs was firstly modified with amino groups and then these amino groups were linked with targeting groups, and (2) a newly developed one-step approach in which the ligand-silane complex is initially synthesized, followed by chemically immobilizing the complex on the surface of SiNPs. In the one-step approach, the molar ratio of reactants was precisely tuned so that there are no reactive groups left on the outer surface of SiNPs. Two essential organelles, mitochondria and the nucleus, were selected to compare the targeting performances of SiNPs synthesized via these two approaches. By characterizing physicochemical properties, including structural properties, the number of amino groups, surface charge, polydispersity, and cell colocalization, we demonstrated that SiNPs synthesized via the one-step approach with no residual linkage groups on their surface showed significantly improved mitochondria- and nucleus-targeting performances. This precise control of surface properties allows for optimized biological behavior and active-targeting efficiency of SiNPs. We anticipate that such simple and efficient synthetic strategies will enable the synthesis of effective SiNPs for active-targeting organelles in various biological applications.
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Mitocôndrias , Nanopartículas , Corantes , Silanos , Dióxido de SilícioRESUMO
Eight previously undescribed diterpenoids, along with eleven previously reported analogues, were obtained from the supercritical CO2 extracts of Torreya grandis aril. The structures of these compounds were elucidated based on HRESIMS, NMR, ECD, and single-crystal X-ray diffraction data. In the MTT assay, compound 18 exhibited significant inhibitory effects on two human colon cancer cell lines, HT-29 and HCT 116 cells, with IC50 values of 7.37 µM and 6.55 µM, respectively. It was found that compound 18 induced apoptosis and significantly inhibited the migration of HCT 116 colon cancer cells in a concentration-dependent manner.
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Antineoplásicos , Neoplasias do Colo , Diterpenos , Taxaceae , Ácidos Tri-Iodobenzoicos , Humanos , Antineoplásicos/farmacologia , Diterpenos/farmacologia , Taxaceae/química , Estrutura MolecularRESUMO
High-speed circuits based on thin film transistors (TFTs) show promising potential applications in biomedical imaging and human-machine interactions. One of the critical requirements for high-speed electronic devices lies in high-frequency switching or amplification at low voltages, typically driven by batteries (â¼3.0 V). To date, however, most electrical performances of metal oxide TFTs are measured under direct current (DC) conditions, and their dynamic switching behaviour is scarcely explored and studied systematically. Here in this work, we present low voltage-driven, high-performance TiO2 thin film transistors, which can be operated at a switching speed of MHz. Our proposed TiO2 TFTs demonstrated a high on-off ratio of 107, together with a subthreshold swing (SS) of â¼150 mV Dec-1 averaged over four orders of magnitude, which can be further reduced below 100 mV Dec-1 when the temperature cools to 77 K. Additionally, the TiO2 TFTs exhibit excellent gate-pulse switching at various frequencies ranging from 1.0 Hz to 1.0 MHz. We also explored the potential application of the TiO2 TFTs as logic gates by constructing a resistive-loaded inverter, which shows stable operation at 10 kHz frequency and various temperatures. Thus, our results show the great potential of TiO2 TFTs as a new platform for high-speed electronic applications.
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Azarshahr County in the northwest of Iran is predominantly covered by Azarshahr travertine, a prevailing sedimentary rock. This geological composition has led to extensive open-pit mining activities, particularly in the western and southwestern parts of the county. The rock's drillability and resistance to excavation play a pivotal role in determining its overall durability and hardness, crucial factors that influence the mining process. These attributes are intimately tied to the compressive strength of the rock. Accurate assessment of rock strength is vital for devising reliable excavation methodologies at mining sites. However, conventional approaches for analyzing rock strength have limitations that undermine the precision of strength estimations. In response, this study endeavors to leverage artificial intelligence techniques, specifically the Multilayer Perceptron (MLP), to enhance the prediction of travertine's compressive strength. To formulate a robust model, a comprehensive database containing data from 150 point-load index (Is) tests on Azarshahr travertine was compiled. This dataset serves as the foundation for the development of the MLP-based predictive model, which proves instrumental in projecting rock compressive strength. The model's accuracy and efficacy were rigorously assessed using the Receiver Operating Characteristic (ROC) curve, employing both training and testing datasets. The modeling outcomes reveal impressive results. The estimated R-squared coefficient attained an impressive value of 0.975 for axial strength and 0.975 for diametral strength. The overall accuracy, as indicated by the Area Under the Curve (AUC) metric, stands at an impressive 0.968. These exceptional performance metrics underscore the efficacy of the MLP model in accurately predicting compressive strength based on the point-load index of samples. The implications of this study are substantial. The predictive model, empowered by the MLP approach, has profound implications for excavation planning and drillability assessment within the studied region's travertine deposits. By facilitating accurate forecasts of rock strength, this model equips mining endeavors with valuable insights for effective planning and execution.
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Although the traditional enzyme-linked immunosorbent assay (ELISA) has been widely applied in pathogen detection and clinical diagnostics, it always suffers from complex procedures, a long incubation time, unsatisfying sensitivity, and a single signal readout. Here, we developed a simple, rapid, and ultrasensitive platform for dual-mode pathogen detection based on a multifunctional nanoprobe integrated with a capillary ELISA (CLISA) platform. The novel capture antibodies-modified capillaries can act as a swab to combine in situ trace sampling and detection procedures, eliminating the dissociation between sampling and detection in traditional ELISA assays. With excellent photothermal and peroxidase-like activity, the Fe3O4@MoS2 nanoprobe with a unique p-n heterojunction was chosen as an enzyme substitute and amplified signal tag to label the detection antibody for further sandwich immune sensing. As the analyte concentration increased, the Fe3O4@MoS2 probe could generate dual-mode signals, including remarkable color changes from the chromogenic substrate oxidation as well as photothermal enhancement. Moreover, to avoid false negative results, the excellent magnetic capability of the Fe3O4@MoS2 probe can be used to pre-enrich the trace analytes, amplifying the detection signal and enhancing the immunoassay's sensitivity. Under optimal conditions, specific and rapid detection of SARS-CoV-2 has been realized successfully based on this integrated nanoprobe-enhanced CLISA platform. The detection limits were 5.41 pg·mL-1 for the photothermal assay and 150 pg·mL-1 for the visual colorimetric assay. More importantly, the simple, affordable, and portable platform can also be expanded to rapidly detect other targets such as Staphylococcus aureus and Salmonella typhimurium in practical samples, making it a universal and attractive tool for multiple pathogen analysis and clinical testing in the post COVID-19 era.
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COVID-19 , Capilares , Humanos , Molibdênio , COVID-19/diagnóstico , SARS-CoV-2 , Ensaio de Imunoadsorção Enzimática/métodos , AnticorposRESUMO
Six lactone derivatives, including four α-pyrones derivatives (1-4), two α-furanone derivatives (5 and 6), were isolated from the Dendrobium pendulum. Structural elucidation of these undescribed lactone derivatives were accomplished on the basis of detailed nuclear magnetic resonance analysis, and the absolute configurations of compounds 1-4 were confirmed by electronic circular dichroism (ECD) techniques. The cytotoxic effects of isolated compounds on human breast cancer cell MDA-MB-231 were evaluated by the MTT assay.
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Antineoplásicos , Dendrobium , Humanos , Estrutura Molecular , Lactonas/farmacologia , Lactonas/química , Dendrobium/química , Espectroscopia de Ressonância MagnéticaRESUMO
To identify potential drug candidates, secondary metabolites of Dendrobium nobile were performed. As a result, two previously undescribed phenanthrene derivatives with a spirolactone ring (1 and 2), along with four known compounds, N-trans-cinnamoyltyramine (3), N-trans-p-coumaroyltyramine (4), N-trans-feruloyltyramine (5), and moscatilin (6), were isolated from Dendrobium nobile. The structures of the undescribed compounds were elucidated using NMR spectroscopy, electronic circular dichroism (ECD) calculations, and extensive spectroscopic data analysis. The cytotoxic effects of compounds on human tongue squamous cells OSC-19 were determined using MTT at concentrations of 2.5 µM, 5 µM, 10 µM, and 20 µM. Compound 6 exhibited potent inhibitory activity against OSC-19 cells with an IC50 of 1.32 µM. Migration assays and western blot assays demonstrated that compound 6 effectively inhibited migration by down-regulating MMP2 and MMP9 at concentrations of 0.5 µM and 1 µM. To investigate its effect on apoptosis, we performed AO/PI staining, flow cytometry, and WB experiments. The results showed that increasing concentrations led to increased red fluorescence, decreased green fluorescence, increased apoptosis rate, decreased expression of bcl-2, caspase 3, caspase 9, and parp proteins, and increased bax expression. Furthermore, the phosphorylation of JNK and P38 was activated, suggesting that compound 6 may induce apoptosis via the MAPK pathway.
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Dendrobium , Humanos , Dendrobium/química , ApoptoseRESUMO
Two new sesquiterpenoids, dendroaduoid A (1) and dendroaduol (2), together with four known sesquiterpenoids were isolated from the stems of Dendrobium aduncum. Their structures were identified by HR-ESI-MS and NMR experiments, and the complete assignments of 1 H and 13 C NMR data for two new sesquiterpenoids were obtained by the aid of HSQC, HMBC, 1 H-1 H COSY, NOESY, and ECD techniques. The cytotoxic effects of the isolated compounds on four tumor cell lines (HCT-116, HepG2, A549, and SW1990) were evaluated using MTT assay. Otherwise, the inhibitory activity of these six sesquiterpenoids on glycosidase was also evaluated.
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Dendrobium , Sesquiterpenos , Linhagem Celular Tumoral , Sesquiterpenos/farmacologiaRESUMO
Dendrobium nobile Lindl. is registered in the Chinese Pharmacopoeia as a traditional medicine. Phytochemical investigation of the ethanol extract of D. nobile Lindl. stems yielded three alkaloid compounds, including two new compounds dendroxine B (2) and denrine B (3) as well as one known compound dendrobine (1). Here, we identified the structure of these compounds using spectroscopic analyses and compared them with those described in previous studies. Compounds 1-3 were found to show protective effect against amyloid-ß 1-42 (Aß1-42 )-induced neurotoxicity in rat pheochromocytoma (PC12) cells, among which dendrobine exhibited the most significant neuroprotective effect. Hoechst 33342/propidium iodide staining indicated that dendrobine ameliorated Aß1-42 -induced apoptosis. Moreover, quantitative real-time polymerase chain reaction and western blot analysis analysis demonstrated that dendrobine suppressed the activation of cyclin-dependent kinase 5 (CDK5), upregulated Bcl-2 expression, and downregulated Bax, cyto-c, and caspase-3 expression. Molecular docking analysis and surface plasmon resonance assay suggested that dendrobine directly bound to CDK5 protein with a KD value of 2.05 × 10-4 M. In summary, alkaloids are the neuroprotective constituents of D. nobile Lindl., and dendrobine protected PC12 cells against Aß1-42 -induced apoptosis by inhibiting CDK5 activation.
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Alcaloides , Dendrobium , Animais , Ratos , Dendrobium/química , Quinase 5 Dependente de Ciclina/farmacologia , Células PC12 , Simulação de Acoplamento Molecular , Alcaloides/farmacologia , ApoptoseRESUMO
Two previously undescribed dihydrophenanthrene derivatives (1 and 2) were isolated along with twelve known analogues from the whole plant of Dendrobium terminale. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis. The NMR data of known phenanthrene derivatives (7 and 9) were revised by 2D NMR. The isolated compounds were evaluated for cytotoxicity against three kinds of tumor cell lines (sw1990, HCT-116, and HepG2). Especially compounds 11 and 14 showed stronger antitumor effects, and the structure-activity relationship of these compounds was discussed.
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Dendrobium , Fenantrenos , Dendrobium/química , Fenantrenos/farmacologia , Fenantrenos/química , Extratos Vegetais/química , Espectroscopia de Ressonância Magnética , Linhagem Celular Tumoral , Estrutura MolecularRESUMO
Determination of cesium ion in soybean oil is of high importance since the increasing risk from releasing of main component of nuclear waste cesium 137. The complex composition and high viscosity of soybean oil make it necessary to convert it into water phase by nitration before detection, so developing a simple, accurate and sensitive method for on-site sensing of Cs+ in soybean oil is still a big challenge. In this work, we report a traffic light-type ratiometric fluorescence strategy for the visual sensing of Cs+ in soybean oil based on dimensional regulation of two dimensional (PEA)2PbI4 perovskite nanosheets (NSs). The PEA+ in (PEA)2PbI4 NSs exchanged with Cs+ and lead to dimension of partial (PEA)2PbI4 NSs progressively increase from 2D to 3D CsPbI3 NCs. Resultantly, the fluorescence of (PEA)2PbI4 NSs decreases with a concomitant fluorescence enhancement of CsPbI3 NCs upon increasing the concentrations of Cs+, and the emission accordingly change from green, yellow to red with a high fluorescence colorimetric resolution up to 5.0 µM, make it successful to achieve on-site sensing of Cs+ in soybean oil just with naked eye in 5 min without any nitration, demonstrating a bright application future for determination of Cs+ in the soybean oil.
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Resíduos Radioativos , Óleo de Soja , Compostos de Cálcio , Césio , Óxidos , Titânio , ÁguaRESUMO
Perovskite nanocrystals (PNCs) have attracted widespread attention as promising materials for the optoelectronic field due to their remarkable photophysical properties and structural tunability. However, their poor stability and the use of toxic organic solvents in the preparation process have severely restricted their practical applications. Herein, a facile, rapid and toxic organic solvent-free synthesis strategy of CsPbBr3 PNCs was developed for the first time via the ligand-assisted reprecipitation (LARP) method using natural deep eutectic solvents (NADESs) as solvents and surface ligands. In this method, the NADESs not only functioned as solvents for green synthesis, but also served simultaneously as surface ligands of CsPbBr3 PNCs to significantly improve their optical properties and stability. The as-synthesized CsPbBr3 PNCs exhibited high photoluminescence quantum yield (PLQY, â¼96.8%), narrow full width at half-maximum (FWHM, â¼18.8 nm) and a high stability that retained 82.9% of PL intensity after 70 days. This work provides a new strategy for the green synthesis of PNCs, which promises feasibility for the industrial large-scale synthesis of high-quality PNCs.
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Metal-organic frameworks (MOFs) have emerged as alternative OER catalysts due to their easy regulation, such as in situ self-reconstruction from MOFs to metal hydroxides through alkaline hydrolysis. Herein, we demonstrate a facile strategy for the in situ transformation of FeCo layered double hydroxide (FeCo-LDH) nanosheets into 1D spindle-shaped FeCo-MOFs for efficient OER. An optimized electrode of FeCo-MOF on a nickel foam (NF) was achieved by adjusting the addition of organic ligands and the reaction time in the hydrothermal reaction. Based on the unique 1D nanostructure and the cation regulation, the obtained FeCo-MOF exhibits a good catalytic performance toward the OER with a low overpotential of 475 mV at 100 mA cm-2, a small Tafel slope of 121.8 mV dec-1, and high long-term durability. This study provides a facile strategy for preparing bimetal-MOFs as catalysts for efficient OER.
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Sensing temperature (T) has gained great attention since T is the most important parameter in daily life, scientific research and industry. A ratiometric fluorescence T sensor is fabricated by doping MAPbBr3 perovskite nanocrystals (PNCs) and rhodamine B (RhB) into a polyacrylonitrile (PAN) matrix and the composite materials are electrospun into optical fibers. The fibers show characteristic emissions at 521 and 587 nm under UV irradiation (λ ex = 365 nm). Both emission intensities gradually increased with elevating T, accompanied with a fluorescence color change from green to yellow. There is a linear relationship between fluorescence intensity ratio (I 521/I 587) and T in the range of 30-45 °C. The T response sensitivity is as high as 4.38% °C-1 at 45 °C.