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Chem Biodivers ; 19(9): e202200188, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35922378

RESUMO

(±)-Involucrasin C (1), a pair of new 2,3-dihydro-1H-indene enantiomers, along with an enantiomeric analog (2), were isolated from Shuteria involucrata. Their structures were established by the basis of comprehensive spectroscopic data analysis and X-ray crystallographic diffraction. Both 1 and 2 significantly inhibited the secretion of pro-inflammatory cytokines IL-6, TNF-α, and IL-1ß, suggesting that these two natural 2,3-dihydro-1H-indene derivatives may be active components of S. involucrata and may block inflammation in the initial stage.


Assuntos
Indenos , Fator de Necrose Tumoral alfa , Anti-Inflamatórios/química , Anti-Inflamatórios/farmacologia , China , Citocinas , Indenos/química , Interleucina-6
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