Advances in performance degradation mechanism and safety assessment of LiFePO4for energy storage.

In the context of 'energy shortage', developing a novel energy-based power system is essential for advancing the current power system towards low-carbon solutions. As the usage duration of lithium-ion batteries for energy storage increases, the nonlinear changes in their aging process pose challenges to accurately assess their performance. This paper focuses on the study LiFeO4(LFP), used for energy storage, and explores their performance degradation mechanisms. Furthermore, it introduces common battery models and data structures and algorithms, which used for predicting the correlation between electrode materials and physical parameters, applying to state of health assessment and thermal warning. This paper also discusses the establishment of digital management system. Compared to conventional battery networks, dynamically reconfigurable battery networks can realize real-time monitoring of lithium-ion batteries, and reduce the probability of fault occurrence to an acceptably low level.

Tumor-to-Gland Volume Ratio versus Tumor-to-Breast Ratio as Measured on CBBCT: Possible Predictors of Breast-Conserving Surgery.

BACKGROUND: Breast-conserving surgery plus postoperative radiotherapy is the standard surgical treatment mode for early breast cancer. Currently, there are no clear predictive indicators to determine whether a patient can choose breast-conserving surgery, which mainly depends on the surgeon's clinical experience and subjective judgment. Cone-beam breast computed tomography (CBBCT) reconstructs the breast 3D image from three mutually perpendicular angles, helping surgeons to locate and accurately measure the volume of the tumor, mammary gland, and breast. We used CBBCT to retrospectively measure the tumor-to-gland volume ratio and tumor-to-breast volume ratio in breast cancer cases. Then, we analyzed the correlation between the surgical methods and ratios in breast cancer patients. METHODS: We collected 100 patients undergoing breast-conserving surgery as the study group, and 100 patients undergoing mastectomy as the control group. All patients chose the surgical approach after comprehensive consideration of examination results and assessment of patient condition. Patients underwent CBBCT examination before surgery. We retrospectively measured the volume of tumor, mammary glands and breast, then calculated tumor-to-gland and tumor-to-breast volume ratios. RESULTS: Tumor volume and the ratios of the two groups statistically differed (P < 0.001), while the mammary gland and breast volume did not (P > 0.05). The average tumor-to-gland volume ratio was 4.32% in the study group and 10.74% in the control group, and the average tumor-to-breast volume ratio was 0.74% in the study group and 1.36% in the control group. In breast-conserving surgery, the 95% reference range of tumor-to-gland ratio is (0, 12.90%), and the 95% reference range of tumor-to-breast ratio is (0, 2.17%). CONCLUSION: The tumor-to-gland volume ratio and tumor-to-breast volume ratio measured using CBBCT are correlated with the choice of surgical methods (breast-conserving surgery or mastectomy) for breast cancer patients. This can be used as possible predictor of breast-conserving surgery to help surgeons.

H19 Knockdown Suppresses Proliferation and Induces Apoptosis by Regulating miR-130a-3p/SATB1 in Breast Cancer Cells.

PURPOSE: Breast cancer (BC) is the most common cancer in women. Emerging evidence has demonstrated that lncRNAs play an important role in BC. The objective of this study was to investigate the impact of the long non-coding RNA (lncRNA), H19/miRNA-130a-3P/special AT-rich sequence-binding protein-1 (SATB1) axis on BC progression. MATERIALS AND METHODS: Expression of lncRNA and RNA was quantified via RT-qPCR. CCK-8, colony formation, wound healing, transwell, and flow cytometric analyses were used to analyze the proliferation, migration, invasion and apoptosis of cells. A dual-luciferase reporter assay and a RNA immunoprecipitation (RIP) assay were used to assess molecular binding. Protein levels were measured by Western blotting. The function of the lncRNA H19 (hereafter referred to as H19) was examined by xenotransplantation. RESULTS: We demonstrated that H19 expression was higher in cancer tissues and cancer cell lines than in adjacent non-tumor tissues and normal cell lines, respectively. H19 silencing inhibited the proliferation, migration and invasion of BC cells, and induced apoptosis. In addition, H19 directly bound to miR-130a-3p and downregulated its expression. We further demonstrated that H19 sponged miRNA-130a-3p, which resulted in SATB1 upregulation, thus promoting BC progression. Silencing of H19 substantially suppressed BC tumorigenesis in vivo. CONCLUSION: Our data uncovered a novel mechanism of BC progression based on the H19-miR-130a-3p-SATB1 axis.

Fiber-Shape Na3V2(PO4)2F3@N-Doped Carbon as a Cathode Material with Enhanced Cycling Stability for Na-Ion Batteries.

To overcome intrinsic low electronic conductance, delicately designed fiber-shape Na3V2(PO4)2F3@N-doped carbon composites (NVPF@C) have been prepared for boosting Na-storage performance. This distinctive interlinked three-dimensional network structure can effectively facilitate electron/Na-ion transportation by decreasing the NVPF particle size to shorten the ionic diffusion paths and introducing a conducting N-doping carbon scaffold to improve electronic conductivity. Benefiting from the favorable structural design and fascinating reaction kinetics, the modified NVPF@C material demonstrates superior sodium-storage performance with 109.5 mAh g-1 high reversible capacity at a moderate current of 0.1 C, excellent rate tolerance of 78.9 mAh g-1 at a high rate of 30 C, and gratifying long-term cyclability (87.8% capacity retention after 1000 cycles at 20 C; 83.4% capacity retention after 1500 round trips at a ultrahigh rate of 50 C). The fascinating electrochemical performance remains stable when NVPF@C was examined as the cathode material for a full cell, suggesting the fiber-shape NVPF@C as one of the most promising applicable materials for sodium-ion batteries. Moreover, the approach of the three-dimensional conductive network by electrospinning is proposed as a strategy of efficiency and promising prospect to enhance the electrochemical property of other materials for sodium-ion batteries.

Determination of Serum Exosomal H19 as a Noninvasive Biomarker for Breast Cancer Diagnosis.

PURPOSE: There is an urgent need for new biomarkers for the diagnosis of breast cancer. Exosomes can communicate with cells through transport molecules, including long-chain noncoding RNA (lncRNA), which is considered as a promising noninvasive biomarker. Here, we aimed to determine the potential of long noncoding RNA (lncRNA) H19 in the circulating exosomes for the diagnosis of breast cancer (BC). MATERIALS AND METHODS: We measured the levels of lncRNA H19 in serum-derived exosomes from patients with breast cancer (BC) or benign breast disease (BBD) and healthy subjects, using quantitative real-time PCR. H19 levels were also measured for pre-operative and post-operative patients. Receiver operating characteristic curve was constructed, and the area under the curve (AUC) was calculated to determine the applicability of exosomal H19 levels as biomarkers in BC. The relationship between H19 relative expression and clinical features of BC patients was also analyzed. RESULTS: Exosomal H19 expression levels were upregulated in patients with BC compared to that in patients with BBD and healthy controls (BC vs BBD, P < 0.001; BC vs healthy subjects, P < 0.001). The median serum exosomal H19 levels were significantly lower in post-operative than that in the pre-operative patients (P < 0.001). The AUC for exosomal H19 analysis was 0.870 (95% CI: 0.774-0.966) with a sensitivity of 87.0% and specificity of 70.6%, which was higher than the AUCs for CA15-3 and CEA, ie, 0.822 and 0.811, respectively. Moreover, exosomal H19 expression levels were associated with lymph node metastasis (P = 0.039), distant metastasis (P = 0.008), TNM stages (P = 0.022), ER (P=0.009), PR (P = 0.018), and Her-2 (P = 0.021). CONCLUSION: Our results indicated that serum exosomal H19 acts as a novel biomarker for the diagnosis of BC.

Hierarchical Nitrogen-Doped Porous Carbon Microspheres as Anode for High Performance Sodium Ion Batteries.

Sodium ion batteries (SIBs) have been considered as a promising alternative to lithium ion batteries (LIBs) for large scale energy storage in the future. However, the commercial graphite anode is not suitable for SIBs because of its low Na+ ions storage capability and poor cycling stability. Recently, another alternative as anode for SIBs, amorphous carbon materials, have attracted tremendous attention because of their abundant resource, nontoxicity, and most importantly, stability. Here, N-doped hierarchical porous carbon microspheres (NHPCS) derived from Ni-MOF have been prepared and used as anode for SIBs. Benefiting from the open porous structure and expanded interlayer distance, the diffusion of Na+ is greatly facilitated and the Na+ storage capacity is significantly enhanced concurrently. The NHPCS exhibit high reversible capacity (291 mA h g-1 at current of 200 mA g-1), excellent rate performance (256 mA h g-1 at high current of 1,000 mA g-1), and outstanding cycling stability (204 mA h g-1 after 200 cycles).

Male accessory breast cancer on the abdominal wall: a case report and literature review.

BACKGROUND: Accessory breast cancer is very rare, particularly in men. Male accessory breast cancer on the abdominal wall has not been documented in the scientific literature so far. We describe a case of male accessory breast cancer on the abdominal wall. CASE PRESENTATION: We describe a male patient suffering a swelling and erosive, enlarged, and hardened abdominal wall mass with pain due to abdominal wall accessory breast cancer. The patient had no obvious disease history, and the initial clinical symptom was a small mass on the abdominal wall. B-ultrasound revealed a solid subcutaneous nodule in the right abdomen with a size of ~2.8 × 2.5 × 1.5 cm. The abdominal wall tumor resection was performed with local anesthesia. Pathological testing revealed a grade II infiltrating ductal carcinoma derived from the accessory mammary gland (right abdominal wall) with neuroendocrine characteristics, showing ER (100% strong positive), PR (100% strong positive), HER-2 (-), ki67 (40% positive), Syn (+), CgA (+), and GCDFP15 (+). CONCLUSION: Nonaxillary accessory breast cancer in males is very rare, with no obvious clinical manifestations, and could be easily ignored. This disease requires great attention from clinicians.

Activated Amorphous Carbon With High-Porosity Derived From Camellia Pollen Grains as Anode Materials for Lithium/Sodium Ion Batteries.

Carbonaceous anode materials are commonly utilized in the energy storage systems, while their unsatisfied electrochemical performances hardly meet the increasing requirements for advanced anode materials. Here, activated amorphous carbon (AAC) is synthesized by carbonizing renewable camellia pollen grains with naturally hierarchical structure, which not only maintains abundant micro- and mesopores with surprising specific surface area (660 m2 g-1), but also enlarges the interlayer spacing from 0.352 to 0.4 nm, effectively facilitating ions transport, intercalation, and adsorption. Benefiting from such unique characteristic, AAC exhibits 691.7 mAh g-1 after 1200 cycles at 2 A g-1, and achieves 459.7, 335.4, 288.7, 251.7, and 213.5 mAh g-1 at 0.1, 0.5, 1, 2, 5 A g-1 in rate response for lithium-ion batteries (LIBs). Additionally, reversible capacities of 324.8, 321.6, 312.1, 298.9, 282.3, 272.4 mAh g-1 at various rates of 0.1, 0.2, 0.5, 1, 2, 5 A g-1 are preserved for sodium-ion batteries (SIBs). The results reveal that the AAC anode derived from camellia pollen grains can display excellent cyclic life and superior rate performances, endowing the infinite potential to extend its applications in LIBs and SIBs.