[Evaluation of intervention effect in the occupational protection of glass fiber workers by occupational health education].

Objective: To understand the mastery of occupational hygienic knowledge and the implementing of occupational health protection measures in the group which were exposed to the procedure of manufacture and use in glass fiber company, and to explore the feasibility of the prevention of the skin injury by occupational health education in glass fiber workers. Methods: We selected 257 on-the-job employees as the research object in a ceramic enterprise in Nanjing from June 2018 to August 2019, with the method of cluster random sampling. According to Solomon's design, the intervention group in which we took measures with health education was divided into RG(1) (O(1)XO(2)) and RG(3) (XO(5)) group, and the control group where we didn't take any intervention was divided into RG(2) (O(3)-O(4)) and RG(4) (-O(6)) group. The intervention effect of health education on the occupational protection of glass fiber workers was evaluated by the results of questionnaire. Results: After training, the average score of occupational health knowledge in the intervention group was 27.34 points higher than that before training, the intervention index was 1.42, 23.62-27.73 points higher than the control glass fiber workers and 33.62-35.52 points higher than the control glass non-glass fiber workers; Compared with the control group, the positive attitude rate of fiber glass workers in the intervention group increased by 13.28%, 13.51%, 11.68% and 11.48%, and the intervention indexes were 1.18, 1.17, 1.14 and 1.15, which was corresponding to using protective cream, wearing gloves, wearing working clothes, washing hands and bathing after work, respectively; Compared with the control group, the implementation rate of occupational protection measures which were represented by wearing gloves、washing hands and bathing for glass fiber workers in the intervention group increased by 29.25% and 7.27% respectively, and the intervention indexes were 1.43 and 1.08 respectively; The skin injury rate of fiberglass workers in the intervention group was reduced by 11.43% comparing to the control group, the intervention index was 1.67. Conclusion: According to the occupational health education of fiberglass workers, it improves the mastery of occupational health knowledge, positive atti-tude rate and the implementation rate of occupational protection measures, meanwhile, it reduces the skin injury rate of the intervention objects to a certain extent.

[Clinical study about anatomical and functional reconstruction for frontolateral vertical partial laryngectomy with ultrathin titanium mesh and fascia flap from the strap muscles].

Objective:To investigate the effect of laryngeal reconstruction in functional and anatomical aspect with ultrathin titanium mesh and myofascial flap in patients underwent frontolateral vertical partial laryngectomy with T2 and T3 glottic laryngeal carcinoma. Method:Ten patients with T2 and T3 glottic laryngeal carcinoma underwent frontolateral vertical partial laryngectomy in different range. The ultrathin titanium mesh was shaped up according to the form of thyroid cartilage in operation while the thyroid perichondrium membrane combined with straped myofascial flap was lined under the titanium mesh to restore the laryngeal cavity space. The pronunciation, swallowing capability and extubation rate were observed after surgery. Result:Nine patients underwent extubation within 2 to 4 weeks after surgery, one patients remove metal tube in two-stage after laryngeal dilation surgery with the Montgomery tube. Swallowing and voice function in these patients recovered well and no deglutition disorder was found. CT scan showed that the Titanium meshs were fixed well without displacement and deformity. Electronic laryngoscopy showed that the mucosa of laryngeal lumen was smooth without laryngeal stenosis, keloid contraction, tissue necrosis or titanium mesh exposure. Conclusion:In the cases of T2, T3 glottic laryngeal cancer patients, laryngeal framework reconstruction with the new type of ultrathin titanium mesh, thyroid cartilage membrane and pedicled fascia plap of strap muscles is a good choice after the vertical frontolateral partial laryngectomy. Even some elective T4 cases with the former part invasion in supra-glottic or infra-glottic region can receive this operation. It can reconstruct the physiological and anatomical structure of the larynx, restore laryngeal function with a sound decanulization rate.

[Research progress of microRNA as a biomarkerof papillary thyroid carcinoma].

Thyroid cancer is a common malignancy derived from the endocrine system and the incidence of thyroid cancer is on the rise. Papillary thyroid carcinoma (PTC) is the most common type, and 90% of PTC patients have long-term survival, but the recurrence rate is still as high as 30%. Current diagnostic and postoperative monitoring techniques have been developed, but their negative rates and interfering factors also occupy an absolute proportion, and lack specific markers for the prognosis of PTC. Studies have shown that microRNAs (miRNAs) are associated with the development, metastasis and invasiveness of PTC and as a biomarker to aid in the diagnosis and monitoring of recurrence, and to determine the prognosis for specific markers. The future of PTC diagnosis, treatment and improve prognosis has broad prospects. This review mainly describes the development of miRNA as biomarkers for the diagnosis, recurrence and prognosis of PTC.

[Autophagy and its research progress in thyroid cancer].

To summarize the autophagy and its research progress in thyroid cancer.In combination with available literatures published in recent years involving the relationship between autophagy and thyroid cancer, the characteristics of autophagy, the role in thyroid cancer were reviewed. The changes of autophagy level will directly or indirectly participate in the pathogenesis and progression of thyroid cancer.Reagents regulating autophagy will have broad prospect of application in thyroid cancer therapy. The autophagy in the thyroid cancer is still poorly understood, and to clarify the molecular mechanism of autophagy and kill thyroid cancer cells by reasonable regulation of autophagy still needs more further studies.

The stereo-, regio-, and chemo-selective conversion of diterpenoids, kamebakaurin to oriaonin.

In this paper, we report the first stereo-, regio-, and chemo-selective conversion of oridonin from kamebakaurin. The overall yield in 7 steps is 9%.

[Microbial degradation of beta-sitosterol: production of delta 4-androstene-3,17-dione].

Degradation of the side chain of beta-sitosterol (Ib) gave delta 4-androstene-3,17-dione (II) and a small amount of delta 1,4-androstene-3,17-dione (III) by Mycobacterium vaccae 209-20. The yield of the product II was 32%.

Studies on steroidal plant-growth regulators (XVII)--a new synthesis of homobrassinolide and (22S, 23S)-22, 23-epi-homobrassinolide.

Homobrassinolide (2) and (22S, 23S)-22,23-epi-homobrassinolide (4) were synthesized from stigmasterol in seven steps respectively in 4.7% and 24.1% overall yields. The ratio of 2 to 4 is 1:5. The key step is the highly regioselective formation of the B-homo-7-oxa-lactone ring by oxidation of an enol silyl ether with 3-chloro-peroxybenzoic acid.

[Study on asymmetric synthesis of steroids. XVI. Synthesis of dl-3-oxa-A-nor steroid].

A synthesis of racemic 3-oxa-A-nor steroid, 8, is reported. The conjugated addition of anion 5 of 5'-methylfuryl dithiane with 4, an intermediate formed from the racemic dionesulfone 3 afforded 6, which was converted to 7 by cyclization under acidic condition. Desulfurization of 7 with tri-n-bu-tyltin hydride gave the title compound 8, which is an intermediate of the target molecule 1b.

Structure of yingzhaosu C and D.

The structures of yingzhaosu C(3) and D(4) have been determined by spectroscopic analysis in combination with chemical degradation.

Anti-idiotypic antibodies: preparation and identification; application to the detection of antigens of Plasmodium falciparum.

Anti-idiotypic antibodies (anti 94D1Id and anti 94C3Id) were prepared by immunizing rabbits with designated monoclonal antibodies (MoAb) 94D1MoAb (94D1Id) and 94C3MoAb (94C3Id) specific for Plasmodium falciparum. The specificity of both was directed against idiotypes of the relevant MoAb. The interaction between 94D1Id and anti94D1Id or 94C3Id and anti94C3Id was almost completely inhibited when sufficient concentration of P. falciparum antigen was added, suggesting that the idiotypes recognized by anti94D1Id or anti94C3Id were located in the antigen binding site of the MoAbs or the construction of the V region of anti-idiotypic antibodies may be similar to that of P. falciparum antigenic determinants combining with MoAb. Each 4i assay (inhibition of idiotype-anti-idiotype interaction) had a different specificity and sensitivity in detecting P. falciparum asexual antigens. The 94C3Id-anti94C3Id system detected a minimal level of 0.001% parasitaemia and did not cross-react with other species, suggesting that 94C3Id-anti94C3Id system is species specific and may become a valuable tool for immunodiagnosis.