[Efficacy of heated humidified high-flow nasal cannula in preterm infants aged less than 32 weeks after ventilator weaning].

OBJECTIVE: To investigate the efficacy of heated humidified high-flow nasal cannula (HHHFNC) and nasal continuous positive airway pressure (nCPAP) in preterm infants aged 26-31(+6) weeks with respiratory distress syndrome after ventilator weaning. METHODS: A total of 161 preterm infants were randomly divided into two groups after ventilator weaning: HHHFNC treatment (n=79) and nCPAP treatment (n=82). The two groups were subdivided into 26-28(+6) weeks and 29-31+6 weeks groups according to the gestational age. The treatment failure rate, reintubation rate within 7 days after extubation, incidence of complications, and mortality during hospitalization were compared between the two groups. RESULTS: The treatment failure rate and reintubation rate showed no significant differences between the HHHFNC and nCPAP groups. The preterm infants aged 26-28(+6) weeks in the HHHFNC group had a significantly higher treatment failure rate than those in the nCPAP group (P<0.05), while the reintubation rate showed no significant difference. As for the preterm infants aged 29-31(+6) weeks, the treatment failure rate and reintubation rate showed no significant differences between the two groups. The incidence of complications and mortality showed no significant differences between the HHHFNC and nCPAP groups. CONCLUSIONS: In preterm infants aged 29-31(+6) weeks, HHHFNC has a similar efficacy as nCPAP after ventilator weaning, while in those aged less than 29 weeks, HHHFNC should be used with great caution if selected as the first-line noninvasive respiratory support.

[Studies on the antioxidant activities of leaves from Senecio argunensis].

OBJECTIVE: To study antioxidant activities of different extracts of Senecio argunensis. METHODS: The antioxidant activities of S. argunensis extracts with acetoacetate, n-Butanol and water were detected by DPPH * free radical-scavenging method and beta-carotene/linoleic acid system. RESULTS: The acetoacetate, n-Butanol and water extracts from S. argunensis eliminated DPPH * in dose-dependent manner, their EC50 values were 0.0198, 0.0219 and 0.092 mg/ml, respectively. The strength order of the antioxidant activities of the three parts in beta-carotene/linoleic acid system was acetoacetate, n-Butanol and water extracts. CONCLUSION: The extracts of the three parts of S. argunensis all have antioxidant activities. Among these extracts, extracts with acetoacetate have the highest antioxidant activity.