1.
Chem Commun (Camb)
; 49(99): 11650-2, 2013 Dec 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24185282
RESUMO
Peroxidatic activation of the anti-tuberculosis pro-drug isoniazid by Mycobacterium tuberculosis catalase-peroxidase (KatG) is regulated by gating residues of a heme access channel. The steric restriction at the bottleneck of this channel is alleviated by replacement of residue Asp137 with Ser, according to crystallographic and kinetic studies.