RESUMO
We investigated central fatigue in 50 patients with chronic fatigue syndrome (CFS) and 50 matched healthy controls (HC). Resting state EEG was collected from 19 scalp locations during a 3â¯min, eyes-closed condition. Current densities were localized using exact low-resolution electromagnetic tomography (eLORETA). The Multidimensional Fatigue Inventory (MFI-20) and the Fatigue Severity Scale (FSS) were administered to all participants. Independent t-tests and linear regression analyses were used to evaluate group differences in current densities, followed by statistical non-parametric mapping (SnPM) correction procedures. Significant differences were found in the delta (1-3â¯Hz) and beta-2 (19-21â¯Hz) frequency bands. Delta sources were found predominately in the frontal lobe, while beta-2 sources were found in the medial and superior parietal lobe. Left-lateralized, frontal delta sources were associated with a clinical reduction in motivation. The implications of abnormal cortical sources in patients with CFS are discussed.
Assuntos
Sistema Nervoso Central/fisiopatologia , Córtex Cerebral/fisiopatologia , Eletroencefalografia , Síndrome de Fadiga Crônica/fisiopatologia , Adulto , Idoso , Ritmo beta , Mapeamento Encefálico , Ritmo Delta , Feminino , Lobo Frontal/fisiopatologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Motivação , Lobo Parietal/fisiopatologia , Descanso , TomografiaRESUMO
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