[The evoked activity of the dorsal root afferent fibres of the spinal cord of white rats in experimental diabetes mellitus].

We analyzed the functional status of the dorsal root of spinal cord in experimental diabetes mellitus (DM), for instance the parameters of the action potential (AP): threshold, chronaxy and the dynamics of the dorsal root excitability. It was revealed the 1,5 times increase in threshold of excitation when compared to the control animals (P<0,001), the amplitude of AP decreased by 21,7% (P<0,05). It was also revealed a significant increase in response to the 2nd stimulus under applying the paired stimuli on the sciatic nerve in animals with experimental DM. Under applying the stimuli of increasing intensity there was found significant decrease in the amplitude of the AP in animals of the experimental group. It was concluded that hyperglycemia made changes to the processes of excitability and refractoriness in the afferent fibers of the spinal cord.

[Hemodynamics, electrophysiological parameters of the heart and differential therapy of attacks of atrial fibrillation in patients with subclinical thyroid dysfunction]. / Osobennosti gemodinamiki, élektrofiziologicheskikh pokazatelei serdtsa i differentsirovannaia terapiia paroksizmov fibrilliatsii predserdii u bol'nykh s subklinicheskoi disfunktsiei shchitovidnoi zhelezy.

Thirty patients with subclinical thyrotoxicosis and 32 with subclinical hypothyroidism with attacks of atrial fibrillation were investigated. At levels of thyroid-stimulating hormone below 0.1 or above 10.0 mIU/l average triiodothyronine and thyroxine levels in patients with subclinical thyrotoxicosis were 89.6 and 73.2%, respectively, higher than in patients with subclinical hypothyroidism. Some relationships were found between levels of thyroid hormones and hemodynamic and electrophysiological parameters of the heart. Differential therapy of attacks of atrial fibrillation was effective in 80 and 62.5% of patients with subclinical thyrotoxicosis or hypothyroidism, respectively.

[Dehydroepiandrosterone and sexual function in men with chronic prostatitis]. / Degidroépiandrosteron i polovaioa funktsiia u muzhchin s khronicheskim prostatitom.

The aim of this study was to determine relationships between the level of DHEA-sulfate (DHEA-S), an erectile function and libido in men with chronic prostatitis. 53 patients (mean age 44.6 +/- 12.0; range 21-68 years) with chronic prostatitis were studied. Libido and erection were estimated and patients were divided into two groups according to their sexual dysfunction: 21 patients with severe sexual dysfunction (SSD) and 32 patients with mild sexual dysfunction (MSD). Testosterone, prolactin and DHEA-S were detected by ELISA. SSD patients had a lower testosterone level than patients with MSD (11.8 +/- 4.6 vs 14.8 +/- 5.9 nmol/l, respectively, p = 0.04) and DHEA-S (1.7 +/- 0.8 vs 2.5 +/- 1.2 microg/ml, respectively, p = 0.01). There was a negative correlation between the age of the patients and an erectile function (r = -0.70; p < 0.001), age and libido (r = -0.57; p < 0.001). The negative correlation was revealed between DHEA-S and age (r = -0.59; p < 0.001). A positive correlation was between DHEA-S and an erectile function (r = 0.45, p = 0.001). There was no correlation between DHEA-S and serum testosterone level (r = 0.10; p = 0.5). Multiple regression analysis showed an independent positive correlation between DHEA-S and erectile function in patients with chronic prostatitis (beta = 0.28; p = 0.02; R2 = 0.40). The findings show that erectile dysfunction independently from age is associated with a lower level of serum DHEA-S in patients with chronic prostatitis.