Assuntos
Anestésicos Locais/farmacologia , Glicoconjugados/metabolismo , Células Caliciformes/metabolismo , Mucosa Respiratória/metabolismo , Traqueia/metabolismo , Trimecaína/farmacologia , Administração Tópica , Anestésicos Locais/administração & dosagem , Animais , Células Caliciformes/efeitos dos fármacos , Masculino , Coelhos , Mucosa Respiratória/efeitos dos fármacos , Traqueia/efeitos dos fármacos , Trimecaína/administração & dosagemRESUMO
The ultrastructure of the rabbit tracheal epithelium was studied 30 minutes after intratracheal administration of two puffs of salbutamol and ipratropium bromide, respectively. The injury to the tracheal epithelium due to the treatment with both bronchospasmolytic drugs was considered moderate to severe. In both experimental groups, the degree of goblet cells' stimulation did not differ significantly, the ciliated cells were less damaged compared with the goblet ones and the morphological signs of the impaired self-cleaning ability were revealed.
Assuntos
Agonistas Adrenérgicos beta/toxicidade , Albuterol/toxicidade , Ipratrópio/toxicidade , Parassimpatolíticos/toxicidade , Traqueia/efeitos dos fármacos , Animais , Epitélio/efeitos dos fármacos , Epitélio/ultraestrutura , Coelhos , Traqueia/ultraestruturaRESUMO
The ultrastructure of rabbit tracheal epithelium was studied 20 min after injection of 0.04 and 0.5 mg of atropin. The tracheae were lined with altered ciliated pseudostratified columnar epithelium. The degree of damage to the epithelial cells was dose dependent. The injury to the tracheal epithelium due to treatment with 0.04 mg of atropin was considered mild. The administration of the higher dose of atropin caused moderately severe epithelial damage. Both experimental groups exhibited morphological signs of impaired self-cleaning ability.
Assuntos
Atropina/administração & dosagem , Traqueia/efeitos dos fármacos , Traqueia/ultraestrutura , Animais , Atropina/farmacologia , Relação Dose-Resposta a Droga , Células Epiteliais , Epitélio/efeitos dos fármacos , Epitélio/ultraestrutura , Microscopia Eletrônica , Coelhos , Fatores de Tempo , Traqueia/citologiaRESUMO
The ultrastructure of the tracheal epithelium was studied 5 and 20 min after intravenous (i.v.) administration of 0.5 mg of acetylcholine. As a result of this treatment, the goblet cells were overstimulated and damaged, and the mechanism of their secretion was accelerated. Only a mild pathological alteration was encountered in the ciliated cells. According to our classification, the degree of secretory element damage was severe, the injury to the ciliary border was moderate. The morphological signs of the severe impairment of the self-cleaning ability of the epithelium were inspissated mucus and very numerous bacteria in the area among free cilia.