Naphthalimide-Tagged Iron(II) Spin Crossover Complex with Synergy of Ratiometric Fluorescence for Thermosensing.

Spin crossover (SCO) materials that possess switchable and cooperative fluorescence have long focused interest in photonic sensor devices to monitor the variations in the physicochemical parameters of the external environment. However, the lack of quantified cooperativity for the SCO transition operating in isolated molecules is detrimental to short-term technological applications. In this study, a pretwisted energy D-A system combining the deep-blue naphthalimide fluorophore (donor) and the FeN6 SCO chromophore (switchable acceptor) has been developed with the formula of Fe(naph-abpt)2(NCS)2·2DMF (1), where naph-abpt is N-[3,5-di(pyridin-2-yl)-4H-1,2,4-triazol-4-yl]-1,8-naphthalimide. Dual emission from the naphthalimide function based on its vibronic structure exhibits a different synergy effect with SCO, providing a new platform for ratiometric fluorescence thermosensing. Theoretical calculations and optical experimental results demonstrate an excellent correlation between luminescence intensity ratio signals and magnetic data of spin transition, promising a high sensitivity of the optical activity of the ligand to the spin state of the active iron(II) ions, with the maximum relative sensitivity as 0.7% K-1 around T1/2.

Enhanced anaerobic digestion of swine manure via a coupled microbial electrolysis cell.

Microbial electrolysis cell coupled anaerobic digestion (MEC-AD) is a new technology in energy recovery and waste treatment, which could be used to recycle swine manure. Here, different applied voltage effects were studied using MEC-AD with swine manure as a substrate. The maximum cumulative biogas and methane yields, both occurring with 0.9 V, were 547.3 mL/g total solid (TS) and 347.7 mL/g TS, respectively. The increased energy can counterbalance the electrical input. First order, logistic, gompertz, and back-propagation artificial neural network (BP-ANN) models were used to study cumulative biogas and methane yields. The BP-ANN model was superior to the other three models. The maximum degradation rate of hemicellulose, cellulose, and lignin was 60.97%, 48.59%, and 31.59% at 0.9 V, respectively. The BP-ANN model establishes a model for cumulative biogas and methane yields using MEC-AD. Thus, MEC-AD enhanced biogas and methane production and accelerated substrate degradation at a suitable voltage.

Clinical Utility of Central and Peripheral Airway Nitric Oxide in Aging Patients with Stable and Acute Exacerbated Chronic Obstructive Pulmonary Disease.

PURPOSE: Exhaled nitric oxide has been used as a marker of airway inflammation. The NO concentration in the central and peripheral airway/alveolar can be measured by a slow and fast exhalation flow rate to evaluate inflammation in different divisions within the respiratory tract. We hypothesized that FeNO200 (exhaled NO at a flow rate of 200mL/s) could be used as an evaluation tool for peripheral airway/alveolar inflammation and corticosteroid therapy in chronic obstructive pulmonary disease (COPD) patients. METHODS: We recruited 171 subjects into the study: 73 healthy controls, 59 stable COPD patients, and 39 acute exacerbations of COPD (AECOPD) patients. Exhaled nitric oxide (FeNO50 (exhaled NO at a flow rate of 50mL/s)), FeNO200 and CaNO (peripheral concentration of NO/alveolar NO) and clinical variables including pulmonary function, COPD Assessment Test (CAT), C-reactive protein concentration (CRP) and circulating eosinophil count were measured among the recruited participants. FeNO50, FeNO200 and CaNO were repeatedly evaluated in 39 AECOPD patients after corticosteroid treatment. RESULTS: FeNO200 was significantly higher in stable COPD and AECOPD patients than in healthy controls. Nevertheless, CaNO could not differentiate COPD from healthy controls. No correlation was found between circulating eosinophil counts or FEV1 and exhaled nitric oxide (FeNO50, FeNO200, CaNO) in COPD patients. For AECOPD patients, 64% of patients had eosinophil counts >100 cells/µL; 59% of patients had FeNO200 >10 ppb; only 31% of patients had FeNO50 > 25 ppb. Among AECOPD patients, the high FeNO50 and FeNO200 groups' levels were significantly lower than their baseline levels, and significant improvements in CAT were seen in the two groups after corticosteroid treatment. These implied a good corticosteroid response in AECOPD patients with FeNO200>10ppb. CONCLUSION: FeNO200 is a straightforward and feasible method to evaluate the peripheral NO concentration in COPD. FeNO200 can be a type 2 inflammation biomarker and a useful tool for predicting corticosteroid therapy in COPD.

Close Relationship between cIAP2 and Human ARDS Induced by Severe H7N9 Infection.

BACKGROUND: cIAP2 is involved in necroptosis as a key upstream regulation factor. We aimed to investigate the role of cIAP2 in ARDS/ALI induced by H7N9 virus through regulating the RIPK1/3 necroptosis pathway. METHODS: Lung tissues of 11 patients who died from ARDS-complicated H7N9 infection between 2013 and 2016 were obtained as the H7N9-ARDS group. Lung tissues near benign lung nodules were acquired as the control group. Histological changes were evaluated by H&E staining. Protein levels of cIAP2, RIPK1, RIPK3, p-RIPK3, MLKL, and p-MLKL in the lung tissues were detected by Western Blot. The mRNA levels of cIAP2, RIPK1, and RIPK3 were detected by real-time PCR. RESULTS: H7N9 virus infection had a high mortality, with ARDS being the leading cause of death. The protein level of cIAP2 in the experimental group was lower than that in the control group (P<0.05). However, the experimental group showed higher RIPK1, RIPK3, and p-RIPK3 protein levels than the control group (P<0.05), as well as the expression level of MLKL and p-MLKL protein, which is a key downstream protein in necroptosis (P<0.05). CONCLUSION: In tissues from patients with fatal H7N9, downregulation of cIAP2 and induction of necroptosis was observed. We could speculate that necroptosis of the pulmonary epithelium is associated with severe H7N9 infection leading to ARDS. Thus, necroptosis inhibition may be a novel therapy for H7N9 influenza virus.

A Pillar-Layered Zn-LMOF with Uncoordinated Carboxylic Acid Sites: High Performance for Luminescence Sensing Fe3+ and TNP.

By using the mixed-linker strategy, a new pillar-layered luminescence Zn-LMOF (JLU-MOF71) ([Zn2Na2(TPHC)(4,4-Bipy)(DMF)]·8H2O) (TPHC = [1,1':2',1″-terphenyl]-3,3″,4,4',4″,5'-hexacarboxylic acid, 4,4-bipy = 4,4-bipyridine, DMF = N, N-dimethylformamide) was successfully synthesized and structurally characterized. JLU-MOF71 is constructed by the 4,4-bipy pillars and 2D layers which consist of Zn2+ and TPHC ligands, and displays a rare fsh topology. Benefiting from the uncoordinated carboxylate sites in the framework, JLU-MOF71 not only can sensitively detect trace amounts of individual Fe3+ and 2,4,6-trinitrophenol (TNP) through luminescence quenching but also exhibits high selectivity when other competing analytes exist. Besides, TNP can also be effectively monitored with the help of the shifting direction of luminescent spectra (red shift) which has rarely been reported before. On the basis of the aforementioned, JLU-MOF71 can be considered as a potential luminescence sensor for detecting Fe3+ and TNP.

Assembly of Zeolite-like Metal-Organic Framework: An Indium-ZMOF Possessing GIS Topology and High CO2 Capture.

An In-ZMOF material, [(CH3)2NH2][In(ABTC)]·3DMF (JLU-MOF52), has been synthesized by using 2,2',5,5'-azobenzenetetracarboxylic acid (H4ABTC) as a linker, which coordinated to four [In(O2C)4]- secondary building units (SBUs) to generate a 3D framework. JLU-MOF52 is constructed by a rare 4 + 4 strategy from 4-connected tetrahedral [In(O2C)4]- SBUs and tetrahedral ligands, which can be described as a (4, 4)-connected and forbidden interpenetrated zeolite-like MOF with GIS topology. The framework exhibits significant advantages in terms of chemical stability. N2 adsorption study of the activated JLU-MOF52 material reveals a Langmuir and a BET surface area is 1302 and 966 m2 g-1, respectively. Furthermore, the adsorption amount of CO2 for JLU-MOF52 is studied under 1 atm, which exhibits the highest CO2 capture ability at 273 K among the ZMOFs materials with GIS topology. These characteristics make JLU-MOF52 promising candidate materials for application in moderating increasing atmospheric CO2 levels.

Phenoxido and alkoxido-bridged dinuclear dysprosium complexes showing single-molecule magnet behaviour.

Two new dysprosium(iii) complexes, [Dy(2)(HL(1))(4)(CO(3))]·4H(2)O (1) and [Dy(2)(L(2))(2)(NO(3))(2)(CH(3)OH)(2)]·4CH(3)CN (2), have been synthesized from the Schiff-base ligands N'-((2-hydroxy-1-naphthyl)methylene)benzohydrazide (H(2)L(1)) and N'-((2-hydroxy-1-naphthyl)methylene) picolinohydrazide (H(2)L(2)). Single-crystal X-ray diffraction studies reveal that four mono-deprotonated H(2)L(1) ligands and two di-deprotonated H(2)L(2) ligands which have undergone keto-enol tautomerism coordinate to the two dysprosium centres of complexes 1 and 2, respectively. The dc magnetic properties of complexes 1 and 2 are different. The phenoxido bridges in complex 1 mediate antiferromagnetic interaction between Dy(III) ions, while ferromagnetic interaction was clearly observed in alkoxido-bridged dinuclear complex 2. Furthermore, both complexes show frequency-dependent ac magnetic susceptibilities, indicating a slow relaxation of the magnetization, typical of SMM behaviour.

A dodecanuclear heterometallic dysprosium-cobalt wheel exhibiting single-molecule magnet behaviour.

A novel dodecanuclear wheel with ten Dy(III) ions and two Co(II) ions bridged by four Schiff-base ligands and sixteen acetates represents the highest-nuclearity 3d-4f example of its type displaying single-molecule magnet behaviour.

(2-Oxido-1-naphthaldehyde benzoyl-hydrazonato-κN,N',O)pyridine-copper(II).

In the mononuclear title compound, [Cu(II)(C(18)H(12)N(2)O(2))(C(5)H(5)N)], the Cu(II) ion is coordinated by two O atoms and one N atom from the dianionic tridentate L(2-) ligand (H(2)L is 2-hy-droxy-1-naphthaldehyde benzoyl-hydrazide) and one N atom from a pyridine mol-ecule in a CuN(2)O(2) distorted square-planar coordination environment.

Bis[µ-2-(2-benzoyl-hydrazinylidenemeth-yl)-6-methoxy-phenolato][2-(2-benzoyl-hydrazinylidenemeth-yl)-6-methoxy-phenolato]dimanganese(II) perchlorate methanol solvate.

In the title complex, [Mn(2)(C(15)H(13)N(2)O(3))(3)]ClO(4)·CH(3)OH, the two Mn(II) ions are bridged by two phenolate O atoms from two ligands, forming an Mn(2)O(2) quadrangle. Each Mn(II) ion has a distorted octa-hedral coordination geometry. One Mn(II) ion is coordinated by two N atoms and four O atoms from two ligands, and the other is coordinated by one N atom and five O atoms from three ligands. A dimer is formed by inter-molecular N-H⋯O hydrogen bonds. The dimers, perchlorate anions and methanol solvent mol-ecules are further connected into a chain along [01] through N-H⋯O and O-H⋯O hydrogen bonds.

Bis{2-[(2-benzoyl-hydrazin-1-yl-idene)meth-yl]-6-meth-oxy-phenolato}iron(III) chloride monohydrate.

In the title mononuclear iron(III) complex, [Fe(C(15)H(13)N(2)O(3))(2)]Cl·H(2)O, the Fe(III) atom has a distorted octa-hedral geometry and is six-coordinated by four O atoms and two N atoms from two ligands. In the crystal structure, the complex cations, Cl(-) anions and water mol-ecules are connected into a chain along [100] through N-H⋯O, O-H⋯Cl and N-H⋯Cl hydrogen bonds. Two adjacent chains are linked by O-H⋯O hydrogen bonds.