RESUMO
PURPOSE: To evaluate the safety and effectiveness of gadodiamide-enhanced magnetic resonance (MR) angiography with single and triple doses in the assessment of abdominal arterial stenoses. MATERIALS AND METHODS: One hundred five patients were included in the randomized, double-blind, phase III multicenter trial. Results of MR angiography with 0.1 mmol/kg and 0.3 mmol/kg doses of gadodiamide were compared with those of digital subtraction angiography (DSA) and according to dose. RESULTS: No serious adverse events were observed. The mean contrast index at the region proximal to the primary stenosis was significantly higher in the triple-dose group (P =.03). Mean 95% CI values for the difference in depicted degree of stenosis between DSA and postcontrast MR angiography improved from -3.4% +/- 4.7 (SD) in the single-dose group to -1.2% +/- 4.7 in the triple-dose group. Mean values for overall image quality on the visual analogue scale improved with the triple dose (P =.02). Confidence in diagnosis was high at postcontrast MR angiography in 88% and 96% of cases in the single- and triple-dose groups, respectively. CONCLUSION: Gadodiamide-enhanced MR angiography performed with single and triple doses is safe and effective for assessing major abdominal arterial stenoses. Although high agreement between MR angiography and DSA was achieved with both doses, triple-dose MR angiography was superior in the evaluations of image quality, degree of arterial stenoses, and confidence in diagnosis.
Assuntos
Abdome/irrigação sanguínea , Arteriopatias Oclusivas/diagnóstico , Meios de Contraste/administração & dosagem , Gadolínio DTPA , Aumento da Imagem , Angiografia por Ressonância Magnética , Imageamento por Ressonância Magnética , Idoso , Idoso de 80 Anos ou mais , Angiografia Digital , Meios de Contraste/efeitos adversos , Relação Dose-Resposta a Droga , Método Duplo-Cego , Feminino , Gadolínio DTPA/administração & dosagem , Gadolínio DTPA/efeitos adversos , Humanos , Masculino , Pessoa de Meia-Idade , Sensibilidade e EspecificidadeRESUMO
The identification of the risk groups, in what concerns dental caries, is difficult because the etiology of the disease is multifactorial. Some indicators were selected to overcome these difficulties. Once the risk groups are known, the principle precautions of the prevention strategy are established.