Assessment of algorithms for mitosis detection in breast cancer histopathology images.

The proliferative activity of breast tumors, which is routinely estimated by counting of mitotic figures in hematoxylin and eosin stained histology sections, is considered to be one of the most important prognostic markers. However, mitosis counting is laborious, subjective and may suffer from low inter-observer agreement. With the wider acceptance of whole slide images in pathology labs, automatic image analysis has been proposed as a potential solution for these issues. In this paper, the results from the Assessment of Mitosis Detection Algorithms 2013 (AMIDA13) challenge are described. The challenge was based on a data set consisting of 12 training and 11 testing subjects, with more than one thousand annotated mitotic figures by multiple observers. Short descriptions and results from the evaluation of eleven methods are presented. The top performing method has an error rate that is comparable to the inter-observer agreement among pathologists.

Recovering articulated pose: a comparison of two pre and postimposed constraint methods.

We contrast the performance of two methods of imposing constraints during the tracking of articulated objects, the first method preimposing the kinematic constraints during tracking and, thus, using the minimum degrees of freedom, and the second imposing constraints after tracking and, hence, using the maximum. Despite their very different formulations, the methods recover the same pose change. Further comparisons are drawn in terms of computational speed and algorithmic simplicity and robustness, and it is the last area which is the most telling. The results suggest that using built-in constraints is well-suited to tracking individual articulated objects, whereas applying constraints afterward is most suited to problems involving contact and breakage between articulated (or rigid) objects, where the ability to test tracking performance quickly with constraints turned on or off is desirable.