Enhancing life with celiac disease: unveiling effective tools for assessing health-related quality of life.

Celiac disease (CD) is an autoimmune chronic enteropathy provoked by gluten ingestion in genetically predisposed individuals. Considering it´s only safe treatment is a lifelong gluten-free diet, the burden of living with the disease becomes evident, as well as the need to assess CD health-related quality of life (HRQOL). This review aims to identify and analyze the instruments used to evaluate the HRQOL of adults with CD. This integrative review using a systematic approach was designed to achieve high scientific standards. Accordingly, the search strategy was developed and executed as recommended by the guideline of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Detailed individual searches were developed to Pubmed, Science Direct, Scopus, Web of Science, and Google Scholar. After careful analysis of the papers, 43 studies were included, in which seven instruments were identified: Celiac Disease Questionnaire (CDQ) (n=21), Celiac Disease Specific Quality of Life Instrument (CD-QOL) (n=17), Celiac Disease Assessment Questionnaire (CDAQ) (n=4), CeliacQ-7 (n=1), CeliacQ-27 (n=1), Black and Orfila´s self-developed instrument (n=1) and the Coeliac Disease Quality of Life Questionnaire (CDQL) (n=1). The CDQ and CD-QOL were the two most applied instruments. Since the first focuses on the physical and mental symptoms related to the disease and the second focuses on the emotional repercussions of adhering to the GFD treatment for life (dysphoria), the CDQ application is an interesting option for countries that struggle with public policies for CD patients and patients with active CD. The CD-QOL could be used for countries with strict regulations for CD and gluten-free products and populations in remission. When comparing results among different populations, it is preferable to utilize culturally validated instruments, which have been applied across multiple countries, providing greater comparability between study findings.

Shortcuts to adiabatic population inversion via time-rescaling: stability and thermodynamic cost.

A shortcut to adiabaticity is concerned with the fast and robust manipulation of the dynamics of a quantum system which reproduces the effect of an adiabatic process. In this work, we use the time-rescaling method to study the problem of speeding up the population inversion of a two-level quantum system, and the fidelity of the fast dynamics versus systematic errors in the control parameters. This approach enables the generation of shortcuts from a prescribed slow dynamics by simply rescaling the time variable of the quantum evolution operator. It requires no knowledge of the eigenvalues and eigenstates of the Hamiltonian and, in principle, no additional coupling fields. From a quantum thermodynamic viewpoint, we also demonstrate that the main properties of the distribution of work required to drive the system along the shortcuts are unchanged with respect to the reference (slow) protocol.

Clinical and epidemiological aspects of Candidemia in eight medical centers in the state of Parana, Brazil: Parana Candidemia Network.

OBJECTIVES: Candida spp. has been reported as one of the common agents of nosocomial bloodstream infections and is associated with a high mortality. Therefore, this study evaluated the clinical findings, local epidemiology, and microbiological aspects of candidemia in eight tertiary medical centers in the state of Parana, South of Brazil. METHODS: In this study, we reported 100 episodes of candidemia in patients admitted to eight different hospitals in five cities of the state of Parana, Brazil, using data collected locally (2016 and 2017) and tabulated online. RESULTS: The incidence was found to be 2.7 / 1000 patients / day and 1.2 / 1000 admissions. C. albicans was responsible for 49% of all candidemia episodes. Cancer and surgery were the two most common underlying conditions associated with candidemia. The mortality rate within 30 days was 48%, and removal of the central venous catheter (p = 0.029) as well as empirical or prophylactic exposure to antifungals were both related to improved survival (p = 0.033). CONCLUSIONS: This study highlights the high burden and mortality rates of candidemia in hospitals from Parana as well as the need to enhance antifungal stewardship program in the enrolled medical centers.

Probing the reciprocal lattice associated with a triangular slit to determine the orbital angular momentum for a photon.

The orbital angular momentum conservation of light reveals different diffraction patterns univocally dependent on the topological charge of the incident light beam when passing through a triangular aperture. It is demonstrated that these patterns, which are accessed by observing the far-field measurement of the diffracted light, can also be obtained using few photon sources. In order to explain the observed patterns, we introduce an analogy of this optical phenomenon with the study of diffraction for the characterization of the crystal structure of solids. We demonstrate that the finite pattern can be associated with the reciprocal lattice obtained from the direct lattice generated by the primitive vectors composing any two of the sides of the equilateral triangular slit responsible for the diffraction. Using the relation that exists between the direct and reciprocal lattices, we provide a conclusive explanation as to why the diffraction pattern of the main maxima is finite. This can shed a new light on the investigation of crystallographic systems.

Multirange Ising model on the square lattice.

We study the Ising model on the square lattice (Z^{2}) and show, via numerical simulation, that allowing interactions between spins separated by distances 1 and m (two ranges), the critical temperature, T_{c}(m), converges monotonically to the critical temperature of the Ising model on Z^{4} as m→∞. Only interactions between spins located in directions parallel to each coordinate axis are considered. We also simulated the model with interactions between spins at distances of 1, m, and u (three ranges), with u a multiple of m; in this case our results indicate that T_{c}(m,u) converges to the critical temperature of the model on Z^{6}. For percolation, analogous results were proven for the critical probability p_{c} [B. N. B. de Lima, R. P. Sanchis, and R. W. C. Silva, Stochast. Process. Appl. 121, 2043 (2011)STOPB70304-414910.1016/j.spa.2011.05.009].

Health Benefits of Green Banana Consumption: A Systematic Review.

Despite the growing demand for green banana (GB) products, there is no review study regarding their potential health benefits. We aimed to compare the health benefits among different GB products by a systematic review. We researched six electronic databases (PubMed, EMBASE, Scopus, Science Direct, Web of Science, and Google Scholar) from inception to March 2019. We found 1009 articles in these databases. After duplicate removal, we screened 732 articles' titles and abstracts, and selected 18 potentially relevant studies for full-text reading. We added five records from the reference list of the fully-read articles and seven suggested by the expert. Twelve articles were excluded. In the end, 18 studies were considered for this systematic review. Ten studies were conducted with green banana flour and eight with the green banana pulp/biomass. Most of the GB health benefits studied were related to the gastrointestinal symptoms/diseases, followed by the glycemic/insulin metabolism, weight control, and renal and liver complications associated to diabetes. Only one study did not confirm the health benefit proposed. It is necessary to standardize the GB dose/effect to different age groups and different health effects considering the GB variety and ripeness level. Further studies are necessary to present better detailing of GB product and their health effects considering all the raw-material characteristics.

Evaluation of the effectiveness of red mud-supported catalysts in combination with ozone and TiO2 in the treatment of solution containing benzene, toluene, and xylene.

Ozone and a Fe2+/TiO2-based catalyst were examined in the degradation of a synthetic solution of benzene toluene and xylene (BTX) in an advanced oxidation process (AOP). The catalyst beads were made from the slurry waste of aluminum production process, by inserting the TiO2 content and subsequent calcination. The reduction of the BTX concentration load was monitored by the reduction of chemical oxygen demand (COD) and BTX concentration. Different levels were used on factors: pH, time of treatment, initial concentration of BTX, and percentage of TiO2. The process was conducted in a bubble column reactor with the insertion of catalyst beads. A response surface methodology technique (CCD) was used to build a model based on COD reduction results. The model was optimized using the normal-boundary intersection (NBI) algorithm to maximize COD reduction and minimize the variance attributed to the process. Optimization led to COD reductions of 80% in 2 h of experiment. Correlation analysis of coefficient models from experimental data R2adj was 0.9966, showing a good fit of model data. In the optimized conditions, the possible increase of the biodegradability ratio of the BTX solution, through the biochemical oxygen demand (BOD) and COD, was also analyzed. Under pre-treatment conditions, the BOD/COD ratio was 0.13. After the treatment, it increased to 0.56. Graphical abstract ᅟ.

How a single particle simultaneously modifies the physical reality of two distant others: a quantum nonlocality and weak value study.

The concept of wave-particle duality, which is a key element of quantum theory, has been remarkably found to manifest itself in several experimental realizations as in the famous double-slit experiment. In this specific case, a single particle seems to travel through two separated slits simultaneously. Nevertheless, it is never possible to measure it in both slits, which naturally appears as a manifestation of the collapse postulate. In this respect, one could as well ask if it is possible to "perceive" the presence of the particle at the two slits simultaneously, once its collapse could be avoided. In this article, we use the recently proposed entanglement mediation protocol to provide a positive answer to this question. It is shown that a photon which behaves like a wave, i.e., which seems to be present in two distant locations at the same time, can modify two existing physical realities in these locations. Calculations of the "weak trace" left by such photon also enforce the validity of the present argumentation.