RESUMO
OBJECTIVE: To perform a quantitative analysis of the lung parenchyma and pulmonary vasculature of patients with pulmonary hypertension (PH) on computed tomography angiography (CTA) images, using automated software. MATERIALS AND METHODS: We retrospectively analyzed the CTA findings and clinical records of 45 patients with PH (17 males and 28 females), in comparison with a control group of 20 healthy individuals (7 males and 13 females); the mean age differed significantly between the two groups (53 ± 14.7 vs. 35 ± 9.6 years; p = 0.0001). RESULTS: The automated analysis showed that, in comparison with the controls, the patients with PH showed lower 10th percentile values for lung density, higher vascular volumes in the right upper lung lobe, and higher vascular volume ratios between the upper and lower lobes. In our quantitative analysis, we found no differences among the various PH subgroups. We inferred that a difference in the 10th percentile values indicates areas of hypovolemia in patients with PH and that a difference in pulmonary vascular volumes indicates redistribution of the pulmonary vasculature and an increase in pulmonary vasculature resistance. CONCLUSION: Automated analysis of pulmonary vessels on CTA images revealed alterations and could represent an objective diagnostic tool for the evaluation of patients with PH.
Resumo. OBJETIVO: Avaliar, quantitativamente, as alterações do parênquima e da vasculatura pulmonar em exames de angiotomografia computadorizada (angio-TC) de pacientes com hipertensão pulmonar (HP), utilizando programa de análise totalmente automática. MATERIAIS E MÉTODOS: Avaliamos, retrospectivamente, prontuários e exames de angio-TC de 45 pacientes com HP (28 mulheres e 17 homens; idade de 53 ± 14,7 anos), em comparação com um grupo controle mais jovem sem comorbidades detectadas (13 mulheres e 7 homens; idade de 35 ± 9,6 anos). Os grupos diferiram estatisticamente quanto à idade (p = 0,0001). RESULTADOS: Análise automática mostrou valores menores do percentil 10 da densidade dos pulmões, maior volume vascular do lobo superior direito e volume vascular relativo entre lobos superiores e inferiores nos pacientes com HP, quando comparados com o grupo controle. Não encontramos diferenças da análise quantitativa por angio-TC entre grupos de pacientes com HP. Inferimos que a diferença nos valores do percentil 10 indique a presença das áreas de oligoemia nos pacientes com HP, enquanto as diferenças nos volumes vasculares indiquem redistribuição da trama e aumento da resistência vascular pulmonar. CONCLUSÃO: A análise quantitativa automática da vasculatura pulmonar em imagens de angio-TC identificou alterações e pode representar ferramenta diagnóstica objetiva na avaliação da HP.
RESUMO
Smoking cessation still is a great challenge for smokers and health care professionals. Most subjects try cigarettes in adolescence under predominant environmental influences, and some psychological features are clearly associated with the establishment of continuous cigarette use. As a result, it is acceptable to assume that the risk of becoming regular smokers should be higher for subjects exhibiting imperfect psychological well-being. Since nicotine exhibits recognized psychopharmacological actions, an important reason for smoking would be the comfort of smokers' emotional afflictions. In this scenario, cigarettes might be seen as effective coping instruments for smokers. We hypothesize that a simple measure covering major emotional features of smokers might become a useful instrument for predicting the chances of success in attempts to quit smoking. The development of this new test aimed to measure the degree of smokers' emotional imbalance has the potential to predict the chances of success in response to standard therapy, as well as the need for introduction of intensive individualized psychological or psychiatric interventions. Preliminary analyses of a new test called Smokers' Emotional Index (SEI) support such a hypothesis. The SEI scores showed significant correlations with the values of the Fagerström test of nicotine dependence (FTND) for adult smokers. More numerous and better correlation coefficients were also observed between aspects of smoking history with SEI punctuations than with FTND scores. A clinical trial is proposed to test this hypothesis that could help to improve the results of current approaches to smoking cessation.