The impact of dark chocolate intake on arterial elasticity in individuals with HIV/AIDS undergoing ART: a randomized, double-blind, crossover trial.

An increase in the frequency of cardiovascular diseases has been observed in the HIV/AIDS population. Studies involving healthy subjects or subjects with other diseases have shown benefits of chocolate supplementation on endothelial function and vasodilation. We evaluate the impact of chocolate consumption on arterial elasticity in people living with human immunodeficiency virus - PLHIV. A double-blind, crossover trial including 110 PLHIV (19 to 59 years) on antiretroviral therapy - ART for at least 6 months and with a viral load of <500 copies per mL was conducted. All subjects were randomly assigned to 15-d dietary supplements containing dark chocolate or placebo with a 15-d washout period. Each participant received one of the two sequences: A (dark chocolate, placebo chocolate); B (placebo chocolate, dark chocolate). Arterial elasticity was measured using the HDI/PulseWave™ CR-2000 CardioVascular Profiling System®. Body composition, lipid profile, C-reactive protein, and thiobarbituric acid reactive substances were also assessed. Analysis of variance (ANOVA) for repeated measures using the Stata 11.0® program was used for cross-over analysis. Most subjects were men (59.0%) and Caucasian (46.1%) and the mean age was 44.6 ± 7.1 years. The mean time since diagnosis of HIV infection was 13.7 ± 5.3 years and the mean duration of ART was 12.9 ± 4.2 years. Chocolate consumption resulted in significant alterations in the large artery elasticity index - LAEI (p = 0.049) and the mean concentration of HDL-c was higher after supplementation with dark chocolate (p = 0.045). This is the first study to evaluate the effect of chocolate on arterial elasticity in PLHIV. The results showed that dark chocolate consumption for 15 days improved the elastic properties of the LAEI in PLHIV. These findings, added to the noninvasive method used, may expand the knowledge of CVDs in this population.

[Hemoglobin concentration in children from birth to one year of age]. / Concentração de hemoglobina em crianças do nascimento até um ano de vida.

This study aimed to describe the evolution of hemoglobin concentration considering the following factors: birth weight, growth rate, and food intake. The cross-sectional study focused on infants (<1 year of age) whose growth and development were monitored by public health services in cities located in the five geographic regions of Brazil. Some 51.7% of the children aged 6 to 12 months presented anemia. Estimation of [Hb] concentration by a theoretical equation suggested that endogenous iron is able to maintain normal Hb levels in the first three months of life. Prevalence of reduced Hb was higher in low birth weight infants. Growth rate, verified by the difference between present weight and birth weight in Z scores, was not the relevant factor for hemoglobin concentration. The relevance of breastfeeding was evident in the initial months of life. However, complementary foods did not influence infant Hb concentration. The high prevalence of low Hb levels calls attention to the need for programs to control anemia.

[Risks associated with the weaning process in children born in a university hospital: a prospective cohort in the first year of life, São Paulo, 1998-1999]. / Riscos associados ao processo de desmame entre crianças nascidas em hospital universitário de São Paulo, entre 1998 e 1999: estudo de coorte prospectivo do primeiro ano de vida.

This study describes breastfeeding practices with children born in a university hospital in the city of S o Paulo, Brazil, and identifies factors associated with duration of breastfeeding and exclusive breastfeeding. A cohort of 506 children was identified; of these, it was possible to analyze information on feeding practices for 450 infants at least until the second month of life. Daily information on infant feeding was recorded by mothers in a food frequency questionnaire. Survival analysis techniques (Kaplan-Meier and Cox) were used. Median duration of breastfeeding and exclusive breastfeeding were 205 and 23 days, respectively. The principal factors related to exclusive breastfeeding were mother's age (hr young/old = 1.22; 95% CI = 1.006-1.486) and mother's schooling (hr primary/university = 2.13; 95% CI = 1.381-3.307 and hr secondary/university = 1.78; 95% CI = 1.145-2.792), which could be related to knowledge concerning the benefits of exclusive breastfeeding.