Non-surgical treatment as an alternative for the management of central giant cell granuloma: a systematic review.

OBJECTIVE: To evaluate the effectiveness of non-surgical treatment as an alternative in the management of central giant cell granuloma (CGCG). MATERIAL AND METHODS: A literature search was carried out in accordance with the PRISMA statement in order to answer the question "Are non-surgical treatments effective as an alternative in the treatment of CGCG?". Two examiners independently assessed eligibility, risk of bias, and extracted data, which included therapeutic protocol, side effects, and need for surgical supplementation. RESULTS: Among 1712 studies, 15 were included, totaling 145 patients. Calcitonin, intralesional corticosteroids, and denosumab were the medications used. For calcitonin (n = 61), complete remission was found in 30 cases. For intralesional triamcinolone (n = 68), reduction in size was observed in most cases (n = 39). Four cases received subcutaneous denosumab and showed absence of active bone metabolism in the region, of which three presented ossification. Combination of drug therapies (n = 29) was reported in one study and included subcutaneous interferon and oral imatinib. More and less side effects were found for interferon and corticosteroids, respectively. Forty percent of patients required additional surgical treatment. CONCLUSION: Despite the side effects presented and the need for additional surgery in some patients, in general, all non-surgical treatments could provide positive results as an alternative for the management of CGCG, especially with regard to reducing the size of the lesion. CLINICAL RELEVANCE: CGCG is a benign bone lesion that mainly affects young individuals. Although the most common therapy is surgery, its contraindication in some patients, the large extension, and high recurrence rate of the aggressive variant have led the search for non-surgical therapies.

Adjuvant therapies in the management of medication-related osteonecrosis of the jaws: Systematic review.

BACKGROUND: We investigated the efficacy of hyperbaric oxygen (HBO), low-intensity laser (LIL), and platelet-rich plasma (PRP) in the management of medication-related osteonecrosis of the jaws (MRONJ). METHODS: A literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Two examiners independently assessed eligibility and risk of bias and extracted data. RESULTS: There was improvement in 75.6% of the 41 patients submitted to HBO, with positive effects on pain relief and decreased size and number of lesions at a faster rate, with better effects when the drug was discontinued. For LIL, 158 (64.2%) of the 246 patients/sites improved the symptoms and 98 (39.8%) healed completely. Fourteen (17.3%) of the 81 patients treated with PRP significantly improved the symptoms and 65 (80.2%) completely healed. CONCLUSIONS: These therapies served as safe and effective adjuvant modalities for MRONJ treatment. The lack of randomized clinical trials evidences the need for more high-quality investigations on the subject.

Prevalencia de alteraciones en el complejo estilohiodeo en radiografías panorámicas digitales / Prevalence of alterations of the stylohyoid complex in digital panoramic radiographs

Introducción: alteraciones de este aparato estilohioideo son frecuentes y se manifiestan por el alargamiento del proceso estiloides y también por la osificación del ligamento estilohioideo. Los cambios pueden ser asintomáticos o pueden desencadenar una serie de síntomas como el dolor en cabeza. Objetivo: determinar la prevalencia del alargamiento del proceso estiloide y de la osificación del ligamento estilohioideo en radiografías panorámicas, atendiendo a la distribución según edad, sexo y lado afectado. Métodos: se tomaron 300 radiografías panorámicas digitales de los archivos de un Servicio de Radiología Dental. Fueron seleccionadas al azar entre las realizadas en 2012, y evaluadas por un único examinador. Fueron consideradas las radiografías en las cuales el proceso estiloide del hueso temporal superaba en más de 1 cm el borde más inferior del cartílago del lóbulo de la oreja y aquellas en la que el ligamento estilohioideo aparecía radiopaco. Resultados: en este estudio, se encontraron 108 radiografías (36 por ciento) con estas condiciones. Hubo una mayor prevalencia de alargamiento del proceso estiloide y/o la osificación del ligamento estilohioideo en mujeres (63 por ciento); se presentó bilateralmente en 72 por ciento de los casos, con mayor prevalencia en el rango etario de 61 a 70 años. Conclusión: la prevalencia de alteraciones en el complejo estilohioideo en las radiografías analizadas fue de 36 por ciento, la mayoría con presentación bilateral; predominó en mujeres del grupo etario referido(AU)

Introduction: alterations of the stylohyoid chain are common, taking the shape of styloid process elongation and stylohyoid ligament ossification. Changes may either be asymptomatic or trigger a number of symptoms such as headache. Objective: determine the prevalence of styloid process elongation and stylohyoid ligament ossification in panoramic radiographs based on distribution by age, sex and affected side. Methods: examination was conducted of 300 digital panoramic radiographs from the registries of a dental radiology service. Radiographs were randomly selected from among those performed in 2012, and evaluated by a single researcher. The radiographs considered were those in which the temporal styloid process exceeded in more than 1 cm the lowermost edge of the earlobe cartilage and those in which the stylohyoid ligament was radiopaque. Results: the study found 108 radiographs (36 percent) meeting these requirements. There was a higher prevalence of styloid process elongation and/or stylohyoid ligament ossification among women (63 percent), whereas the condition was bilateral in 72 percent of the cases, with a predominance of the 61-70 age group. Conclusion: prevalence of alterations of the stylohyoid complex in the radiographs analyzed was 36 percent. Most alterations were bilateral. There was a predominance of women from the above-mentioned age group(AU)

Uncommon trajectory variations of the mandibular canal and of the mandibular incisive canal: case report.

PURPOSE: This paper aims to report and discuss a case in which unusual anatomical variations were observed in the mandibular canal (MC) and the mandibular incisive canal (MIC) in a same patient. MATERIALS AND METHODS: A 49-year-old healthy female was referred for mandibular dental implant placement. Panoramic radiography and cone beam computed tomography (CBCT) were performed. Cross-sections, axial, coronal, panoramic reconstructions and volume rendering were obtained. RESULTS: The panoramic radiograph did not show any evidence of abnormality. CBCT showed a bifid MC on the right side. It extended to the buccal cortex, exteriorized for 6 mm and returned to its conventional trajectory to reach the mental foramen. On the left side, the MIC initially followed its normal trajectory for 4 mm but, in the canine region, it also extended to the buccal cortex and exteriorized. CONCLUSION: The advent of CBCT in Dentistry allowed a greater accuracy in the diagnosis of anatomical variations in the jaws, preventing injury to the neurovascular bundle and enabling an adequate surgical planning in the region.

Congenital granular cell lesion: clinical, microscopic and immunohistochemical aspects in a case of multiple lesions.

Congenital granular cell lesion of the newborn, also known as congenital epulis, is a rare benign oral cavity tumor presenting at birth. Usually, it appears as a solitary mass arising in the mouth and originates from the anterior alveolar ridge. The objective of the present article is to report a case of congenital granular cell lesion in an 8-day-old female newborn. The patient presented four intraoral pedunculated lesions. Diagnosis, treatment, microscopic and immunohistochemical characteristics are also discussed.

Ameloblastic fibro-odontoma: a diagnostic challenge.

An 11-year-old girl presented to our department to have a second opinion regarding a lesion involving her left mandible. She had previously undergone several radiographic exams including panoramic, helical, and cone-beam computed tomography. Radiographic examinations revealed a well-defined radiolucent region, which contained an irregular radiopaque mass of 3 cm in diameter, localized to the left angle of the mandible. Our presumptive diagnosis was complex odontoma. Excisional biopsy was performed, and microscopic features showed strands and islands of odontogenic epithelium showing peripheral palisading and loosely arranged central cells, identical to stellate reticulum, embedded in a myxoid cell-rich stroma resembling the dental papilla. Dentin and enamel were also presented. The diagnosis was ameloblastic fibro-odontoma, which is a rare mixed odontogenic tumor, derived from epithelial and ectomesenchymal elements that form the dental tissues.

Evaluation of halitosis and sialometry in patients submitted to head and neck radiotherapy.

OBJECTIVES: The aim of this study was to investigate the parameters of halitosis and sialometry in patients who had undergone head and neck radiotherapy, correlating oral concentration of volatile sulfur compounds (VSC) with the presence of tongue coating, salivary flow rate and BANA test. MATERIAL AND METHODS: 35 patients allocated in two groups were examined: group I (control)--patients with systemic and oral health; group II--patients submitted to head and neck radiotherapy. All volunteers were submitted to halitosis measurements through a sulphide monitor, evaluation of tongue coating weight, non-stimulated sialometry and BANA test. RESULTS: The results were analyzed through analysis of variance, Pearson®s correlation and Student's t-test, showing that there was statistically significant difference in halimetry between the groups, where the irradiated patients showed halitosis. There was a relation between the presence of tongue coating and the levels of VSCs in both groups and it was also noted that the irradiated patients showed a decreased salivary flow rate compared to healthy patients. CONCLUSION: On the conditions of the present research, it was concluded that halitosis can be considered an adverse effect of radiotherapy, connected to hiposalivation and poor oral health.