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1.
Nutrients ; 16(17)2024 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-39275257

RESUMO

This study explores how the Household Dietary Diversity Score (HDDS) and spatial visualization can inform food governance in Chile, focusing on socio-demographic and geographical determinants affecting food consumption patterns. A national household database (n = 4047), including households from 2019 (n = 3967; 98.02%) and 2020 (n = 80; 1.98%), provided by the "Family Support Program of Food Self-Sufficiency" (FSPFS) of the Ministry of Social Development and Family, was analyzed. The findings revealed that Chilean vulnerable households were led mostly by women (86.6%), with an age average of 55.9 ± 15.6 years old, versus 68.9 ± 12.9 years in the case of men. The intake frequency analysis showed that dairy, fruits, and vegetables were below the recommended values in at least half of the households, and that fats and sugars were above recommended levels. Regarding the HDDS (0-189), the national average was 91.4 ± 20.6 and was significantly influenced by the number of minors in the households, water access, food access issues, and residing in the Zona Sur. Finally, the spatial visualization showed that the Zona Central had higher consumption of fruits and vegetables, while the extreme zones Norte Grande and Zona Austral showed higher intakes of fats and sugars. These findings emphasize the importance of leveraging data insights like the HDDS and spatial visualization to enhance food security and inform food governance strategies.


Assuntos
Dieta , Características da Família , Abastecimento de Alimentos , Análise Espacial , Humanos , Chile , Masculino , Feminino , Pessoa de Meia-Idade , Abastecimento de Alimentos/estatística & dados numéricos , Dieta/estatística & dados numéricos , Idoso , Frutas , Adulto , Fatores Socioeconômicos , Verduras , Comportamento Alimentar
2.
Radiologia (Engl Ed) ; 65 Suppl 2: S71-S73, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-37858355

RESUMO

Emphysematous osteomyelitis is an extremely rare entity consisting of the presence of intraosseous gas that can extend to the joints and adjacent soft tissues. It is an aggressive infectious process associated with high mortality, especially in patients with risk factors such as tumors or diabetes mellitus. Because early diagnosis and immediate treatment are crucial to prevent the potentially devastating consequences of this condition, imaging tests such as computed tomography play a fundamental role in its diagnosis and management. Therefore, radiologists must be aware that intraosseous gas is a rare but alarming sign that is pathognomonic of emphysematous osteomyelitis, especially in the axial skeleton.


Assuntos
Enfisema , Osteomielite , Humanos , Osteomielite/diagnóstico por imagem , Osteomielite/terapia , Osteomielite/complicações , Enfisema/complicações , Enfisema/diagnóstico por imagem , Fatores de Risco , Tomografia Computadorizada por Raios X , Diagnóstico Diferencial
3.
Polymers (Basel) ; 15(6)2023 Mar 14.
Artigo em Inglês | MEDLINE | ID: mdl-36987228

RESUMO

Due to the energy requirements for various human activities, and the need for a substantial change in the energy matrix, it is important to research and design new materials that allow the availability of appropriate technologies. In this sense, together with proposals that advocate a reduction in the conversion, storage, and feeding of clean energies, such as fuel cells and electrochemical capacitors energy consumption, there is an approach that is based on the development of better applications for and batteries. An alternative to commonly used inorganic materials is conducting polymers (CP). Strategies based on the formation of composite materials and nanostructures allow outstanding performances in electrochemical energy storage devices such as those mentioned. Particularly, the nanostructuring of CP stands out because, in the last two decades, there has been an important evolution in the design of various types of nanostructures, with a strong focus on their synergistic combination with other types of materials. This bibliographic compilation reviews state of the art in this area, with a special focus on how nanostructured CP would contribute to the search for new materials for the development of energy storage devices, based mainly on the morphology they present and on their versatility to be combined with other materials, which allows notable improvements in aspects such as reduction in ionic diffusion trajectories and electronic transport, optimization of spaces for ion penetration, a greater number of electrochemically active sites and better stability in charge/discharge cycles.

4.
Polymers (Basel) ; 14(24)2022 Dec 14.
Artigo em Inglês | MEDLINE | ID: mdl-36559845

RESUMO

The electrochemical polymerization of polypyrrole nanowires is carried out using potentiodynamic and galvanostatic methods in order to enhance the performance of the modified electrodes as capacitor devices. The electrochemical, spectroscopic, and morphological properties are determined through cyclic voltammetry, Raman spectroscopy and scanning electron microscopy, respectively, corroborating the presence of PPy-nw in dimensions of 30 nm in diameter. Characterization as a capacitor revealed that the nanowire structure enhances key parameters such as specific capacitance with 60 times greater value than bulk polymer modification, in addition to a significant increase in stability. In this way, it is verified that electrodes modified with polypyrrole nanowires obtained in situ by electrochemical methods constitute an excellent candidate for the development of capacitors.

5.
Appl Physiol Nutr Metab ; 47(3): 328-336, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34807739

RESUMO

The primary purpose of this study was to determine prevalence of the Male Athlete Triad (MAT) conditions: low energy availability (EA), low bone mineral density (BMD), and low testosterone in male collegiate athletes from different sports. Participants included 44 collegiate male athletes (age, 20.4 ± 0.2 years; body mass index, 25.3 ± 1.3 kg/m2) from 7 sports (cross country, soccer, basketball, wrestling, track, golf, and baseball). Resting metabolic rate, 3-day food intake, 7-day exercise energy expenditure, body composition, and reproductive and metabolic hormones were assessed. Of the total participants, 15% had low EA, 0% had low BMD, 28% had low total testosterone (TT), and 80% had low calculated free testosterone (cFT). There were no significant correlations between EA, BMD, TT, and cFT. Insulin and sex hormone binding globulin (SHBG) were below and on the upper end of the reference range for healthy male adults, respectively. Insulin was negatively correlated with total (r = -0.330, p = 0.043) and lumbar spine BMD z-scores (r = -0.413, p = 0.010). Low TT and low cFT were the most prevalent MAT conditions among all athletes. Further research should investigate the relationship between insulin and SHBG and the role of these hormones in the MAT. Novelty: Assessment of energy availability alone is not sufficient to identify physiological disturbances in collegiate male athletes. Low total and/or free testosterone may be present in some collegiate male athletes, regardless of BMD status. Low insulin and high SHBG concentration may portray the presence of conditions of the MAT in male collegiate athletes.


Assuntos
Basquetebol , Densidade Óssea , Adulto , Atletas , Composição Corporal , Exercício Físico , Humanos , Masculino , Adulto Jovem
6.
J Hosp Infect ; 105(4): 757-765, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32565368

RESUMO

BACKGROUND: Carbapenem non-susceptible Enterobacterales (CNSE) can be broadly divided into those that produce carbapenemases (carbapenemase-producing Enterobacterales (CPE)), and those that harbour other mechanisms of resistance (non-carbapenemase-producing CNSE (NCP-CNSE)). AIM: To determine the predictors of CNSE nosocomial incidence rates according to their mechanism of resistance. METHODS: A time-series analysis was conducted (July 2013 to December 2018) to evaluate the relationship in time between hospital antibiotic use and the percentage of adherence to hand hygiene with the CNSE rates. FINDINGS: In all, 20,641 non-duplicated Enterobacterales isolates were identified; 2.2% were CNSE. Of these, 48.1% and 51.9% were CPE and NCP-CNSE, respectively. Of the CPE, 78.3% possessed a blaOXA-232 gene. A transfer function model was identified for CNSE, CPE, and OXA-232 CPE that explained 20.8%, 19.3%, and 24.2% of their variation, respectively. According to the CNSE and CPE models, an increase in piperacillin-tazobactam (TZP) use of 1 defined daily dose (DDD) per 100 hospital patient-days (HPD) would lead to an increase of 0.69 and 0.49 CNSE and CPE cases per 10,000 HPD, respectively. The OXA-232 CPE model estimates that an increase of 1 DDD per 100 HPD of TZP use would lead to an increase of 0.43 OXA-232 CPE cases per 10,000 HPD. A transfer function model was not identified for NCP-CNSE, nor was there an association between the adherence to handhygiene and the CNSE rates. CONCLUSION: The use of TZP is related in time with the CPE nosocomial rates, mostly explained by its effect on OXA-232 CPE.


Assuntos
Antibacterianos/farmacologia , Enterobacteriáceas Resistentes a Carbapenêmicos/efeitos dos fármacos , Carbapenêmicos/farmacologia , Farmacorresistência Bacteriana , Infecções por Enterobacteriaceae/tratamento farmacológico , Antibacterianos/uso terapêutico , Proteínas de Bactérias/genética , Enterobacteriáceas Resistentes a Carbapenêmicos/enzimologia , Enterobacteriáceas Resistentes a Carbapenêmicos/genética , Uso de Medicamentos , Hospitais , Humanos , Incidência , Testes de Sensibilidade Microbiana , Fatores de Tempo , beta-Lactamases/genética
7.
Animals (Basel) ; 9(10)2019 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-31618915

RESUMO

Only 30% of households in Bairro Boroma (Boroma neighborhood) have a regular protein intake, mainly due to the lack of a proper cold chain. We analyzed the level of knowledge about a local dried meat called chinkui, examining the relationship between this knowledge and its value for strengthening local food security. Through surveys of Bairro Boroma goat herders (n = 23) about "chinkui awareness" and passive observation of chinkui preparation (n = 5) from local biotype goats, we found that chinkui was known to most goat herders (91.3%), but was used only irregularly, mainly because knowledge transmission has decreased over time. From passive observation, we found that the amount of dried meat obtained from an animal rarely exceeded a yield of 10% and its performance and safety depended on weather conditions and the absence of other animals in the area of preparation. It is, therefore, recommended to strengthen initiatives to increase the amount of chinkui, based on local knowledge, so as to enhance its frequency of consumption and the possibility of using it as a sustainable alternative source of protein.

8.
Eur J Cancer Care (Engl) ; 27(4): e12854, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29726050

RESUMO

Breast cancer is the most common neoplasm among women worldwide. Improvements in early detection and treatment have resulted in improved survival rates; however, the continuation of unhealthy behaviours after diagnosis can increase the risk of second primary tumours. The aim of the study was to evaluate the effectiveness of two nurse-led health education interventions aiming at improving dietary behaviours among women diagnosed with breast cancer. Participants (n = 492) were included in a double-blind randomized controlled trial with three arms: a control group received usual care; women in the first intervention group received a booklet containing dietary advice; women in the second intervention group received the same booklet plus a tailored telephone intervention delivered by a trained nurse. One year after the intervention, women in both intervention groups were more likely to adhere to the recommendation of decreasing the consumption of animal fats compared with the control group (OR:5.0; 95% CI:1.5-16.9 and OR:6.6; 95% CI:2.0-22.6, respectively). Moreover, compared with the control group, the adjusted probability of eating the recommended amount of fruit and vegetables was higher in the second intervention group (OR:2.7; 95% CI:1.4-5.3). In summary, the booklet containing dietary advice for breast cancer survivors, either alone or supplemented with a nurse-led telephone intervention, was effective in promoting adherence to diet recommendations.


Assuntos
Neoplasias da Mama/enfermagem , Sobreviventes de Câncer , Dietoterapia , Educação de Pacientes como Assunto/métodos , Padrões de Prática em Enfermagem , Gorduras na Dieta , Método Duplo-Cego , Feminino , Frutas , Humanos , Pessoa de Meia-Idade , Folhetos , Verduras
9.
Talanta ; 178: 679-685, 2018 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-29136880

RESUMO

A glassy carbon electrode (GCE) was surface-modified with carbon quantum dots (CQDs) and applied for the effective enhancement of the electrochemical signal for dopamine and uric acid determination. CQDs were prepared from graphite by a green modification of the Hummers method. They were characterized by FTIR-ATR, XPS, solid-state NMR, fluorescence and Raman spectroscopies. TPD-MS analysis was applied to characterize the functionalization of the surface. The CQDs were assembled on the glassy carbon electrode by adsorption because of the large number of carboxy groups on their surface warrants effective adsorption. The modified GCE exhibits a sensitivity that is almost 10 times better than of the bare GCE. The lower limits of detection are 1.3µM for uric acid and 2.7µM for dopamine.


Assuntos
Carbono/química , Eletroquímica/instrumentação , Pontos Quânticos/química , Dopamina/análise , Dopamina/química , Eletrodos , Ácido Úrico/análise , Ácido Úrico/química
10.
Phys Rev Lett ; 117(16): 166804, 2016 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-27792363

RESUMO

We investigate Fabry-Perot interference in an ultraclean carbon nanotube resonator. The conductance shows a clear superstructure superimposed onto conventional Fabry-Perot oscillations. A sliding average over the fast oscillations reveals a characteristic slow modulation of the conductance as a function of the gate voltage. We identify the origin of this secondary interference in intervalley and intravalley backscattering processes which involve wave vectors of different magnitude, reflecting the trigonal warping of the Dirac cones. As a consequence, the analysis of the secondary interference pattern allows us to estimate the chiral angle of the carbon nanotube.

11.
Br J Nutr ; 116(7): 1229-1235, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27641762

RESUMO

It has been previously shown that Lactobacillus plantarum CRL 2130 is able to produce riboflavin in soyamilk. The aim of the present study was to evaluate the efficiency of this riboflavin-bio-enriched soyamilk to revert and/or prevent the nutritional deficiency of riboflavin using different animal models. When used to supplement the diets of previously depleted animals, it was shown that the growth, riboflavin status and morphology of the small intestines reverted to normal parameters and were similar to animals supplemented with commercial riboflavin. In the prevention model, the same tendency was observed, where animals that received soyamilk fermented with L. plantarum CRL 2130 did not show signs of riboflavin deficiency. This new bio-fortified soya-based product could be used as part of normal diets to provide a more natural alternative to mandatory fortification with riboflavin for the prevention of its deficiency.


Assuntos
Fermentação , Lactobacillus plantarum/metabolismo , Deficiência de Riboflavina/prevenção & controle , Riboflavina/biossíntese , Leite de Soja/química , Animais , Dieta , Feminino , Camundongos , Camundongos Endogâmicos BALB C , Riboflavina/administração & dosagem , Deficiência de Riboflavina/etiologia , Leite de Soja/metabolismo
12.
Enferm Intensiva ; 27(4): 146-154, 2016.
Artigo em Espanhol | MEDLINE | ID: mdl-27542686

RESUMO

BACKGROUND: The implementation of evidence based practice is essential in clinical practice. However, it is still a challenge in critical care patients. AIM: To identify the barriers for conducting research that nursing professionals perceive in intensive care and medical emergency departments, as well as to investigate the areas of interest and motivations to carry out research projects. METHOD: Cross-sectional and multicentre study carried out in 4 intensive care units and in one Medical Emergency Department emergency pre-hospital carein Catalonia on 2014. The instrument used was The Barriers to Research Utilization Scale which had been previously validated into Spanish. A descriptive and bivariate analysis was performed. A statistical significance of P<.05 was assumed. RESULTS: One hundred seventy-two questionnaires were obtained (69.9% response). Of the total, 135 were from critical care, 27 to pre-hospital care, and 10 from both. Just over half (57.3%) had research experience, although 44.4% had related training. The questionnaire dimension considered most relevant was organisational characteristics. The most important barriers were: there is not enough time at work [3.11 (SD 1.21)], physicians do not collaborate in its implementation [2.99 (SD 1.22)], and nurses are isolated with respect to other professionals [2.86 (SD 1.32)]. Significant differences were observed in the barriers according to research experience and work place. The main motivation was to be updated in critical patient care. CONCLUSIONS: The main barriers perceived are related to the organisation. There are differences in the barriers according to research experience and work place.


Assuntos
Atitude do Pessoal de Saúde , Serviços Médicos de Emergência , Unidades de Terapia Intensiva , Motivação , Pesquisa em Enfermagem , Enfermagem , Adulto , Estudos Transversais , Feminino , Humanos , Masculino , Autorrelato
13.
Med Intensiva ; 39(5): 298-302, 2015.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-25895627

RESUMO

Dispatch-assisted bystander cardiopulmonary resuscitation in out-of-hospital cardiac arrest has been shown as an effective measure to improve the survival of this process. The development of a unified protocol for all dispatch centers of the different emergency medical services can be a first step towards this goal in our environment. The process of developing a recommendations document and the realization of posters of dispatch-assisted cardiopulmonary resuscitation, agreed by different actors and promoted by the Spanish Resuscitation Council, is presented.


Assuntos
Reanimação Cardiopulmonar , Despacho de Emergência Médica , Primeiros Socorros , Parada Cardíaca Extra-Hospitalar/terapia , Call Centers , Reanimação Cardiopulmonar/educação , Reanimação Cardiopulmonar/métodos , Primeiros Socorros/métodos , Humanos , Pôsteres como Assunto , Guias de Prática Clínica como Assunto , Telefone
15.
Biomed Res Int ; 2014: 239708, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25003109

RESUMO

The aim of this study was to evaluate the normalized response speed (Vrn) of the knee musculature (flexor and extensor) in high competitive level volleyball players using tensiomyography (TMG) and to analyze the muscular response of the vastus medialis (VM), rectus femoris (RF), vastus lateralis (VL), and biceps femoris (BF) in accordance with the specific position they play in their teams. One hundred and sixty-six players (83 women and 83 men) were evaluated. They belonged to eight teams in the Spanish women's superleague and eight in the Spanish men's superleague. The use of Vrn allows avoiding possible sample imbalances due to anatomical and functional differences and demands. We found differences between Vrn in each of the muscles responsible for extension (VM, RF, and VL) and flexion (BF) regardless of the sex. Normalized response speed differences seem to be larger in setters, liberos and outside players compared to middle blockers and larger in males when compared to females. These results of Vrn might respond to the differences in the physical and technical demands of each specific position, showing an improved balance response of the knee extensor and flexor musculature in male professional volleyball players.


Assuntos
Atletas , Articulação do Joelho/fisiologia , Músculo Esquelético/fisiologia , Voleibol , Adulto , Fenômenos Biomecânicos , Feminino , Humanos , Masculino , Caracteres Sexuais , Adulto Jovem
16.
Talanta ; 114: 17-24, 2013 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-23953435

RESUMO

In this communication, a new methodology for the simultaneous and automated monitoring of biosorption processes of multimetal mixtures of polluting heavy metals on vegetable wastes based on flow-injection potentiometry (FIP) and electronic tongue detection (ET) is presented. A fixed-bed column filled with grape stalks from wine industry wastes is used as the biosorption setup to remove the metal mixtures from the influent solution. The monitoring system consists in a computer controlled-FIP prototype with the ET based on an array of 9 flow-through ion-selective electrodes and electrodes with generic response to divalent ions placed in series, plus an artificial neural network response model. The cross-response to Cu(2+), Cd(2+), Zn(2+), Pb(2+) and Ca(2+) (as target ions) is used, and only when dynamic treatment of the kinetic components of the transient signal is incorporated, a correct operation of the system is achieved. For this purpose, the FIA peaks are transformed via use of Fourier treatment, and selected coefficients are used to feed an artificial neural network response model. Real-time monitoring of different binary (Cu(2+)/ Pb(2+)), (Cu(2+)/ Zn(2+)) and ternary mixtures (Cu(2+)/ Pb(2+)/ Zn(2+)), (Cu(2+)/ Zn(2+)/ Cd(2+)), simultaneous to the release of Ca(2+) in the effluent solution, are achieved satisfactorily using the reported system, obtaining the corresponding breakthrough curves, and showing the ion-exchange mechanism among the different metals. Analytical performance is verified against conventional spectroscopic techniques, with good concordance of the obtained breakthrough curves and modeled adsorption parameters.


Assuntos
Poluentes Ambientais/análise , Resíduos Industriais/análise , Metais Pesados/análise , Caules de Planta/química , Vitis , Adsorção , Cálcio/análise , Cálcio/química , Eletrodos , Monitoramento Ambiental , Poluentes Ambientais/química , Indústria Alimentícia , Análise de Fourier , Ionóforos/química , Membranas Artificiais , Metais Pesados/química , Redes Neurais de Computação , Plastificantes/química , Cloreto de Polivinila/química , Potenciometria , Vinho
17.
Semergen ; 39(8): 440-4, 2013.
Artigo em Espanhol | MEDLINE | ID: mdl-23583187

RESUMO

There are currently 6 million immigrants living in Spain. Half of them are women, the majority of whom are of childbearing age. These women, who suffer high rates of induced abortion, form a special group who require a special approach to their reproductive health. In order to study the use of contraceptive methods in this population, a review was made of 1100 clinical histories from our Sexual Health and Reproduction Clinic. Latin American women were the most prevalent group who came to seek information about contraception, followed by Eastern Europeans and Moroccans. Fewer Asian and Sub-Saharan women sought these services. The contraceptives most frequently used were the intrauterine device (used mostly by Latin American and Eastern European women), and combined oral contraception, most used by Moroccan women. It is important to advise the immigrant women about contraceptive methods, taking into account their preferences, in order to improve adherence to the method.


Assuntos
Comportamento de Escolha , Anticoncepção , Emigrantes e Imigrantes , Anticoncepção/estatística & dados numéricos , Características Culturais , Feminino , Humanos , Fatores Sociológicos , Espanha
18.
Biol Sport ; 30(3): 195-9, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-24744488

RESUMO

The aim of this study was to simulate the activity pattern of rink hockey by designing a specific skate test (ST) to study the energy expenditure and metabolic responses to this intermittent high-intensity exercise and extrapolate the results from the test to competition. Six rink hockey players performed, in three phases, the 20-metre multi-stage shuttle roller skate test, a tournament match and the ST. Heart rate was monitored in all three phases. Blood lactate, oxygen consumption, ventilation and respiratory exchange ratio were also recorded during the ST. Peak HR was 190.7±7.2 beats · min(-1). There were no differences in peak HR between the three tests. Mean HR was similar between the ST and the match (86% and 87% of HRmax, respectively). Peak and mean ventilation averaged 111.0±8.8 L · min(-1) and 70.3±14.0 L (·) min(-1) (60% of VEmax), respectively. VO2max was 56.3±8.4 mL · kg(-1) · min(-1), and mean oxygen consumption was 40.9±7.9 mL · kg(-1) (·) min(-1) (70% of VO2max). Maximum blood lactate concentration was 7.2±1.3 mmol · L-1. ST yielded an energy expenditure of 899.1±232.9 kJ, and energy power was 59.9±15.5 kJ · min(-1). These findings suggest that the ST is suitable for estimating the physiological demands of competitive rink hockey, which places a heavy demand on the aerobic and anaerobic systems, and requires high energy consumption.

19.
Talanta ; 93: 285-92, 2012 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-22483912

RESUMO

An automated flow injection potentiometric (FIP) system with electronic tongue detection (ET) is used for the monitoring of biosorption processes of heavy metals on vegetable wastes. Grape stalk wastes are used as biosorbent to remove Cu(2+) ions in a fixed-bed column configuration. The ET is formed by a 5-sensor array with Cu(2+) and Ca(2+)-selective electrodes and electrodes with generic response to heavy-metals, plus an artificial neural network response model of the sensor's cross-response. The real-time monitoring of both the Cu(2+) and the cation exchanged and released (Ca(2+)) in the effluent solution is performed by using flow-injection potentiometric electronic tongue system. The coupling of the electronic tongue with automation features of the flow-injection system allows us to accurately characterize the Cu(2+) ion-biosorption process, through obtaining its breakthrough curves, and the profile of the Ca(2+) ion release. In parallel, fractions of the extract solution are analysed by spectroscopic techniques in order to validate the results obtained with the reported methodology. The sorption performance of grape stalks is also evaluated by means of well-established sorption models.


Assuntos
Cobre/metabolismo , Equipamentos e Provisões Elétricas , Poluentes Ambientais/metabolismo , Análise de Injeção de Fluxo/instrumentação , Potenciometria/instrumentação , Verduras/metabolismo , Vitis/metabolismo , Biodegradação Ambiental , Cálcio/química , Cobre/química , Cobre/isolamento & purificação , Poluentes Ambientais/química , Poluentes Ambientais/isolamento & purificação , Troca Iônica , Redes Neurais de Computação , Fatores de Tempo , Água/química
20.
Microsc Res Tech ; 75(8): 1033-43, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22461425

RESUMO

The mammalian skin has developed sensory structures (mechanoreceptors) that are responsible for different modalities of mechanosensitivity like touch, vibration, and pressure sensation. These specialized sensory organs are anatomically and functionally connected to a special subset of sensory neurons called mechanosensory neurons, which electrophysiologically correspond with Aß fibers. Although mechanosensory neurons and cutaneous mechanoreceptors are rather well known, the biology of the sense of touch still remains poorly understood. Basically, the process of mechanosensitivity requires the conversion of a mechanical stimulus into an electrical signal through the activation of ion channels that gate in response to mechanical stimuli. These ion channels belong primarily to the family of the degenerin/epithelium sodium channels, especially the subfamily acid-sensing ion channels, and to the family of transient receptor potential channels. This review compiles the current knowledge on the occurrence of putative mechanoproteins in mechanosensory neurons and mechanoreceptors, as well as the involvement of these proteins on the biology of touch. Furthermore, we include a section about what the knock-out mice for mechanoproteins are teaching us. Finally, the possibilities for mechanotransduction in mechanoreceptors, and the common involvement of the ion channels, extracellular membrane, and cytoskeleton, are revisited.


Assuntos
Mecanorreceptores/metabolismo , Mecanotransdução Celular , Células Receptoras Sensoriais/metabolismo , Tato/fisiologia , Animais , Membrana Celular/metabolismo , Proteínas do Citoesqueleto/metabolismo , Canais Epiteliais de Sódio/metabolismo , Mamíferos , Proteínas de Membrana/metabolismo , Camundongos , Camundongos Knockout , Canais de Potássio/metabolismo , Fenômenos Fisiológicos da Pele , Canais de Potencial de Receptor Transitório/metabolismo
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