RESUMO
We performed this prospective, randomised, investigator-masked, parallel-group study to compare Fluorometholone-Gentamicin eye drops with Maxitrol (dexamethasone, neomycin, polymyxin B) eye drops in the reduction of ocular bacterial flora and control of ocular inflammation after cataract surgery. One hundred and twelve (FML-Genta 54, Maxitrol 58) patients of both sexes undergoing cataract and posterior chamber lens implant surgery for visually disabling cataract were enrolled in the study and examined pre-operatively and post-operatively on days 1, 6-8 and 24-34. The baseline parameters were similar in the two study groups. The conjunctival bacterial colony count on day 6-8 post-operatively was significantly less on FML-Genta compared with Maxitrol (p = 0.033). There was no statistically significant difference between the two treatments in the degree of intra-ocular inflammation as assessed by flare and cells in the anterior chamber. Both treatments were judged to be equal in the global assessment of the success of therapy and local tolerance by the study patients and doctors. Fluorometholone-gentamicin eye drops were more effective than Maxitrol eye drops in the reduction of ocular bacterial flora while being as well-tolerated and as effective as Maxitrol in the control of ocular inflammation after cataract surgery.
Assuntos
Antibacterianos/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Extração de Catarata/efeitos adversos , Fluormetolona/uso terapêutico , Fluprednisolona/uso terapêutico , Gentamicinas/uso terapêutico , Neomicina/uso terapêutico , Polimixina B/uso terapêutico , Complicações Pós-Operatórias/prevenção & controle , Administração Tópica , Idoso , Antibacterianos/administração & dosagem , Antibacterianos/efeitos adversos , Anti-Inflamatórios/administração & dosagem , Anti-Inflamatórios/efeitos adversos , Bactérias/efeitos dos fármacos , Bactérias/crescimento & desenvolvimento , Contagem de Colônia Microbiana , Túnica Conjuntiva/microbiologia , Método Duplo-Cego , Combinação de Medicamentos , Quimioterapia Combinada , Endoftalmite/etiologia , Endoftalmite/prevenção & controle , Infecções Oculares/etiologia , Infecções Oculares/prevenção & controle , Feminino , Fluormetolona/administração & dosagem , Fluormetolona/efeitos adversos , Fluprednisolona/administração & dosagem , Fluprednisolona/efeitos adversos , Gentamicinas/administração & dosagem , Gentamicinas/efeitos adversos , Glucocorticoides , Humanos , Lentes Intraoculares , Masculino , Neomicina/administração & dosagem , Neomicina/efeitos adversos , Soluções Oftálmicas , Polimixina B/administração & dosagem , Polimixina B/efeitos adversos , Complicações Pós-Operatórias/etiologia , Estudos ProspectivosRESUMO
Using a new method to determine the scotoma pressure by means of an Amsler grid chart and an ophthalmodynamometer in addition to three other parameters (the brachialis blood pressure and the intra-ocular pressure), a sensitivity factor F was calculated, useful to classify patients with visual field defects due to glaucoma simplex.