RESUMO
Two patients are presented in which documented periods of asystole were caused by temporal epilepsy. Pacemaker implantation prevented total collapse but episodes of near collapse continued. After institution of anti-epileptic drug treatment both patients are free of symptoms.
RESUMO
In a 33-year-old man with an abnormal ECG three weeks after an episode of a sore throat, laboratory investigations revealed signs of a recent streptococcal infection. Mitral valvular and aortic valvular regurgitation were confirmed by echocardiography. The diagnosis of acute rheumatic fever was established according to the Jones criteria.
Assuntos
Febre Reumática/diagnóstico , Cardiopatia Reumática/diagnóstico por imagem , Adulto , Insuficiência da Valva Aórtica/diagnóstico por imagem , Insuficiência da Valva Aórtica/etiologia , Ecocardiografia , Eletrocardiografia , Humanos , Masculino , Insuficiência da Valva Mitral/diagnóstico por imagem , Insuficiência da Valva Mitral/etiologia , Febre Reumática/complicaçõesRESUMO
In two male patients, aged 53 and 21 years, lithium intoxication was suspected. The diagnosis was apparently confirmed by blood testing (the lithium concentrations amounted to 3.68 and 1.82 mmol/l, respectively). Retrospectively however it was found that blood sampling tubes with lithium-heparin as the anticoagulant had been used. No lithium intoxication was present in the patients. Clear instructions in writing are necessary to prevent this error.
Assuntos
Sangria/instrumentação , Lítio/sangue , Lítio/intoxicação , Adulto , Anticoagulantes/farmacologia , Erros de Diagnóstico , Humanos , Carbonato de Lítio/uso terapêutico , Masculino , Pessoa de Meia-IdadeRESUMO
Glycation is a non-enzymatic modification of proteins by sugars, probably responsible for the initiation of complications in diabetes patients and aging individuals. Our in vitro experiments show an inhibition of sugar attachment in the presence of Diclofenac. The levels of advanced glycation products, measured as specific fluorescent groups, were also lowered due to Diclofenac. These results were compared with inhibition by Aspirin (acetylsalicylic acid), a known inhibitor of the glycation process. The protection by Diclofenac is based on a non-covalent interaction of the drug with serum albumin. There is evidence that Diclofenac specifically blocks at least one of the major glycation sites of human serum albumin.