Autoimplantation Therapy in Extensive and Recalcitrant Dermatophytosis: A Case Series.

Dermatophytosis is one of the most common diseases worldwide and is difficult to treat due to its recalcitrant nature. Conventional treatment modalities are associated with frequent relapses due to the absence of a host immune interaction. Here, we present a case series of three patients with difficult-to-treat and recalcitrant dermatophytosis who were treated with homologous autoimplantation. Complete clearance of dermatophytosis was observed after three months in two of the patients and after two and a half months in one patient without the use of any antifungals. No relapses were observed within six months of follow-up. The outcomes of the three patients presented in this case series support homologous autoimplantation as a safe and effective procedure for the treatment of recalcitrant dermatophytosis. The procedure requires only a single visit that can be performed either alone or in combination with other modalities.

Incidental finding of abdominal splenosis with mononucleated cell infiltration leading to a diagnosis of acute myeloid leukemia.

Splenosis refers to ectopic splenic implants that are often found incidentally years after splenic rupture/splenectomy, and the nodules of splenosis are usually small, less than 3 cm for the majority. We report a case of splenosis with a 5-centimeter large mass in the anterior abdomen in a 79 year-old male with a remote history of splenic rupture/splenectomy. Unexpectedly, needle core biopsy of the abdominal mass demonstrated splenic tissue with a mononucleated cell infiltrate blurring the splenic architecture that was highlighted only by CD8 stain. This finding prompted a bone marrow examination resulting in the diagnosis of acute myeloid leukemia in the patient. Retrospectively, enlargement of this ectopic spleen may have been caused by this leukemic infiltrate. This case underscores the importance of being aware of this rare pathological condition and its retained vulnerability for involvement by hematolymphoid neoplasms, as well as significance of identifying splenic architecture highlighted by CD8 stain to reach a correct diagnosis.

Comparative study of autoimplantation therapy and intralesional injection of MMR vaccine in warts treatment.

Autoimplantation is a simple technique and considered as a novel method of immunotherapy in treating warts. Intralesional immunotherapy by mumps, measles, and rubella (MMR) vaccine is also a promising treatment modality for multiple warts. To compare the efficacy and safety of both the methods in treating multiple warts, the study included 80 patients divided into two groups (Group A and Group B), each containing 40 patients. Informed consent was taken from each patient before enrollment into the study. Group A patients were treated by autoimplantation technique every 2 weeks for a maximum of four treatments. Similarly, Group B patients received MMR intralesional injection at a dose of 0.5 ml every 2 weeks for a maximum of four treatments. Complete clearance of the donor wart was observed in 60% patients in Group A, whereas complete clearance in the Group B injected by MMR was 72.5%. On the other hand, a significant difference (p < .05) was found in the therapeutic response among nonmanipulated warts in both groups, where complete clearance was observed in 47.5% of Group A patients versus 20% of Group B patients. Autoimplantation is a suitable approach for patients with multiple warts associated with distant lesions, while MMR injection is ideal for a single or fewer number of warts.

Reimplante dentario después de 72 horas avulsionado / Dental re-implantation 72 hours after avulsion

La reimplantación dentaria ha sido uno de los procedimientos más exigente de rigor y precisión en cuanto a las condiciones que deben existir para lograr el éxito esperado. El propósito de esta presentaciòn es mostrar la evolución y tratamiento del auto-implante del incisivo lateral superior izquierdo, 72 horas después de avulsionado. Se trata de paciente masculino de 18 años de edad, con antecedentes de salud. Acude a consulta luego de tres días de avulsionado el incisivo lateral superior izquierdo por trauma. Se le explicó al paciente el posible fracaso del tratamiento por el tiempo transcurrido, puesto que la inmediatez con que sea tratado favorece el éxito. Se le realizó el reimplante dentario y ferulizó. Se realizó el tratamiento endodóntico al diente en dos sesiones de una semana entre ellas. Se realizaron evoluciones trimestrales y luego semestrales. Casi cinco años después, la evidencia radiográfica no muestra complicaciones existentes y clínicamente presenta una apariencia normal. Los resultados obtenidos fueron satisfactorios y después de cinco años el paciente se mantiene con su diente en boca completamente asintomático(AU)

The dental re-implantation is one of the procedures demanding most rigor and precision in terms of the conditions required to achieve the expected success. Our purpose is to present the evolution and treatment of a case of auto-implantation of the upper left lateral incisor 72 hours after avulsion. The patient was a male 18 year-old with a history of ill health presents three days after avulsion of the upper left lateral incisor as a result of trauma. The patient was informed of the possible failure of the treatment due to the time elapsed. In cases such as this one, immediate treatment is essential to achieve success. Dental re-implantation and ferulization were performed. The tooth was treated endodontically on two visits one week apart. Checkups were conducted which were quarterly at first and then biannual. Almost five years later, radiographic evidence shows no complications and clinical appearance is normal. The results were satisfactory. The patient has preserved his tooth for five years and his status is totally asymptomatic(AU)

A novel modification of the autoimplantation therapy for the treatment of multiple, recurrent and palmoplantar warts.

BACKGROUND: Ideal treatment for warts should be effective, safe, have less morbidity and provide long-lasting immunity against human papilloma virus. This can optimally achieved by the stimulation of the immune system against the virus. The autoimplantation of warts, autowart injection and quadrivalent vaccines have been used for this purpose. Autoimplanatation is a simple technique where the subcutis deep wart tissue is harvested as a donor and implanted into the uninvolved skin. However, this led to two wounds, at donor and recipient sites. AIM: The aim was to evaluate the safety and efficacy of a novel modification of autoimplantation therapy in the treatment of multiple, recurrent and palmoplantar warts. SUBJECTS AND METHODS: Thirty-three patients with multiple, recurrent and palmoplantar warts were enrolled. Instead of taking a bit of the wart tissue, the donor tissue was harvested by paring the wart. The pared tissue was implanted deep into the subcutis by stab incision done using the same surgical blade no. 11. The resolution of all warts within 3 months after the procedure was considered successful. Patients with complete clearance were followed up for 1 month for any recurrence. RESULTS: Out of 35 patients, 27 patients were available for follow-up. A total of 20 (74.1%) patients showed a complete clearance of warts within 3 months. Partial clearance was seen in 1 patient. Erythematous nodules developed at the site of implantation in 3 (11.1%) patients. There was relapse in one patient. CONCLUSION: A modified technique of autoimplantation of warts employing the pared stratum corneum tissue from the wart is a simple, effective, less traumatic and rapid procedure in the treatment of multiple, recurrent and palmoplantar warts.