RESUMO
A plasmacytoma is a single, isolated tumour of abnormal plasma cells. It can develop within the bone, known as solitary plasmacytoma of bone, or outside the bone, referred to as extraosseous (extramedullary) plasmacytoma, without spreading to other parts of the body. Plasmacytoma, an uncommon presentation in the posterior mediastinum, usually arises as solitary or multiple lesions in bone or soft tissues. The standard treatment involves definitive radiotherapy, potentially curative for extramedullary cases. The prognosis varies, being more favourable without concurrent multiple myeloma and worsening with high-risk cytogenetics. The case involves a male in his early 80s with an extensive medical history presenting with difficulty swallowing and dyspnoea. The diagnosis revealed a rare posterior mediastinal plasmacytoma associated with multiple myeloma, emphasising the importance of prompt diagnosis and treatment.
Assuntos
Neoplasias do Mediastino , Mieloma Múltiplo , Plasmocitoma , Humanos , Masculino , Plasmocitoma/diagnóstico , Plasmocitoma/patologia , Plasmocitoma/radioterapia , Plasmocitoma/diagnóstico por imagem , Mieloma Múltiplo/diagnóstico , Mieloma Múltiplo/complicações , Neoplasias do Mediastino/patologia , Neoplasias do Mediastino/diagnóstico , Idoso de 80 Anos ou maisRESUMO
A woman in her 20s with no medical history was diagnosed with bulky stage II classic Hodgkin's lymphoma after an 8-week history of shortness of breath, cough and lethargy. A regimen of doxorubicin (Adriamycin), bleomycin, vinblastine and dacarbazine (ABVD) was commenced with six cycles planned. During the first cycle, the patient was profoundly hypertensive. She then suffered two self-terminating tonic-clonic seizures.Examination and investigations diagnosed posterior reversible encephalopathy syndrome (PRES), which resolved completely in 11 days with strict blood pressure control and withholding chemotherapy. Treatment was further complicated by anthracycline-induced cardiomyopathy, requiring a switch in regimen to gemcitabine BVD.The patient made a full recovery from neurology and cardiology perspectives and completed six cycles of chemotherapy, achieving a complete metabolic response by the tumour. We illustrate the case, describe differential diagnoses and management of PRES, its association with chemotherapy and the successful chemotherapy rechallenge.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica , Bleomicina , Cardiomiopatias , Dacarbazina , Doxorrubicina , Doença de Hodgkin , Síndrome da Leucoencefalopatia Posterior , Vimblastina , Humanos , Doença de Hodgkin/tratamento farmacológico , Feminino , Síndrome da Leucoencefalopatia Posterior/induzido quimicamente , Síndrome da Leucoencefalopatia Posterior/diagnóstico , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Cardiomiopatias/induzido quimicamente , Cardiomiopatias/diagnóstico , Doxorrubicina/efeitos adversos , Dacarbazina/efeitos adversos , Bleomicina/efeitos adversos , Vimblastina/efeitos adversos , Vimblastina/uso terapêutico , Adulto , Diagnóstico Diferencial , Antraciclinas/efeitos adversos , Gencitabina , Imageamento por Ressonância MagnéticaRESUMO
Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory condition that can be either familial or acquired and, if untreated, frequently results in multiorgan failure and death. Treatment of HLH typically requires a combination of glucocorticoids and cytotoxic chemotherapy. We describe the case of a woman who presented with signs and symptoms concerning for HLH who was later found to have a primary central nervous system (CNS) diffuse large B-cell lymphoma. Her HLH symptoms were successfully treated with high doses of dexamethasone, and her primary CNS lymphoma was treated with high-dose methotrexate and rituximab. This is a rare case of HLH secondary to primary CNS lymphoma where HLH was controlled with steroids alone and did not require the use of an etoposide-based regimen or cyclophosphamide, doxorubicin, vincristine and prednisone.
Assuntos
Neoplasias do Sistema Nervoso Central , Etoposídeo , Linfo-Histiocitose Hemofagocítica , Linfoma Difuso de Grandes Células B , Humanos , Linfo-Histiocitose Hemofagocítica/tratamento farmacológico , Linfo-Histiocitose Hemofagocítica/complicações , Feminino , Etoposídeo/uso terapêutico , Etoposídeo/administração & dosagem , Neoplasias do Sistema Nervoso Central/tratamento farmacológico , Neoplasias do Sistema Nervoso Central/complicações , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Linfoma Difuso de Grandes Células B/complicações , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Dexametasona/uso terapêutico , Dexametasona/administração & dosagem , Rituximab/uso terapêutico , Rituximab/administração & dosagem , Metotrexato/uso terapêutico , Metotrexato/administração & dosagem , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
Low-grade appendiceal mucinous neoplasm (LAMN) may culminate as a mucin-secreting disease known as pseudomyxoma peritonei (PMP). Once the diagnosis of LAMN and PMP is made, cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS and HIPEC) are indicated.Herein, we present a female patient in her 50s who was diagnosed with an ovarian mass for which she underwent laparoscopic oophorectomy. As the pathology of the ovary showed a tumour of gastrointestinal origin, she then underwent CRS and HIPEC with a final pathology of LAMN. Six weeks later, a mucinous lesion confined to the abdominal wall was detected on a postoperative CT. Suspected for port-site metastasis at the laparoscopic trocar site, we treated this lesion using the same principles of treatment as the intra-abdominal disease. The abdominal wall mass was surgically resected, and the cavity created was irrigated with mitomycin C. On 30 months of follow-up, the patient had no evidence of disease.
Assuntos
Neoplasias do Apêndice , Procedimentos Cirúrgicos de Citorredução , Quimioterapia Intraperitoneal Hipertérmica , Laparoscopia , Neoplasias Ovarianas , Ovariectomia , Humanos , Feminino , Neoplasias Ovarianas/terapia , Neoplasias Ovarianas/patologia , Pessoa de Meia-Idade , Ovariectomia/efeitos adversos , Laparoscopia/efeitos adversos , Procedimentos Cirúrgicos de Citorredução/efeitos adversos , Quimioterapia Intraperitoneal Hipertérmica/efeitos adversos , Neoplasias do Apêndice/terapia , Neoplasias do Apêndice/patologia , Neoplasias Peritoneais/secundário , Neoplasias Peritoneais/terapia , Adenocarcinoma Mucinoso/terapiaRESUMO
Dermatofibrosarcoma protuberans (DFSP) is an aggressive tumour with multiple local recurrences and rare metastatic potential. Fibrosarcomatous transformation occurs in a few cases of DFSP which makes them more aggressive in terms of recurrence and metastasis. Here we report the case of a woman in her late 30s who presented with massive lower gastrointestinal (GI) bleeding with a history of multiple surgeries for DFSP on her anterior abdominal wall. The bleeding source was identified to be a mass lesion in the jejunum, which was excised. The patient recovered well and the histopathology revealed fibrosarcoma of the jejunum. Follow-up investigations showed multiple lung nodules, ascites and abdominal lymph nodes suggesting progressive disease. She is currently receiving chemotherapy and progressing well 3 months postoperatively. Patients with fibrosarcomatous changes within DFSP must be followed up closely as it is associated with increased metastatic potential.
Assuntos
Dermatofibrossarcoma , Hemorragia Gastrointestinal , Neoplasias do Jejuno , Neoplasias Cutâneas , Humanos , Dermatofibrossarcoma/complicações , Dermatofibrossarcoma/patologia , Dermatofibrossarcoma/diagnóstico , Dermatofibrossarcoma/secundário , Feminino , Hemorragia Gastrointestinal/etiologia , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/complicações , Neoplasias Cutâneas/secundário , Adulto , Neoplasias do Jejuno/secundário , Neoplasias do Jejuno/complicações , Neoplasias do Jejuno/cirurgiaRESUMO
Pheochromocytomas are rare tumours originating in chromafï¬n cells, representing 0.1%-1% of all secondary hypertension cases. The majority are benign and unilateral, characterised by the production of catecholamines and other neuropeptides. Mainly located in the adrenal gland, they are more frequent between the third and fifth decades of life. Iodine-131 metaiodobenzylguanidine (131I-MIBG), a radiopharmaceutical agent used for scintigraphic localisation of pheochromocytomas, has been employed to treat malignant pheochromocytomas since 1983 in a few specialised centres around the world. We reviewed our clinical experience in one such case of a young lady who presented with history of abdominal pain, headache and lower back pain. On evaluation, ultrasonography revealed a right adrenal mass and elevated urine vanillylmandelic acid levels. Following surgical resection and histopathological confirmation of pheochromocytoma, MIBG scintigraphy revealed osseous metastases and hence, she underwent 131I-MIBG therapy.
Assuntos
3-Iodobenzilguanidina , Neoplasias das Glândulas Suprarrenais , Feocromocitoma , Compostos Radiofarmacêuticos , Humanos , 3-Iodobenzilguanidina/uso terapêutico , Feminino , Neoplasias das Glândulas Suprarrenais/secundário , Compostos Radiofarmacêuticos/uso terapêutico , Adulto , Intervalo Livre de Doença , Radioisótopos do Iodo/uso terapêutico , Neoplasias Ósseas/secundário , Neoplasias Ósseas/radioterapia , CintilografiaRESUMO
Sarcoid -like reactions (SLRs) can occur in several malignancies adjacent to primary tumour location or the draining lymph nodes. The presence of peritumoural and intratumoural SLR in patients suffering from renal cell carcinoma (RCC) has been reported in few instances. However, the association of RCC with SLR in spleen, liver and other organs in the absence of systemic sarcoidosis is very rare.We present an unusual case of a gentleman in his 30s, who presented with a lesion in the left kidney along with non-specific lesions (likely granulomatous) in liver, spleen and lungs. Partial Nnephrectomy specimen confirmed conventional/clear cell RCC. The histopathology revealed an extensive epithelioid granulomatous reaction affecting both peritumoural and intratumoural areas. Follow-up images demonstrated an almost complete resolution of lesions in the spleen, liver and lungs. Our case supports the hypothesis that non-caseating granulomas of SLR could be a manifestation of an immunologically mediated antitumour response.
Assuntos
Carcinoma de Células Renais , Neoplasias Renais , Sarcoidose , Humanos , Carcinoma de Células Renais/cirurgia , Masculino , Neoplasias Renais/patologia , Neoplasias Renais/cirurgia , Sarcoidose/complicações , Sarcoidose/tratamento farmacológico , Adulto , Nefrectomia , GranulomaRESUMO
Malignant phyllodes tumours (PTs) are aggressive neoplasms with high rates of local recurrence and distant metastasis. With no known effective chemotherapy and no approved targeted therapy in the setting of metastatic disease, prognosis is limited with an often-relapsing course of disease. We report a case of a woman in her late 30s with a diagnosis of recurrent metastatic malignant PT who was found to have acrometastases of the malignant PT to the right distal index and small digits. We emphasise the potential for atypical patterns of metastases in patients with malignant PT and the need to recognise acrometastasis as an unusual but morbid manifestation of disease. Given the high growth rate of malignant PTs, the lack of systemic treatment options, and the ensuing distress for patients, prompt diagnosis and early intervention is crucial.
Assuntos
Neoplasias Ósseas , Neoplasias da Mama , Recidiva Local de Neoplasia , Tumor Filoide , Humanos , Tumor Filoide/patologia , Tumor Filoide/secundário , Tumor Filoide/diagnóstico , Feminino , Neoplasias da Mama/patologia , Adulto , Neoplasias Ósseas/secundárioRESUMO
We present a case detailing the diagnosis and management of a periprosthetic giant cell tumour in a female patient in her 70s, who had undergone total knee arthroplasty (TKA) for primary osteoarthritis in her right knee 7 years prior. The patient reported 4 months of painful weight-bearing. Various imaging modalities, including plain radiographs, CT scans and MRI, revealed a sizeable lytic lesion beneath the TKA prosthesis, along with loosening of the tibial component.Blood tests and analyses of synovial fluid ruled out periprosthetic joint infection, and a biopsy confirmed the diagnosis of a giant cell tumour of the bone. Treatment entailed en bloc resection of the tumour and revision of the TKA using a hinged, oncological-type megaprosthesis. Surgical procedures involved careful resection of the proximal tibia, preservation of vasculature and the creation of a medial gastrocnemius muscle flap. Following surgery, the patient underwent supervised rehabilitation with a functional brace.
Assuntos
Artroplastia do Joelho , Neoplasias Ósseas , Tumor de Células Gigantes do Osso , Prótese do Joelho , Reoperação , Tíbia , Humanos , Feminino , Tíbia/cirurgia , Tíbia/patologia , Tíbia/diagnóstico por imagem , Artroplastia do Joelho/métodos , Tumor de Células Gigantes do Osso/cirurgia , Tumor de Células Gigantes do Osso/patologia , Tumor de Células Gigantes do Osso/diagnóstico por imagem , Neoplasias Ósseas/cirurgia , Neoplasias Ósseas/patologia , Idoso , Falha de PróteseAssuntos
Procedimentos Cirúrgicos Minimamente Invasivos , Recidiva Local de Neoplasia , Neoplasias do Colo do Útero , Humanos , Feminino , Neoplasias do Colo do Útero/cirurgia , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Pessoa de Meia-Idade , Histerectomia/efeitos adversos , Histerectomia/métodos , AdultoRESUMO
SummarySquamous cell carcinoma (SCC) is an uncommon and frequently aggressive subtype of gallbladder cancer known for its poor outcomes compared with other gallbladder tumours. Gallbladder SCC typically presents as higher grade and more advanced than adenocarcinoma, resulting in lower estimated survival. Early recognition of these tumours is ideal, but infrequently achieved. Herein is a case of a male patient in his 80s with new onset abdominal pain who was initially diagnosed with cholecystitis, but diagnostic imaging revealed a gallbladder mass. Surgical resection and pathology revealed pure SCC of the gallbladder without local organ invasion or metastatic disease. Pure SCC histology of the gallbladder is rare, with limited studies on clinical presentation, natural history, and optimal treatment.
Assuntos
Carcinoma de Células Escamosas , Neoplasias da Vesícula Biliar , Humanos , Masculino , Neoplasias da Vesícula Biliar/cirurgia , Neoplasias da Vesícula Biliar/patologia , Neoplasias da Vesícula Biliar/diagnóstico , Neoplasias da Vesícula Biliar/diagnóstico por imagem , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/cirurgia , Carcinoma de Células Escamosas/diagnóstico , Idoso de 80 Anos ou mais , Diagnóstico Diferencial , Tomografia Computadorizada por Raios X , Vesícula Biliar/patologia , Vesícula Biliar/cirurgia , Vesícula Biliar/diagnóstico por imagem , ColecistectomiaRESUMO
Transverse testicular ectopia (TTE) is an infrequent ectopic testis where both testes descend via the same inguinal canal, located in the same hemiscrotum, and augments the risk of developing testicular tumours. Type II TTE is accompanied by persistent Müllerian duct syndrome, where the Müllerian structures persist for various reasons. Here, we present a case of an adult in his early 30s, who presented with a right testicular swelling and was diagnosed as type II TTE and testicular mixed germ cell tumour after surgery. We could find only 13 similar cases of TTE and testicular tumours in the literature. Our case highlights the importance of clinical acumen with detailed history, meticulous clinical examination, radiological investigations and a detailed pathological examination while dealing with such sporadic presentations.
Assuntos
Transtorno 46,XY do Desenvolvimento Sexual , Neoplasias Embrionárias de Células Germinativas , Neoplasias Testiculares , Testículo , Humanos , Masculino , Neoplasias Testiculares/cirurgia , Neoplasias Testiculares/diagnóstico , Neoplasias Testiculares/complicações , Neoplasias Testiculares/diagnóstico por imagem , Neoplasias Embrionárias de Células Germinativas/cirurgia , Neoplasias Embrionárias de Células Germinativas/complicações , Neoplasias Embrionárias de Células Germinativas/diagnóstico , Neoplasias Embrionárias de Células Germinativas/diagnóstico por imagem , Adulto , Testículo/anormalidades , Testículo/cirurgia , Testículo/diagnóstico por imagem , Transtorno 46,XY do Desenvolvimento Sexual/diagnóstico , Transtorno 46,XY do Desenvolvimento Sexual/cirurgia , Transtorno 46,XY do Desenvolvimento Sexual/complicações , Coristoma/cirurgia , Coristoma/diagnóstico , Coristoma/complicações , Coristoma/diagnóstico por imagemRESUMO
We present a novel case of a malignant transformation of an extremity soft tissue angioleiomyoma to leiomyosarcoma in a man in his late 70s who presented with a painful and increasing lump on his anterior tibia. Initial imaging and biopsy showed a benign angioleiomyoma which was excised for symptomatic reasons. An analysis of the resulting specimen revealed a 50×42×15 mm smooth muscle neoplasm consistent with angioleiomyoma with a 22×11 mm entirely intralesional nodular component in keeping with a grade 1 leiomyosarcoma. The malignant constituent of the lesion was entirely encased in benign angioleiomyoma negating the need for further surgery. Systemic staging investigation revealed no evidence of metastatic disease spread final staging as per the eighth edition of the American Joint Committee on Cancer (AJCC) Staging T1N0M0 R0 Stage 1 a.
Assuntos
Angiomioma , Leiomiossarcoma , Tíbia , Humanos , Masculino , Leiomiossarcoma/patologia , Leiomiossarcoma/cirurgia , Leiomiossarcoma/diagnóstico por imagem , Tíbia/patologia , Tíbia/diagnóstico por imagem , Angiomioma/patologia , Angiomioma/cirurgia , Angiomioma/diagnóstico por imagem , Idoso , Transformação Celular Neoplásica/patologia , Neoplasias de Tecidos Moles/patologia , Neoplasias de Tecidos Moles/cirurgia , Neoplasias de Tecidos Moles/diagnóstico por imagem , Biópsia , Neoplasias Ósseas/patologia , Neoplasias Ósseas/cirurgia , Neoplasias Ósseas/diagnóstico por imagemRESUMO
This abstract describes a case of the growth of a serous borderline tumour recurrence and cyst to papillary projection ratio with associated ultrasound images. The aetiology, presentation and management of such cases are explored and compared to the literature.
Assuntos
Recidiva Local de Neoplasia , Humanos , Recidiva Local de Neoplasia/patologia , Feminino , Ultrassonografia , Neoplasias Ovarianas/patologia , Neoplasias Ovarianas/diagnóstico por imagem , Neoplasias Ovarianas/diagnóstico , Pessoa de Meia-IdadeRESUMO
Ependymomas are neuroepithelial tumours arising from ependymal cells surrounding the cerebral ventricles that rarely metastasise to extraneural structures. This spread has been reported to occur to the lungs, lymph nodes, liver and bone. We describe the case of a patient with recurrent CNS WHO grade 3 ependymoma with extraneural metastatic disease. He was treated with multiple surgical resections, radiation therapy and salvage chemotherapy for his extraneural metastasis to the lungs, bone, pleural space and lymph nodes.
Assuntos
Neoplasias Ósseas , Ependimoma , Neoplasias Pulmonares , Neoplasias Pleurais , Humanos , Masculino , Ependimoma/secundário , Ependimoma/patologia , Ependimoma/diagnóstico por imagem , Neoplasias Pulmonares/secundário , Neoplasias Pulmonares/patologia , Neoplasias Pleurais/secundário , Neoplasias Pleurais/patologia , Neoplasias Pleurais/diagnóstico por imagem , Neoplasias Ósseas/secundário , Metástase Linfática/diagnóstico por imagem , Neoplasias Encefálicas/secundário , Neoplasias Encefálicas/diagnóstico por imagem , Linfonodos/patologia , Linfonodos/diagnóstico por imagemRESUMO
A male in his 20s, a tobacco chewer, presented to the outpatient department with a history of painless, slowly progressive swelling in the floor of the mouth. After a thorough history and clinical examination, MRI was done and the tumour was completely excised. Histopathological examination revealed the mass to be a solitary fibrous tumour, confirmed with immunohistochemical markers. On subsequent follow-ups, the patient was found to be asymptomatic with no clinical signs of recurrence.
Assuntos
Imageamento por Ressonância Magnética , Soalho Bucal , Neoplasias Bucais , Tumores Fibrosos Solitários , Humanos , Masculino , Tumores Fibrosos Solitários/cirurgia , Tumores Fibrosos Solitários/patologia , Tumores Fibrosos Solitários/diagnóstico por imagem , Tumores Fibrosos Solitários/diagnóstico , Neoplasias Bucais/patologia , Neoplasias Bucais/cirurgia , Neoplasias Bucais/diagnóstico , Neoplasias Bucais/diagnóstico por imagem , Soalho Bucal/patologia , Adulto , Adulto JovemRESUMO
Marjolijn's ulcer is a malignant ulcer in a burn scar. Types of malignancy are squamous cell carcinoma, basal cell carcinoma and malignant melanoma. Soft tissue sarcoma case reports indicate only one type of cancer. We present a patient in her 60s with a 10-year-old burn scar developing a biopsy-proven squamous cell carcinoma on the lateral aspect of the left thigh with metastatic superficial inguinal node. A wide excision and grafting of ulcer with ilioinguinal dissection done on left side. On the 12th postoperative day 2, subcutaneous swellings adjacent to the grafted area developed, on biopsy revealed to be pleomorphic sarcoma. PET CT scan revealed tumour deposits in the muscles of the left lower limb, liver and lung. There are no case reports of synchronous carcinoma and sarcoma in a burn scar. The case is reported for its rarity and the decision-making dilemma.
Assuntos
Queimaduras , Carcinoma de Células Escamosas , Sarcoma , Neoplasias Cutâneas , Neoplasias de Tecidos Moles , Feminino , Humanos , Queimaduras/complicações , Queimaduras/patologia , Carcinoma de Células Escamosas/patologia , Cicatriz/complicações , Cicatriz/patologia , Sarcoma/complicações , Sarcoma/cirurgia , Neoplasias Cutâneas/patologia , Neoplasias de Tecidos Moles/complicações , Úlcera/complicações , Pessoa de Meia-Idade , IdosoRESUMO
Malignant peripheral nerve sheath tumour (MPNST) is an aggressive soft tissue sarcoma with a poor prognosis, affecting most commonly the extremities. The lungs constitute the most frequent location for distant metastases. Half of all MPNSTs arise in patients with neurofibromatosis type 1, while approximately 10% are radiation induced and the rest are sporadic.The authors present a pregnant woman in her 40s with a sporadic MPNST of the lower limb and with lung metastases at diagnosis. Treatment consisted of interilioabdominal amputation, followed by adjuvant chemotherapy. Partial response and disease stabilisation were achieved with chemotherapy.Surgical resection with negative margins is the only potentially curative therapy, while radiation therapy and chemotherapy might be useful in the neoadjuvant or adjuvant setting, but their advantage in survival is not demonstrated. In the reported case, chemotherapy permitted the achievement of partial response and stabilisation of the disease.
Assuntos
Fraturas Espontâneas , Neoplasias de Bainha Neural , Neurofibrossarcoma , Feminino , Gravidez , Humanos , Coxa da Perna/patologia , Neoplasias de Bainha Neural/complicações , Neoplasias de Bainha Neural/cirurgia , Neoplasias de Bainha Neural/diagnóstico , Gestantes , Fêmur/patologiaRESUMO
Hepatoid adenocarcinoma (HAC) of the mediastinum is a rare extrahepatic tumour that pathologically and morphologically resembles hepatocellular carcinoma. Extrahepatic HACs primarily occur in the stomach, ovaries, lung, gallbladder, pancreas and uterus. Patients with mediastinal HAC tend to be male smokers over forty years of age. Clinical symptoms of HAC are non-specific and varied in nature; therefore, diagnosis can be challenging and often delayed. Diagnostic investigations encompass haematological, radiological and histological assessment. Surgical resection is reserved for early-stage patients; however, since diagnosis may be delayed, most patients present with metastatic disease, for which the treatment of choice is platinum-based chemotherapy.
Assuntos
Adenocarcinoma , Carcinoma Hepatocelular , Neoplasias Hepáticas , Feminino , Humanos , Masculino , Mediastino/diagnóstico por imagem , Mediastino/patologia , Adenocarcinoma/diagnóstico , Carcinoma Hepatocelular/patologia , Pâncreas/patologia , Neoplasias Hepáticas/patologiaRESUMO
Breast cryoablation for palliative and curative treatment of breast cancer has been performed for decades. Although there is a recent resurgence of interest in breast cryoablation with curative intent for unifocal, hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer, this report highlights the essential role that cryoablation can play in the palliative treatment of multicentric oestrogen and progesterone receptor-negative and human epidermal growth factor receptor 2-negative (triple-negative) breast cancer, meeting the select pretreatment objectives such as breast or nipple pain relief and prevention of tumour erosion through the skin or nipple in patients who have failed or cannot tolerate the standard of care treatment.