Same-Sex Relationships and Criminal Behavior: A Total Population Study in The Netherlands.

Sexual minority groups experience elevated risk across a range of adverse outcomes. Previous studies from the USA showed that these risks include contact with the criminal justice system for sexual minority females but not for males. This study examined whether this relationship between sexual minority status and criminal behavior was also found in a more secular country like the Netherlands with more progressive attitudes toward sexual minorities. Furthermore, the study aimed to examine whether this relationship applied to various types of crime and could be explained by unmeasured familial factors. Longitudinal data from the Dutch national population, including 75,362 individuals in a same-sex relationship and 3,464,906 individuals in opposite-sex relationships, were used to compare the risk of crime among males and females in same-sex and opposite-sex unions. Discordant sibling models were included to increase control over possible sources of confounding from shared familial factors. Analyses were repeated for six types of crime, including property offenses, violence, vandalism, and public order offenses, traffic offenses, drugs offenses, and other offenses. The results showed that the direction of the associations between same-sex relationships and offending differed for men and women. In general, men in same-sex relationships were less likely to be a suspect of crime compared to those in opposite-sex relationships [odds ratio (OR) = 0.685; p < .001]. Women in same-sex relationships exhibited higher risk than those in opposite-sex unions (OR = 1.560; p < .001). Similar patterns emerged for most crime types and the discordant sibling models yielded conclusions that were substantively similar to those among the total population.

No causal relationship between early motherhood and offspring adolescent offending: Empirical evidence from a genetically-informed study.

Previous studies have consistently shown that young maternal age at birth is associated with an increased risk for problematic behavior in offspring. Less is known about the mechanisms underlying this association, as it could either reflect a causal effect or a spurious relationship. This study aims to gain more insights in these underlying mechanisms by studying the relationship between early motherhood and offspring adolescent offending. The sample includes all individuals who were born in the Netherlands between 1991 and 2001 (N=2,098,815). All variables were extracted from register data of Statistics Netherlands, including police registrations to measure adolescent offending. Logistic regression analyses were used to examine the relationship between maternal age at birth and offspring adolescent offending, with and without control variables. Moreover, a children of discordant siblings model was applied to further control for unmeasured familial confounders (i.e., shared environmental and genetic confounders). In line with previous studies, the results show a significant negative relationship between early motherhood and offspring offending. However, no significant effect was found in the children of discordant siblings analysis, which suggests that this relationship is confounded by unmeasured familial factors. These results illustrate the importance of applying genetically informed research designs when studying intergenerational relationships.

Neurocognitive and Psychiatric Markers for Addiction: Common vs. Specific Endophenotypes for Heroin and Amphetamine Dependence.

BACKGROUND: The differential utility of neurocognitive impulsivity and externalizing/ internalizing traits as putative endophenotypes for dependence on heroin vs. amphetamine is unclear. OBJECTIVE: This exploratory study aims to determine: (1) whether neurocognitive impulsivity dimensions and externalizing/internalizing traits are correlated between siblings discordant for heroin and amphetamine dependence; and (2) which of these associations are common across substances and which are substance- specific. METHODS: Pearson correlations between individuals with 'pure' heroin and amphetamine dependence and their unaffected biological siblings (n = 37 heroin sibling pairs; n = 30 amphetamine sibling pairs) were run on 10 neurocognitive measures, 6 externalizing measures, and 5 internalizing measures. Sibling pair effects were further examined using regression. RESULTS: Siblings discordant for heroin dependence were significantly correlated on delay aversion on the Cambridge Gambling Task, risk-taking on the Balloon Analogue Risk Task, sensation seeking, and hopelessness. Siblings discordant for amphetamine dependence were significantly correlated on the quality of decision-making on the Cambridge Gambling Task, discriminability on the Immediate Memory Task, commission errors on the Go/No Go Task, trait impulsivity, ADHD and anxiety sensitivity. CONCLUSION: Dimensions of impulsivity and externalizing/internalizing traits appear to aggregate among siblings discordant for substance dependence. Risk-taking propensity, sensation seeking and hopelessness were specific for heroin sibling pairs. Motor/action impulsivity, trait impulsivity, and anxiety sensitivity were specific to amphetamine sibling pairs. Decisional/choice impulsivity was common across both heroin and amphetamine sibling pairs. These findings provide preliminary evidence for the utility of neurocognitive impulsivity and externalizing/ internalizing traits as candidate endophenotypes for substance dependence in general and for substance-specific dependencies.

Measuring shared variants in cohorts of discordant siblings with applications to autism.

We develop a method of analysis [affected to discordant sibling pairs (A2DS)] that tests if shared variants contribute to a disorder. Using a standard measure of genetic relation, test individuals are compared with a cohort of discordant sibling pairs (CDS) to derive a comparative similarity score. We ask if a test individual is more similar to an unrelated affected than to the unrelated unaffected sibling from the CDS and then, sum over such individuals and pairs. Statistical significance is judged by randomly permuting the affected status in the CDS. In the analysis of published genotype data from the Simons Simplex Collection (SSC) and the Autism Genetic Resource Exchange (AGRE) cohorts of children with autism spectrum disorder (ASD), we find strong statistical significance that the affected are more similar to the affected than to the unaffected of the CDS (P value ∼ 0.00001). Fathers in multiplex families have marginally greater similarity (P value = 0.02) to unrelated affected individuals. These results do not depend on ethnic matching or gender.

Maternal concern about child weight in a study of weight-discordant siblings.

OBJECTIVE: This study examined concern about child weight in mothers of weight-discordant siblings and determined the accuracy of maternal self-report versus measured child height, weight, and corresponding body mass index (BMI; kg/m(2) ) z-score. DESIGN AND SAMPLE: Discordant sibling design. Forty-seven mothers of 5- to 12-year-old, weight-discordant siblings. MEASURES: Mothers self-reported their concern about child weight for each child separately and for a subset of children, self-reported their heights and weights. Siblings' height, weight, waist circumference, and adiposity were measured. RESULTS: The majority (83%) of mothers expressed concern about their overweight/obese child's weight and 20% of mothers expressed concern about their normal-weight child's weight (p < .001). Difference scores in maternal concern about child weight were positively associated with difference scores in sibling BMI z-score (r = 0.42; p = .01) and percent body fat (r = 0.56; p < .001). For overweight/obese children only, maternal-reported child heights and weights were significantly lower compared to the measured values (p < .03). CONCLUSIONS: One fifth of mothers of weight-discordant siblings were unconcerned about their overweight/obese child's weight and for overweight/obese children only, mothers tended to underreport children's height and weight. Mothers' concern for their overweight/obese child's weight was greater for sibling pairs who were more discordant in their weight.