Fusion of Higher Order Spectra and Texture Extraction Methods for Automated Stroke Severity Classification with MRI Images.

This paper presents a scientific foundation for automated stroke severity classification. We have constructed and assessed a system which extracts diagnostically relevant information from Magnetic Resonance Imaging (MRI) images. The design was based on 267 images that show the brain from individual subjects after stroke. They were labeled as either Lacunar Syndrome (LACS), Partial Anterior Circulation Syndrome (PACS), or Total Anterior Circulation Stroke (TACS). The labels indicate different physiological processes which manifest themselves in distinct image texture. The processing system was tasked with extracting texture information that could be used to classify a brain MRI image from a stroke survivor into either LACS, PACS, or TACS. We analyzed 6475 features that were obtained with Gray-Level Run Length Matrix (GLRLM), Higher Order Spectra (HOS), as well as a combination of Discrete Wavelet Transform (DWT) and Gray-Level Co-occurrence Matrix (GLCM) methods. The resulting features were ranked based on the p-value extracted with the Analysis Of Variance (ANOVA) algorithm. The ranked features were used to train and test four types of Support Vector Machine (SVM) classification algorithms according to the rules of 10-fold cross-validation. We found that SVM with Radial Basis Function (RBF) kernel achieves: Accuracy (ACC) = 93.62%, Specificity (SPE) = 95.91%, Sensitivity (SEN) = 92.44%, and Dice-score = 0.95. These results indicate that computer aided stroke severity diagnosis support is possible. Such systems might lead to progress in stroke diagnosis by enabling healthcare professionals to improve diagnosis and management of stroke patients with the same resources.

Autism Spectrum Disorder Diagnostic System Using HOS Bispectrum with EEG Signals.

Autistic individuals often have difficulties expressing or controlling emotions and have poor eye contact, among other symptoms. The prevalence of autism is increasing globally, posing a need to address this concern. Current diagnostic systems have particular limitations; hence, some individuals go undiagnosed or the diagnosis is delayed. In this study, an effective autism diagnostic system using electroencephalogram (EEG) signals, which are generated from electrical activity in the brain, was developed and characterized. The pre-processed signals were converted to two-dimensional images using the higher-order spectra (HOS) bispectrum. Nonlinear features were extracted thereafter, and then reduced using locality sensitivity discriminant analysis (LSDA). Significant features were selected from the condensed feature set using Student's t-test, and were then input to different classifiers. The probabilistic neural network (PNN) classifier achieved the highest accuracy of 98.70% with just five features. Ten-fold cross-validation was employed to evaluate the performance of the classifier. It was shown that the developed system can be useful as a decision support tool to assist healthcare professionals in diagnosing autism.

Epileptic seizure recognition using EEG wavelet decomposition based on nonlinear and statistical features with support vector machine classification.

Epileptic seizure (ES) is a neurological brain dysfunction. ES can be detected using the electroencephalogram (EEG) signal. However, visual inspection of ES using long-time EEG recordings is a difficult, time-consuming and a costly procedure. Thus, automatic epilepsy recognition is of primary importance. In this paper, a new method is proposed for automatic ES recognition using short-time EEG recordings. The method is based on first decomposing the EEG signals on sub-signals using discrete wavelet transform. Then, from the obtained sub-signals, different non-linear parameters such as approximate entropy (ApEn), largest Lyapunov exponents (LLE) and statistical parameters are determined. These parameters along with phase entropies, calculated through higher order spectrum analysis, are used as an input vector of a multi-class support vector machine (MSVM) for ES recognition. The proposed method is evaluated using the standard EEG database developed by the Department of Epileptology, University of Bonn, Germany. The evaluation is carried out through a large number of classification experiments. Different statistical metrics namely Sensitivity (Se), Specificity (Sp) and classification accuracy (Ac) are calculated and compared to those obtained in the scientific research literature. The obtained results show that the proposed method achieves high accuracies, which are as good as the best existing state-of-the-art methods studied using the same EEG database.

Quantitative diagnosis for bearing faults by improving ensemble empirical mode decomposition.

In the bearing health assessment issues, using the adaptive nonstationary vibration signal processing methods in the time-frequency domain, lead to improving of early fault detection. On the other hand, the noise and random impulses which contaminates the input data, are a major challenge in extracting fault-related features. The main goal of this paper is to improve the Ensemble Empirical mode decomposition (EEMD) algorithm and combine it with a new proposed denoising process and the higher order spectra to increase the accuracy and speed of the fault severity and type detection. The main approach is to use statistical features without using any dimension reduction and data training. To eliminate unrelated components from faulty condition, the best combination of denoising parameters based on the wavelet transform, is determined by a proposed performance index. In order to enhance the efficiency of the EEMD algorithm, a systematic method is presented to determine the proper amplitude of the additive noise and the Intrinsic Mode Functions (IMFs) selection scheme. The fault occurrence detection and the fault severity level identification are performed by the Fault Severity Index (FSI) definition based on the energy level of the Combined Fault-Sensitive IMF (CFSIMF) envelope using the central limit theorem. Also, taking the advantages of a bispectrum analysis of CFSIMF envelope, fault type recognition can be achieved by Fault Type Index (FTI) quantification. Finally, the proposed method is validated using experimental data set from two different test rigs. Also, the role of the optimum denoising process and the algorithm of systematic selection of the EEMD parameters are described regardless of its type and estimating the consistent degradation pattern.

Optimized multi-level elongated quinary patterns for the assessment of thyroid nodules in ultrasound images.

Ultrasound imaging is one of the most common visualizing tools used by radiologists to identify the location of thyroid nodules. However, visual assessment of nodules is difficult and often affected by inter- and intra-observer variabilities. Thus, a computer-aided diagnosis (CAD) system can be helpful to cross-verify the severity of nodules. This paper proposes a new CAD system to characterize thyroid nodules using optimized multi-level elongated quinary patterns. In this study, higher order spectral (HOS) entropy features extracted from these patterns appropriately distinguished benign and malignant nodules under particle swarm optimization (PSO) and support vector machine (SVM) frameworks. Our CAD algorithm achieved a maximum accuracy of 97.71% and 97.01% in private and public datasets respectively. The evaluation of this CAD system on both private and public datasets confirmed its effectiveness as a secondary tool in assisting radiological findings.

A Hybrid Approach Based on Higher Order Spectra for Clinical Recognition of Seizure and Epilepsy Using Brain Activity.

INTRODUCTION: This paper proposes a reliable and efficient technique to recognize different epilepsy states, including healthy, interictal, and ictal states, using Electroencephalogram (EEG) signals. METHODS: The proposed approach consists of pre-processing, feature extraction by higher order spectra, feature normalization, feature selection by genetic algorithm and ranking method, and classification by support vector machine with Gaussian and polynomial radial basis function kernels. The proposed approach is validated on a public benchmark dataset to compare it with previous studies. RESULTS: The results indicate that the combined use of above elements can effectively decipher the cognitive process of epilepsy and seizure recognition. There are several bispectrum and bicoherence peaks at every bi-frequency plane, which reveal the location of the quadratic phase coupling. The proposed approach can reach, in almost all of the experiments, up to 100% performance in terms of sensitivity, specificity, and accuracy. CONCLUSION: Comparing between the obtained results and previous approaches approves the effectiveness of the proposed approach for seizure and epilepsy recognition.

Computer-aided diagnosis of psoriasis skin images with HOS, texture and color features: A first comparative study of its kind.

Psoriasis is an autoimmune skin disease with red and scaly plaques on skin and affecting about 125 million people worldwide. Currently, dermatologist use visual and haptic methods for diagnosis the disease severity. This does not help them in stratification and risk assessment of the lesion stage and grade. Further, current methods add complexity during monitoring and follow-up phase. The current diagnostic tools lead to subjectivity in decision making and are unreliable and laborious. This paper presents a first comparative performance study of its kind using principal component analysis (PCA) based CADx system for psoriasis risk stratification and image classification utilizing: (i) 11 higher order spectra (HOS) features, (ii) 60 texture features, and (iii) 86 color feature sets and their seven combinations. Aggregate 540 image samples (270 healthy and 270 diseased) from 30 psoriasis patients of Indian ethnic origin are used in our database. Machine learning using PCA is used for dominant feature selection which is then fed to support vector machine classifier (SVM) to obtain optimized performance. Three different protocols are implemented using three kinds of feature sets. Reliability index of the CADx is computed. Among all feature combinations, the CADx system shows optimal performance of 100% accuracy, 100% sensitivity and specificity, when all three sets of feature are combined. Further, our experimental result with increasing data size shows that all feature combinations yield high reliability index throughout the PCA-cutoffs except color feature set and combination of color and texture feature sets. HOS features are powerful in psoriasis disease classification and stratification. Even though, independently, all three set of features HOS, texture, and color perform competitively, but when combined, the machine learning system performs the best. The system is fully automated, reliable and accurate.

Application of higher-order spectra for automated grading of diabetic maculopathy.

Diabetic macular edema (DME) is one of the most common causes of visual loss among diabetes mellitus patients. Early detection and successive treatment may improve the visual acuity. DME is mainly graded into non-clinically significant macular edema (NCSME) and clinically significant macular edema according to the location of hard exudates in the macula region. DME can be identified by manual examination of fundus images. It is laborious and resource intensive. Hence, in this work, automated grading of DME is proposed using higher-order spectra (HOS) of Radon transform projections of the fundus images. We have used third-order cumulants and bispectrum magnitude, in this work, as features, and compared their performance. They can capture subtle changes in the fundus image. Spectral regression discriminant analysis (SRDA) reduces feature dimension, and minimum redundancy maximum relevance method is used to rank the significant SRDA components. Ranked features are fed to various supervised classifiers, viz. Naive Bayes, AdaBoost and support vector machine, to discriminate No DME, NCSME and clinically significant macular edema classes. The performance of our system is evaluated using the publicly available MESSIDOR dataset (300 images) and also verified with a local dataset (300 images). Our results show that HOS cumulants and bispectrum magnitude obtained an average accuracy of 95.56 and 94.39% for MESSIDOR dataset and 95.93 and 93.33% for local dataset, respectively.

An automated detection of glaucoma using histogram features.

Glaucoma is a chronic and progressive optic neurodegenerative disease leading to vision deterioration and in most cases produce increased pressure within the eye. This is due to the backup of fluid in the eye; it causes damage to the optic nerve. Hence, early detection diagnosis and treatment of an eye help to prevent the loss of vision. In this paper, a novel method is proposed for the early detection of Glaucoma using a combination of magnitude and phase features from the digital fundus images. Local binary patterns (LBP) and Daugman's algorithm are used to perform the feature set extraction. The histogram features are computed for both the magnitude and phase components. The Euclidean distance between the feature vectors are analyzed to predict glaucoma. The performance of the proposed method is compared with the higher order spectra (HOS) features in terms of sensitivity, specificity, classification accuracy and execution time. The proposed system results 95.45% output for sensitivity, specificity and classification. Also, the execution time for the proposed method takes lesser time than the existing method which is based on HOS features. Hence, the proposed system is accurate, reliable and robust than the existing approach to predict the glaucoma features.

Seizure detection, seizure prediction, and closed-loop warning systems in epilepsy.

Nearly one-third of patients with epilepsy continue to have seizures despite optimal medication management. Systems employed to detect seizures may have the potential to improve outcomes in these patients by allowing more tailored therapies and might, additionally, have a role in accident and SUDEP prevention. Automated seizure detection and prediction require algorithms which employ feature computation and subsequent classification. Over the last few decades, methods have been developed to detect seizures utilizing scalp and intracranial EEG, electrocardiography, accelerometry and motion sensors, electrodermal activity, and audio/video captures. To date, it is unclear which combination of detection technologies yields the best results, and approaches may ultimately need to be individualized. This review presents an overview of seizure detection and related prediction methods and discusses their potential uses in closed-loop warning systems in epilepsy.

Automated diagnosis of Age-related Macular Degeneration using greyscale features from digital fundus images.

Age-related Macular Degeneration (AMD) is one of the major causes of vision loss and blindness in ageing population. Currently, there is no cure for AMD, however early detection and subsequent treatment may prevent the severe vision loss or slow the progression of the disease. AMD can be classified into two types: dry and wet AMDs. The people with macular degeneration are mostly affected by dry AMD. Early symptoms of AMD are formation of drusen and yellow pigmentation. These lesions are identified by manual inspection of fundus images by the ophthalmologists. It is a time consuming, tiresome process, and hence an automated diagnosis of AMD screening tool can aid clinicians in their diagnosis significantly. This study proposes an automated dry AMD detection system using various entropies (Shannon, Kapur, Renyi and Yager), Higher Order Spectra (HOS) bispectra features, Fractional Dimension (FD), and Gabor wavelet features extracted from greyscale fundus images. The features are ranked using t-test, Kullback-Lieber Divergence (KLD), Chernoff Bound and Bhattacharyya Distance (CBBD), Receiver Operating Characteristics (ROC) curve-based and Wilcoxon ranking methods in order to select optimum features and classified into normal and AMD classes using Naive Bayes (NB), k-Nearest Neighbour (k-NN), Probabilistic Neural Network (PNN), Decision Tree (DT) and Support Vector Machine (SVM) classifiers. The performance of the proposed system is evaluated using private (Kasturba Medical Hospital, Manipal, India), Automated Retinal Image Analysis (ARIA) and STructured Analysis of the Retina (STARE) datasets. The proposed system yielded the highest average classification accuracies of 90.19%, 95.07% and 95% with 42, 54 and 38 optimal ranked features using SVM classifier for private, ARIA and STARE datasets respectively. This automated AMD detection system can be used for mass fundus image screening and aid clinicians by making better use of their expertise on selected images that require further examination.

Diagnosis of Hashimoto's thyroiditis in ultrasound using tissue characterization and pixel classification.

Hashimoto's thyroiditis is the most common type of inflammation of the thyroid gland, and accurate diagnosis of Hashimoto's thyroiditis would be helpful to better manage the disease process and predict thyroid failure. Most of the published computer-based techniques that use ultrasound thyroid images for Hashimoto's thyroiditis diagnosis are limited by lack of procedure standardization because individual investigators use various initial ultrasound settings. This article presents a computer-aided diagnostic technique that uses grayscale features and classifiers to provide a more objective and reproducible classification of normal and Hashimoto's thyroiditis-affected cases. In this paradigm, we extracted grayscale features based on entropy, Gabor wavelet, moments, image texture, and higher order spectra from the 100 normal and 100 Hashimoto's thyroiditis-affected ultrasound thyroid images. Significant features were selected using t-test. The resulting feature vectors were used to build the following three classifiers using tenfold stratified cross validation technique: support vector machine, k-nearest neighbor, and radial basis probabilistic neural network. Our results show that a combination of 12 features coupled with support vector machine classifier with the polynomial kernel of order 1 and linear kernel gives the highest accuracy of 80%, sensitivity of 76%, specificity of 84%, and positive predictive value of 83.3% for the detection of Hashimoto's thyroiditis. The proposed computer-aided diagnostic system uses novel features that have not yet been explored for Hashimoto's thyroiditis diagnosis. Even though the accuracy is only 80%, the presented preliminary results are encouraging to warrant analysis of more such powerful features on larger databases.