Cajal and his love for Nature: a sentimental essence in the legacy of neurosciences.

Santiago Ramón y Cajal (1852-1934) revolutionized the branches of neuroscience in a forceful way, and he did it with extreme delicacy and candor. His scientific writings and drawings are full of allusions to Nature, a fact that demonstrates how he saw, understood and enjoyed it with exquisite sensitivity and pressing emotion. Neuroscience awakened in him the utmost curiosity to delve into the powerful mysteries of the mind, and neurohistology allowed him to satisfy his deepest concerns for fascinating scenarios, a desire not sufficiently fulfilled throughout the fields, mountains and forests of his childhood and youth. Through that wonderful microscopic world Cajal changed the size of the dreamed landscapes but not the dimension of the longed-for adventures. Exploring and entering unknown paths he unraveled some of the greatest enigmas that the nervous system hid, but he would do so with a deep feeling toward the infinite beauty that Nature itself offered him. In short, Nature was the vital axis of Cajal's overwhelming and complex personality, his most genuine essence and the inexhaustible source of inspiration where he poured his imagination and fantasy. He became a vocational adventurer, an insatiable explorer, a talented artist and an exquisite humanist. An eminently romantic soul who knew how to link Nature and Neuroscience with unconditional and perpetual emotionality.

Socioeconomic Disparities in Urban Forest Diversity and Structure in Green Areas of Santiago de Chile.

Urban trees enhance biodiversity, provide ecosystem services, and improve quality of life in cities. Despite their benefits, trees are not distributed equitably, and many cities exhibit a "luxury effect". Given the importance of public green space for providing access to urban tree benefits, we investigated the relationship between socioeconomic level and tree diversity and structure in 60 green areas in Santiago de Chile. Species richness and total tree abundance did not significantly vary among socioeconomic levels; however, a differential effect was found according to species origin. Introduced tree species exhibited similar abundance and species richness across socioeconomic levels, but native tree species were more abundant and richer in higher socioeconomic level areas compared to lower ones. Tree cover was higher in the high and medium socioeconomic level areas than in the low socioeconomic level area. A higher average DBH was found in the medium socioeconomic level area, which may be explained by older neighborhoods and a legacy of the luxury effect. Our findings reveal that socioeconomic groups are associated with differences in tree cover, width, and the number of native species in public green areas. Consequently, urban residents have different provisions of ecosystem services and opportunities to interact with natural heritage. Increasing the amount of tree cover and native species available to vulnerable groups will reduce disparities.

Bodily Practices and Meanings Articulated in the Physical Exercise of Older Adults in Santiago de Chile Post-COVID-19.

This article presents the results of almost nine months of ethnographic research on the relationship between physical exercise and health in older people in the post-COVID-19 context. Via exploratory-descriptive qualitative research and the use of a convenient sample, I shed light on this relationship using the stories and life experiences of 40 older people (10 men and 30 women, including two women instructors for senior classes) who exercise regularly. The meanings they attributed to physical exercise during COVID-19 and after it are explained, emphasising first that there is no health in a context of not feeling safe; once there is a feeling of security, the most relevant meanings can be exposed in three directions. First, exercise produces a sense of identity linked to "being an athlete" and "belonging to a group". Second, exercising is valued as participating in something meaningful (the meanings range from self-realisation, independence, and autonomy to feelings of happiness). Finally, and linked to the sense of identity, those who train alone show more commitment and total hours spent in physical exercise and physical activity than those who train in groups. Even though older people are not a homogeneous group, they generally faced the pandemic as an ageist situation that affected their lives and how they saw sports and health. This article describes the strategies they used during COVID-19 related to exercise and well-being and those used once the pandemic restrictions were no longer present. The qualitative aspects that physical exercise brings to this population are highlighted. The research results give voice to older people, showing their heterogeneity and the meanings and practices that unite them. These inputs are rich material for studies on physical activity, older people, and well-being.

Cajal, the neuronal theory and the idea of brain plasticity.

This paper reviews the importance of Cajal's neuronal theory (the Neuron Doctrine) and the origin and importance of the idea of brain plasticity that emerges from this theory. We first comment on the main Cajal's discoveries that gave rise and confirmed his Neuron Doctrine: the improvement of staining techniques, his approach to morphological laws, the concepts of dynamic polarisation, neurogenesis and neurotrophic theory, his first discoveries of the nerve cell as an independent cell, his research on degeneration and regeneration and his fight against reticularism. Second, we review Cajal's ideas on brain plasticity and the years in which they were published, to finally focus on the debate on the origin of the term plasticity and its conceptual meaning, and the originality of Cajal's proposal compared to those of other authors of the time.

The Pilgrimage on the Camino de Santiago and Its Impacts on Marital and Familial Relationships: An Exploratory Study.

This paper presents the results of a survey conducted among people walking the pilgrimage route to the shrine of St James in Santiago de Compostela. The aim of the research was to investigate how a pilgrimage on the Camino de Santiago among a married couple or family affects marital or familial relationships, whether walking the trail to Compostela together influences the behaviour of family members towards each other and whether it forms positive attitudes and behaviour. The empirical basis of the study is the results of a survey among respondents who made the Camino de Santiago pilgrimage, as well as in-depth interviews conducted with 24 spouses of pilgrims along the Way of St James. The study revealed that doing the pilgrimage as a married couple or family had a positive impact on intra-family relationships. According to the interviewees, going on the pilgrimage together helped to strengthen marital bonds and trust, improve communication and mutual connection, show care and affection and improve contact with children.

Feet in Hell, Spirit in Heaven: Spiritual Transformation of Chinese Travelers on the Camino de Santiago.

The study aims to understand the precursors, catalysts, and dimensions of the spiritual transformation of Chinese travelers on the Camino de Santiago, a pilgrimage-tourist route in Spain. This research has adopted the theoretical framework of spiritual transformation by Pargament and his colleagues in collecting the transformative experience of Chinese Camino travelers reported in 139 blogs and stories. Thematic analysis is employed in analyzing the data. The study results show that Chinese travelers underwent spiritually transformative experiences, as observed in the changes in their relationship to themselves, others, nature, and the transcendent. These four dimensions are interconnected and experienced as something integrated with Chinese cultural and spiritual traditions. This study also explores the transculturality of spiritual experience, the important role of embodied engagement, and the critical and essential qualities of liminality in the transformative process on the Camino de Santiago.

Differential effects of early life adversity on male and female rhesus macaque lifespan.

Early life adversity predicts shorter adult lifespan in several animal taxa. Yet, work on long-lived primate populations suggests the evolution of mechanisms that contribute to resiliency and long lives despite early life insults. Here, we tested associations between individual and cumulative early life adversity and lifespan on rhesus macaques at the Cayo Santiago Biological Field Station using 50 years of demographic data. We performed sex-specific survival analyses at different life stages to contrast short-term effects of adversity (i.e., infant survival) with long-term effects (i.e., adult survival). Female infants showed vulnerability to multiple adversities at birth, but affected females who survived to adulthood experienced a reduced risk later in life. In contrast, male infants showed vulnerability to a lower number of adversities at birth, but those who survived to adulthood were negatively affected by both early life individual and cumulative adversity. Our study shows profound immediate effects of insults  on female infant cohorts and suggests that affected female adults are more robust. In contrast, adult males who experienced harsh conditions early in life showed an increased mortality risk at older ages as expected from hypotheses within the life course perspective. Our analysis suggests sex-specific selection pressures on life histories and highlights the need for studies addressing the effects of early life adversity across multiple life stages.

Monkeypox Virus in Wastewater Samples from Santiago Metropolitan Region, Chile.

Sewage surveillance provides useful epidemiologic and public health information on viral infections at the population level. We detected monkeypox virus DNA from sewage samples covering 85% of the population in Santiago Metropolitan Region Chile. We also isolated infective viruses from those samples. Wastewater surveillance could complement clinical surveillance for monkeypox virus.

Abundance of Non-Native Birds in the City: Spatial Variation and Relationship with Socioeconomics in a South American City.

Cities commonly support a high abundance of non-native species that can affect both wildlife and human health; however, their distribution across the urban environment and their relationship with socioeconomics are not well documented. Here, we map the abundance of three non-native birds in a Latin American city-domestic pigeon (Columba livia f. domestica), house sparrow (Passer domesticus), and monk parakeet (Myiopsitta monachus)-and investigate the effect of socioeconomics on their abundance. We found that C. livia f. domestica exhibited a random distribution of abundance across the city but reached its greatest abundance in low-income areas. P. domesticus exhibited an aggregated distribution of abundance, being most abundant in the southern and western areas of the city and in low-income areas. M. monachus exhibited an aggregated distribution of abundance, being most abundant in the northeastern part of the city and reaching its greatest abundance in high-income areas. Low-income areas likely provide high abundance of food, shelter, and nesting sites for both C. livia f. domestica and P. domesticus, whereas high income areas have greater tree cover and larger trees in which M. monachus can build communal nests. Our study finds that the abundance of non-native birds varies across the city and between socioeconomic groups; therefore, targeted management is needed in different city zones to limit negative effects on native species and prevent zoonotic diseases.

Cover images of the Journal of Comparative Physiology A and the stories behind them.

The cover images of the 2023 issues of the Journal of Comparative Physiology A, as well as its logo image, are presented at full size and high resolution, together with the stories behind them. These images are testament to the artistic quality of the scientific illustrations published in the Journal of Comparative Physiology A.

The biology of aging in a social world: Insights from free-ranging rhesus macaques.

Social adversity can increase the age-associated risk of disease and death, yet the biological mechanisms that link social adversities to aging remain poorly understood. Long-term naturalistic studies of nonhuman animals are crucial for integrating observations of social behavior throughout an individual's life with detailed anatomical, physiological, and molecular measurements. Here, we synthesize the body of research from one such naturalistic study system, Cayo Santiago, which is home to the world's longest continuously monitored free-ranging population of rhesus macaques (Macaca mulatta). We review recent studies of age-related variation in morphology, gene regulation, microbiome composition, and immune function. We also discuss ecological and social modifiers of age-markers in this population. In particular, we summarize how a major natural disaster, Hurricane Maria, affected rhesus macaque physiology and social structure and highlight the context-dependent and domain-specific nature of aging modifiers. Finally, we conclude by providing directions for future study, on Cayo Santiago and elsewhere, that will further our understanding of aging across different domains and how social adversity modifies aging processes.

Pleistocene South American native ungulates (Notoungulata and Litopterna) of the historical Roth collections in Switzerland, from the Pampean Region of Argentina.

The fossil collections made by early explorers in South America have been fundamental to reveal the past diversity of extinct mammals and unravel their evolutionary history. One important early explorer in South America was the Swiss-Argentine palaeontologist Kaspar Jacob Roth, known as Santiago Roth (1850, Herisau, Switzerland-1924, Buenos Aires, Argentina), who made significant collections of fossil mammals that are housed in museums in Europe and Argentina. The important collections of Roth in Switzerland include iconic Pleistocene megafauna from the Pampean Region (Argentina). The palaeontological significance of the Pampean Region relies on its abundant record of fossil vertebrates that documents diversity dynamics and paleoenvironmental change in southern South America, serving as the basis for the South American biostratigraphical scale of the late Neogene and Quaternary. The South American native ungulates (SANUs) were hoofed placental mammals that radiated in South America. The clades Notoungulata and Litopterna include, among others, the last representatives of SANUs megafauna in the continent. We revise and describe for the first time the SANUs specimens from the Pampean Region of the Roth collections in Switzerland. The collections include two species of notoungulates (Toxodon cf. T. platensis and Mesotherium cristatum) and one litoptern species (Macrauchenia patachonica). The occurrences are restricted to the early and middle Pleistocene (pre-Lujanian Stages/Ages). Although the SANUs diversity in the Roth collections is low in comparison with other groups (e.g., xenarthrans), some of the specimens are very complete, including skulls and postcranial remains. The completeness of the Ma. patachonica material allows an update and reinterpretation of some of the details of the dentition and the postcranial skeleton of this iconic species. In addition to its historical importance, the SANU specimens from the Roth collections provide important information to study the paleobiology and evolution of South American megafauna and evaluate hypotheses about their extinction in the continent.

Las colecciones de fósiles realizadas por los primeros exploradores en América del Sur han sido fundamentales para revelar la diversidad pasada de los mamíferos sudamericanos y desentrañar su historia evolutiva. Un importante explorador en América del Sur fue el paleontólogo suizo-argentino Kaspar Jacob Roth, conocido como Santiago Roth (1850, Herisau, Suiza-1924, Buenos Aires, Argentina), quien realizó importantes colecciones de mamíferos fósiles que se encuentran en museos de Europa y Argentina. Las colecciones de Roth en Suiza incluyen la icónica megafauna del Pleistoceno de la Región Pampeana (Argentina). La importancia paleontológica de la Región Pampeana se basa en su abundante registro de vertebrados fósiles que documenta la diversidad y el cambio paleoambiental en el sur de Sudamérica, sirviendo como base para la escala bioestratigráfica sudamericana del Neógeno tardío y Cuaternario. Los ungulados nativos sudamericanos (SANUs, por sus siglas en inglés) eran mamíferos placentarios con pezuñas que radiaron en Sudamérica. Los clados Notoungulata y Litopterna incluyen, entre otros, los últimos representantes de la megafauna de SANUs en el continente. En este trabajo, revisamos y describimos por primera vez los SANUs de la Región Pampeana de las colecciónes de Roth en Suiza. Las colecciónes incluyen dos especies de notungulados (Toxodon cf. T. platensis y Mesotherium cristatum) y una especie de litopterna (Macrauchenia patachonica). Las ocurrencias están restringidas al Pleistoceno temprano y medio (Pisos/Edades anteriores al Lujanense). Aunque la diversidad de SANU en las colecciónes Roth es baja en comparación con otros grupos (por ejemplo, xenarthros), algunos de los especímenes son muy completos, e incluyen cráneos y restos poscraneales. Lo completo del material de Ma. patachonica permite una actualización y reinterpretación de algunos de los detalles de la dentición y el esqueleto poscraneal de esta icónica especie. Además de su importancia histórica, los SANUs de la colección Roth brindan información importante para estudiar la paleobiología y evolución de la megafauna sudamericana y evaluar hipótesis sobre su extinción en el continente.

Yearly variation coupled with social interactions shape the skin microbiome in free-ranging rhesus macaques.

While skin microbes are known to mediate human health and disease, there has been minimal research on the interactions between skin microbiota, social behavior, and year-to-year effects in non-human primates-important animal models for translational biomedical research. To examine these relationships, we analyzed skin microbes from 78 rhesus macaques living on Cayo Santiago Island, Puerto Rico. We considered age, sex, and social group membership, and characterized social behavior by assessing dominance rank and patterns of grooming as compared to nonsocial behaviors. To measure the effects of a shifting environment, we sampled skin microbiota (based on sequence analysis of the 16S rRNA V4 region) and assessed weather across sampling periods between 2013 and 2015. We hypothesized that, first, monkeys with similar social behavior and/or in the same social group would possess similar skin microbial composition due, in part, to physical contact, and, second, microbial diversity would differ across sampling periods. We found significant phylum-level differences between social groups in the core microbiome as well as an association between total grooming rates and alpha diversity in the complete microbiome, but no association between microbial diversity and measures of rank or other nonsocial behaviors. We also identified alpha and beta diversity differences in microbiota and differential taxa abundance across two sampling periods. Our findings indicate that social dynamics interact with yearly environmental changes to shape the skin microbiota in rhesus macaques, with potential implications for understanding the factors affecting the microbiome in humans, which share many biological and social characteristics with these animals. IMPORTANCE Primate studies are valuable for translational and evolutionary insights into the human microbiome. The majority of primate microbiome studies focus on the gut, so less is known about the factors impacting the microbes on skin and how their links affect health and behavior. Here, we probe the impact of social interactions and the yearly environmental changes on food-provisioned, free-ranging monkeys living on a small island. We expected animals that lived together and groomed each other would have more similar microbes on their skin, but surprisingly found that the external environment was a stronger influence on skin microbiome composition. These findings have implications for our understanding of the human skin microbiome, including potential manipulations to improve health and treat disease.

Advancing methods for the biodemography of aging within social contexts.

Several social dimensions including social integration, status, early-life adversity, and their interactions across the life course can predict health, reproduction, and mortality in humans. Accordingly, the social environment plays a fundamental role in the emergence of phenotypes driving the evolution of aging. Recent work placing human social gradients on a biological continuum with other species provides a useful evolutionary context for aging questions, but there is still a need for a unified evolutionary framework linking health and aging within social contexts. Here, we summarize current challenges to understand the role of the social environment in human life courses. Next, we review recent advances in comparative biodemography and propose a biodemographic perspective to address socially driven health phenotype distributions and their evolutionary consequences using a nonhuman primate population. This new comparative approach uses evolutionary demography to address the joint dynamics of populations, social dimensions, phenotypes, and life history parameters. The long-term goal is to advance our understanding of the link between individual social environments, population-level outcomes, and the evolution of aging.

Skeletal age during hurricane impacts fluctuating asymmetry in Cayo Santiago rhesus macaques.

As natural disasters become more frequent due to climate change, understanding the biological impact of these ecological catastrophes on wild populations becomes increasingly pertinent. Fluctuating asymmetry (FA), or random deviations from bilateral symmetry, is reflective of developmental instability and has long been positively associated with increases in environmental stress. This study investigates craniofacial FA in a population of free-ranging rhesus macaques (Macaca mulatta) that has experienced multiple Category 3 hurricanes since the colony's inception on Cayo Santiago, including 275 individuals from ages 9 months to 31 years (F = 154; M = 121). Using geometric morphometrics to quantify FA and a linear mixed-effect model for analysis, we found that sex, age, and decade of birth did not influence the amount of FA in the individuals included in the study, but the developmental stage at which individuals experienced these catastrophic events greatly impacted the amount of FA exhibited (p = .001). Individuals that experienced these hurricanes during fetal life exhibited greater FA than any other post-natal developmental period. These results indicate that natural disasters can be associated with developmental disruption that results in long-term effects if occurring during the prenatal period, possibly due to increases in maternal stress-related hormones.

A medida que los desastres naturales se vuelven más frecuentes debido al cambio climático, entender el impacto biológico de estas catástrofes ecológicas en poblaciones silvestres va en aumento pertinente. La asimetría fluctuante (AF), o desviaciones aleatorias de simetría bilateral, es reflejo de inestabilidad durante el desarrollo y se ha asociado positivamente con incrementos en estrés ambiental durante mucho tiempo. Este estudio investiga AF craneofacial en una población de macacos rhesus (Macaca mulatta) en libertad que ha experimentado múltiples huracanes categoría 3 desde el inicio de la colonia en Cayo Santiago, e incluye 275 individuos de 9 meses a 31 años de edad (F = 154; M = 121). Usando morfometría geométrica para cuantificar AF y un modelo lineal de efectos mixtos para análisis, encontramos que el sexo, la edad y la década de nacimiento no influyeron en la cantidad de AF en los individuos incluidos en el estudio, pero la etapa de desarrollo en la que los individuos experimentaron estos eventos catastróficos impactó altamente la cantidad de AF exhibida (p = .001). Los individuos que experimentaron estos huracanes durante el período fetal exhibieron mayor AF que cualquier otro período de desarrollo posnatal. Estos resultados indican que los desastres naturales pueden asociarse con trastornos del desarrollo que tienen efectos a largo plazo si ocurren durante el período prenatal, posiblemente debido al aumento de hormonas maternas relacionadas con el estrés.

Evento científico "REUMA Santiago 2023"

Fotorreportaje realizado durante los días 16 y 17 de junio de 2023en el curso del evento científico REUMA Santiago 2023, organizado por el capítulo de reumatología de la ciudad de Santiago de Cuba.

Photo report made on June 16 and 17, 2023 during the REUMA Santiago 2023 scientific event, organized by the rheumatology chapter of the city of Santiago de Cuba.

A new stream treefrog of the genus Hyloscirtus (Amphibia, Hylidae) from the Río Negro-Sopladora National Park, Ecuador.

Recent surveys in the Río Negro-Sopladora National Park revealed a striking new species of Hyloscirtus. The new species is easily diagnosed from all other congeners by its large body size (64.9 mm SVL in adult female); broad dermal fringes in fingers and toes; prepollex not projected into a prepollical spine and hidden under thenar tubercle; dorsum greyish-green, with paler-hued reticulum, yellow spots and black speckles; throat, venter, flanks and hidden surfaces of limbs golden-yellow with large black blotches and spots; fingers, toes and webbing yellow with black bars and spots; iris pale pink with black periphery. It is currently known only from its type locality, in the high montane forest on the southern slopes of the Cordillera Oriental of the Andes, southeastern Ecuador. The new species might be related to the H.larinopygion species group based on its morphology.

Is there a relationship between socioeconomic level, vegetation cover, free-roaming cats and dogs, and the diversity of native birds? A study in a Latin American capital city.

Understanding how social and environmental factors influence biodiversity can contribute to sustainable development and promote environmental justice in cities. This knowledge is especially important in developing countries with strong social and environmental inequalities. This study investigates native bird diversity in relation to the socioeconomic level of neighborhoods, their plant cover, and the abundance of free-roaming cats and dogs in a Latin American city. Two causal hypotheses were tested: 1) socioeconomic level (defined by education and income) influence native bird diversity indirectly, as an effect mediated by plant cover, as well as directly; 2) in addition, socioeconomic conditions also influence free-roaming cats and dogs which could affect native bird diversity. To test these hypotheses, data were collected at 120 sites located in neighborhoods of different socioeconomic levels across the city of Santiago de Chile and fit to Structural Equation Models. Evidence supported the second hypothesis: in wealthier neighborhoods there was greater plant cover that, in turn, positively influenced native bird diversity; in addition, fewer free-roaming cats and dogs were found in these neighborhoods but they had no effect on native bird diversity. Results suggest that increasing plant cover, especially in more socioeconomically vulnerable neighborhoods, would contribute to urban environmental justice and more equitable opportunities to access native bird diversity.

Hurricanes affect diversification among individual life courses of a primate population.

Extreme climatic events may influence individual-level variability in phenotypes, survival and reproduction, and thereby drive the pace of evolution. Climate models predict increases in the frequency of intense hurricanes, but no study has measured their impact on individual life courses within animal populations. We used 45 years of demographic data of rhesus macaques to quantify the influence of major hurricanes on reproductive life courses using multiple metrics of dynamic heterogeneity accounting for life course variability and life-history trait variances. To reduce intraspecific competition, individuals may explore new reproductive stages during years of major hurricanes, resulting in higher temporal variation in reproductive trajectories. Alternatively, individuals may opt for a single optimal life-history strategy due to trade-offs between survival and reproduction. Our results show that heterogeneity in reproductive life courses increased by 4% during years of major hurricanes, despite a 2% reduction in the asymptotic growth rate due to an average decrease in mean fertility and survival by that is, shortened life courses and reduced reproductive output. In agreement with this, the population is expected to achieve stable population dynamics faster after being perturbed by a hurricane ( ρ = 1.512 ; 95% CI: 1.488, 1.538), relative to ordinary years ρ = 1.482 ; 1.475 , 1.490 . Our work suggests that natural disasters force individuals into new demographic roles to potentially reduce competition during unfavourable environments where mean reproduction and survival are compromised. Variance in lifetime reproductive success and longevity are differently affected by hurricanes, and such variability is mostly driven by survival.

Cincuenta años de desarrollo de la ortodoncia en Santiago de Cuba / Fifty years of development of orthodontics in Santiago de Cuba: en

En el presente trabajo se resaltan las facetas y los aportes sustanciales de personalidades que contribuyeron con sus esfuerzos al inicio del proceso de enseñanza de la ortodoncia y a la formación de nuevos especialistas. Se enfatizan los principales aportes a la bibliografía científica, docente e investigativa, tanto en el país como en el extranjero. Finalmente, se pretende resumir el desarrollo creciente de la ortodoncia en los 50 años de iniciada la formación académica en Santiago de Cuba, la cual se nutrió de nuevos profesionales capaces de conservar los principios y valores éticos propiciados por sus antecesores, con evidentes resultados científico-técnicos y calidad en el desempeño profesional.

This article highlights the facets and substantial contributions of personalities that added with their efforts to the beginning of orthodontics teaching process and the training of new specialists. The main contributions to scientific, educational and investigative literature, either in the country or abroad are emphasized. Finally, it is sought to summarize the growing development of orthodontics in the 50 years of academic training in Santiago de Cuba, with new professionals able to conserve the principles and ethical values promoted by their predecessors, with evident scientific-technical results and quality in professional performance.