The polyphyletic origins of glycyl-tRNA synthetase and lysyl-tRNA synthetase and their implications.

I analyzed the polyphyletic origin of glycyl-tRNA synthetase (GlyRS) and lysyl-tRNA synthetase (LysRS), making plausible the following implications. The fact that the genetic code needed to evolve aminoacyl-tRNA synthetases (ARSs) only very late would be in perfect agreement with a late origin, in the main phyletic lineages, of both GlyRS and LysRS. Indeed, as suggested by the coevolution theory, since the genetic code was structured by biosynthetic relationships between amino acids and as these occurred on tRNA-like molecules which were evidently already loaded with amino acids during its structuring, this made possible a late origin of ARSs. All this corroborates the coevolution theory of the origin of the genetic code to the detriment of theories which would instead predict an early intervention of the action of ARSs in organizing the genetic code. Furthermore, the assembly of the GlyRS and LysRS protein domains in main phyletic lineages is itself at least evidence of the possibility that ancestral genes were assembled using pieces of genetic material that coded these protein domains. This is in accordance with the exon theory of genes which postulates that ancestral exons coded for protein domains or modules that were assembled to form the first genes. This theory is exemplified precisely in the evolution of both GlyRS and LysRS which occurred through the assembly of protein domains in the main phyletic lineages, as analyzed here. Furthermore, this late assembly of protein domains of these proteins into the two main phyletic lineages, i.e. a polyphyletic origin of both GlyRS and LysRS, appears to corroborate the progenote evolutionary stage for both LUCA and at least the first part of the evolutionary stages of the ancestor of bacteria and that of archaea. Indeed, this polyphyletic origin would imply that the genetic code was still evolving because at least two ARSs, i.e. proteins that make the genetic code possible today, were still evolving. This would imply that the evolutionary stages involved were characterized not by cells but by protocells, that is, by progenotes because this is precisely the definition of a progenote. This conclusion would be strengthened by the observation that both GlyRS and LysRS originating in the phyletic lineages leading to bacteria and archaea, would demonstrate that, more generally, proteins were most likely still in rapid and progressive evolution. Namely, a polyphyletic origin of proteins which would qualify at least the initial phase of the evolutionary stage of the ancestor of bacteria and that of archaea as stages belonging to the progenote.

The bricolage mode of emergency medical teams in China: deficient and in urgent need of transformation-A qualitative study.

Introduction: Emergency medical rescue plays a vital role in alleviating the harm of all kinds of emergencies to people's physical and mental health and life safety. The current emergency medical teams (EMTs) formation model is not unified. We focused on the disadvantages of the bricolage mode of China EMTs and put forward empirical-based countermeasures to improve the emergency management ability of EMTs. Methods: From March to September 2022, 23 leaders of EMTs in North China (Tianjin) were selected by objective sampling method to conduct one-to-half structured in-depth interviews. Nvivo12.0 software was used for three-level coding. The disadvantages of the bricolage model of EMT were analyzed. Results: Based on the three-level coding, 150 initial concepts, 36 sub-coding, 17 main coding, six categories, and two core categories were sorted out. Management structure, internal stability, and support are recognized as the crucial elements armed with the EMTs. Discussion: The bricolage EMTs have disadvantages such as a chaotic management structure, weak internal stability, and inadequate support. It is necessary to construct full-time EMTs that incorporate a standardized personnel admission mechanism, full-time training and exercise mechanism, diversified incentive mechanism, and multi-agent cooperation mechanism, etc.

Entrepreneurial bricolage and entrepreneurial performance: The role of business model innovation and market orientation.

Newly established enterprises in China face significant challenges and opportunities, with persistently high mortality rates. Navigating market challenges and establishing sustainable competitive advantages are pressing issues for contemporary businesses. This study delves into the bridging role of business model innovation between entrepreneurial bricolage and entrepreneurial performance, with market orientation influencing the relationship boundaries. We examined 288 Chinese small and medium-sized enterprises, investigating the relationships among entrepreneurial bricolage, business model innovation, market orientation, and entrepreneurial performance. Empirical results indicate: (1) Entrepreneurial bricolage positively influences business model innovation, and business model innovation positively impacts entrepreneurial performance. (2) Business model innovation plays a fully mediating positive role between entrepreneurial bricolage and entrepreneurial performance. (3) Market orientation positively moderates the impact of entrepreneurial bricolage on business model innovation and entrepreneurial performance, and it also positively moderates the impact of business model innovation on entrepreneurial performance. (4) Market orientation positively moderates the impact of entrepreneurial bricolage, mediated by business model innovation, on entrepreneurial performance. The study results contribute to a more effective understanding of the mechanisms through which entrepreneurial bricolage and business model innovation influence entrepreneurial performance, as well as how market orientation moderates their relationships and how enterprises sustain competitive advantages.

Exploring feminist political economy and feminist critical discourse analysis as methodologies in critical nursing research.

AIMS: This paper explores two critical feminist methodologies for nursing research: feminist political economy and feminist critical discourse analysis. The aim was to appreciate varied methodological approaches available for nurses to understand complexities in healthcare environments, above and beyond socially normative ways of knowing. DESIGN: Discursive paper. DATA SOURCES: Published articles from nursing databases (CINAHL and ProQuest; no date restrictions) and interdisciplinary databases (Women's Studies International, Sociological Abstracts and Ovid MEDLINE; publication dates between 2017 and 2022). METHODS: A discursive paper exploring and critically synthesizing the literature on feminist political economy and feminist critical discourse analysis to demonstrate how each methodological approach can be used in nursing. RESULTS: The findings of this discursive paper suggest there is an opportunity to draw on interdisciplinary studies for creative insights into how these methodologies may be helpful for nurses' scholarship and programmes of research. Although few nursing studies explicitly name a feminist political economy or feminist critical discourse analysis approach, several studies apply principles of these methodological approaches. CONCLUSION: There is an opportunity for these methodologies to be applied within the same project when there is a fit between the research questions and aims of both methodologies (studies where notions of gender and power are considered central and there are potential insights from exploring social progress, structures and the material, along with the social relations of discourses). IMPLICATIONS FOR THE PROFESSION AND/OR PATIENT CARE: Feminist political economy and feminist critical discourse analysis offer novel options for methodological analyses. IMPACT: Application of these methodologies may benefit critical nursing scholars looking for diverse critical methodological avenues to explore and to broaden nursing's methodological toolbox towards meeting social justice aims. PATIENT OR PUBLIC CONTRIBUTION: No patient or public contribution.

Bricolage as an expression of self and of cultural and familial foodways among people living in prison-'You make what you can with anything you can get'.

In this article, we use Lévi-Strauss's (1962, The savage mind, University of Chicago Press) concept of 'bricolage' to explore informal food preparation among men in Scottish prisons. The art of 'making do with whatever is at hand', in innovative and creative ways, to give new functions to everyday items has recently been reimagined and applied to the field of food. It has been used to explore the practice of informal food networks in resource poor environments; investigate how small food businesses come up with new and innovative recipes ideas; and study the way Michelin-starred chefs responded to the COVID-19 pandemic through philanthropic activities. Our aim is to use bricolage as a lens through which to answer questions about whether more autonomy over food might contribute to overall health and wellbeing in prisons. Drawing on in-depth empirical data from qualitative interviews with 20 men in Scottish prisons, we explore how bricolage is used to escape the monotony of prison-issued meals and the tedium of the prison regime; counter threats to self and identity; create and maintain social relationships through joint enterprise and commensality; and create culinary experiences that afford a sense of control and normality in an environment synonymous with 'spoiled identity' (Goffman, 1961, Asylums: Essays on the social situation of mental patients and other inmates, Penguin.).

Resource Scarcity and Humanitarian Social Innovation: Observations from Hunger Relief in the Context of the COVID-19 Pandemic.

Humanitarian social enterprises (HSEs) are facing mounting pressure to incorporate social innovation into their practice. This study thus identifies how HSEs leverage organizational capabilities toward developing social innovation. Specifically, it considers how resource scarcity and operating circumstances affect the capabilities used by HSEs for developing social innovation, using a longitudinal case study approach with qualitative data from 12 hunger-relief HSEs operating in the United States. Based on 59 interviews with 31 managers and directors and related documents, several propositions are posited. The findings suggest that resource availability (i.e., scarcity vs. abundance) leads some HSEs to focus on developing social innovation using their collaborative capabilities, while others leverage their absorptive capacity. Further, HSEs adjust their approach to developing social innovation based on whether they are operating in ordinary circumstances (i.e., before the COVID pandemic) or extraordinary ones (i.e., during the COVID pandemic). Interestingly, the findings suggest that the organizational capabilities used by HSEs are adjusted as these enterprises become more familiar with extraordinary operating circumstances. For example, at the onset of the COVID-19 pandemic, resource-scarce HSEs focused on parallel bricolage to develop social innovation. Subsequently, they focused on selective bricolage. The findings offer novel insights by relating the social innovation of social enterprises to crisis management. Supplementary Information: The online version contains supplementary material available at 10.1007/s10551-021-05014-9.

Momentum lost or creating new constellations? Insights from an exercise-at-work project during the COVID-19 pandemic - a mixed methods approach.

Exercise-at-work programmes have been identified as venues to decrease inequalities in physical activity and exercise between socioeconomic groups and to improve employees' health and wellbeing. Drawing on a multiple institutional logics perspective and adopting a mixed-methods approach, this paper investigates how employees, exercise-ambassadors and managers at five Danish workplaces experience Covid-19 induced changes to a 1-year exercise-at-work project, and how these changes impacted upon the workplace. Our results suggest that Covid-19 and the altered format of exercise and delivery polarized employees' opportunities for exercise at work. However, the generally positive experiences of exercise-at-work activities and their influence on social environment and collaboration (identified prior to Covid-19 lockdown) remained among those employees who continued with activities. Self-organized adaptions and models of employee exercise which emerged suggest that community logic endured despite the crisis. We show how Covid-19 induced organizational changes led to interplays between institutional logics, with family and state logics becoming more prominent. Specifically, the exercise-at-work programme changed from an aligned model, with complementary logics and minimal conflict, to a model where logics of profession and corporation became dominant at the expense of community logic (exercise-ambassadors activities), but constrained by a state and a family logic.

Executive cognitive ability and business model innovation in start-ups: The role of entrepreneurial bricolage and environmental dynamism.

Extant literature suggested that executive cognitive ability is a critical perspective to answering why and how enterprises perform business model innovation. However, the effect of executive cognitive ability on business model innovation is still insufficiently explored. Drawing on entrepreneurial bricolage theory, we developed a moderated mediation model which takes entrepreneurial bricolage as the mediating mechanism and environmental dynamics as the moderating mechanism to explain how executive cognitive ability influences business model innovation. We collected the data of 316 executives of Chinese start-ups through questionnaires for the model test. Results showed that new venture executives' cognitive ability significantly positively affects business model innovation by mediating with entrepreneurial bricolage. Environmental dynamism positively moderates the effect of executives' cognitive ability on business model innovation. Moreover, environmental dynamism positively moderates the mediating role of entrepreneurial bricolage in executive cognitive ability and business model innovation. This study broadens the research scope of entrepreneurial bricolage theory from the perspective of cognitive ability and provides ideas for new ventures' business model innovation.

A Study From a Psychological Perspective of High Performance to Explore the Relationship Among Resource Bricolage, Social Capital, Entrepreneurial Attitude, and Intention.

COVID-19 caused a serious increase in competition due to limited resources. Obviously, it influenced the entrepreneurs' motivation. The entrepreneurial intention, social capital, and resource bricolage ability of individuals were important issues. Thus, exploring an individual's mindset from a psychological perspective of high performance was the advanced issue to deal with social capital promotion. This study developed an instrument adapted from related scales that consisted of 27 items and four factors: social capital, entrepreneurial attitude, resource bricolage, and entrepreneurial intention. The data was collected through an online survey in China and Taiwan by purposive sampling. A total of 692 valid samples provided data for the statistical process. A multiple regression technique was employed in the data process. The instrument passed the validity and reliability test. Data analysis results showed that social capital can positively predict entrepreneurial attitude and entrepreneurial intention. Furthermore, entrepreneurial attitude will affect entrepreneurial intention dramatically. Yet, resource bricolage ability has no moderating effect on social capital and entrepreneurial intention. In addition, resource bricolage ability plays a moderating role between entrepreneurial attitude and entrepreneurial intention. Moreover, it was found that participants demonstrated a high entrepreneurial intention when there was a high entrepreneurial attitude with high resource bricolage ability when the moderating effect was examined. In this study, some practical suggestions are provided for researchers, educators, and entrepreneurs.

The Impact of Resource Bricolage on Entrepreneurial Orientation in Start-ups: The Moderating Roles of TMT Heterogeneity and TMT Behavioral Integration.

Prior studies demonstrate the role of resources in shaping a firm's entrepreneurial orientation from the resource-based view. We expand this line of research by theorising and testing the impact of resource bricolage on entrepreneurial orientation. Based on the data of 295 start-ups, we find that when start-ups face resource constraints, the strategy of resource bricolage has a significant positive effect on entrepreneurial orientation, and the relationship is positively moderated by top management team (TMT) heterogeneity. Meanwhile, the relationship is negatively moderated by TMT behavioral integration. The results are expected to provide theoretical guidance for start-ups to overcome resource constraints and achieve smooth survival and growth.

The Effect of Big Data Analytics Capability on Competitive Performance: The Mediating Role of Resource Optimization and Resource Bricolage.

Although big data analytics capability (BDAC) leads to competitive performance, the mechanism of the relationship is still unclear. To narrow the research gap, this paper investigates the mediating roles of two forms of resource integration (resource optimization and resource bricolage) in the relationship between two forms of BDAC [big data analytics (BDA) management capability and BDA technology capability] and competitive performance. Supported by Partial Least Squares-Structural Equation Modeling (PLS-SEM) and the cross-sectional survey data from 219 Chinese enterprises, the results show that the resource bricolage plays a significantly mediating role in the relationships between BDA management capability and competitive performance as well as in the relationship between BDA technology capability and competitive performance. Furthermore, the mediating effect in the former relationship is stronger than that in the latter relationship. Additionally, BDA technology capability only has a direct effect on resource bricolage, while BDA management capability has a stronger effect on resource optimization than that on resource bricolage. Finally, resource bricolage has a stronger impact on competitive performance than resource optimization. These findings contribute to understanding how enterprises could apply different forms of BDAC to other kinds of resource integration to achieve outstanding competitive performance.

Developing Social Entrepreneurship Orientation: The Impact of Internal Work Locus of Control and Bricolage.

Using core self-evaluation theory, the current study assesses the effect of internal work locus of control and bricolage on social entrepreneurship orientation. We adopted the cross-sectional survey design using a sampling frame to engage 400 top executives of social enterprises in mainland China. Three hundred and seventy-two of the executives replied, presenting a response rate of 93%. Results of structural equation modeling analysis show significant positive relationships between internal work locus of control, bricolage, and social entrepreneurship orientation. The positive mediating effect of bricolage on the relationship between internal work locus of control and social entrepreneurship orientation was also found to be true. Consequently, to foster social entrepreneurship orientation, top executives of social enterprises need to gather available resources for bricolage tasks. These findings contribute new knowledge to how internal work locus of control affects social entrepreneurship orientation through the bricolage activity of Chinese social enterprises. Through core self-evaluation theory, we demonstrate the effect of internal work locus of control as a preceding factor in the relationship between bricolage and social entrepreneurship orientation.

Correlations of Resource Bricolage and Exaptation With Low-Cost Breakthrough Innovations: Moderating Effect of Organizational Agility.

The mechanism influencing resource bricolage driving low-cost breakthrough innovations remains unclear. By introducing exaptation and organizational agility, this study creates a regulated mediation model, explores effects of resource bricolage on low-cost breakthrough innovations, and analyzes the moderating effect of organizational agility and mediation effect of exaptation. The results revealed that resource bricolage exerted a significant positive impact on low-cost breakthrough innovations, and exaptation played a mediation role between resource bricolage and low-cost breakthrough innovations. In addition, both marketing agility and operational agility positively regulated the correlation between resource bricolage and exaptation. Further research revealed that the mediation effect of exaptation was positively regulated by marketing agility and operational agility, respectively. Overall, this study enriches the discussion of the impact mechanism of breakthrough innovations by resource bricolage and provides valuable enlightenment for enterprises to implement innovation-driven development strategies in the context of economic transformation.

Impact of different types of entrepreneurial alertness on entrepreneurial opportunities identification.

In the context of resource constraints, how different dimensions of entrepreneurial alertness affect the entrepreneurial opportunity recognition of new ventures is an important issue worth studying. From entrepreneurial cognition theory and bricolage theory perspectives, we systematically investigate the intrinsic relationships among entrepreneurial alertness, entrepreneurial bricolage, entrepreneurial passion, and entrepreneurial opportunity recognition. Further, it explored the intrinsic mechanism of role in exploring entrepreneurial opportunity recognition. This study applied stepwise regression analyses and the Bootstrap method to test the hypotheses on a sample of 295 questionnaires of the new venture. The findings revealed that entrepreneurial alertness is positively related to entrepreneurial opportunity recognition. Entrepreneurial bricolage is positively related to entrepreneurial opportunity recognition. Entrepreneurial bricolage partially mediates between entrepreneurial alertness and entrepreneurial opportunity recognition. Entrepreneurial passion positively moderates the relationship between entrepreneurial bricolage and entrepreneurial opportunity identification. The study guides new ventures to enhance entrepreneurial alertness and reasonably use entrepreneurial bricolage to explore entrepreneurial opportunities.

Le savoir y faire de la gambiarra / O saber saber fazer da gambiarra / The applied know-how of the workaround

Pour discuter le thème plus général de l'invention qui se présente dans la clinique psychanalytique, cet article propose de penser la question des solutions de contournement comme des cas particuliers d'invention marqués par la dimension de la précarité. Cette précarité nous intéresse dans la mesure où elle nous permet d'accéder à une lecture non idéalisée de ce que Lacan formule comme invention sur le destin donné au symptôme dans le terme d'une psychanalyse, qui serait une manière de faire avec quelque chose pour laquelle il n'y a pas de programmation symbolique définie. Dans cette perspective, nous pensons que la pratique du psychanalyste actualise le bricolage de la solution de contournement comme une fuite vers la singularité inventive.

Visando discutir o tema mais geral da invenção que se apresenta no âmbito da clínica psicanalítica, este trabalho propõe pensar a questão da gambiarra como um caso particular de invenção marcada pela dimensão da precariedade. Essa precariedade interessa na medida em que nos permite alcançar uma leitura não idealizada do que Lacan formula como invenção acerca do destino dado ao sintoma no termo de uma psicanálise, que seria um modo de se haver com algo para o qual não se dispõe de uma programação simbólica definida. Nessa perspectiva, acreditamos que a prática do psicanalista atualiza a bricolagem da gambiarra como um escape para a singularidade inventiva.

In order to discuss the more general theme of the invention that presents itself in the scope of psychoanalytic clinic, this work propose to think about the issue of the workaround as a particular case of invention marked by the dimension of precariousness. This precariousness is of interest hereto the extent that it allows us to achieve a non-idealized reading of what Lacan formulates as an invention to describe the destiny given to the symptom at the end of a psychoanalysis, which would be a way of dealing with something for which there is no predefined symbolic setting. From this perspective, we believe that the psychoanalyst's practice updates the DIY aspect of the workaround as an escape towards the inventive singularity.

Spiritual Inspiration of Village Cadres and Inclusive Innovation of Bricolage in Rural Autonomy in China.

In the rural autonomous context of China, inclusive innovation of bricolage is a widespread phenomenon. However, the existing research rarely considers villagers as the main actors of innovation. In a research survey of 23 provinces in China, we studied the internal mechanism of inclusive innovation of bricolage. We found that the spiritual inspiration of the village cadres is positively related to inclusive innovation of bricolage behavior of villagers. Moreover, the results revealed that affective commitment to the village of the villagers plays a mediating role in the relationship between the spiritual inspiration of the village cadres and inclusive innovation of bricolage behavior of villagers. In addition, our findings reveal that resilience of villagers plays a moderating role in the relationship between the spiritual inspiration of the village cadres and inclusive innovation of bricolage behavior of villagers.

Inovação e bricolagem sociais com intermediação após um desastre em Córrego d'Antas / Innovación y bricolaje sociales con intermediación después de un desastre en Córrego d'Antas / Social innovation, social bricolage, and brokerage after a disaster in Córrego d'Antas

Resumo Estudamos como uma comunidade brasileira respondeu a um desastre com várias inovações sociais (IS) propiciadas por bricolagem social e intermediação com stakeholders. O artigo busca explicar tais processos e sua inter-relação. A abordagem metodológica foi majoritariamente indutiva, utilizando entrevistas abertas e semiestruturadas e análise documental, além da experiência do autor principal, que residiu na localidade antes, durante e após o desastre. Nossos resultados sugerem que este abalou o equilíbrio social da comunidade de diversas maneiras e desencadeou ondas subsequentes de IS ligadas a bricolagem social e intermediação, as quais se amenizaram parcialmente ao longo do tempo. A originalidade e o valor do artigo derivam do contexto único e negligenciado de recuperação pós-desastre em um país emergente e da aplicação de avanços na conceitualização da intermediação e de sua relação com a bricolagem social e a IS.

Resumen Estudiamos cómo una comunidad brasileña respondió a un desastre con varias innovaciones sociales (IS) propiciadas por el bricolaje social y la intermediación con stakeholders. El artículo busca explicar tales procesos y su interrelación. El enfoque metodológico fue principalmente inductivo, utilizando entrevistas abiertas y semiestructuradas y análisis documental, además de la experiencia del autor principal que residió en la localidad antes, durante y después del desastre. Nuestros resultados sugieren que dicho acontecimiento afectó el equilibrio social de la comunidad de diversas maneras y desencadenó oleadas subsiguientes de IS relacionadas con el bricolaje social y la intermediación que se atenuaron parcialmente con el tiempo. La originalidad y el valor del artículo derivan del contexto único y de abandono de recuperación posdesastre en un país emergente y de la aplicación de avances en la conceptualización de la intermediación y de su relación con el bricolaje social y la IS.

Abstract We studied how a Brazilian community responded to a disaster using social innovations (SI) developed based on social bricolage and brokerage with stakeholders. The paper seeks to explain these processes and their interrelation. The methodological approach was primarily inductive, using semi-structured and open-ended interviews, document analysis, and the residential experience of the senior author before, during, and after the disaster. Our results suggest that the disaster upset the social balance of the community in several ways and triggered waves of subsequent SI related to social bricolage and brokerage that faded somewhat over time. Originality and value of the paper derive both from the unique and neglected context of post-disaster recuperation in a developing country and from the application of advances in the conceptualization of brokerage and its relation to social bricolage and SI.