Regional disparities in primary cesarean delivery rates in Japan: the role of obstetrician availability.

Background: The prevalence of cesarean section procedures is on the rise worldwide, necessitating a deeper understanding of the factors driving this trend to mitigate potential adverse consequences associated with unnecessary cesarean section deliveries. Objectives: This study aims to investigate the rate of primary cesarean deliveries (PCD), a potential key indicator of obstetric care quality. Study Design: A national retrospective cohort study was conducted utilizing extensive data from the National Database of Health Insurance Claims and Specific Health Checkups of Japan spanning the years 2012 to 2018. The study examined the temporal trends in PCD rates and the indications for these procedures across different prefectures. Additionally, the study employed the obstetrician disproportionality index, as published by the Ministry of Health, Labour, and Welfare, to assess the influence of obstetrician availability on PCD rates. Results: Throughout the study period from 2012 to 2018, the rate of PCD in Japan remained relatively stable at approximately 14%. The primary indications for PCD in 2018 included labor arrest (18.3%), malpresentation (16.5%), nonreassuring fetal status (6.5%), and macrosomia (6.0%). Substantial regional disparities in PCD rates were observed, ranging from 8.9% to 20.4% among prefectures in 2018. Notably, prefectures categorized in the bottom 10 of the obstetrician disproportionality index exhibited significantly higher PCD rates compared to the top 10 prefectures (P=.0232), with a similar trend noted for PCD due to labor arrest (P=.0288). Furthermore, a negative correlation was identified between the obstetrician disproportionality index and PCD rates at the prefectural level (r=-0.3119, P=.0328). Conclusions: Our study presents a comprehensive analysis of PCD rates in Japan, shedding light on regional disparities and highlighting the notable influence of obstetrician availability on clinical decision-making. This study contributes to the ongoing discourse on the escalating global trend in cesarean sections and the importance of healthcare resource allocation in maternal care.

Factors Affecting Elective and Non-elective Cesarean Sections: A Multinomial Regression Analysis Using Robson's Classification in a Southeast European Country.

BACKGROUND: Albania, a middle-income Southeast European country, is experiencing an increase in cesarean section rates. This study aims to analyze cesarean section practices in Albania using the Robson classification to identify patterns and provide insights into elective and non-elective cesarean trends. METHODS: This retrospective cohort study was conducted at the University Hospital of Obstetrics and Gynecology "Koco Gliozheni" in Albania, a leading tertiary hospital, from January to May 2023, involving 5,315 consecutive women who delivered during this period, including both live births and stillbirths, with a gestational age minimum of 28 weeks to align with standards of viability. We defined a function to systematically evaluate each case based on multiple criteria: parity, fetal presentation, onset of labor, previous deliveries, number of fetuses, and gestational age according to the Robson classification. Multinomial multiple regression was used to estimate the relationship between each of the above-mentioned variables and the likelihood of each type of cesarean delivery compared to normal births. RESULTS: The participants' mean age was 28.2 years (59.6% <30 years vs. 40.4% ≥30 years), while gestational age varied (12.1% before 37 weeks, the majority (72.3%) between 37 and 40 weeks, and 15.6% > 40 weeks). In elective cesarean sections, maternal age (odds ratio (OR) = 1.06) and gestational age (OR = 1.13) were associated with increased odds, with women with previous cesarean deliveries showing significantly higher odds (OR = 20.6), breech position (OR = 15.7), and multiple pregnancies elevating odds (OR = 7.3), whereas in non-elective cesarean sections, similar associations were observed with slightly different odds ratios which were maternal age (OR = 1.07), gestational age (OR = 1.16), previous cesarean delivery (OR = 6.3), breech position (OR = 8.5), and multiple pregnancies (OR = 5.1). Significant disparities in cesarean section rates were observed across various groups, with rates ranging from as low as 0.74% in Group 1 to as high as 89.24% in Group 5, and notable contributions from Group 2 with a rate of 69.95% and Group 6 with a rate of 81.29%. CONCLUSION: In conclusion, this study emphasizes the significance of factors such as maternal age, gestational age, previous cesarean deliveries, fetal presentation, number of fetuses, and multiple pregnancies in impacting the rates of elective, non-elective, and overall cesarean sections in Albania, highlighting the need for targeted strategies to improve maternal and fetal health outcomes.

Quantitative and calculated estimated blood loss in cesarean deliveries for twin and singleton pregnancies: a retrospective analysis.

PURPOSE: This study retrospectively assessed blood loss during cesarean deliveries for twin and singleton pregnancies using two distinct methods, quantitative estimation measured during cesarean sections and hematocrit-based calculated estimation. METHODS: We included scheduled cesarean deliveries for twin or singleton pregnancies at ≥ 34 weeks of gestation. Quantitative blood loss was recorded based on the blood volume in the graduated collector bottle and by weighing the blood-soaked textiles during cesarean sections. The blood loss was calculated using the change in hematocrit levels before and after the cesarean delivery. RESULTS: We evaluated 403 cases including 44 twins and 359 singletons. Quantitative blood loss during cesarean section was significantly higher in twin pregnancies than that in singleton pregnancies (1117 [440] vs 698 [378] mL; p < 0.001). However, no significant differences were observed in the calculated blood loss between the two groups on the day after delivery (487 mL [692 mL] vs 507 mL [522 mL]; p = 0.861). On post-delivery days 4-5, twin pregnancies were associated with a significantly higher calculated blood loss than singleton pregnancies (725 [868] mL vs 444 [565] mL, p = 0.041). Although a significant moderate correlation between quantitative and calculated blood loss was observed in singleton pregnancies (r = 0.473, p < 0.001), no significant correlation was observed between twin pregnancies (r = 0.053, p = 0.735). CONCLUSION: Quantitative blood loss measurements during cesarean section may be clinically insufficient in twin pregnancies. Incorporating blood tests and continuous assessments are warranted for enhanced blood loss evaluation, especially in twin pregnancies, owing to the risk of persistent bleeding.

The effect of cesarean section on the dimensions and ratios of mons pubis.

BACKGROUND: Pregnancy and labor can impact women's body contours. After a cesarean section, some women may experience aesthetic issues such as the formation of a panniculus and a bulging mons pubis. This study aimed to investigate the impact of cesarean sections on the dimensions of the mons pubis and their ratios. METHODS: The study included 194 multiparous Caucasian women. Participants' ages ranged from 18 to 40 years, and their BMI ranged from 18 to 30. They were divided into two BMI groups. Each group was further subdivided based on the mode of delivery into vaginal delivery (VD) and cesarean section (CS) groups. Manual measurements of the three dimensions of the mons pubis (monal height, monal width, and monal length) were conducted. Measurements were recorded in centimeters in the lithotomy position using iGaging 8-inch digital outside calipers. Monal height is the distance between the anterior surface of the symphysis pubis and the maximum height of the mons pubis (calculated by measuring the distance between the anterior wall of the vagina and the maximum height of the mons pubis minus the distance between the anterior wall of the vagina and the anterior surface of the symphysis pubis). Monal width is the maximum transverse distance between the merging borders of the mons pubis and the fat of the lower abdominal wall. Monal length is the maximum longitudinal distance between the merging upper border of the mons pubis and the fat of the lower abdominal wall and the upper end of the pudendal cleft. RESULTS: No significant statistical difference was observed between the three dimensions of the mons pubis in vaginal delivery and cesarean section populations in the two groups. The changes in the ratios between the two groups' different monal dimensions in the cesarean section population are minimal and do not follow a consistent pattern. There were no significant differences between the dimensions of single and repeated CS populations, with non-trendy changes in the different ratios in the repeated CS group. CONCLUSION: Even when repeated, cesarean section minimally affects the dimensions and ratios of the mons pubis. However, more studies with standardized fascial and subcutaneous fat closure are needed.

Exploring functional metabolites and proteomics biomarkers in late-preterm and natural-born pigs.

Introduction: Pigs are often used to study the intestinal development of newborns, particularly as preterm pig models that mimic the intestinal growth of human preterm infants. Neonatology's study of delivery mode's impact on neonatal development is crucial. Methods: We established 14 newborn pigs delivered via cesarean sections (C-section, at 113 days of gestational age, CS group) and 8 naturally born pigs were used as controls (at 114 days of gestational age, NF group). The impact of two alternative delivery procedures (C-section and natural birth) on the levels of short-chain fatty acids (SCFAs) and organic acids in the hepatic and intestines of newborn pigs were compared using metabolomics. The underlying molecular pathways are examined at the "protein-metabolite" level by integrating proteomic data. Results: The findings demonstrated that the mode of delivery changed the metabolism of SCFAs in newborn pigs, perhaps by affecting the physiology levels of cyclic intermediates such as lactate and malate in the pyruvate metabolic pathway. Additionally, by participating in the fatty acid metabolism pathway, two distinct proteins (FASN and HSD17B4) may impact the physiological concentration of these tiny metabolites. Discussion: In conclusion, this study provided reliable animal model data for understanding the physiological SCFA metabolic information and its affecting mechanism of large-gestational age preterm infants.

Trends and Inequalities in Maternal and Newborn Health Services for Unplanned Settlements of Lusaka City, Zambia.

Living conditions and other factors in urban unplanned settlements present unique challenges for improving maternal and newborn health (MNH), yet MNH inequalities associated with such challenges are not well understood. This study examined trends and inequalities in coverage of MNH services in the last 20 years in unplanned and planned settlements of Lusaka City, Zambia. Geospatial information was used to map Lusaka's settlements and health facilities. Zambia Demographic Health Surveys (ZDHS 2001, 2007, 2013/2014, and 2018) were used to compare antenatal care (ANC), institutional delivery, and Cesarean section (C-section) coverage, and neonatal mortality rates between the poorer 60% and richer 40% households. Health Management Information System (HMIS) data from 2018 to 2021 were used to compute service volumes and coverage rates for ANC1 and ANC4, and institutional delivery and C-sections by facility level and type in planned and unplanned settlements. Although the correlation is not exact, our data analysis showed close alignment; and thus, we opted to use the 60% poorer and 40% richer groups as a proxy for households in unplanned versus planned settlements. Unplanned settlements were serviced by primary centers or first-level hospitals. ZDHS findings show that by 2018, at least one ANC visit and institutional delivery became nearly universal throughout Lusaka, but early and four or more ANC visits, C-sections, and neonatal mortality rates remained worse among poorer than richer women in ZDHS. In HMIS, ANC and institutional delivery volumes were highest in public facilities, especially in unplanned settlements. The volume of C-sections was much greater within facilities in planned than unplanned settlements. Our study exposed persistent gaps in timing and use of ANC and emergency obstetric care between unplanned and planned communities. Closing such gaps requires strengthening outreach early and consistently in pregnancy and increasing emergency obstetric care capacities and referrals to improve access to important MNH services for women and newborns in Lusaka's unplanned settlements.

Trial of labor versus elective cesarean delivery for patients with two prior cesarean sections: a systematic review and meta-analysis.

OBJECTIVE: Cesarean section (CS) rates have been on the rise globally, leading to an increasing number of women facing the decision between a Trial of Labor after two Cesarean Sections (TOLAC-2) or opting for an Elective Repeat Cesarean Section (ERCS). This study evaluates and compares safety outcomes of TOLAC and ERCS in women with a history of two previous CS deliveries. METHODS: PubMed, MEDLINE, EMbase, and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched for studies published until 30 June 2023. Eligible studies were included based on predetermined criteria, and a random-effects model was employed to pool data for maternal and neonatal outcomes. RESULTS: Thirteen studies with a combined sample size of 101,011 women who had two prior CS were included. TOLAC-2 was associated with significantly higher maternal mortality (odds ratio (OR)=1.50, 95% confidence interval (CI)= 1.25-1.81) and higher chance of uterine rupture (OR = 7.15, 95% CI = 3.44-14.87) compared to ERCS. However, no correlation was found for other maternal outcomes, including blood transfusion, hysterectomy, or post-partum hemorrhage. Furthermore, neonatal outcomes, such as Apgar scores, NICU admissions, and neonatal mortality, were comparable in the TOLAC-2 and ERCS groups. CONCLUSION: Our findings suggest an increased risk of uterine rupture and maternal mortality with TOLAC-2, emphasizing the need for personalized risk assessment and shared decision-making by healthcare professionals. Additional studies are needed to refine our understanding of these outcomes in the context of TOLAC-2.

The effect of platelet-rich plasma on intra-abdominal adhesions in rabbit uterine horn model.

OBJECTIVE: This study was carried out to investigate the effect of autologous platelet-rich plasma (PRP) on intra-abdominal adhesion at the cesarean section incision line in the uterus. MATERIAL AND METHODS: As experimental animals 16 white New Zealand rabbits, 5-months-old, unmated, were used. Animals were divided into two groups the control group and PRP application group. In each group, a transverse incision was made to the uterus to mimic the cesarean section and sutured. Relaparotomy was performed 21 days after the first operation. RESULTS: When the groups were evaluated in terms of inflammation, there was a significant difference between the two groups. When the groups were evaluated in terms of Mason's Trichrome staining and fibrosis, There was a significant difference between groups. When the groups were evaluated in terms of vascular endothelial growth factor-1, there was also a significant difference between the groups. In an experimental rabbit uterine horn adhesion model, PRP is effective in preventing post-operative adhesion formation. CONCLUSIONS: This result may guide clinical studies using autologous PRP to prevent post-operative adhesion formation after gynecological operations.

OBJETIVO: Este estudio se llevó a cabo para investigar el efecto del plasma rico en plaquetas (PRP) autólogo sobre la adhesión intraabdominal en la línea de incisión de la cesárea en el útero. MATERIAL Y MÉTODOS: Como animales de experimentación se utilizaron 16 conejos blancos de Nueva Zelanda, de 5 meses de edad, sin aparear. Los animales se dividieron en dos grupos como grupo de control y grupo de aplicación de PRP. En cada grupo, se hizo una incisión transversal al útero para imitar la cesárea y se suturó. La relaparotomía se realizó 21 días después de la primera operación. RESULTADOS: Cuando los grupos se evaluaron en términos de inflamación, hubo una diferencia significativa entre los dos grupos. Cuando los grupos se evaluaron en términos de tinción MT y fibrosis, hubo una diferencia significativa entre los grupos. Cuando los grupos se evaluaron en términos de VEGF-1, también hubo una diferencia significativa entre los grupos. En un modelo experimental de adherencia al cuerno uterino de conejo, el PRP es eficaz para prevenir la formación de adherencias posoperatorias. CONCLUSIONES: Este resultado puede guiar los estudios clínicos que utilizan PRP autólogo para prevenir la formación de adherencias postoperatorias después de operaciones ginecológicas.

Modelos de assistência e taxa de parto cesáreo/vaginal em hospitais com diferentes tipos de gestão: uma análise de 2558496 partos / Assistance models to parturition and cesarean rate in hospitals with different types of management: an analysis of 2558496 parturition

Objetivo: Descrever a tendência temporal no Município de São Paulo do parto cesáreo em relação ao parto vaginal, e sua distribuição por maternidades de diferentes tipos de gestão (pública, privada ou ensino/escola) a partir da observação dos dados do Sistema de Informação de Nascidos Vivos - SINASC. Métodos: trata-se de estudo descritivo, retrospectivo, com utilização de fonte secundária de dados, tendo como alvo os partos ocorridos em maternidades com gestão pública, privada e ensino/escola do Município de São Paulo. A casuística referiu-se à totalidade dos partos ocorridos entre os anos de 2003 e 2018. Foi proposto o cálculo da relação de partos cesáreos sobre os partos vaginais. Utilizou-se a Análise de Variância de Kruskall-Wallis com a finalidade de comparar as relações de partos cesáreos/vaginais de acordo com a gestão hospitalar. Resultados: a amostra se totalizou em 2.559.496 partos, sendo que a proporção de partos cesáreos foi de 31,7% (pública), 84,1% (privada) e 36,6% (ensino/escola), respectivamente. A relação de partos cesáreos/vaginais foi de 0.58 na gestão pública, 5.40 na gestão privada e 0.47 na gestão escolar (p<0,0001*). Quanto a mudança anual da taxa de parto cesáreo/vaginal observou-se uma relação temporal similar entre os anos de 2003 e 2018 [pública (0.40-0.51); privada (4.6-6.6); Escola/ensino (0.55-0.60)]. Conclusões: A relação parto cesário/ vaginal se diferenciou nas instituições com gestão pública e de ensino/escola da instituição privada (ocorre 10 vezes mais parto cesáreo nas instituições privadas) apresentando pequena variação neste cenário ao longo dos anos.

Objective: To describe the temporal trend in the city of São Paulo of cesarean delivery in relation to vaginal delivery, and its distribution among maternity hospitals of different types of management (public, private or teaching / school) from the observation of data from the Information System of Live Births - SINASC. Methods: This is a descriptive, retrospective study using a secondary data source, targeting deliveries in public, private and teaching / school maternity hospitals managed in the city of São Paulo. The series referred to all deliveries that occurred between 2003 and 2018. It was proposed to calculate the ratio of cesarean deliveries to vaginal deliveries. Kruskall-Wallis analysis of variance was used to compare cesarean / vaginal birth ratios according to hospital management. Results: the sample totaled 2,559,496 deliveries, and the proportion of cesarean deliveries was 31.7% (public), 84.1% (private) and 36.6% (teaching / school), respectively. The ratio of cesarean / vaginal deliveries was 0.58 in public management, 5.40 in private management and 0.47 in school management (p <0.0001 *). Regarding the annual change in cesarean / vaginal rate, a similar temporal relationship was observed between 2003 and 2018 [public (0.40-0.51); private (4.6-6.6); School / teaching (0.55-0.60)]. Conclusions: The relationship between cesarean section and vaginal delivery differed in publicly and teaching / school institutions of the private institution (there are 10 times more cesarean section in private institutions), showing little variation in this scenario over the years.

Induction of Labor using Misoprostol in a Tertiary Hospital in the Southeast of Brazil / Indução de parto utilizando misoprostol em um hospital terciário no sudeste do Brasil

Abstract Purpose To assess cases of labor induction with vaginal 25-μg tablets of misoprostol and maternal outcomes in a tertiary hospital in southeastern Brazil. Methods This was a retrospective cohort study of 412 pregnant women with indication for labor induction. Labor induction was performed with vaginal 25-μg tablets ofmisoprostol in pregnant women with Bishop scores < 6. Stepwise regression analysis was used to identify the factors present at the beginning of induction that could be used as predictors of successful labor induction. Results A total of 69% of the pregnant women who underwent labor induction progressed to vaginal delivery, and 31% of the women progressed to cesarean section. One or two misoprostol tablets were used in 244 patients (59.2%). Of the 412 patients, 197 (47.8%) required oxytocin later on in the labor process, after induction with misoprostol. The stepwise regression analysis showed that only Bishop scores of 4 and 5 and previous vaginal delivery were independent factors with statistical significance in the prediction of successful vaginal labor induction (β = 0.23, p < 0.001, for a Bishop score of 4 and 5, and β = 0.22, p < 0.001, for previous vaginal delivery). Conclusion Higher Bishop scores and previous vaginal delivery were the best predictors of successful labor induction with vaginal 25-μg tablets of misoprostol.

Resumo Objetivo Avaliar os casos de indução do trabalho de parto com misoprostol 25 mcg por via vaginal e seus desfechos maternos em um hospital terciário do Sudeste do Brasil. Métodos Realizou-se um estudo retrospectivo de coorte com 412 gestantes com indicações para indução de trabalho de parto. A indução do trabalho de parto foi realizada com misoprostol 25 mcg vaginal em gestantes com índice de Bishop < 6. Realizou-se análise de regressão stepwise para identificar os fatores presentes ao início da indução que poderiam ser usados como prognosticadores do sucesso da indução do trabalho de parto. Resultados A indução de trabalho de parto determinou 69% de partos normais, sendo que 31% evoluíram para cesárea. Em relação ao número de comprimidos de misoprostol, 1 ou 2 comprimidos foram utilizados em 244 pacientes (59,2%). Das 412 pacientes, 197 (47,8%) necessitaramde ocitocina após a indução commisoprostol para dar continuidade ao trabalho de parto. Na análise de regressão stepwise, apenas a presença de índice de Bishop 4 e 5 e parto vaginal prévio foram fatores independentes com significância estatística na predição do sucesso da indução emobter parto vaginal (β = 0,23, p < 0,001, para índice de Bishop 4 e 5, e β = 0,22, p < 0,001, para parto vaginal prévio). Conclusão Maiores índices de Bishop e parto vaginal prévio são os maiores prognosticadores do sucesso de indução de trabalho de parto com misoprostol 25 mcg vaginal.

Partos cesáreos e a escolha da data de nascimento no Município de São Paulo / Caesarean sections and the choice of date of birth in the Municipality of São Paulo, Brazil

O Brasil tem uma das maiores taxas de partos cesáreos do mundo, e esse valor tem aumentado anualmente. O presente estudo teve como objetivo analisar possíveis mudanças na data de nascimento decorrentes desse aumento. Foram obtidos os dados dos 1.933.137 nascidos vivos ocorridos no Município de São Paulo entre 2001 e 2010, divididos segundo tipo de parto e data exata de nascimento. Em 2001, a taxa de cesarianas foi de 48,9%, passando a 56,8% em 2010. O dia da semana com menor número de nascimentos (domingo) aumentou a diferença em relação aos outros dias de 111,4 (IC95%: 101,7 - 121,0) em 2001 para 143,1 (IC95%: 135,0 - 151,3) em 2010. Os dois dias com menos nascimentos (Natal e Dia de Finados), apresentaram diferença estatisticamente significativa em relação aos outros dias do ano (p < 0.05) durante praticamente todo o período (a exceção foi o Dia de Finados em 2009). A data com o maior número de nascimentos (Dia Internacional da Mulher) apresentou diferença significativa em 2005 e 2010. O aumento no número de partos cesáreos tem tido efeito significativo na data de nascimento, o que pode trazer consequências no planejamento administrativo de instituições de saúde.

Brazil has one of the highest rates of cesarean births, and the number has been growing annually. The scope of this study was to test the possible consequences arising from this increase on the date of birth. The 1,933,137 live births that occurred in São Paulo, Brazil, from 2001 to 2010 were analyzed by type of delivery and exact date of birth. In 2001, 48.9% of all births were by cesarean section, increasing to 56.8% in 2010. During th is period, the difference between the number of births occurring on Sundays (the day of the week with the lowest number) increased from 111.4 (95%CI: 101.7 - 121.0) in 2001, to 143.1 (95%CI: 135.0 - 151.3) in 2010. The two dates with the lowest number of births (Christmas day and the Day of the Dead), had a statistically significant (p < 0.05) difference from the other days of the year during most of the period (the exception being the Day of the Dead in 2009). The date with the highest number of births (International Women's Day) showed a statistically significant d ifference in 2005 and 2010. The increase in the number of cesarean births has had a significant impact on date of birth, which could have consequences for the administrative planning of health institutions.