[On the question of increasing the qualification of staff for the purposes of forensic-chemical and chemical-toxicological analysis: results of the questionnaire of expert chemists]. / K voprosu povysheniya kvalifikatsii kadrov dlya tselei sudebno-khimicheskogo i khimiko-toksikologicheskogo analiza: rezul'taty anketirovaniya khimikov-ekspertov.

Today, one of the most effective tools for high-quality training of specialists at the postgraduate level is continuous professional development (CPD). Additional professional education of specialists in the field of forensic chemical and chemical-toxicological analysis with higher non-medical education (pharmaceutical, chemical, biological) is carried out on the basis of pharmaceutical and medical higher educational institutions, autonomous non-profit organizations through the implementation of additional professional training programs. The timing, forms, content and technology of training by organizations implementing the corresponding educational program are of great importance. Analysis of the results of the questionnaire survey of expert chemists, carried out according to the original questionnaire in 2020-2021 in some regions of Russia, showed the main directions of development of the training system, forms and methods of teaching, the need to develop appropriate software.

[Analysis of the feasibility of a forensic chemical investigation in clobazam poisoning]. / Analiz vozmozhnosti provedeniya sudebno-khimicheskogo issledovaniya pri otravlenii klobazamom.

The study objective was to determine the relevance of methods to detect clobazam poisoning during the forensic and chemical toxicological examination. The lack of a systematic approach to clobazam identification and assay as a part of forensic chemical and chemical toxicological analyses was demonstrated. The published data on the study of clobazam in biological objects are inconsistent and incomplete, precluding the conduction of focused forensic chemical and toxicological investigations on biological objects with required validity. Various methods of forensic chemical and toxicological investigation of clobazam in biological objects were studied and presented. Data are presented on various physicochemical test methods (TLC, HPLC, UV spectrometry, GC, and GC-MS) for clobazam detection.

[On the issue of the detection of pregabalin and lorazepam in the cases of their joint presence for the purpose of chemical toxicological studies]. / Izuchenie pregabalina i lorazepama pri sovmestnom prisutstvii dlia tselei khimiko-toksikologicheskogo issledovaniia.

Data on the detection of joint presence of pregabalin and lorazepam in the biological objects and material evidence. Aim of this study is to develop a method of the detection of pregabalin and lorazepam in urine. The proposed approach to sample preparation of a biological object and the detection of lorazepam and pregabalin allows the detection of toxicants in cases of their joint presence. It can be used in the analysis of urine in cases of acute poisoning for detoxification therapy or chemical toxicological analysis as a preliminary and confirmatory study for the presence of abuse of these drugs.

[The choice of the conditions for the preparation of the pregabalin samples from the biological fluids with the use of the liquid-liquid and solid phase extraction techniques]. / Vybor uslovii probopodgotovki pregabalina iz biologicheskikh zhidkostei metodami zhidkost'-zhidkostnoi i tverdofaznoi ékstraktsii.

The objective of the present study was the development of the methods for the isolation and identification of pregabalin for the purpose of chemical toxicological analysis (CTA). The authors describe the methods used to obtain pregabalin from the model mixtures of urine and blood plasma with the use of liquid-liquid and solid phase extraction. In addition, a method for the quantitative determination of pregabalin by means of combined gas chromatography mass-spectrometry was applied.

[The distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organism of the warm-blooded animals after its intra-gastric administration]. / Raspredelenie 2-(dimetilamino)étil-(1-gidroksitsiklopentil)(fenil)atsetata v organizme teplokrovnykh zhivotnykh pri vnutrizheludochnom vvedenii.

The objective of the present study was to elucidate the distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organism of the warm-blooded animals after its intra-gastric administration. The methods applied in the study included thin layer chromatography in silicagel, aci-nitroprosalt staining reaction, UV-spectrophotometry,, and GC-mass spectrometry. The identification and the quantitation of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organs and blood of the warm-blooded animals were carried out within 20, 150, and 360 min after a single intra-gastric administration of 1300 ml of this poisonous substance. It was shown that the largest amounts of 2-(dimethylamino)ethyl-(1-hydrpxycyclopentyl)(phenyl)acetate at the above time-points were present in the tissue of the stomach and small intestine, brain, muscles, spleen, and lungs of the animals.

[The peculiar features of the distribution of 2-(dimethylamino)ethyl- (1-hydroxycyclopentyl) (phenyl) acetate in the organism of warm-blooded animals after its intravenous administration]. / Osobennosti raspredeleniia 2-(dimetilamino)étil-(1-gidroksitsiklopentil)(fenil)atsetata v organizme teplokrovnykh zhivotnykh pri vnutrivennom vvedenii.

The objective of the present study was to elucidate the dynamics of the distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl) acetate in the organism of warm-blooded animals (rats) after its intravenous administration to the animals. The identification and the quantitative determination of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl) acetate present in the organs and blood of the warm-blooded animals were carried out with the use of chromatography in a thin layer of silica gel, chromogenic reaction for the synthesis of the acinitro salt, UV spectrophotometry, and gas chromatography mass-spectrometry (GCh-MS). The quantitation was performed on days 5, 20, 150, and 360 minutes after the intravenous administration of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl) acetate to the rats. The maximum amounts of cyclopentolate were found in the spleen, brain, lungs, and heart of the experimental animals.