Case example of a female solo sailor competing in the Vendée Globe reveals extraordinary biological demands.

The Vendée Globe is a non-stop, unassisted, single-handed round the world sailing race. It is regarded as the toughest sailing race, requiring high cognitive functioning and constant alertness. Little is known about the amount of sleep restriction and nutritional deficit experienced at sea and effects that fatigue have on sailors' performance. This report aimed to investigate these aspects by monitoring one of the female participants of the latest Vendée Globe. Sleep, food intake and stress were self-reported daily using specific app. Cognitive assessments were digitally completed. Heart rate and activity intensity were measured using a wrist-worn wearable device. Mean self-report sleep duration per 24 h was 3 hours 40 minutes. By the end of the 95 race days, the sailor reached a caloric deficit of 27,900 kcal. On average, the sailor spent 50 minutes per day in moderate-to-vigorous activity. Cognitive assessments did not show any effect of fatigue or stress on completion time or performance. Recent technological and communication advancement for offshore sailors, enabled continuous data to be monitored in near real time, even from the Southern Ocean. Moving forward this will enable greater understanding of when sailors will be at risk of poor decision making, illness or injury.

From pole to pole, life-long research of sleep in extreme environments.

In November 1965, Michel Jouvet accepted me into his laboratory in Lyon as a medical student at a time when sleep research was an adventure. After 4 years of investigations in cats, I obtained my medical doctorate. Being a military physician, I was posted to Antarctica for wintering over and was initiated by Jean Rivolier into the psychology of small isolated human groups. I recorded 180 polysomnographic (PSG) nights in eight of my companions. This was my first contribution to research on human sleep under extreme environments and conditions. I then entered René Hénane's military thermophysiology laboratory, where I analyzed thermal exchanges during human sleep in the heat. Back to the cold, I spent 2 years in Canada and analyzed sleep during the Arctic winter under the direction of Manny W. Radomski, who headed the Defense and Civil Institute of Environmental Medicine and judged my PhD dissertation along with my first two mentors. Throughout my career, I worked in collaboration with Manny Radomski under the auspices of the Franco-Canadian Accord for Defence Research. We studied sleep and exercise, sleep deprivation, and recovery with and without chemical help. He also gave me support during several investigations in Africa. There, I studied normal sleep under various tropical climates (warm and dry in Niger, warm and humid in Côte d'Ivoire and Congo, temperate mid-mountain in Angola). I determined that human African trypanosomiasis, the ravaging sleeping sickness or tsetse disease, is not a hypersomnia, but a disorder of circadian rhythms, notably in the sleep-wake cycle.

Unveiling Antibacterial Potential and Physiological Characteristics of Thermophilic Bacteria Isolated from a Hot Spring in Iran.

The increasing worldwide demand for antimicrobial agents has significantly contributed to the alarming rise of antimicrobial resistance, posing a grave threat to human life. Consequently, there is a pressing need to explore uncharted environments, seeking out novel antimicrobial compounds that display exceptionally efficient capabilities. Hot springs harbor microorganisms possessing remarkable properties, rendering them an invaluable resource for uncovering groundbreaking antimicrobial compounds. In this study, thermophilic bacteria were isolated from Mahallat Hot Spring, Iran. Out of the 30 isolates examined, 3 strains exhibited the most significant antibacterial activities against Escherichia coli and Staphylococcus aureus. Furthermore, the supernatants of the isolated strains exhibited remarkable antibacterial activity, displaying notable resistance to temperatures as high as 75 °C for 30 min. It was determined that the two strains showed high similarity to the Bacillus genus, while strain Kh3 was classified as Saccharomonospora azurea. All three strains exhibited tolerance to NaCl. Bacillus strains demonstrated optimal growth at pH 5 and 40 °C, whereas S. azurea exhibited optimal growth at pH 9 and 45 °C. Accordingly, hot springs present promising natural reservoirs for the isolation of resilient strains possessing antibacterial properties, which can be utilized in disease treatment or within the food industry.

Elastic and piezoelectric properties of ß-glycine - a quantum crystallography view on intermolecular interactions and a high-pressure phase transition.

The effect of hydrostatic compression on the elastic and electronic properties of ß-glycine was studied using a quantum crystallography approach. The interrelations between the changes in the microscopic quantum pressure in the electronic continuum, macroscopic compressibility and piezoelectricity were considered. The geometries and energies of hydrogen bonds in the crystal structure of ß-glycine were considered as functions of pressure before and after a phase transition into the ß'-phase in relation to the mechanism of this phase transition.

Physical Mechanism of Selective Healing of Nanopores in Condensed Matter under the Influence of Laser Irradiation and Plasma.

The investigation of the features of laser control over the state of nanoscale objects in solid materials is an urgent task of condensed matter physics. We experimentally established the potential for the simultaneous enhancement of hardness and resistance to surface cracking in a titanium alloy due to selective laser irradiation. The regularities of selective heating near nanopores and the influence of the nanopore system on the features of isotherm propagation have been revealed. A physical model is proposed for the healing of nanopores situated in the surface layer of the sample. According to this model and as a result of laser irradiation and laser plasma, a brief transition of the material surface to extreme conditions is initiated.

Challenges and Advances in Rechargeable Batteries for Extreme-Condition Applications.

Rechargeable batteries are widely used as power sources for portable electronics, electric vehicles and smart grids. Their practical performances are, however, largely undermined under extreme conditions, such as in high-altitude drones, ocean exploration and polar expedition. These extreme environmental conditions not only bring new challenges for batteries but also incur unique battery failure mechanisms. To fill in the gap, it is of great importance to understand the battery failure mechanisms under different extreme conditions and figure out the key parameters that limit battery performances. In this review, the authors start by investigating the key challenges from the viewpoints of ionic/charge transfer, material/interface evolution and electrolyte degradation under different extreme conditions. This is followed by different engineering approaches through electrode materials design, electrolyte modification and battery component optimization to enhance practical battery performances. Finally, a short perspective is provided about the future development of rechargeable batteries under extreme conditions.

A review of the phosphorus removal of polyphosphate-accumulating organisms in natural and engineered systems.

Increasing eutrophication has led to a continuous deterioration of many aquatic ecosystems. Polyphosphate-accumulating organisms (PAOs) can provide insight into the human response to this challenge, as they initiate enhanced biological phosphorus removal (EBPR) through cyclical anaerobic phosphorus release and aerobic phosphorus uptake. Although the limiting environmental factors for PAO growth and phosphorus removal have been widely discussed, there remains a gap in the knowledge surrounding the differences in the type and phosphorus removal efficiencies of natural and engineered PAO systems. Furthermore, due to the limitations of PAOs in conventional wastewater treatment environments, there is an urgent need to find functional PAOs in extreme environments for better wastewater treatment. Therefore, it is necessary to explore the effects of extreme conditions on the phosphorus removal efficiency of PAOs as well as the types, sources, and characteristics of PAOs. In this paper, we summarize the response mechanisms of PAOs, denitrifying polyphosphate-accumulating organisms (D-PAOs), aerobic denitrifying polyphosphate-accumulating organisms (AD-PAOs), and sulfur-related PAOs (S-PAOs). The mechanism of nitrogen and phosphorus removal in PAOs is related to the coupling cycles of carbon, nitrogen, phosphorus, and sulfur. The genera of PAOs differ in natural and engineered systems, but PAOs have more diversity in aquatic environments and soils. Recent studies on the impact of several parameters (e.g., temperature, carbon source, pH, and dissolved oxygen) and extracellular polymer substances on the phosphorus removal efficiency of PAOs in natural and engineered systems are further discussed. Most of the PAOs screened under extreme conditions still had high phosphorus removal efficiencies (>80.0 %). These results provide a reference for searching for PAOs with different adaptations to achieve better wastewater treatment.

Experimental study on overtopping dam-break of a tailing reservoir under extreme conditions.

There is a high risk of dam breakage in tailing reservoirs under extreme conditions. Once a dam breaks, it causes serious pollution to the surrounding ecological environment. To explore the effects of a tailings dam break under extreme conditions (flood conditions, drainage failure, flood discharge failure, and dam saturation), the mechanism underlying an overtopping dam break must be accurately understood. In this study, fine-grained tailings and perlite were selected to create composite model sand, and a prototype tailing reservoir was restored at a scale of 1:200. Furthermore, the dam-break process and results were analyzed and summarized by performing an overtopping dam-break test on the tailing reservoir under extreme conditions. The results show that the tailing discharge process has a high sand content, strong sand-carrying capacity, and high speed. The amount of model sand discharge accounted for 15.13% of the total storage capacity, and the amount of tailings deposition in the downstream area accounted for 95.21% of the discharge, which were both greater than the results of similar physical model tests and actual tailings dam failure accidents. An overtopping dam break in a tailing pond is a progressively destructive process. The dam break mechanism can be divided into two stages: prior breach penetration and subsequent breach horizontal expansion. In the process of a tailings dam break, the motion state of the tailings particles is transformed between the bed-load and suspended-load movement states. These results can provide important reference for the reinforcement of mine management and the formulation of preventive measures, which are essential to improving the safety of tailings reservoirs and protecting the ecological environment.

Disrupted circadian rhythms in the plateau pika.

The plateau pika (Ochotona curzoniae) is the most populous mammal on the 'third pole', the Qinghai-Tibet Plateau, and is presumed to have inhabited the region before the plateau rose up from sea level. Herein we discuss the disrupted circadian rhythm in the plateau pika and the gene polymorphism behind this phenotype, placing these findings in the broader context of circadian rhythms under extreme conditions.

Magneto-Optical Sensing of the Pressure Driven Magnetic Ground States in Bulk CrSBr.

Competition between exchange interactions and magnetocrystalline anisotropy may bring new magnetic states that are of great current interest. An applied hydrostatic pressure can further be used to tune their balance. In this work, we investigate the magnetization process of a biaxial antiferromagnet in an external magnetic field applied along the easy axis. We find that the single metamagnetic transition of the Ising type observed in this material under ambient pressure transforms under hydrostatic pressure into two transitions, a first-order spin-flop transition followed by a second-order transition toward a polarized ferromagnetic state near saturation. This reversible tuning into a new magnetic phase is obtained in layered bulk CrSBr at low temperature by varying the interlayer distance using high hydrostatic pressure, which efficiently acts on the interlayer magnetic exchange and is probed by magneto-optical spectroscopy.

Incommensurate magnetic structure of CrAs at low temperatures and high pressures.

The magnetic structure of chromium arsenide CrAs is studied with neutron powder diffraction at ambient pressure in the temperature range 1.5-300 K as well as with neutron single-crystal diffraction at 2 K and 0.12 GPa. The material undergoes an anti-isostructural phase transition at TN = 267 K and atmospheric conditions, in which both orthorhombic phases have the same space-group symmetry (Pnma, Z = 4) but different distortions of the parent hexagonal structure of the NiAs type (P63/mmc, Z = 2). The magnetic structure below TN is incommensurate with the propagation vector k = (0, 0, kc). At ambient pressure, the component kc decreases from kc = 0.3807 (7) at 260 K to kc = 0.3531 (6) at 50 K. Below this temperature, it is basically constant. With increasing pressure at 2 K, kc is also constant within standard uncertainties [kc = 0.353 (2)]. For the analysis of the magnetic structure, a group-theoretical approach based on the space group of the nuclear structure and its subgroups is used. To avoid falling into false minima in the refinements, a random search for magnetic moments in the models is implemented. In the literature, the magnetic structure has been determined on the basis of powder diffraction data as a double helix propagating along the c axis. Although this double-helical model leads to satisfactory agreement factors for our powder data, it does not reproduce the intensities of the magnetic satellite reflections measured on single-crystal data in a satisfactory way and can therefore be discarded. Instead, several other models are found that lead to better agreement. Each of them is spiral-like with directional components in all three directions and with no spin-density wave character that would cause a non-constant magnetic moment. In all these models, the ordering of the spins is neither a pure helix nor a pure cycloid. Instead, the unit vectors of the spin rotation planes make an angle α, 0° < α < 90°, with respect to the c* direction. The model in superspace group P21.1'(α0γ)0s yields the best agreement factors in the refinements of the neutron single-crystal and powder diffraction data. This model is unique as it is the only one in which all the magnetic moments rotate with the same chirality.

Correction and integration of solid-angle data from the azimuthally resolving 2D detector at ID06-LVP, ESRF.

The unique diffraction geometry of ESRF beamline ID06-LVP offers continuous static 2D or azimuthally resolving data collections over all accessible solid angles available to the tooling geometry. The system is built around a rotating custom-built Pilatus3 CdTe 900k-W detector from Dectris, in a configuration equivalent to three butted 300k devices. As a non-standard geometry, here the method of alignment, correction and subsequent integration for any data collected over all solid angles accessible, or over any azimuthal range contained therein, are provided and illustrated by parameterizing and extending existing pyFAI routines. At 1° integrated intervals, and typical distances (2.0 m), the system covers an area of near 2.5 m2 (100 Mpx square equivalent), to 0.65 Šresolution, at 53 keV from a total dataset of some 312 Mpx. Standard FWHMs of SRM660a LaB6 vary from 0.005° to 0.01°, depending on beam size, energy and sample dimensions, and are sampled at an elevated rate. The azimuthal range per static frame ranges from <20° to ∼1° over the full range of the detector surface. A full 2θ-intensity data collection at static azimuth takes 1-3 s typically, and can be reduced to ms-1 rates for measurements requiring time-rate determination. A full solid-angle collection can be completed in a minute. Sample detector distances are accessible from 1.6 m to 4.0 m.

Exploring the length scales, timescales and chemistry of challenging materials (Part 1).

This themed issue explores the different length scales and timescales that determine the physics and chemistry of a variety of key materials, explored from the perspective of a wide range of disciplines, including physics, chemistry, materials science, Earth science and biochemistry. The topics discussed include catalysis, chemistry under extreme conditions, energy materials, amorphous and liquid structure, hybrid organic materials and biological materials. The issue is in two parts, with the present part exploring glassy and amorphous systems and materials at high pressure. This article is part of the theme issue 'Exploring the length scales, timescales and chemistry of challenging materials (Part 1)'.

A MHz X-ray diffraction set-up for dynamic compression experiments in the diamond anvil cell.

An experimental platform for dynamic diamond anvil cell (dDAC) research has been developed at the High Energy Density (HED) Instrument at the European X-ray Free Electron Laser (European XFEL). Advantage was taken of the high repetition rate of the European XFEL (up to 4.5 MHz) to collect pulse-resolved MHz X-ray diffraction data from samples as they are dynamically compressed at intermediate strain rates (≤103 s-1), where up to 352 diffraction images can be collected from a single pulse train. The set-up employs piezo-driven dDACs capable of compressing samples in ≥340 µs, compatible with the maximum length of the pulse train (550 µs). Results from rapid compression experiments on a wide range of sample systems with different X-ray scattering powers are presented. A maximum compression rate of 87 TPa s-1 was observed during the fast compression of Au, while a strain rate of ∼1100 s-1 was achieved during the rapid compression of N2 at 23 TPa s-1.

Efficient decolorization of melanoidin in raw molasses wastewater by thermophilic esterase in actual extreme conditions.

This work was developed to explore the versatility of thermophilic esterase for decolorizing raw molasses wastewater at high temperature and acidic pH. Combining covalent crosslinking method with deep eutectic solvent, a thermophilic esterase from Pyrobaculum calidifontis was immobilized on chitosan/macroporous resin composite carrier. The application of this immobilized thermophilic esterase eliminated 92.35% of colorants in raw molasses wastewater, achieving maximal decolorization efficiency across all the enzymes tested. Strikingly, this immobilized thermophilic esterase was capable of engaging in continuous activity for a 5-day period while removing 76.23% of pigments from samples. It effectively and continuously eliminated BOD5 and COD, effectively and directly facilitating raw molasses wastewater decolorization under extreme conditions more readily than control group. In addition, this thermophilic esterase was believed to achieve decolorization through an addition reaction that disrupted conjugated system of melanoidins. Together, these results highlight an efficient and practical means of achieving enzyme-based molasses wastewater decolorization.

Multi-Hazard Effects of Crosswinds on Cascading Failures of Conventional and Interspersed Railway Tracks Exposed to Ballast Washaway and Moving Train Loads.

The interspersed railway track is an enhanced timber railway track, spot-replacing damaged wooden sleepers with new concrete sleepers to improve the bearing capacity of existing railway lines. Although this interspersed solution is characterised by low cost and short maintenance time, the interspersed tracks have worse stability than concrete tracks and can deteriorate quickly when exposed to extreme weather conditions such as heavy rains and floods. In many cases, heavy rains and floods are accompanied by strong winds. Ballast washaway can often be observed under flood conditions while the mass of trains is unevenly distributed on two rails due to the effect of lateral wind load and rail irregularities. The current work is the first in the world to investigate the collective multi-hazard effects of ballast washway and uneven axle loads on the vulnerability of conventional and interspersed railway tracks using nonlinear FEM software, STRAND 7. The train bogie is modelled by two sets of point loads. The maximum displacement, bending moment and twists have been studied to evaluate the worst condition. The novel insights will help the railway industry develop proper operations of interspersed railway tracks against naturally hazardous conditions.

Ionic Liquid "Water Pocket" for Stable and Environment-Adaptable Aqueous Zinc Metal Batteries.

The strong reactivity of water in aqueous electrolytes toward metallic zinc (Zn), especially at aggressive operating conditions, remains the fundamental obstacle to the commercialization of aqueous zinc metal batteries (AZMBs). Here, a water-immiscible ionic liquid diluent 1-ethyl-3-methylimidazolium bis(fluorosulfonyl)amide (EmimFSI) is reported that can substantially suppress the water activity of aqueous electrolyte by serving as a "water pocket", enveloping the highly active H2 O-dominated Zn2+ solvates and protecting them from parasitic reactions. During Zn deposition, the cation Emim+ and anion FSI- function respectively in mitigating the tip effect and regulating the solid electrolyte interphase (SEI), thereby favoring a smooth Zn deposition layer protected by inorganic species-enriched SEI featuring high uniformity and stability. Combined with the boosted chemical/electrochemical stability endowed by the intrinsic merits of ionic liquid, this ionic liquid-incorporated aqueous electrolyte (IL-AE) enables the stable operation of Zn||Zn0.25 V2 O5 ·nH2 O cells even at a challenging temperature of 60 °C (>85% capacity retention over 400 cycles). Finally, as an incidental but practically valuable benefit, the near-zero vapor pressure nature of ionic liquid allows the efficient separation and recovery of high-value components from the spent electrolyte via a mild and green approach, promising the sustainable future of IL-AE in realizing practical AZMBs.

[Of neurological disorders in extreme conditions and emergency situations]. / Korrektsiya nevrologicheskikh narushenii v ekstremal'nykh usloviyakh i chrezvychainykh situatsiyakh.

The review examines the features of neurological disorders that develop in a contingent of people staying in war zones, extreme conditions and emergency situations. The structure of combat injuries is currently dominated by shrapnel and mine-explosive head injuries, craniocerebral trauma, compression and concussion of the brain. Traumatic wounds and features of military service in conditions of high risk and extreme physical exertion are accompanied by asthenia, cognitive disorders and mental disorders of varying severity. Substantiated is the use of Cortexin in craniocerebral and combined combat injuries received by military personnel and civilians in the centers of hostilities; with asthenic and anxiety-depressive disorders, cognitive impairment, sleep disorders, as well as to increase the body's resistance to adverse and extreme effects.

High-Pressure Tuning of Magnon-Polarons in the Layered Antiferromagnet FePS3.

Magnetic layered materials have emerged recently as promising systems to introduce magnetism in structures based on two-dimensional (2D) materials and to investigate exotic magnetic ground states in the 2D limit. In this work, we apply high hydrostatic pressures up to P ≈ 8.7 GPa to the bulk layered antiferromagnet FePS3 to tune the collective lattice excitations (phonons) in resonance with magnetic excitations (magnons). Close to P = 4 GPa, the magnon-phonon resonance is achieved, and the strong coupling between these collective modes leads to the formation of new quasiparticles, the magnon-polarons, evidenced in our low-temperature Raman scattering experiments by a particular avoided crossing behavior between the phonon and the doubly degenerate antiferromagnetic magnon. At the pressure-induced magnon-phonon resonance, three distinct coupled modes emerge. As it is mainly defined by intralayer properties, we show that the energy of the magnon is nearly pressure-independent. We additionally apply high magnetic fields up to B = 30 T to fully identify and characterize the magnon excitations and to explore the different magnon-polaron regimes for which the phonon has an energy lower than, equal to, or higher than the magnon energy. The description of our experimental data requires introducing a phonon-phonon coupling not taken into account in actual calculations.