Sustainable metals: integrating science and systems approaches.

This article introduces a special issue of the transactions arising from a Royal Society Discussion Meeting on 'sustainable metals'. Recognizing that progress to date toward the goals of 'sustainability' has been limited, the meeting aimed to open up a new level of interdisciplinary dialogue, collaboration and discussion of disruptive approaches. In this paper, the major concerns of sustainability are enumerated, and climate change is identified as the most urgent. The constraints on deploying technical innovations at scale and speed are discussed, suggesting that much of the required change will require using existing technologies differently, and many opportunities of this type have been overlooked. These constraints also give useful direction for future research and suggest an expanded future role for scientists. Previously, scientists and technologists have aimed largely to 'solve' problems in sustainability through invention. This introductory paper argues that they have an equally important role as participants in the complex societal discussions required to identify pathways to change. Scientific expertise is as important for explaining what cannot be achieved in time or at scale, as it is for promoting the excitement of invention.This article is part of the discussion meeting issue 'Sustainable metals: science and systems'.

Statistical assessment for reusing permeate from dewatering water treatment sludge process: more sustainability in environmental sanitation.

Sludge from water treatment plants (WTPs) is usually processed by physicochemical clarification followed by thickening, which results in the production of an effluent from dewatering/drying sludge processes that can potentially impact the environment. This paper assessed the viability of employing sludge dewatering water from a water treatment sludge plant (WTSP) in São Paulo State, Brazil, for reuse purposes. Water quality variables were monitored in the effluent and receiving stream. The data were analyzed by paired samples Student t-test (parametric significance test), paired samples Wilcoxon signed rank test (non-parametric significance test), and principal component analysis (multivariate analysis). Despite the distribution of data, typically not Gaussian, both Student and Wilcoxon methods agreed in 9 out of 10 studied parameters regarding the influence of WTSP discharge on waterbody; only for total manganese the Wilcoxon approach provided better fit than Student. Principal component analysis helped to evince correlations among all variables. Results provided useful information for understanding the vocation of WTSP effluent for reuse. For direct non-potable reuse, recirculating the final effluent back to the WTP for two months saved 92,000 m3 of water, the volume of drinking water demanded by the city (n = 292,000 inhabitants) in approximately 30 h.

Leveraging Numerical Simulation Technology to Advance Drug Preparation: A Comprehensive Review of Application Scenarios and Cases.

BACKGROUND/OBJECTIVES: Numerical simulation plays an important role in pharmaceutical preparation recently. Mechanistic models, as a type of numerical model, are widely used in the study of pharmaceutical preparations. Mechanistic models are based on a priori knowledge, i.e., laws of physics, chemistry, and biology. However, due to interdisciplinary reasons, pharmacy researchers have greater difficulties in using computer models. METHODS: In this paper, we highlight the application scenarios and examples of mechanistic modelling in pharmacy research and provide a reference for drug researchers to get started. RESULTS: By establishing a suitable model and inputting preparation parameters, researchers can analyze the drug preparation process. Therefore, mechanistic models are effective tools to optimize the preparation parameters and predict potential quality problems of the product. With product quality parameters as the ultimate goal, the experiment design is optimized by mechanistic models. This process emphasizes the concept of quality by design. CONCLUSIONS: The use of numerical simulation saves experimental cost and time, and speeds up the experimental process. In pharmacy experiments, part of the physical information and the change processes are difficult to obtain, such as the mechanical phenomena during tablet compression and the airflow details in the nasal cavity. Therefore, it is necessary to predict the information and guide the formulation with the help of mechanistic models.

Interdisciplinarity through internationality: Results from a US-Mexico graduate course bridging computational and plant science.

Interdisciplinarity is used to integrate and synthesize new research directions between scientific domains, but it is not the only means by which to generate novelty by bringing diverse perspectives together. Internationality draws upon cultural and linguistic diversity that can potentially impact interdisciplinarity as well. We created an interdisciplinary class originally intended to bridge computational and plant science that eventually became international in scope, including students from the United States and Mexico. We administered a survey over 4 years designed to evaluate student expertise. The first year of the survey included only US students and demonstrated that biology and computational student groups have distinct expertise but can learn the skills of the other group over the course of a semester. Modeling of survey responses shows that biological and computational science expertise is equally distributed between US and Mexico student groups, but that nonetheless, these groups can be predicted based on survey responses due to subspecialization within each domain. Unlike interdisciplinarity, differences arising from internationality are mostly static and do not change with educational intervention and include unique skills such as working across languages. We end by discussing a distinct form of interdisciplinarity that arises through internationality and the implications of globalizing research and education efforts.

Making the most of bioimaging data through interdisciplinary interactions.

The increasing technical complexity of all aspects involving bioimages, ranging from their acquisition to their analysis, has led to a diversification in the expertise of scientists engaged at the different stages of the discovery process. Although this diversity of profiles comes with the major challenge of establishing fruitful interdisciplinary collaboration, such collaboration also offers a superb opportunity for scientific discovery. In this Perspective, we review the different actors within the bioimaging research universe and identify the primary obstacles that hinder their interactions. We advocate that data sharing, which lies at the heart of innovation, is finally within reach after decades of being viewed as next to impossible in bioimaging. Building on recent community efforts, we propose actions to consolidate the development of a truly interdisciplinary bioimaging culture based on open data exchange and highlight the promising outlook of bioimaging as an example of multidisciplinary scientific endeavour.

Later-Life Creativity and Successful Aging in Neoliberal Agendas.

BACKGROUND AND OBJECTIVES: Although the model of successful aging is already well discussed and has received considerable critical responses, its intersection with the growing enthusiasm for creative engagement among older adults needs further exploration. This article contributes to the growing literature on later-life creativity by examining its relationship with the discourse of successful aging. RESEARCH DESIGN AND METHODS: The study employs critical humanities-based perspectives and the literature on later-life to address creativity in older age within contemporary neoliberal imperatives. RESULTS: While successful aging is as an antithesis to the narrative of decline, it often fails to capture alternative meanings of aging and the creative engagement in later life. The commercialization and commodification of creativity often function to discipline individuals towards a culture of productivity, optimization, and innovation. However, many older individuals challenge these notions as they create their own models of aging well and authentically that do not align with the ideals of successful aging. DISCUSSION AND IMPLICATIONS: Reductionist, individualistic, and capital-driven understandings of later-life creativity can be broadened by employing critical interdisciplinary approaches, which also help rethink the current meanings of old age and aging. The article will be of interest to scholars, policymakers, artists, and practitioners in gerontological scholarship and the humanities.

[The contribution of the adapted physical activity and health teacher in psychiatry]. / Apports de l'enseignant en activité physique adaptée et santé en psychiatrie.

A teacher of adapted physical activity and health (EAPAS) is a paramedical professional. A professional degree in sciences and techniques of physical and sports activities, with a specialization in adapted physical activity and health, is a prerequisite for this profession. These studies can be supplemented by a professional master's degree. EAPAS practitioners can work in the medico-social, somatic, psychiatric, geriatric and functional rehabilitation sectors. In mental health, they work as part of multi-disciplinary teams, with institutional support. They act on medical prescription to achieve psychological, physical, motivational and social benefits.

Accounting for extinction dynamics unifies the geological and biological histories of Indo-Australian Archipelago.

Biogeographical reconstructions of the Indo-Australian Archipelago (IAA) have suggested a recent spread across the Sunda and Sahul shelves of lineages with diverse origins, which appears to be congruent with a geological history of recent tectonic uplift in the region. However, this scenario is challenged by new geological evidence suggesting that the Sunda shelf was never submerged prior to the Pliocene, casting doubt on the interpretation of recent uplift and the correspondence of evidence from biogeography and geology. A mismatch between geological and biogeographical data may occur if analyses ignore the dynamics of extinct lineages, because this may add uncertainty to the timing and origin of clades in biogeographical reconstructions. We revisit the historical biogeography of multiple IAA taxa and explicitly allow for the possibility of lineage extinction. In contrast to models assuming zero extinction, we find that all of these clades, including plants, invertebrates and vertebrates, have a common and widespread geographic origin, and each has spread and colonized the region much earlier than previously thought. The results for the eight clades re-examined in this article suggest that they diversified and spread during the early Eocene, which helps to unify the geological and biological histories of IAA.

Medicine, Life, and Transformations of Matter.

This Ambix special issue explores premodern alchemical ideas and practices in their entanglements with medicine. It employs diverse methods, from traditional close reading to the new distant-reading framework of computational humanities, to investigate alchemical thought over a timespan of several centuries. In medieval times, everyday practices could offer heuristic models of material transformation - such as the fermentation of bread as a model for metallic transmutation (Schmechel). Paracelsus relied on "fire" to link his natural philosophy with his medical alchemy; new computational methods show how his ideas evolved over time (Hedesan). Early modern medical pluralism favoured the thriving of chemical medicine in Italy; diplomatic efforts introduced chemical remedies into acknowledged pharmacopoeias (Clericuzio). An English physician offers William Cavendish both practical distillation recipes and the hope of learning more about the principles of chemistry (Begley). In eighteenth-century France, Diderot draws on chemical ideas to blur the conceptual boundary between living and non-living matter (Wolfe). The papers largely adhere to integrated history and philosophy of science (iHPS) and to a pragmatist "operational ideal of knowledge" (Chang). They showcase the interdisciplinarity of premodern scientific thought and examine how medicine and alchemy, but also theory and (everyday) practice informed each other fruitfully across the ages.

Trouble on the horizon: anticipating biological invasions through futures thinking.

Anticipating future biosecurity threats to prevent their occurrence is the most cost-effective strategy to manage invasive alien species. Yet, biological invasions are complex, highly uncertain processes. High uncertainty drives decision-making away from strategic preventative measures and towards operational outcomes aimed at post-invasion management. The limited success of preventative measures in curbing biological invasions reflects this short-term mindset and decision-makers should instead apply strategic foresight to imagine futures where biosecurity threats are minimised. Here, four major futures thinking tools (environmental scanning, driver-mapping, horizon scanning, and scenario planning) that describe probable, possible, plausible and preferable futures are assessed in terms of their potential to support both research and policy addressing biological invasions. Environmental scanning involves surveying existing data sources to detect signals of emerging alien species through knowledge of changes in either the likelihood or consequences of biological invasions. Several approaches are widely used for biosecurity including automated scans of digital media, consensus-based expert scoring, and prediction markets. Automated systems can be poor at detecting weak signals because of the large volume of 'noise' they generate while expert scoring relies on prior knowledge and so fails to identify unknown unknowns which is also true of prediction markets that work well for quite specific known risks. Driver-mapping uses expert consensus to identify the political, economic, societal, technological, legislative, and environmental forces shaping the future and is a critical component of strategic foresight that has rarely been applied to biological invasions. Considerable potential exists to extend this approach to develop system maps to identify where biosecurity interventions may be most effective and to explore driver complexes to determine megatrends shaping the future of biological invasions. Horizon scanning is a systematic outlook of potential threats and future developments to detect weak signals of emerging issues that exist at the margins of current thinking. Applications have been strongly focused on emerging issues related to research and technological challenges relevant to biosecurity and invasion science. However, most of these emerging issues are already well known in current-day research. Because horizon scanning is based on expert consensus, it needs to embrace a diversity of cultural, gender, and disciplinary diversity more adequately to ensure participants think intuitively and outside of their own subject boundaries. Scenario planning constructs storylines that describe alternative ways the political, economic, social, technological, legislative, and environmental situation might develop in the future. Biological invasion scenario planning has favoured structured approaches such as standardised archetypes and uncertainty matrices, but scope exists to apply more intuitive thinking by using incasting, backcasting, or causal layered analysis. Futures thinking in biological invasions has not engaged with decision-makers or other stakeholders adequately and thus outcomes have been light on policy and management priorities. To date, strategic foresight addressing biological invasions has applied each approach in isolation. Yet, an integrated approach to futures thinking that involves a diverse set of stakeholders in exploring the probable, possible, plausible, and preferable futures relating to biological invasions is crucial to the delivery of strategic biosecurity foresight at both national and global scales.

Qualitative social and human science research focusing on actors in and around dairy farming- An invited review.

Qualitative research related to humans, dairy cows, calves and farming has been published by scientists from a variety of disciplines in many journals targeting dairy science audiences. We aimed to investigate how scientific communities other than those working in dairy science describe, analyze and discuss dairy farming, because we found it important to bring this research to the attention of dairy scientists. In total, 117 articles were identified as involving one or more qualitative research methods in relation to dairy cattle. The review brought out a wealth of perspectives, new insights and discussions related to dairy cattle, farmers, farming and the sector, and in relation to societal issues and food and ecological landscapes. A broad range of qualitative research methods were used, and the literature targeted issues at the animal, farm, societal, food system and landscape level. Some raised critical questions about existing structures, highlighted unfairness in the industry, or pointed to new potential futures and contemporary agendas. We expect that it will be inspirational and stimulating for researchers to review new sources of literature and suggest a closer interdisciplinary collaboration among researchers from different disciplines for the future development of research involving dairy cattle. Further, it could be relevant and even necessary to engage in such interaction to avoid increasing polarization around future development of the sector, for example related to climate change or how industrialization seems to push inequity or ignore the agency of animals themselves. Exploring perspectives of farming from different angles could enrich the outcomes of future dairy research.

Asserting the visibility of social work in science.

Scientific evidence has shown that Social Work has frequently been considered a second-level discipline in the traditional sexist hierarchy, because pioneers and most social workers are women. The twofold objective of this article is to analyze the dynamics that overcome this consideration and to put forward actions to go further in the near future. The factors that limit these actions and those that make them possible are studied. This article exposes the dynamics of the current transformation of Social Work, namely, the increase in the importance of social impact in social research, the increase in interdisciplinarity, and the impact of interdisciplinary research.

Designing an Interdisciplinary Health Course: A Qualitative Study of Undergraduate Students' Experience of Interdisciplinary Curriculum Design and Learning Experiences.

OBJECTIVES: Research into interdisciplinary education, where concrete examples and empirical evidence of interdisciplinary teaching is explored, is limited. Furthermore, there are no standardized guidelines on best practices for designing and implementing an interdisciplinary curriculum. Recently, in healthcare settings there has been a drive to adopt interdisciplinary or transdisciplinary practices, creating a need for training individuals capable of working across discipline-specific boundaries, or to even adopt a transdisciplinary practice. This is partially attributed to recognizing that local and global complex health challenges are interlinked and share common factors and often require a new integrated approach to management. In response, a new interdisciplinary course using a modified snowflake model of interdisciplinary course design was launched at a medical school. The course aimed to provide a broad foundation for lifelong learning with a strong emphasis on the development of knowledge, skills, and professional values essential for interdisciplinary and transdisciplinary practice in applied health promotion for individuals and society. METHODS: A semi-structured focus group with students (n = 15% of the inaugural cohort) having completed at least 1 year of the course was undertaken to investigate student perspectives on best approaches for the development and delivery of interdisciplinary learning and teaching. RESULTS: Results highlighted the importance of providing training and opportunity for students to practice integration within the curriculum. Additionally, it was noted that including a module to introduce students to different disciplines and guiding students to explore their inherent interconnectedness is essential in helping them develop interdisciplinary thinking and skills. Crucially, the role of integrated assessments was also recognized as fundamental for demonstrating and practicing interdisciplinarity. CONCLUSION: Overall, this study provides valuable insights and recommendations for educators with the objective of developing interdisciplinary learning in new or existing higher education courses or those seeking to prepare learners for contemporary and emergent societal challenges more generally.

Multidisciplinary Teams in Musculoskeletal Infection - From a Pathologist's Perspective.

Multidisciplinary team (MDT) meetings have emerged as a promising approach for the treatment of cancer patients. These meetings involve a team of healthcare professionals from different disciplines working together to develop a holistic, patient-centered treatment. Although MDT meetings are well established in oncology, they play a minor role in other diseases. Recent evidence suggests that the implementation of MDT meetings can improve patient outcomes in musculoskeletal infections. The aim of this retrospective, observational study was to present the agenda of our multidisciplinary limb board including live microscopy with a special focus on the pathologist's role. The descriptive analysis of the limb board included 66 cases receiving live microscopy at the meeting and a total of 124 histopathological findings and 181 stainings. We could elucidate that pathologists seem to play an important role especially in clarifying the correct diagnosis. In 80.3 % of the findings, the pathologist specified the clinical diagnosis of the requesting physician leading to a consensus-based treatment plan for each patient. The implementation of MDT meetings including live microscopy in patients with musculoskeletal infections holds potential benefits, such as improved communication, scientific collaboration, and raising clinicians' awareness and understanding of histopathology findings. However, potential challenges, such as organizational effort and technical prerequisites should be considered.

Integrating bioengineering, super-resolution microscopy and mechanobiology in autophagy research: addendum to the guidelines (4th edition).

Recent key technological developments, such as super-resolution microscopy and microfabrication, enabled investigation of biological processes, including macroautophagy/autophagy, with unprecedented spatiotemporal resolution and control over experimental conditions. Such disruptive innovations deepened our capability to provide mechanistic understandings of the autophagic process and its causes. This addendum aims to expand the guidelines on autophagy in three key directions: optical methods enabling visualization of autophagic machinery beyond the diffraction-limited resolution; bioengineering enabling accurate designs and control over experimental conditions; and theoretical advances in mechanobiology connecting autophagy and mechanical processes of the cell. Abbreviation: 3D: three-dimensional; SIM: structured illumination microscopy; STORM: stochastic optical reconstruction microscopy.

Slow convergence: Career impediments to interdisciplinary biomedical research.

Despite the long-standing calls for increased levels of interdisciplinary research as a way to address society's grand challenges, most science is still disciplinary. To understand the slow rate of convergence to more interdisciplinary research, we examine 154,021 researchers who received a PhD in a biomedical field between 1970 and 2013, measuring the interdisciplinarity of their articles using the disciplinary composition of references. We provide a range of evidence that interdisciplinary research is impactful, but that those who conduct it face early career impediments. The researchers who are initially the most interdisciplinary tend to stop publishing earlier in their careers-it takes about 8 y for half of the researchers in the top percentile in terms of initial interdisciplinarity to stop publishing, compared to more than 20 y for moderately interdisciplinary researchers (10th to 75th percentiles). Moreover, perhaps in response to career challenges, initially interdisciplinary researchers on average decrease their interdisciplinarity over time. These forces reduce the stock of interdisciplinary researchers who can train future cohorts. Indeed, new graduates tend to be less interdisciplinary than the stock of active researchers. We show that interdisciplinarity does increase over time despite these dampening forces because initially disciplinary researchers become more interdisciplinary as their careers progress.

Let the foxes run free: Arresting bioethics' inward turn.

As bioethics matures, a number of voices have called for a narrowing of what officially "counts" as bioethics. Bioethics defined broadly, they argue, creates a space that lacks objectivity and rigor, jeopardizing the credibility of the profession. Although a variety of proposed solutions exist, most advance a definitional narrowing of bioethics. In doing so, they mimic the siloed nature of the academy writ large, an institution that organizes itself through the logic of atomization, the belief that knowledge is generated through the process of isolation, examination, theorization, and ultimately reintegration. Borrowing language from Isaiah Berlin's essay "The Hedgehog and the Fox," I argue that bioethics has thrived precisely because it stands distinct from other departments of learning, constituting one of the few places within the academy where true inter, multi, and cross-disciplinary scholarship can thrive. Reducing bioethics to an internally defined set of axiomatic rationales does violence to this vision, eroding, in the process, one of the field's greatest assets.

Navigating causal reasoning in sustainability science.

When reasoning about causes of sustainability problems and possible solutions, sustainability scientists rely on disciplinary-based understanding of cause-effect relations. These disciplinary assumptions enable and constrain how causal knowledge is generated, yet they are rarely made explicit. In a multidisciplinary field like sustainability science, lack of understanding differences in causal reasoning impedes our ability to address complex sustainability problems. To support navigating the diversity of causal reasoning, we articulate when and how during a research process researchers engage in causal reasoning and discuss four common ideas about causation that direct it. This articulation provides guidance for researchers to make their own assumptions and choices transparent and to interpret other researchers' approaches. Understanding how causal claims are made and justified enables sustainability researchers to evaluate the diversity of causal claims, to build collaborations across disciplines, and to assess whether proposed solutions are suitable for a given problem.

Association between Chronic Misophonia-Induced Stress and Gastrointestinal Pathology in Children-A Hypothesis.

Misophonia is a neurophysiological disorder with behavioral implications, is complex and multifactorial in origin, and is characterized by an atypical and disproportionate emotional response to specific sounds or associated visual stimuli. Triggers include human-generated sounds, mainly sounds related to feeding and breathing processes, and repetitive mechanical sounds. In response to the triggering stimulus, the patient experiences immediate, high-intensity, disproportionate physical and emotional reactions that affect their quality of life and social functioning. The symptoms of misophonia can occur at any age, but onset in childhood or adolescence is most common. Affected children live in a constant state of anxiety, suffer continuous physical and emotional discomfort, and are thus exposed to significant chronic stress. Chronic stress, especially during childhood, has consequences on the main biological systems through the dysregulation of the hypothalamic-pituitary-adrenal axis, including the gastrointestinal tract. Here, we provide arguments for a positive correlation between misophonic pathology and gastrointestinal symptoms, and this hypothesis may be the starting point for further longitudinal studies that could investigate the correlations between these childhood vulnerabilities caused by misophonia and their effect on the gastrointestinal system. Further research to study this hypothesis is essential to ensure correct and timely diagnosis and optimal psychological and pharmacological support.

Integrating Machine Learning and Color Chemistry: Developing a High-School Curriculum toward Real-World Problem-Solving.

Artificial intelligence (AI) is rapidly transforming our world, making it imperative to educate the next generation about both the potential benefits and challenges associated with AI. This study presents a cross-disciplinary curriculum that connects AI and chemistry disciplines in the high school classroom. Particularly, we leverage machine learning (ML), an important and simple application of AI to instruct students to build an ML-based virtual pH meter for high-precision pH read-outs. We used a "codeless" and free ML neural network building software - Orange, along with a simple chemical topic of pH to show the connection between AI and chemistry for high-schoolers who might have rudimentary backgrounds in both disciplines. The goal of this curriculum is to promote student interest and drive in the analytical chemistry domain and offer insights into how the interconnection between chemistry and ML can benefit high-school students in science learning. The activity involves students using pH strips to measure the pH of various solutions with local relevancy and then building an ML neural network model to predict the pH value based on color changes of pH strips. The integrated curriculum increased student interest in chemistry and ML and demonstrated the relevance of science to their daily lives and global issues. This approach is transformative in developing a broad spectrum of integration topics between chemistry and ML and understanding their global impacts.