RESUMO
The case of a 24-year-old male patient affected by follicular occlusion tetrad (acne conglobata, hidradenitis suppurativa, pilonidal cyst and dissecting cellulitis of the scalp) associated with clinical signs of pachyonychia congenita (PC)-2 (focal palmoplantar keratoderma, plantar pain, onycodystrophy and multiple cysts) is reported. The diagnosis was supported by genetic analysis that showed heterozygous mutation within the exon 1 of KRT17 gene. This case may reflect different expressions of a phenotypic spectrum induced by a common genetic alteration.
Assuntos
Acne Conglobata/diagnóstico , Celulite (Flegmão)/diagnóstico , Hidradenite Supurativa/diagnóstico , Queratina-17/genética , Paquioníquia Congênita/genética , Seio Pilonidal/diagnóstico , Dermatoses do Couro Cabeludo/diagnóstico , Dermatopatias Genéticas/diagnóstico , Hidradenite Supurativa/genética , Humanos , Masculino , Paquioníquia Congênita/diagnóstico , Síndrome , Adulto JovemRESUMO
BACKGROUND: Hidradenitis suppurativa is one member of the follicular occlusion triad: acne conglobata, hidradenitis suppurativa, and dissecting cellulitis of the scalp. The presence of acantholysis and desmoglein autoantibodies in hidradenitis suppurativa is rare. CASE PRESENTATION: We report a case of 68-year-old male with a diagnosis of gluteal hidradenitis suppurativa co-presenting pemphigus-like findings including acantholysis and positive desmoglein autoantibodies. CONCLUSION: To our knowledge, comorbidity of gluteal hidradenitis suppurativa and pemphigus-like findings has not been reported before. This case implies a relationship between two different conditions; the follicular occlusion triad and pemphigus, highlighting a potential induction of pemphigus-like lesion by chronic inflammatory process.
Assuntos
Acantólise/imunologia , Autoanticorpos/sangue , Hidradenite Supurativa/diagnóstico , Pênfigo/diagnóstico , Acantólise/diagnóstico , Acne Conglobata/diagnóstico , Idoso , Autoanticorpos/imunologia , Nádegas , Desmogleína 1/imunologia , Desmogleína 3/imunologia , Diagnóstico Diferencial , Hidradenite Supurativa/complicações , Hidradenite Supurativa/imunologia , Humanos , Masculino , Pele/imunologia , Pele/patologiaRESUMO
El acné es la enfermedad dermatológica más común de la adolescencia. Aunque casi todos los casos remiten alrededor de la tercera década de la vida, cuando este problema conlleva una carga emocional para el paciente se requiere indicar tratamiento. En esta actualización, los autores revisan los distintos grados de compromiso de esta patología, el tratami-ento y los niveles de evidencia que tiene cada uno de ellos, con el objetivo de facilitar a los médicos de atención primaria el manejo de los pacientes que presentan esta enfermedad. (AU)
Acne is the most common dermatological condition in adolescents. Even though almost all cases will resolve around the third decade of life, treatment is indicated when this health problem carries an emotional burden for the patient. In this update, the authors review the grades of involvement of the disease and the available treatments according to levels of evidence, with the aim of helping primary care physicians to manage the patients presenting this illness. (AU)