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1.
Rinsho Shinkeigaku ; 64(7): 453-459, 2024 Jul 27.
Artigo em Japonês | MEDLINE | ID: mdl-38910118

RESUMO

Temporal lobe epilepsy is known to present with various cognitive impairments, among which memory deficits are frequently reported by patients. Memory deficits can be classified into two types: classical hippocampal amnesia, which is characterized by abnormalities detected in neuropsychological assessments, and atypical memory deficits, such as accelerated long-term amnesia and autobiographical memory impairment, which cannot be identified using standard testing methods. These deficits are believed to arise from a complex interplay among structural brain abnormalities, interictal epileptic discharges, pharmacological factors, and psychological states. While fundamental treatments are limited, there are opportunities for interventions such as environmental adjustments and rehabilitation. This review article aims to provide a comprehensive overview of the types, underlying pathophysiology, and intervention methods for memory disorders observed in patients with temporal lobe epilepsy.


Assuntos
Epilepsia do Lobo Temporal , Transtornos da Memória , Epilepsia do Lobo Temporal/complicações , Humanos , Transtornos da Memória/etiologia , Hipocampo , Amnésia/etiologia
3.
J Neurotrauma ; 41(15-16): e1961-e1975, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38553904

RESUMO

After moderate to severe traumatic brain injury (TBI), sleep disturbance commonly emerges during the confused post-traumatic amnesia (PTA) recovery stage. However, the evaluation of early sleep disturbance during PTA, its recovery trajectory, and influencing factors is limited. This study aimed to evaluate sleep outcomes in patients experiencing PTA using ambulatory gold-standard polysomnography (PSG) overnight and salivary endogenous melatonin (a hormone that influences the sleep-wake cycle) assessment at two time-points. The relationships between PSG-derived sleep-wake parameters and PTA symptoms (i.e., agitation and cognitive disturbance) were also evaluated. In a patient subset, PSG was repeated after PTA had resolved to assess the trajectory of sleep disturbance. Participants with PTA were recruited from Epworth HealthCare's inpatient TBI Rehabilitation Unit. Trained nurses administered overnight PSG at the patient bedside using the Compumedics Somté portable PSG device (Compumedics, Ltd., Australia). Two weeks after PTA had resolved, PSG was repeated. On a separate evening, two saliva specimens were collected (at 24:00 and 06:00) for melatonin testing. Results of routine daily hospital measures (i.e., Agitated Behavior Scale and Westmead PTA Scale) were also collected. Twenty-nine patients were monitored with PSG (mean: 41.6 days post-TBI; standard deviation [SD]: 28.3). Patients' mean sleep duration was reduced (5.6 h, SD: 1.2), and was fragmented with frequent awakenings (mean: 27.7, SD: 15.0). Deep, slow-wave restorative sleep was reduced, or completely absent (37.9% of patients). The use of PSG did not appear to exacerbate patient agitation or cognitive disturbance. Mean melatonin levels at both time-points were commonly outside of normal reference ranges. After PTA resolved, patients (n = 11) displayed significantly longer mean sleep time (5.3 h [PTA]; 6.5 h [out of PTA], difference between means: 1.2, p = 0.005). However, disturbances to other sleep-wake parameters (e.g., increased awakenings, wake time, and sleep latency) persisted after PTA resolved. This is the first study to evaluate sleep disturbance in a cohort of patients as they progressed through the early TBI recovery phases. There is a clear need for tailored assessment of sleep disturbance during PTA, which currently does not form part of routine hospital assessment, to suggest new treatment paradigms, enhance patient recovery, and reduce its long-term impacts.


Assuntos
Amnésia , Lesões Encefálicas Traumáticas , Melatonina , Polissonografia , Recuperação de Função Fisiológica , Transtornos do Sono-Vigília , Humanos , Lesões Encefálicas Traumáticas/complicações , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Amnésia/etiologia , Transtornos do Sono-Vigília/etiologia , Recuperação de Função Fisiológica/fisiologia , Adulto Jovem , Saliva/metabolismo
4.
Epileptic Disord ; 26(3): 311-321, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38477907

RESUMO

OBJECTIVE: Enduring anterograde amnesia is caused by lesions in bilateral mesial temporal lobes. However, whether transient dysfunction of bilateral mesial temporal regions induces reversible amnesia has not been proven. We investigated this association in patients with epilepsy and analyzed the electroclinical correlation during pure amnestic seizures (PAS). PAS are defined as seizures with anterograde amnesia as the only ictal manifestation, accompanied by preserved responsiveness and other cognitive functions. METHODS: We retrospectively searched our intracranial EEG database to find PAS. Pure ictal amnesia was confirmed by immediate and comprehensive ictal examinations. RESULTS: Among 401 patients who underwent intracranial EEG recording, three patients with temporal lobe epilepsy (TLE) manifesting PAS were identified. The patients talked and behaved normally during seizure but did not remember the episodes afterwards. Ictal discharges were confined to bilateral mesial temporal regions, with no or mild involvement of surrounding structures. Spread of low-voltage fast activities to bilateral mesial temporal regions corresponded to onset of ictal anterograde amnesia. Two patients underwent unilateral mesial temporal resection and became seizure-free with improvement in cognitive functions. SIGNIFICANCE: PAS is a rare ictal semiology in TLE. Bilateral mesial temporal regions that play a critical role in memory encoding are presumably the symptomatogenic zones for PAS.


Assuntos
Epilepsia do Lobo Temporal , Convulsões , Humanos , Epilepsia do Lobo Temporal/fisiopatologia , Epilepsia do Lobo Temporal/cirurgia , Adulto , Masculino , Feminino , Estudos Retrospectivos , Convulsões/fisiopatologia , Amnésia Anterógrada/fisiopatologia , Amnésia Anterógrada/etiologia , Eletroencefalografia , Eletrocorticografia , Pessoa de Meia-Idade , Amnésia/fisiopatologia , Amnésia/etiologia , Lobo Temporal/fisiopatologia
5.
Brain Inj ; 38(2): 142-149, 2024 01 28.
Artigo em Inglês | MEDLINE | ID: mdl-38328966

RESUMO

OBJECTIVE: The aim of this scoping review was to identify behavioral disturbances exhibited by patients in post-traumatic amnesia (PTA). While behavioral disturbances are common in PTA, research into their presentation and standardized measures for their assessment are limited. DESIGN: The study protocol was registered with PROSPERO (CRD42021268275). A scoping review of databases was performed according to pre-determined criteria on 29 July 2021 and updated on 13 July 2022. A conventional content analysis was used to examine and categorize behavioral disturbances. RESULTS: Thirty papers met the inclusion criteria, of which 27 reported observations and/or scores obtained on behavioral scales, and 3 on clinician interviews and surveys. None focused exclusively on children. Agitation was the most frequently assessed behavior, and Agitated Behavior Scale was the most used instrument. Content analysis, however, bore eight broad behavioral categories: disinhibition, agitation, aggression, lability, lethargy/low mood, perceptual disturbances/psychotic symptoms, personality change and sleep disturbances. CONCLUSION: Our study revealed that while standardized assessments of behavior of patients in PTA are often limited to agitation, clinical descriptions include a range of behavioral disturbances. Our study highlights a significant gap in the systematic assessment of a wide range of behavioral disturbances observed in PTA.


Assuntos
Lesões Encefálicas Traumáticas , Comportamento Problema , Criança , Humanos , Amnésia/etiologia , Amnésia/diagnóstico , Amnésia Retrógrada , Ansiedade , Agressão
6.
J Orthop Surg Res ; 19(1): 34, 2024 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-38183050

RESUMO

OBJECTIVE: A comparative study of joint amnesia in patients undergoing total hip arthroplasty with the direct anterior approach and posterior approach was conducted through a comprehensive evaluation. METHODS: The literature on joint amnesia in postoperative patients who underwent total hip arthroplasty by the direct anterior approach and the posterior approach was systematically searched in PubMed, Embase, Web of Science, Cochrane Library, CNKI, CBM, Wanfang, and VIP databases from the time of library construction until February 13, 2023. Meta-analysis was performed using RevMan 5.3 software after independent searching, screening of the literature, data extraction, and quality assessment of the included studies by two investigators in strict accordance with the guidelines for conducting meta-analyses. RESULTS: A total of one RCT and six cohort studies were included in this meta-analysis. Meta-analysis results indicated that at 1 month postoperatively (MD = 2.08, 95% CI (0.20, 3.96), P = 0.03), 3 months (MD = 10.08, 95% CI (1.20, 18.96), P = 0.03), and 1 year (MD = 6.74, 95% CI (1.30, 12.19), P = 0.02), DAA total hip arthroplasty was associated with better FJS compared to PA at 1 year postoperatively. However, there was no statistical significance in FJS between the two groups at 5 years postoperatively (MD = 1.35, 95% CI (- 0.58, 3.28), P = 0.17). CONCLUSION: Current evidence suggests that the degree of joint amnesia after THA for DAA was not found to be superior to that of PA. Further, these findings require confirmation by including a larger number of high-quality randomized controlled studies. STUDY DESIGN: Systematic review; Level of evidence, 3.


Assuntos
Artroplastia de Quadril , Humanos , Artroplastia de Quadril/efeitos adversos , Amnésia/etiologia , Bases de Dados Factuais , Período Pós-Operatório , Controle de Qualidade
7.
Neurocase ; 29(6): 186-190, 2023 12.
Artigo em Inglês | MEDLINE | ID: mdl-38700142

RESUMO

Isolated fornix anterior column infarction has rarely been described and is difficult to assess accurately using conventional magnetic resonance imaging (MRI). We report the case of a 75-year-old female who experienced acute anterograde amnesia. MRI performed within 24 h after amnesia onset showed an isolated infarction of the bilateral anterior columns of the fornix on diffusion-weighted imaging (DWI). Her symptoms persisted for up to 50 days, and diffusion tensor imaging (DTI) showed disruption of the fiber tracts of the fornix. when acute amnesia syndrome onset, fornix anterior column infarction should be considered, and optimized DWI and DTI methods are needed to study the fornix in vivo in future research.


Assuntos
Imagem de Tensor de Difusão , Fórnice , Humanos , Feminino , Fórnice/diagnóstico por imagem , Fórnice/patologia , Idoso , Imagem de Difusão por Ressonância Magnética , Amnésia Anterógrada/etiologia , Amnésia/etiologia , Amnésia/diagnóstico por imagem , Infarto Cerebral/diagnóstico por imagem , Infarto Cerebral/complicações
9.
Rev. Esc. Enferm. USP ; 46(spe): 30-37, out. 2012. tab
Artigo em Português | LILACS, BDENF - enfermagem (Brasil) | ID: lil-659827

RESUMO

Este estudo compara a qualidade de vida das vítimas que apresentaram amnésia pós-traumática de longa duração com as demais e analisa a relação entre qualidade de vida e duração da amnésia pós-traumática, computando ou não o período de coma. Estudo de coorte prospectivo, com coleta de dados durante a internação hospitalar e avaliação da qualidade de vida no período de estabilidade da recuperação pós-traumática. Participaram desta investigação vítimas de trauma crânio-encefálico contuso, maiores de 14 anos, sem antecedentes de demência ou trauma crânio-encefálico, internadas em hospital de referência para atendimento de trauma nas primeiras 12 horas pós-evento. Os resultados referentes à qualidade de vida foram mais desfavoráveis em três domínios do grupo com amnésia de longa duração. Correlações entre duração da amnésia e domínios de qualidade de vida foram mais expressivas quando excluído o período de coma, indicando que este tempo não deve ser computado na duração da amnésia pós-traumática.


The present study aims to compare quality of life of victims with long and short term post-traumatic amnesia and to analyze the relation between quality of life and length of amnesia, including or not the comatose period. This prospective cohort study, gathered data during the hospital stay and 3 and 6 months post- trauma. Blunt traumatic brain injury patients, over 14 years old, with no prior diagnosis of dementia or brain injury, admitted to a trauma center 12 hours post-trauma were included. The results were unfavorable among patients with long term amnesia. Correlation between length of post-traumatic amnesia and quality of life domains were more expressive when excluded comatose period, indicating that it must not be computed in the length of post-traumatic amnesia.


Este estudio tuvo compara la calidad de vida de las víctimas que tuvieron amnesia post-traumática a largo plazo, con los (las) demás y analizar la relación entre la calidad de vida y duración de la amnesia post-traumática, computando o nó el periodo de estado de coma. Estudio prospectivo de cohorte utilizando datos de hospitales y de la calidad de vida de víctimas de traumatismo craneoencefálico, internados en un hospital de referencia para la atención del trauma. Los resultados relativos a la calidad de vida eran más desfavorables en el grupo a largo plazo de amnesia. Las correlaciones entre la duración de la amnesia post-traumática y los dominios de la calidad de vida fueron más significativos cuando se excluyó el periodo de estado de coma, lo que indica que este tiempo no debe ser contado en la duración de la amnesia post-traumática.


Assuntos
Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Amnésia/etiologia , Traumatismos Craniocerebrais/complicações , Qualidade de Vida , Estudos Prospectivos
10.
Rev. chil. neuro-psiquiatr ; 29(2): 124-9, abr.-jun. 1991. tab, ilus
Artigo em Espanhol | LILACS | ID: lil-104937

RESUMO

El aprendizaje procedural y episódico es estudiado en un paciente masculino de 41 años, portador de un síndrome de Korsakoff crónico post-traumático y cuya tomografía computarizada mostró dilatación bilateral de los cuernos frontales y agrandamiento ventricular. Se realizaron 10 sesiones diarias, entrenando la lectura de logotomas y párrafos invertidos. Hubo una significativa disminución del número de errores en el tiempo de lectura, a pesar de no recordar los entrenamientos previos. Esto confirma la disociación entre el episodio olvidado y la preservación de la memoria procedural, disociación que podría ser útil en el entrenamiento conductual


Assuntos
Amnésia/etiologia , Deficiências da Aprendizagem/diagnóstico , Amnésia/diagnóstico , Testes Psicológicos
11.
Rev. chil. neuro-psiquiatr ; 27(1): 73-6, ene.-mar. 1989. ilus
Artigo em Espanhol | LILACS | ID: lil-67651

RESUMO

Se presenta un paciente con un tumor del cuerpo calloso con obnubilación, amnesia de tipo axial y una desconexión interhemisférica somestésica y visual (hemialexia y afasia hemianóptica). A pesar de ser zurdo, la evidencia clínica sugiere que el hemisferio especializado para el lenguaje era el izquierdo. Se plantea que este hemisferio tiene capacidad de juicio lógico y que el derecho tiene capacidad de juicio de realidad


Assuntos
Pessoa de Meia-Idade , Humanos , Masculino , Corpo Caloso , Neoplasias Hipotalâmicas/complicações , Amnésia/etiologia , Dislexia Adquirida , Hemianopsia/etiologia
12.
Rev. chil. neuro-psiquiatr ; 23(2): 141-4, abr.-jun. 1985. ilus
Artigo em Espanhol | LILACS | ID: lil-27599

RESUMO

Se presenta el caso de un paciente que sufrió un infarto talámico izquierdo que se manifestó con obnubilación, afasia y hemiparesia derecha transitorias y con una amnesia persistente. La amnesia sería consecuencia de una lesión del núcleo dorsomedial, que tiene importantes conexiones con la corteza orbitaria y el sistema límbico. Esta amnesia es predominantemente verbal, reproduciendo asimetría funcional de los hemisferios cerebrales


Assuntos
Pessoa de Meia-Idade , Humanos , Masculino , Amnésia/etiologia , Infarto , Doenças Talâmicas/complicações , Transtornos da Memória/etiologia
14.
Paris; Felix Alcan; 1907. 258 p.
Monografia em Francês | Coleciona SUS (Brasil), IMNS | ID: biblio-927912
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