RESUMO
The NCI invests heavily in research resources to serve the research community, including datasets, biospecimen banks, and networks of institutions in which clinical trials and other human subjects research are conducted. These resources often begin as grant-funded infrastructure initiated by scientists based on their own scientific interests, with a subsequent recognition of additional scientific uses. Although converting existing project-specific research activities into research resources may appear efficient in terms of time and financial investment, challenges can arise that undermine this efficiency and jeopardize future use. Here, we describe three challenges in the conversion process: (i) project-based infrastructure versus a research resource for a broader research community; (ii) complexity versus ease of use; and (iii) individual professional goals versus research resource priorities. We use our experience with the NCI-funded Cancer Research Network, particularly the Virtual Data Warehouse, to illustrate each challenge, concluding with strategies to mitigate each one. As studies grow in size and complexity, an ever-increasing volume of data, biospecimens, and human subjects research networks will be available for conversion to resources for scientific questions beyond those originally proposed. Addressing likely challenges thoughtfully can result in a more efficient conversion process and ultimately greater scientific impact.
Assuntos
Pesquisa Biomédica/economia , Recursos em Saúde/economia , Revisão da Pesquisa por Pares/normas , Bancos de Tecidos/organização & administração , Pesquisa Biomédica/métodos , Regulamentação Governamental , Recursos em Saúde/normas , Humanos , Armazenamento e Recuperação da Informação , National Cancer Institute (U.S.) , Bancos de Tecidos/economia , Bancos de Tecidos/normas , Estados UnidosRESUMO
Implementing and maintaining the information technology (IT) infrastructure of a brain bank can be a daunting task for any brain bank coordinator, particularly when access to both funds and IT professionals is limited. Many questions arise when attempting to determine which IT products are most suitable for a brain bank. The requirements of each brain bank must be assessed carefully to ensure that the chosen IT infrastructure will be able to meet those requirements successfully and will be able to expand and adapt as the size of the brain bank increases. This chapter provides some valuable insights to be considered when implementing the IT infrastructure for a brain bank and discusses the pros and cons of various approaches and products.
Assuntos
Encéfalo , Tecnologia da Informação , Bancos de Tecidos , Humanos , Tecnologia da Informação/economia , Tecnologia da Informação/estatística & dados numéricos , Bancos de Tecidos/economia , Bancos de Tecidos/tendênciasRESUMO
It has become clear over the past decades that studying postmortem human brain tissue is one of the most effective ways to increase our knowledge of the pathogenesis and etiology of neuropathologic and psychiatric diseases. Many breakthroughs in neuroscience have depended on the availability of human brain tissue. However, the process of brain banking presents many different challenges, including the high cost that is associated with collecting the samples and with providing the diagnostics, storage, and distribution. Funding is generally from research and facility grants and donations but all are irregular, uncertain, and only cover the costs for a determined period of time. For professional brain banks with extensive prospective donor programs and that are open-access it can be very beneficial to draft a business plan to achieve long-term sustainability. Such a business plan should identify the interests of the stakeholders and address the implementation of cost efficiency and cost recovery systems.
Assuntos
Encéfalo , Marketing de Serviços de Saúde , Bancos de Tecidos , Humanos , Marketing de Serviços de Saúde/economia , Marketing de Serviços de Saúde/métodos , Marketing de Serviços de Saúde/tendências , Modelos Econométricos , Bancos de Tecidos/economia , Bancos de Tecidos/estatística & dados numéricos , Bancos de Tecidos/tendênciasRESUMO
If a temporal rather than spatial concept of waste is adopted, novel categories emerge which are useful for identifying and understanding logics of temporality at play in determining what is kept in contemporary brain banks, and reveal that brain banks are constituted by more than stored materials. First, I apply the categories analytically on a recent UK brain banking discussion among professionals. This analysis highlights the importance of data in brain banks, as well as the centrality of ideas about pasts and futures in the discussions. Secondly, I investigate the case of a seven decades old, Danish brain bank which had been reduced to its physically stored material for 24 years, before being reinstituted in 2006. This case demonstrates the importance of material and conceptual infrastructures that co-constitute a collection, as they make up an experimental system that is crucial to maintaining the collection's continued relevance and usefulness as a scientific institution.
Assuntos
Encéfalo , Bancos de Tecidos/economia , Humanos , Bancos de Tecidos/estatística & dados numéricosRESUMO
Well-characterized human brain tissue is crucial for scientific breakthroughs in research of the human brain and brain diseases. However, the collection, characterization, management, and accessibility of brain human tissue are rather complex. Well-characterized human brain tissue is often provided from private, sometimes small, brain tissue collections by (neuro)pathologic experts. However, to meet the increasing demand for human brain tissue from the scientific community, many professional brain-banking activities aiming at both neurologic and psychiatric diseases as well as healthy controls are currently being initiated worldwide. Professional biobanks are open-access and in many cases run donor programs. They are therefore costly and need effective business plans to guarantee long-term sustainability. Here we discuss the ethical, legal, managerial, and financial aspects of professional brain banks.
Assuntos
Pesquisa Biomédica , Encéfalo , Manejo de Espécimes , Bancos de Tecidos , Pesquisa Biomédica/ética , Pesquisa Biomédica/legislação & jurisprudência , Pesquisa Biomédica/tendências , Encefalopatias/diagnóstico , Humanos , Transtornos Mentais/diagnóstico , Manejo de Espécimes/economia , Manejo de Espécimes/ética , Manejo de Espécimes/métodos , Manejo de Espécimes/normas , Bancos de Tecidos/economia , Bancos de Tecidos/ética , Bancos de Tecidos/legislação & jurisprudência , Bancos de Tecidos/tendências , Doadores de TecidosRESUMO
Expanding research interests in molecular profiling over the past several years have led researchers in academia and pharmaceutical and biotechnology companies to significantly increase their need for access to tissue specimens collected through clinical care and clinical trials. As a result, tissue allocation has become a growing issue for many clinical and translational investigators. High-quality biospecimens are needed by all stakeholders in order to have scientifically accurate studies and results. At the center of the process are the patients, who have increasingly become active partners in the clinical research enterprise as individuals and through highly sophisticated patient advocacy organizations. All stakeholders must recognize that human specimens, including tissue, represent a valuable and unique resource that must have proper acquisition, handling, custodianship, and consent for use in accordance with best practices for biospecimen resources.
Assuntos
Consentimento Livre e Esclarecido , Neoplasias , Manejo de Espécimes/normas , Bancos de Tecidos , Pesquisa Translacional Biomédica/métodos , Humanos , Bancos de Tecidos/economia , Bancos de Tecidos/normas , Pesquisa Translacional Biomédica/legislação & jurisprudência , Pesquisa Translacional Biomédica/normasRESUMO
Part II of this article discusses and provides guidance on the equipment and systems necessary to operate a repository. The various types of storage equipment and monitoring and support systems are presented in detail. While the material focuses on the large repository, the requirements for a small-scale startup are also presented. Cost estimates and a cost model for establishing a repository are presented. The cost model presents an expected range of acquisition costs for the large capital items in developing a repository. A range of 5,000-7,000 ft(2) constructed has been assumed, with 50 frozen storage units, to reflect a successful operation with growth potential. No design or engineering costs, permit or regulatory costs, or smaller items such as the computers, software, furniture, phones, and barcode readers required for operations have been included.
Assuntos
Criopreservação/instrumentação , Manejo de Espécimes/instrumentação , Bancos de Tecidos/economia , Automação Laboratorial/economia , Automação Laboratorial/instrumentação , Criopreservação/economia , Equipamentos e Provisões/economia , Humanos , Modelos Econômicos , Manejo de Espécimes/economiaAssuntos
Acessibilidade aos Serviços de Saúde/ética , Disparidades em Assistência à Saúde/ética , Transplante de Células-Tronco/ética , Acessibilidade aos Serviços de Saúde/economia , Disparidades em Assistência à Saúde/economia , Humanos , População Rural , Transplante de Células-Tronco/economia , Células-Tronco/citologia , Células-Tronco/fisiologia , Bancos de Tecidos/economia , Bancos de Tecidos/éticaRESUMO
The importance of accessing high quality clinical samples for translational research is now firmly recognised. Traditionally these samples were collected and curated by individuals with an interest in a particular disease type. In recent years the idea of centralising and storing tissue collections in the form of tissue banks or biobanks has developed. As a result a number of biobanks have been established in many different countries. These can be either single centres or multi centre collaborations, often in the form of a federated network. This chapter outlines the development of breast tissue banking in a global context and discusses some of the challenges that lie ahead for the field, in particular how to meet the growing needs of researchers, how to make the best use of donated samples and how to increase the visibility of samples residing in biobanks to researchers.
Assuntos
Mama/citologia , Bancos de Tecidos , Neoplasias da Mama/patologia , Feminino , Humanos , Bancos de Tecidos/economiaRESUMO
This article addresses the important issue of the standardization of the biobank process. It reports on i) the implementation of standard operating procedures for the processing of liquid-based cervical cells, ii) the standardization of storage conditions, and iii) the ultimate establishment of nationwide standardized biorepositories for cervical specimens. Given the differences in the infrastructure and healthcare systems of various county councils in Sweden, these efforts were designed to develop standardized methods of biobanking across the nation. The standardization of cervical sample processing and biobanking is an important and widely acknowledged issue. Efforts to address these concerns will facilitate better patient care and improve research based on retrospective and prospective collections of patient samples and cohorts. The successful nationalization of the Cervical Cytology Biobank in Sweden is based on three vital issues: i) the flexibility of the system to adapt to other regional systems, ii) the development of the system based on national collaboration between the university and the county councils, and iii) stable governmental financing by the provider, the Biobanking and Molecular Resource Infrastructure of Sweden (BBMRI.se). We will share our experiences with biorepository communities to promote understanding of and advances in opportunities to establish a nationalized biobank which covers the healthcare of the entire nation.
Assuntos
Bancos de Espécimes Biológicos/organização & administração , Colo do Útero/citologia , Bancos de Tecidos/normas , Bancos de Espécimes Biológicos/legislação & jurisprudência , Bancos de Espécimes Biológicos/normas , Pesquisa Biomédica , Feminino , Humanos , Sistema de Registros , Suécia , Bancos de Tecidos/economia , Bancos de Tecidos/legislação & jurisprudência , Esfregaço VaginalRESUMO
Femoral head donation at the time of hip replacement surgery provides a much needed resource of bone allograft to orthopaedic surgeons. Prior to 2005, potential femoral head donors were identified and consented in the hospital setting on the day of surgery. This resulted in over 40 % of donations failing post operatively suggesting that more effort could be given to pre-operative screening resulting in substantial savings in the cost associated with collection and testing of donors who were subsequently failed. The Donor Liaison role was implemented in 2005 to coordinate a Femoral Head Donation program maximising the number of successful donations through pre-operative screening. This study reviews the effectiveness of pre-operative screening of potential femoral head donors at PlusLife from 2002-2012. A retrospective audit of the database was undertaken 2002-2012 and medical/social reasons for pre-operative and postoperative failures were collated into 4 main categories to enable comparison: malignancy, autoimmune conditions, variant Creutzfeldt Jakob disease risk and general medical/social reasons. The number of femoral heads failed post operatively has decreased significantly from 26 % in 2003 to 6 % in 2012. A cost of $121,000 was expended on femoral heads failed post operatively in 2004, as compared to $20,350 in 2012. Donors excluded due to the 4 main categories (medical/social history) were identified pre-operatively in over 80 % of all cases. Preoperative screening of femoral head donors through a coordinated Femoral Head Donation Program is a safe and cost effective method.
Assuntos
Artroplastia de Quadril/economia , Transplante Ósseo/economia , Cabeça do Fêmur/cirurgia , Bancos de Tecidos , Transplante Ósseo/legislação & jurisprudência , Análise Custo-Benefício , Cabeça do Fêmur/patologia , Humanos , Papel do Médico , Estudos Retrospectivos , Bancos de Tecidos/economia , Bancos de Tecidos/legislação & jurisprudência , Austrália OcidentalRESUMO
A calculation grid developed by an international expert group was tested across biobanks in six countries to evaluate costs for collections of various types of biospecimens. The assessment yielded a tool for setting specimen-access prices that were transparently related to biobank costs, and the tool was applied across three models of collaborative partnership.
Assuntos
Pesquisa Biomédica/economia , Comércio/economia , Manejo de Espécimes/economia , Bancos de Tecidos/economia , Pesquisa Biomédica/organização & administração , Orçamentos , Comércio/organização & administração , Comportamento Cooperativo , Análise Custo-Benefício , Europa (Continente) , Humanos , Modelos Econômicos , Modelos Organizacionais , Bancos de Tecidos/organização & administração , Fluxo de TrabalhoAssuntos
Pesquisa Biomédica/economia , Encefalopatias , Encéfalo , Ensaios Clínicos como Assunto/economia , Apoio à Pesquisa como Assunto , Encefalopatias/diagnóstico , Encefalopatias/prevenção & controle , Encefalopatias/terapia , Ensaios Clínicos como Assunto/tendências , Humanos , National Institute of Neurological Disorders and Stroke (USA) , Prevenção Primária/tendências , Bancos de Tecidos/economia , Estados UnidosRESUMO
High quality human biospecimens, such as tissue, blood, cell derivatives, and associated patient clinical information, are key elements of a scientific infrastructure that supports discovery and identification of molecular biomarkers and diagnostic agents. The goal of most biorepositories is to collect, process, store, and distribute human biospecimen for use in basic, translational and clinical research. A biorepository serving as the central hub provides investigators with an invaluable resource with appropriately examined and characterized biospecimens with associated patient clinical information. Expertise in standardization, quality control, and information technology, and awareness of cutting edge research developments are generally required for biorepository development and management. The availability of low cost whole genome profiles of individual tumors has opened up new possibilities for personalized medicine to deliver the most appropriate treatments to individual patients with minimal toxicity. A biorepository in support of personalized medicine thus requires the highest standards of operation and adequate funding, training and certification. This review provides an overview of the development of an institutional cancer biorepository for clinical research and personalized medicine advancement.
Assuntos
Biomarcadores Tumorais/genética , Neoplasias/genética , Medicina de Precisão , Manejo de Espécimes/normas , Bancos de Tecidos/organização & administração , Pesquisa Biomédica/organização & administração , Genoma Humano , Humanos , Achados Incidentais , Consentimento Livre e Esclarecido , Neoplasias/diagnóstico , Neoplasias/patologia , Controle de Qualidade , Estabilidade de RNA , Bancos de Tecidos/economia , Bancos de Tecidos/éticaRESUMO
Macedonia is a small country, and the current state has been independent for only 22 years. Medical research, which requires an extensive infrastructure, has been limited. We describe our experience in developing Macedonian research through a mutually beneficial collaboration between institutions in Macedonia and the United States.
Assuntos
Pesquisa Biomédica/economia , Encéfalo/patologia , Comportamento Cooperativo , Países Desenvolvidos/economia , Países em Desenvolvimento/economia , Cooperação Internacional , Psiquiatria/economia , Apoio à Pesquisa como Assunto/economia , Bancos de Tecidos/economia , Pesquisa Biomédica/organização & administração , Humanos , Psiquiatria/organização & administração , República da Macedônia do Norte , Apoio à Pesquisa como Assunto/organização & administração , Manejo de Espécimes/economia , Bancos de Tecidos/organização & administração , Estados UnidosRESUMO
OBJECTIVE: To estimate the current availability of donor cryopreserved oocytes and to describe the emerging phenomenon of commercial egg banks (CEBs) in the United States. DESIGN: Cross-sectional survey of CEBs. SETTING: E-mail, telephone, and fax survey of all CEB scientific directors, conducted April 2012. PATIENT(S): None. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Number and location of CEBs in the United States, years in existence, number of donors, number of available oocytes, level of donor anonymity, donor screening, cost of oocytes to recipients, freezing/thawing technique, pregnancy statistics. RESULT(S): Seven CEBs were identified and surveyed (response rate: 100%). The CEBs used three distinct operational models, had been in existence for a median of 2 years (range: 1 to 8 years), with a median 21.5 (range: 6 to 100) donors and 120 (range: 20 to 1,000) currently available oocytes. The median recommended minimum number of eggs to obtain was six (range: four to seven), at an estimated mean cost per oocyte of $2,225 (range: $1,500 to $2,500). An estimated 3,130 oocytes from 294 donors are currently stored for future use. Of these CEBs, 6 (86%) of 7 use vitrification as cryopreservation method. To date, 8,780 frozen donor oocytes from CEBs have been used for in vitro fertilization, resulting in 602 pregnancies. Pregnancy rates per oocyte, available for 5 (71%) of 7 CEBs, were 532 (7.5%) of 7,080 for CEBs using vitrification and 70 (10%) of 700 for the single CEB using slow freezing as cryopreservation method. CONCLUSION(S): Frozen donor eggs are currently widely available in the United States. Three different operational models are currently used, resulting in more than 600 pregnancies from oocytes obtained at CEBs. The majority of CEBs use vitrification as cryopreservation technique.
Assuntos
Doação de Oócitos/economia , Oócitos , Medicina Reprodutiva/economia , Medicina Reprodutiva/organização & administração , Bancos de Tecidos/economia , Bancos de Tecidos/organização & administração , Comércio , Estudos Transversais , Criopreservação , Feminino , Humanos , Doação de Oócitos/estatística & dados numéricos , Gravidez , Taxa de Gravidez , Medicina Reprodutiva/estatística & dados numéricos , Bancos de Tecidos/estatística & dados numéricos , Doadores de Tecidos/provisão & distribuição , Estados Unidos/epidemiologiaRESUMO
The number of biobanks, in particular hospital-integrated tumor biobanks (HITB), is increasing all around the world. This is the consequence of an increase in the need for human biological resources for scientific projects and more specifically, for translational and clinical research. The robustness and reproducibility of the results obtained depend greatly on the quality of the biospecimens and the associated clinical data. They also depend on the number of patients studied and on the expertise of the biobank that supplied the biospecimens. The quality of a research biobank is undoubtedly reflected in the number and overall quality of the research projects conducted with biospecimens provided by the biobank. Since the quality of a research project can be measured from the impact factor of resulting publications, this also provides some indication of the quality of a research biobank. It is necessary for the biobank community to define "surrogate" quality indicators, and to establish systems of evaluation in relation to current and future resource requirements. These indicators will help in the realistic assessment of biobanks by institutions and funding bodies, and they will help biobanks demonstrate their value, raise their quality standards, and compete for funding. Given that biobanks are expensive structures to maintain, funding issues are particularly important, especially in the current economic climate. Use of performance indicators may also contribute to the development of a biobank impact factor or "bioresource research impact factor" (BRIF). Here we review four major categories of indicators that appear to be useful for the evaluation of a(m) HITB (quality, activity, scientific productivity, and "visibility"). In addition, we propose a scoring system to measure the chosen indicators.
Assuntos
Bancos de Tecidos/organização & administração , Bancos de Tecidos/normas , Pesquisa Translacional Biomédica , Hospitais , Humanos , Fator de Impacto de Revistas , Controle de Qualidade , Bancos de Tecidos/economiaRESUMO
The consent process involves three steps; referral for contact, preliminary interview, and informed consent discussion. We propose that the efficiency and frequency of the consent process for individual biobank related projects increases when the referral for contact is conducted by an independent "Permission to Contact" (PTC) platform within a health research organization. A PTC platform established at our center in 2007 obtains "permission to be contacted about future cancer research" from approximately 1200 patients annually. With ethics board approval, the British Columbia (BC) Cancer Agency's Tumour Tissue Repository (TTR) deployed a post-procedure consent protocol designed to obtain initial referrals from the PTC platform. This protocol was initially deployed for breast and gastrointestinal (GI) cancer patients (48% of patients), and later expanded as an option for all patients. We examined the impact on biobank accrual over a 4-year period spanning implementation of the post-procedure protocol. Within the first 2 years, while deploying an existing pre-procedure consent protocol, the TTR received, on average, 38.5 referrals/month, and consented 36.5 patients/month. Over the next 24 months, referral and consent rates increased to 68.5/month and 45.6/month, respectively, while operating both pre-procedure and post-procedure protocols. This represents a significant increase in overall referrals (1.78 fold) and consented patients (1.25 fold). For breast and GI cancer patients, referrals and consents, increased even further (2.4 and 1.6 fold, respectively). Overall, the consented/declined/unknown decision rates in the first period were 95.3%/1.2%/3.5% (n=918 approached patients), while rates in the second period were 86%/2.3%/11.7% (n=1272 approached patients). Overall, consent process costs fell by 14% per case. Patient engagement can be positively influenced by connecting a biobank with a PTC platform enhancing efficiency in obtaining consent, which is a key determinant of tumor biobank costs.
Assuntos
Consentimento Livre e Esclarecido/estatística & dados numéricos , Bancos de Tecidos/economia , Bancos de Tecidos/normas , Pesquisa Biomédica , Colúmbia Britânica , Feminino , Humanos , Consentimento Livre e Esclarecido/psicologia , Neoplasias , Encaminhamento e ConsultaRESUMO
With this analysis we would like to raise some issues that emerge as a result of recent evolutions in the burgeoning field of human cells, tissues, and cellular and tissue-based product (HCT/P) transplantation, and this in the light of the current EU regulatory framework. This paper is intended as an open letter addressed to the EU policy makers, who will be charged with the review and revision of the current legislation. We propose some urgent corrections or additions to cope with the rapid advances in biomedical science, an extensive commercialization of HCT/Ps, and the growing expectation of the general public regarding the ethical use of altruistically donated cells and tissues. Without a sound wake-up call, the diverging interests of this newly established 'healthcare' industry and the wellbeing of humanity will likely lead to totally unacceptable situations, like some of which we are reporting here.